Biotechnologisch-Biomedizinisches Zentrum

 



Picture Maria Fedorova

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Dr. Maria Fedorova

Research group leader

Research focus:

Our research aims to understand molecular effects of reactive oxygen and nitrogen species (ROS/RNS) in onset and development of numerous human pathologies including cardiovascular and metabolic diseases (in particular obesity and type 2 diabetes). Elevated ROS/RNS levels result in oxidative modifications of main cellular biomolecules including lipids and proteins.

We are working on development and applications of modern bioanalytical techniques (chromatography and high resolution mass spectrometry) for detection and quantification of low abundant modified lipids and proteins in complex biological samples.

Availability of large multi-Omics datasets in combination with functional biochemical assays allows us to integrate data on oxidized lipids and proteins using systems biology/systems medicine environment in order to understand effects of oxidative modifications in pathogenesis of human disorders.

Currently we are focusing on the three main projects:

"Oxidative protein modifications caused by reactive oxygen and nitrogen species in cell cultures and rat models of hypoxia and nitrosative stress"

Funded by German Research Consul (Deutsche Forschungsgemeinschaft , DFG)

Marie Sklodowska-Curie Actions Innovative Training Network "Mass spectrometry training in protein lipoxidation analysis for inflammation"

Funded by EU, Horizon 2020

"Integration of oxidative stress into systems medicine view for obesity and obesity related complications"

Funded by Federal Ministry of Education and Research (Bundesministerium für Bildung und Forschung, BMBF).

Maria Fedorova´s CV:

2012-present | Research group leader

Center for Biotechnology and Biomedicine, Institute of Bioanalytical Chemistry, Faculty of Chemistry and Mineralogy, University of Leipzig, Germany

2010-2012 | Postdoctoral fellow

Center for Biotechnology and Biomedicine, Institute of Bioanalytical Chemistry, Faculty of Chemistry and Mineralogy, University of Leipzig, Germany

2006-2010 | PhD thesis

Thesis title: "Analysis of protein modifications formed by oxidative stress in vivo"

Center for Biotechnology and Biomedicine, Institute of Bioanalytical Chemistry, Faculty of Chemistry and Mineralogy, University of Leipzig, Germany

2003-2006 | M.Sc. in Biology

Thesis title: "Oxidative modification of actin after action of general X-ray radiation"

Department of Biochemistry, Biology and Soil Science Faculty, St. Petersburg State University, Russia

1999-2004 | B.Sc. in Biology

Thesis title: "Comparative study of glycoxidative modification of alpha- and beta-like actin isoforms"

Department of Biochemistry, Biology and Soil Science Faculty, St. Petersburg State University, Russia


 
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