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Dennis Westphal


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Dennis Westphal

PhD Student

Email: dennis.westphal (at) bbz.uni-leipzig.de

Tel. +49 (0) 341 97 31 334


Research project:

My PhD research focuses on the identification of modified Proteins and Lipids in synovial fluid of patients suffering from rheumatoid arthritis, which is an inflammatory autoimmune disease connected with oxidative stress. Thus reactive oxygen species can be formed in an increased amount leading to the modifications of proteins via direct oxidation or reactions with lipid peroxidation products (LPP). The analysis of the highly complex samples is performed by nanoUPLC coupled to high resolution mass spectrometry systems (LTQ Orbitrap XL, Synapt G2 Si).


Education:

2015 – present | PhD study

University of Leipzig, Leipzig, Germany

Thesis title "Analysis of oxidative stress derived modification of proteins and lipids in synovial fluid during rheumathoid arthritis"

2012 – 2015 | Master of science

University of Leipzig, Leipzig, Germany

Thesis title "Optimization of analytical and bioinformatic approaches for LC-MS/MS analysis of carbonylated proteins"

2013             | Semester abroad

Ohio University in Athens, Ohio, USA

2009 – 2012 | Bachelor of science

University of Leipzig, Leipzig, Germany

Thesis title "Characterization of lanthanide dyes"


Publications:

  1. Annibal, A., Riemer, T., Jovanovic, O., Westphal, D., Griesser, E., Pohl, E. E., Schiller, J., Hoffmann, R., and Fedorova, M. (2016) Structural, biological and biophysical properties of glycated and glycoxidized phosphatidylethanolamines. Free radical biology & medicine 95, 293-307.



 
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