Fakultaet fuer Chemie und Mineralogie

Welcome to the Homepage of the Schneider Research Group

Recent Publications

M. Schlegel, P. Coburger, C. Schneider
"A Novel Sc(OTf)3-Catalyzed (2+2+1)-Cycloannulation/Aza-Friedel-Crafts Alkylation Sequence toward Multicyclic 2-Pyrrolines"
Chem. Eur J. 201823, in press. Read this publication

M. Schlegel, C. Schneider
"Rapid Construction of Complex 2-Pyrrolines through Lewis Acid-Catalyzed, Sequential Three-Component Reactions via in situ-Generated 1-Azaallyl Cations"
Org Lett. 201820, 3119-3123. Read this publication

M. Kretzschmar, F. Hofmann, D. Moock, C. Schneider
"Intramolecular Aza Diels-Alder Reactions of ortho-Quinone Methide Imines – Rapid, Catalytic, and Enantioselective Assembly of Benzannulated Quinolizidines"
Angew. Chem. 2018, 130, 4864-4868. Read this publication
Angew. Chem. Int. Ed. 2018574774-4778Read this publication

J. Appun, F. Stolz, S. Naumov, B. Abel, C. Schneider
"Modular Synthesis of Dipyrroloquinolines – A Combined Synthetic and Mechanistic Study"
J. Org. Chem. 2018, 83, 1737-1744. Read this publication

S. A. Pfeiffer, B. M. Rudisch, P. Glaeser, M. Spanka, F. Nitschke, A. A. Rubitzki, C. Schneider, S. Nagl, D. Belder
"Continuous purification of reaction products by micro free-flow electrophoresis enabled by large area deep-UV fluorescence imaging"
Anal. Bioanal. Chem. 2018, 410, 853-862. Read this publication

C. Schneider, M. Sickert
"The Mannich Reaction"
Science of Synthesis Knowledge Updates (M. Christmann, Ed.), Georg Thieme Verlag KG 2017/3, 315.
ISBN: 978-3-13-241419-8
DOI:
10.1055/sos-SD-140-00225

K. Gebauer, F. Reuß, M. Spanka, C. Schneider
"Relay Catalysis: Manganese(III) Phosphate-Catalyzed Asymmetric Addition of β-Dicarbonyls to ortho-Quinone Methides Generated by Catalytic Aerobic Oxidation"
Org. Lett. 2017, 19, 4588-4591. Read this publication
Highlighted in Synfacts 2018, 14, 63. Read this publication

J. Appun, M. Boomhoff, P. Hoffmeyer, I. Kallweit, M. Pahl, D. Belder, C. Schneider
"A New and Highly Stereoselective Synthesis of Tetrahydrofurans"
Angew. Chem. 2017, 1296862-6865. Read this publication
Angew. Chem. Int. Ed. 2017, 566758-6761. Read this publication
Highlighted in CHEMIE.DE 2017. Read this publication
Highlighted in Synfacts 2017, 13, 795. Read this publication
Official press release of the University Leipzig, 14.06.2017, 141/2017. Read this publication

M. Schlegel, C. Schneider
"Lewis Acid-Catalyzed Nucleophilic Addition of Indoles to in situ-Generated 2-Amidoallyl Cations"
J. Org. Chem. 2017, 82, 5986-5992. Read this publication

S. Schulze, M. Pahl, F. Stolz, J. Appun, B. Abel, C. Schneider, D. Belder
"Liquid beam desorption mass spectrometry for the investigation of continuous flow reactions in microfluidic chips"
Anal. Chem. 2017, 89, 6175-6181. Read this publication

T. Hodik, C. Schneider
"Brønsted Acid-Catalyzed, Enantioselective Synthesis of 1,4-Dihydroquinoline-3-Carboxylates via In Situ Generated ortho-Quinone Methide Imines"
Org. Biomol. Chem. 2017, 15, 3706-3716. Read this publication

B. Abel, F. Stolz, J. Appun, S. Naumov, C. Schneider
"A complex catalytic reaction caught in the act: Intermediates and products online by liquid µ-beam mass spectrometry and theoretical modeling"
ChemPlusChem. 2017, 81, 233-240. Read this publication

C. Weilbeer, M. Sickert, S. Naumov, C. Schneider
"The Brønsted Acid-Catalyzed, Enantioselective Aza-Diels-Alder Reaction for the Direct Synthesis of Chiral Piperidones"
Chem. Eur. J. 2017, 23, 513-518. Read this publication

K. Gebauer, C. Schneider
"The First Organocatalytic Cope Rearrangement (Highlight)"
Angew. Chem. 2016, 128, 14416-14417. Read this publication
Angew. Chem. Int. Ed. 2016, 55, 14208-14209Read this publication

K. Bera, C. Schneider
"Brønsted Acid Catalyzed [3+2]-Cycloaddition of Cyclic Enamides with in Situ Generated 2-Methide-2H-indoles — Enantioselective Synthesis of Indolo[1,2-a]indoles"
Org. Lett. 2016, 18, 5660-5663. Read this publication

M. Kretzschmar, T. Hodik, C. Schneider
"Brønsted Acid Catalyzed Addition of Enamides to ortho-Quinone Methide Imines — An Efficient and Highly Enantioselective Synthesis of Chiral Tetrahydroacridines"
Angew. Chem. 2016, 128, 9941-9946. Read this publication
Angew. Chem. Int. Ed. 2016, 55, 9788-9792. Read this publication
Highlighted in Synfacts 2016, 12, 970. Read this publication

K. Bera, C. Schneider
"Brønsted Acid Catalyzed [3+2]-Cycloaddition of 2-Vinylindoles with In Situ Generated 2-Methide-2H-indoles — Highly Enantioselective Synthesis of Pyrrolo[1,2-a]indoles"
Chem. Eur. J. 2016, 22, 7074-7078. Read this publication

S. K. Alamsetti, M. Spanka, C. Schneider
"Synergistic Rhodium/Phosphoric Acid-Catalysis for the Enantioselective Additon of Oxonium Ylides to ortho-Quinone Methides"
Angew. Chem. 2016, 128, 2438-2442. Read this publication
Angew. Chem. Int. Ed. 2016, 55, 2392-2396.Read this publication
Highlighted in Synfacts 2016, 12, 376. Read this publication

V. A. Nikolaev, J. J. Medvedev, O. S. Galkina, K. V. Azarova, C. Schneider
"Unusual reactions of diazocarbonyl compounds with α,β-unsaturated δ-amino esters: Rh(II)-catalyzed Wolff rearrangement and oxidative cleavage of N–H-insertion products"
Beilstein J. Org. Chem 2016, 12, 1904-1910. Read this publication

C. Lindemann, C. Schneider
"Quinolizidine-Based Alkaloids – A General Catalytic, Highly Enantio- and Diastereoselective Synthetic Approach"
Synthesis 2016, 48, 828-844. Read this publication

P. R. Nareddy, C. Schneider
"A Highly Enantioselective, Organocatalytic [3+2]-Cycloannulation Reaction towards the de novo-Synthesis of 1-Cyclopentenyl-α-Keto Esters"
Chem. Commun. 2015, 51, 14797-14800. Read this publication
Comment in "Organocatalyzed C-C Ring Construction" 2016. Read this publication

C. Dietze, T. Scholl, S. Ohla, J. Appun, C. Schneider, D. Belder
"Rapid prototyping of microfluidic chips for dead-volume-free MS coupling"
Anal. Bioanal. Chem. 2015, 29, 8735-8743. Read this publication

M. Boomhoff, R. Ukis, C. Schneider
"A Highly Stereocontrolled, One-Pot Approach towards Pyrrolobenzoxazinones and Pyrroloquinazolinones through a Lewis Acid-Catalyzed [3+2]-Cycloannulation Process"
J. Org. Chem. 2015, 80, 8236-8244. Read this publication

J. J. Medvedev, M. V. Meleshina, T. L. Panikorovskii, C. Schneider, V. A. Nikolaev
"Domino Reactions of Diazodicarbonyl Compounds with α,β-Unsaturated-δ-Amino Esters: Convenient Way Towards 2-Oxopiperidines, Dihydropyridinones, and Isoquinolinediones"
Org. Biomol. Chem. 2015, 13, 9107-9117. Read this publication

C. Benz, M. Boomhoff, J. Appun, C. Schneider, D. Belder
"Chip-Based Free-Flow Electrophoresis with Integrated Nanospray Mass-Spectrometry"
Angew. Chem. 2015, 127, 2805–2809. Read this publication
Angew. Chem. Int. Ed. 2015, 54, 2766–2770. Read this publication

S. Saha, C. Schneider
"Directing Group Assisted Nucleophilic Substitution of Propargylic Alcohols via o-Quinone Methide Intermediates: Brønsted Acid Catalyzed, Highly Enantio- and Diastereoselective Synthesis of 7-Alkynyl-12a-acetamido-Substituted Benzoxanthenes"
Org. Lett. 2015, 17, 648–651. Read this publication

S. Saha, S. K. Alamsetti, C. Schneider
"Chiral Brønsted Acid-Catalyzed Friedel-Crafts Alkylation of Electron-Rich Arenes with in situ-Generated Ortho-Quinone Methides: Highly Enantioselective Synthesis of Diarylindolylmethanes and Triarylmethanes"
Chem. Commun 2015, 51, 1461–1464. Read this publication

S. Saha, C. Schneider
"Brønsted Acid-Catalyzed, Highly Enantioselective Addition of Enamides to in situ-Generated Ortho-Quinone Methides – A Domino Approach Towards the Direct Synthesis of Complex Acetamidotetrahydroxanthenes"
Chem. Eur J. 2015, 21, 2348–2352. Read this publication

J. J. Medvedev, O. S. Galkina, A. A. Klinkova, D. S. Giera, L. Hennig, C. Schneider, V. A. Nikolaev
"Domino [4 + 1]-annulation of α,β-unsaturated δ-amino esters with Rh(II)–carbenoids – a new approach towards multi-functionalized N-aryl pyrrolidines"
Org. Biolmol. Chem. 2015, 13, 2640–2651. Read this publication

M. Boomhoff, A. K. Yadav, J. Appun, C. Schneider
"Modular, Flexible, and Stereoselective Synthesis of Pyrroloquinolines – Rapid Assembly of Complex Heterocyclic Scaffolds"
Org. Lett. 2014, 16, 6236–6239. Read this publication

M. C. Pischl, C. F. Weise, S. Haseloff, M.-A. Müller, A. Pfaltz, C. Schneider
"A Highly Stereoselective and Flexible Strategy for the Convergent Synthesis of Long-Chain Polydeoxypropionates – Application towards the Synthesis of the Glycolipid Membrane Components Hydroxyphthioceranic and Phthioceranic Acid"
Chem. Eur. J. 2014, 20, 17360–17374. Read this publication

O. El-Sepelgy, S. Haseloff, S.K. Alamsetti, C. Schneider
"Brønsted Acid-Catalyzed, Conjugate Addition of β-Dicarbonyls to in situ Generated ortho-Quinone Methides – Enantioselective Synthesis of 4 Aryl-4H-Chromenes"
Angew. Chem. 2014, 126, 8057-8061. Read this publication
Angew. Chem. Int. Ed. 2014, 53, 7923-7927. Read this publication
Highlighted in Synfacts 2014, 10, 985. Read this publication

C. Schneider, F. Abels
"Catalytic, Enantioselective Vinylogous Michael Reactions" (Review)
Org. Biomol. Chem. 2014, 12, 3531-3543. Read this publication

F. Abels, C. Lindemann, C. Schneider
"A General Strategy for the Catalytic, Highly Enantio- and Diastereoselective Synthesis of Indolizidine-Based Alkaloids"
Chem. Eur. J. 2014, 20, 1964-1979. Read this publication

S. Basu, V. Gupta, J. Nickel, C. Schneider
"Organocatalytic Enantioselective Vinylogous Michael Reaction of Vinylketene Silyl-N,O-Acetals"
Org. Lett. 2014, 16, 274-277. Read this publication

C. Schneider, C. Weise
"Cope, Oxy-Cope, and Anionic Oxy-Cope Rearrangements"
Comprehensive Organic Synthesis 2nd Edition (G. Molander, P. Knochel, Eds.), Pergamon Press 2014, Vol. 5, 867-911.

C. Schneider, M. Boomhoff
"Aldol Reactions in Domino Processes"
Domino Reactions - Concepts for Efficient Organic Synthesis, (L.F. Tietze, Ed.), Wiley-VCH 2014, 267-294.

M. C. Pischl, C. F. Weise, M.-A. Müller, A. Pfaltz, C. Schneider
"A Convergent and Stereoselective Synthesis of the Glycolipid Components Phthioceranic Acid and Hydroxyphthioceranic Acid"
Angew. Chem. 2013, 125, 9138-9142. Read this publication
Angew. Chem. Int. Ed. 2013, 52, 8968-8972. Read this publication

S. Peruncheralathan, S. Aurich, H. Teller, C. Schneider
"The Ti-BINOLate-Catalyzed, Enantioselective Ring-Opening of meso-Aziridines with Amines"
Org. Biomol. Chem. 2013, 11, 2787-2803. Read this publication

V. Gupta, S. Sudhir V., T. Mandal, C. Schneider
"Organocatalytic, Highly Enantioselective, Vinylogous Mukaiyama-Michael Reaction of Acyclic Dienolsilyl Ethers"
Angew. Chem. 2012, 124, 12778-12781. Read this publication
Angew. Chem. Int. Ed. 2012, 51, 12609-12612. Read this publication
Highlighted in Synfacts 2013, 9, 95. Read this publication
Comment: http://www.organic-chemistry.org/Highlights/2013/08July.shtm

F. Abels, C. Lindemann, E. Koch, C. Schneider
"A General Organocatalytic Approach toward the Enantioselective Total Synthesis of Indolizidine Based Alkaloids"
Org. Lett. 2012, 14, 5972-5975. Read this publication
Comment: http://www.organic-chemistry.org/Highlights/2013/22April.shtm

M. Boomhoff, C. Schneider
"A Novel 3-Component [3+2]-Cycloannulation Process for the Rapid and Highly Stereoselective Synthesis of Pyrrolobenzoxazoles"
Chem. Eur. J. 2012, 18, 4185-4189. Read this publication
Highlighted in Synfacts 2012, 8, 606. Read this publication

C. F. Weise, M. Pischl, A. Pfaltz, C. Schneider
"A General, Asymmetric, and Non-Iterative Synthesis of Trideoxypropionates. Straightforward Syntheses of the Pheromones (+)-Vittatalactone and (+)-Norvittatalactone"
J. Org. Chem. 2012, 77, 1477-1488. Read this publication

A. Marti, S. Peruncheralathan, C. Schneider
„Cationic Late Transition Metal Complexes Catalyze the Ring-Opening of meso-Aziridines with Amines”
Synthesis 2012, 44, 27-36. Read this publication

C. F. Weise, F. Richter, S. Immel, C. Schneider
„The Oxy-Cope Rearrangement of Aldol Products - A Combined Experimental and Theoretical Study”
Eur. J. Org. Chem. 2012, 1520-1529. Read this publication

S. Ohla, R. Beyreiss, S. Fritzsche, P. Gläser, S. Nagl, K. Stockhausen, C. Schneider, D. Belder
„Monitoring on-Chip Pictet-Spengler Reaction by Integrated Analytical Separation and Label-Free Time-Resolved Fluorescence”
Chem. Eur. J. 2012, 18, 1240-1246. Read this publication

F. Abels, C. Schneider
„A Modified and Highly Useful Protocol for the Bronsted Acid-Catalyzed, Enantioselective, Vinylogous Mannich Reaction with Aliphatic Aldimines”
Synthesis 2011, 4050-4058. Read this Publication
Comment: http://www.organic-chemistry.org/Highlights/2012/30July.shtm

S. Fritzsche, S. Ohla, P. Gläser, D. S. Giera, M. Sickert, C. Schneider, D. Belder
„Asymmetrische Organokatalyse und Analyse in einem mikrofluidschen Nanospray-Chip”
Angew. Chem. 2011, 123, 9639-9642. Read this Publication
Angew. Chem. Int. Ed. 2011, 50, 9467-9470. Read this Publication
Highlighted in Chem. Unserer Zeit 2011, 45, 370. Read this Publication

B. M. Ruff, S. Zhong, M. Nieger, M. Sickert, C. Schneider, S. Bräse
„A. Combined Asymmetric Vinylogous Mannich/Diels-Alder Approach for the Stereoselective Synthesis of Highly Functionalized Hexahydroindoles”
Eur. J. Org. Chem. 2011, 6558-6566. Read this Publication

A. Marti, L. Richter, C. Schneider
„Iron-Catalyzed Ring-Opening of meso-Aziridines with Amines”
Synlett 2011, 2513-2516. Read this Publication
Abstract: http://www.organic-chemistry.org/abstracts/lit3/426.shtm

C. F. Weise, M. Pischl, A. Pfaltz, C. Schneider
„A Non-Iterative, Flexible, and Highly Stereoselective Synthesis of Polydeoxypropionates – Synthesis of Vittatalactone”
Chem. Commun. 2011, 47, 3248-3250. Read this Publication

D. S. Giera, C. Schneider
"InCl3-Catalyzed Allylic Friedel-Crafts Reactions towards the Stereocontrolled Synthesis of 1,2,3,4-Tetrahydroquinolines"
Org. Lett. 2010, 12, 4884.  Read this Publication

H. Schönherr, J. Mollitor, C. Schneider
"A Chemoenzymatic Approach to the Stereocontrolled Synthesis of the C1-C11-Fragment of (+)-Peloruside A"
Eur. J. Org. Chem. 2010, 3908.  Read this Publication

C. Schneider, M. Sickert
"Catalytic, Enantioselective Vinylogous Mannich Reactions in Chiral Amine Synthesis, Methods, Developments and Applications (T. Nugent, Ed.)"
Wiley-VCH, Weinheim 2010, 157.

M. Sickert, F. Abels, M. Lang, J. Sieler, C. Birkemeyer, C. Schneider
"The Brønsted Acid-Catalyzed, Enantioselective Vinylogous Mannich Reaction"
Chem. Eur. J. 2010, 16, 2806.  Read this Publication

S. Ghosh, M. V. Nandakumar, H. Krautscheid, C. Schneider
"Copper-Bipyridine-Catalyzed Enantioselective a-Amination of ß-Keto Esters"
Tetrahedron Lett. 2010, 51, 1860.  Read this Publication

M. V. Nandakumar, S. Ghosh, C. Schneider
"Enantioselective Synthesis of a Novel Chiral 2,9-Disubstituted 1,10-Phenanthroline and First Applications in Asymmetric Catalysis"
Eur. J. Org. Chem. 2009, 6393.  Read this Publication

C. Enkisch, C. Schneider
"Sequential Mannich-aza-Michael Reaction for the Stereodivergent Synthesis of Highly Substituted Pyrrolidines"
Eur. J. Org. Chem. 2009, 5549.  Read this Publication

D. S. Giera, M. Sickert, C. Schneider
"A Straightforward Synthesis of (-)-Anabasine through the Catalytic, Enantioselective, Vinylogous Mannich Reaction"
Synthesis 2009, 3797. Read this Publication

S. Peruncheralathan, H. Teller, C.Schneider
"Ti-BINOLat-katalysierte Aminolyse von meso-Aziridinen - ein hochenantioselektiver und direkter Zugang zu 1,2-Diaminen"
Angew. Chem. 2009, 121, 4943.  Read this Publication
Angew. Chem. Int. Ed. 2009, 48, 4849.  Read this Publication
Highlighted in Synfacts 2009, 873. Read this Publication

C. Schneider
"Katalytische, enantioselektive Ringöffnungen von Aziridinen"
Angew. Chem. 2009, 121, 2116.  Read this Publication
Angew. Chem. Int. Ed. 2009, 48, 2082. Read this Publication

D. S. Giera, M. Sickert, C. Schneider
"Brønsted Acid-Catalyzed, Enantioselective, Vinylogous Mannich Reaction of Vinylketene Silyl N,O-Acetals"
Org. Lett. 2008, 10, 4259.  Read this Publication

S. Khaliel, M. V. Nandakumar, H. Krautscheid, C. Schneider
"Organocatalytic Domino Mannich Aza-Michael Reactions towards the Stereoselective Synthesis of Highly Substituted Pipecolic Esters"
Synlett 2008, 2705.  Read this Publication

E. Mai, C. Schneider
"Catalytic, enantioselective synthesis of Boc-protected 1,2-amino alcohols through aminolysis of meso-epoxides with benzophenone imine"
Arkivoc 2008, 9, 216.  Read this Publication

M. Sickert, C. Schneider
"Enantioselektive, Brønstedt-Säure-katalysierte, vinyloge Mannich-Reaktion"
Angew. Chem. 2008, 120, 3687.  Read this Publication
Angew. Chem. Int. Ed. 2008, 47, 3631.  Read this Publication
Highlighted in Synfacts 2008, 756. Read this Publication

A. Tschöp, M. V. Nandakumar, O. Pavlyuk, C. Schneider
"Scandium-Bipyridine-Catalyzed Selenol Addition to Aromatic meso-Epoxides"
Tetrahedron Lett. 2008, 49, 1030.  Read this Publication

S. Peruncheralathan, M. Henze, C. Schneider
"Indium(III) Chloride-Catalyzed Thiolysis of meso-Aziridines"
Tetrahedron Lett. 2007, 48, 6743.  Read this Publication

S. Peruncheralathan, M. Henze, C. Schneider
"Sc(OTf)3-Catalyzed Aminolysis of meso-Aziridines"
Synlett 2007, 2289.  Read this Publication

E. Mai, C. Schneider
"Indium-Bipyridine-Catalyzed, Enantioselective Aminolysis of meso-Epoxides"
Synlett 2007, 2136.  Read this Publication

M.V.Nandakumar, A. Tschöp, H. Krautscheid, C. Schneider
"Indium-Bipyridine-Catalyzed, Enantioselective Thiolysis of meso-Epoxides"
Chem. Commun. 2007, 2756.  Read this Publication
Highlighted in Synfacts 2007, 960. Read this Publication

F. Jakob, C. Schneider
"Enzyme-Catalyzed Kinetic Resolution of 1,3-Anti-Diol Monoesters. Efficient Preparation of Enantiomerically Highly Enriched and Unsymmetrically Substituted 1,3-Anti-Diols"
Eur. J. Org. Chem. 2007, 2958.  Read this Publication

A. Tschöp, A. Marx, A.R. Sreekanth, C. Schneider
"Scandium-Bipyridine-Catalyzed, Enantioselective Alcoholysis of meso-Epoxides"
Eur. J. Org. Chem. 2007, 2318.  Read this Publication

N. Remme, K. Koschek, C. Schneider
"Scandium-Triflate-Catalyzed Transesterification of Carboxylic Esters"
Synlett 2007, 491.  Read this Publication

E. Mai, C. Schneider
"The Scandium-Bipyridine-Catalyzed, Enantioselective Aminolysis of Meso-Epoxides"
Chem. Eur. J. 2007, 13, 2729.  Read this Publication