Biological and Medicinal Chemistry with Inorganic Compounds

  1. Carbaboranes for BNCT
  2. Boron derivatives are important in Boron Neutron Capture Therapy (BNCT) for selective tumour targeting in the presence of healthy cells. Cluster compounds, especially meta- and para-carbaboranes are used to deliver boron to the target cells. Carbaboranes exhibit a high boron content, low toxicity and very high kinetic stability. Additionally, they can be easily incorporated into (bio)chemical structures. New boron compounds are designed by a combination of tumor-targeting strategies: use of phosphonato groups as phosphate mimetics and galactosyl groups that allow specific bonding to lectins on the surface of tumour cells. A further strategy is the incorporation of carbaborane-containing amino acids into carrier peptides.

  3. Carbaboranes as phenyl ring analogues
  4. Besides their three-dimensional aromaticity, carbaboranes also exhibit extremely high hydrophobicity. Therefore, they can be incorporated instead of phenyl groups as pharmacophoric moieties in biologically active structures, e.g., aspirin.
    Asborin

  5. Phosphine-containing amino acids
  6. Phosphine-substituted amino acids are synthesised and coordinated to catalytically active transition metals after incorporation in proteins. The protein pockets should enable stereoselective catalysis.

Institute Colloquia
Graduiertenschule BuildMoNa

Graduiertenschule BuildMoNa
13th Ferrocene Colloquium, 22-24 February 2015