Cell Techniques and Applied Stem Cell Biology  

Shibashish Giri


Dr. rer. nat. Shibashish Giri


Address: Deutscher Platz 5, Room 1.202
04103 Leipzig
Phone: 0341 97- 31 353
Fax: 0341 97- 31 359
E-Mail: shibashish.giri@bbz.uni-leipzig.de

Current activity

Creating human induced pluripotent stem cells using chemical compounds, minicircle DNA, Sendai virus, Disease modelling

Bioartificial liver support, hepatic differentiation, drug metabolism, hepatotoxicity assessments. Scar less healing mechanism, Generation of insulin producing cells, Cardiac differentiation. 2D and 3D image analysis.



1995 -1998

B.Sc (Zoology Hons), Botany, Chemistry. Best Graduate Award for Rairangpur, College (Autonomous), Utkal University, India

1999 - 2001


M.Sc in Zoology with specialization in Cytogenetics from North Orissa University, India

2002 - 2003

M. Phil in Zoology form University of Delhi, India


PhD thesis with the topic "Bioreactor development for hepatocyte culture model, stem cell expansion and efficient hepatic differentiation using self assembling peptides"

Research Experiences and Professional Memberships

since 2008 

Member of the Biomedical-Biotechnological Center, Professorship of Cell Technology and Applied Stem Cell Biology, Medical Faculty, Universität  Leipzig

Dec. 2004 - Oct. 2007 

Researcher in Applied Microbiology Lab, Center for Rural Development and Technology, IIT, Delhi, India

May 2004 - May 2006

Part Time as a Team leader (India) for Tico Tours™ a U.S. based birding tour company.

May 2004 -June 2004

Short Term training Programme in “Genetics and Molecular techniques in Fisheries” from Central Institute of Fisheries Education, Mumbai

Nov 2002 - May 2004

Senior research fellow (SRF) on ICAR research project titled “Molecular mechanisms of egg hardening and egg organization in fish” from Department of Zoology, University of Delhi, Delhi. India


Senior Research fellowship (ICAR, Govt of India) in University of Delh


Certificate of appreciation for assistance CPDHE sponsored Refresher course on current trends in Physiology from Department of zoology, University of Delhi


Best graduate student award in  in Rairangpur College (Autonomous), Rairangpur, Orissa, India)



Zeidler R, Freitas Soarez LB, Bader A, Giri S. Molecular epigenetic targets for livers diseases: Current challenges and future prospects. Drug discovery today 2017 Jul 25

Skrzypczyk A, Giri S, Bader A. Generation of induced pluripotent stem cell line from foreskin fibroblasts. Stem Cell Res. 2016 Sep 15;17(3):572-575

Bader A, Hollmann HJ, Storm GR, Kern L, Giri S, Machens HG. 3-D scar-free regeneration of a gangrenous heel in a diabetic patient and complete reversal of neuropathy instead of upper limb amputation with in vivo and in situ cell therapy. Four year follow-up.itted Stem Cells Translational Medicine. Accepted 18.09.14

Bader A, Giri S. Personalized and regenerative medicine for liver diseases. Curr Stem Cell Res Ther. 2016, 11, 692-705, Epub 2015 Oct 26

Guenter IC, Kern L, Giri S, Machens HG , Bader A. First Results on Three Patients Treated with Topical Recombinant Human Erythropoietin (rhEPO) to Improve Wound Healing in Diabetic Foot Ulcers. Journal of Transplantation & Stem Cell Biology, ISSN 2374-9326, Jan 2015, Volume: 2, Issue: 1

Giri S, Acikgöz A, Bader A. Isolation and Expansion of Hepatic Stem-like Cells from a Healthy Rat Liver and their Efficient Hepatic Differentiation of under Well-defined Vivo Hepatic like Microenvironment in a Multiwell Bioreactor. Journal of Clinical and Experimental Hepatoligy. June 2015, Vo. 5, No. 2, 107-122

Giri P, Ebert S, Braumann DU, Kremer M, Giri S, Machens HG, Bader A. Skin Regeneration of Deep Second-degree Scalding Injuries either by Infusion Pumping of rHuEPO or Topical Application of rHuEPO Gel. Drug Design, Development and Therapy. 2015: 9, 2565-2579

Wegener M, Bader A, Giri S. Regenerate hearts using adult stem cells and induced pluripotent stem cells: New challenges on new targets on heart for safer drug development for heart diseases. Drug Discov Today. 2015 Jun;20(6):667-685. Epub 2015 Feb 23. Review.

Heublein H,  Bader A, Giri S. Preclinical and clinical evidence of stem cell therapies for diabetic wounds: Therapeutic targets for regenerating diabetic wounds. Drug Discov Today. 2015 Jun;20(6):703-717. Epub 2015 Jan 17. Review.

Reinhardt M, Giri S, Bader A. Preclinical challenges and clinical target of nanomaterials in regenerative medicine. (Under revision). Book Chapter. Book chapter. Diverse Applications of Nanotechnology in Biomedicine, Chemistry, and Engineering. Advances in Chemical and Materials Engineering. IGI Global Book Series ACME. Hershey, USA 2015, 350-371

Reinhardt M, Bader A, Giri S. Devices for stem cell isolation and delivery: Current need for drug discovery and cell therapy. Review. Expert Review of Medical Devices. 2015 May;12(3):353-64. Epub 2014 Dec 25

Giri S, Bader A. Immortalization of human fetal hepatocyte by ectopic expression of human telomerase reverse transcriptage, human papilloma virus (E7) and simian virus 40 large T (SV40 T) antigen is an important milestone towards bioartificial liver support. J Clin Exp Hepatol. 2014 Sep;4(3):191-201. Epub 2014 Sep 18.

Giri S, Bader A. Low cost and high quality new drug discovery process using patient-derived induced pluripotent stem cells. Drug Discov Today. 2015 Jan;20(1):37-49. Epub 2014 Nov 15.

Giri P, Ebert S, Braumann DU, Kremer M, Giri S, Machens HG, Bader A. Skin Regeneration of Deep Second-degree Scalding Injuries either by Infusion Pumping of rHuEPO or Topical Application of rHuEPO Gel. Cell Regeneration journal, accepted

Acikgöz A, Langsch A, Bader A, Giri S. Potential Interactions of Herbal Extracts of St. John´s Wort with Metabolites of Diazepam in an Organotypical Sandwich Culture of Primary Porcine Hepatocytes. British Journal of Phamaceutical research 4 (15), 1840-1860, 2014

Giri S, Bader A. Shortcut route for generation of functional hepatocyte cells from human skin allogenically for autologous treatment of chronic liver diseases.  Journal of Clinical and Experimental Hepatology, Volume 4, Issue 1, March 2014, Pages 74-78

Giri S, Bader A. Preclinical liver bud engineering towards clinical target for liver diseases. Journal of Clinical and Experimental Hepatology, Volume 4, Issue 1, March 2014, Pages 71-74

Giri S, Bader A. Chemistry, biology and therapeutic potential of bio-molecules for activation, proliferation and commitment of endogenous resident stem cells for cell/tissue/organ repair: A holistic approach to regenerative medicine. Chemical Reviews. Accepted on 19 April 2012

Acikgöz A, Giri S, Cho MG, Bader A. Morphological and Functional Analysis of Hepatocyte Spheroids Generated on Poly-HEMA-Treated Surfaces under the Influence of Fetal Calf Serum and Nonparenchymal Cells. Biomolecules 2013, 3(1), 242-269

Giri S, Braumann UD, Giri P, Acikgöz A, Scheibe P, Nieber K, Bader A. Nanostructured self-assembling peptides as a defined extracellular matrix for long-term functional maintenance of primary hepatocytes in a bioartificial liver modular device. Int J Nanomedicine. 2013;8:1525-39. Epub 2013 Apr 18

Giri S, Bader A. Engineering biomimetic microenvironment using biomaterials, soluble signals for ex vivo expansion and differentiation of stem cells: Strategic challenges for creation of clinical grades for stem cell therapy. In: Biomaterials for Stem Cell Therapy: State of Art and Vision for the Future. CRC Press. Taylor & Francis Group, January 15, 2013. 279-316, Editor DeBartolo L, Bader A.

Bader A, Ebert S, Giri S, Kremer M, Liu S, Nerlich A, Guenter C, Smith D, Machens H-G. Skin regeneration with conical and hair follicle structure of deep second degree scalding injuries via combined expression of EPO receptor and beta common receptor by local subcutaneous injection of nanosized rhEPO. Int J Nanomedicine. 2012;7:1227-37. Epub 2012 Mar 6

Giri S, Acikgöz A, Pathak P, Gutschker S, Krusten A, Nieber K, Bader A. Three Dimensional Cultures of Rat Liver Cells Using a Natural Self-assembling Nanoscaffold in a Clinically Relevant Bioreactor for Bioartificial Liver Construction: J Cell Physiol. 2012 Jan;227(1):313-27.

Giri S, Bader A. Improved Preclinical Safety Assessment using Micro-BAL Devices: The Potential Impact on Human Discovery and Drug Attrition. Drug Discov Today. 2011 May;16(9-10):382-97. Epub 2011 Feb 24

Bader A
, Lorenz K, Richter A, Scheffler K, Kern L, Ebert S, Giri S, Behrens M, Dornseifer U, Macciarini P, Machens HG. Role of trauma cytokines and erythropoietin and its therapeutic potential for acute and chronic wounds. Rejuvenation Research, 2011 Feb;14(1):57-66.

Giri S, Nieber K, Bader A. Hepatotoxicity and hepatic metabolism of available drugs and xenobiotics: current problems and possible solutions in preclinical stages. Expert Opin Drug Metab Toxicol. 2010 Aug;6(8):895-917

Maringka M, Giri S, Nieber K, Açikgöz A, Bader A. Biotransformation of diazepam in a clinical relevant flat membrane bioreactor model using primary porcine hepatocytes. Fundam Clin Pharmacol. 2011 Jun;25(3):343-53. doi: 10.1111/j.1472-8206.2010.00857.x.

Giri S, Nieber K, Bader A. Hepatotoxicity and hepatic metabolism of available drugs and xenobiotics: current problems and possible solutions in preclinical stages. Expert Opin Drug Metab Toxicol. 2010 Aug;6(8):895-917.

Giri S, Weingartz U, Nieber K, Acikgöz A, Bader A. Cryopresvation of primary porcine hepatocyte in organotypical sandwich culture model in a clinical relevent flat membrane bioreactor. Biotechnol Lett. 2010 Jun;32(6):765-71. Epub 2010 Mar 7

Maringka M, Giri S, Bader A. (2009) Preclinical characterization of primary porcine hepatocyte in a clinical relevant flat membrane bioreactor. Biomaterials. 2010 Jan; 31(1):156-72. Epub 2009 Oct 8.

Giri S, Nieber K, Acikgöz A, Pavlica S, Keller M, Bader A. Telomerase activity and hepatic functions of rat embryonic liver progenitor cell in nanoscaffold coated model bioreactor. Mol Cell Biochem. 2009 Oct 9. [Epub ahead of print]

Frühauf JH, Mertsching H; Giri S; Frühauf NR, Bader A. Porcine endogenous retrovirus (PERV) released by a bioartificial liver infects primary human cells (2009) . Liver Int. 2009 Nov;29(10):1553-61. Epub 2009 Aug 14

Langsch A, Giri S, Acikgöz A, Jasmund I, Frericks B, Bader A. Interspecies difference in liver-specific functions and biotransformation of testosterone of primary rat, porcine and human hepatocyte in an organotypical sandwich culture. Toxicology Letters. 2009 Aug 10;188(3):173-9. Epub 2009 Apr 2.

Acikgöz A, Karim N, Giri S, Schmidt-Heck W, Bader A. Two compartment model of diazepam biotransformation in an organotypical culture of primary human hepatocytes.  Toxicololgy and Applied Pharmacology. 2009 Jan 15;234(2):179-91. Epub 2008 Oct 15.Priya Pathak, V. K katiyar and Shibashish Giri. Cancer research - Nanoparticle, Nanobiosensor and their role in Cancer research, Journal of Nanotechnology Online, Vol 3, 1-14, 2007.

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