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Main Research

Technologies

Currently Prof. Hoffmann's research group focusses on biochemical and medical projects. These long-term projects rely on different bioanalytical techniques newly developed technologies and optimized methods.

Research projects financed by grants can be catagorized by the following topics:

1. Antimicrobial Peptides: De-novo sequencing, identification of bacterial target proteins, development of bioactive compounds for the treatment of Gram-negative bacteria, interaction with membranes
   
2. Posttranslational Modifications: Functional, structural and analytical aspects
  • enzymatic modifications: phosphorylation, methylation, glycosylation etc.
  • non-enzymatic modifications: oxidation, glycation and glycoxidation

  • 3. Proteomics und Protein analysis
  • luminescence techniques: time-resolved fluorescence spectroscopy, multiplexing, diagnostics
  • highly sensitive diagnostics: fluorescence techniques, Immuno-PCR
  • separatoion methods: (multi-dimensional) chromatography, electrophoresis und capillary electrophoresis
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    4. Peptide synthesis
  • modified peptides
  • bioactive peptides
  • peptid/peptid- and peptid/protein-ligation
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    12.12.2008 -->12.12.2008