Publications 2022

Anton SE, Kayser C, Maiellaro I, Nemec K, Möller J, Koschinski A, Zaccolo M, Annibale P, Falcke M, Lohse MJ, Bock A
Receptor-associated independent cAMP nanodomains mediate spatiotemporal specificity of GPCR signaling.
Cell 2022; 185(7): 1130-1142
ISSN 0092-8674    
Impact factor: 66.850

Barth LAG, Nebe M, Kalwa H, Velluva A, Kehr S, Kolbig F, Prabutzki P, Kiess W, Le Duc D, Garten A, Kirstein AS
Phospholipid Scramblase 4 (PLSCR4) Regulates Adipocyte Differentiation via PIP3-Mediated AKT Activation.
Int J Mol Sci 2022; 23(17): 9787    
ISSN 1422-0067
Impact factor: 6.208

Bluhm Y, Raudszus R, Wagner A, Urban N, Schaefer M, Hill K    
Valdecoxib blocks rat TRPV2 channels.    
Eur J Pharmacol 2022; 915: 174702    
ISSN 0014-2999    
Impact factor: 5.195

Borchardt H, Kogel A, Kalwa H, Weirauch U, Aigner A
Therapeutic miR-506-3p Replacement in Pancreatic Carcinoma Leads to Multiple Effects including Autophagy, Apoptosis, Senescence, and Mitochondrial Alterations In Vitro and In Vivo.
Biomedicines 2022; 10(7): 1692
ISSN 2227-9059
Impact factor: 4.757

Chai XN, Ludwig FA, Müglitz A, Gong Y, Schaefer M, Regenthal R, Krügel U
A Pharmacokinetic and Metabolism Study of the TRPC6 Inhibitor SH045 in Mice by LC-MS/MS.    Int J Mol Sci 2022; 23(7): 3635
ISSN 1422-0067
Impact factor: 6.208

Eckhardt S, Franke H, Schwarz S, Lachenmeier DW
Risk Assessment of Coffee Cherry (Cascara) Fruit Products for Flour Replacement and Other Alternative Food Uses.    Molecules 2022; 27(23): 8435
ISSN 1420-3049
Impact factor: 4.927

Gil B, Smith J, Tang Y, Illes P, Engel T
Beyond Seizure Control: Treating Comorbidities in Epilepsy via Targeting of the P2X7 Receptor.    
Int J Mol Sci 2022; 23(4): 2380
ISSN 1422-0067
Impact factor: 6.208

Hinkelmann S, Springwald AH, Starke A, Kalwa H, Wölk C, Hacker MC, Schulz-Siegmund M
Microtissues from mesenchymal stem cells and siRNA-loaded cross-linked gelatin microparticles for bone regeneration.
Mater Today Bio 2022; 13: 100190
ISSN 2590-0064
Impact factor: 7.348

Jiang T, Samapati R, Klassen S, Lei D, Erfinanda L, Jankowski V, Simmons S, Yin J, Arenz C, Dietrich A, Gudermann T, Adam D, Schaefer M, Jankowski J, Flockerzi V, Nüsing R, Uhlig S, Kuebler WM
Stimulation of the EP3 receptor causes lung edema by activation of TRPC6 in pulmonary endothelial cells.
Eur Respir J 2022; 60(4): 2102635
ISSN 0903-1936
Impact factor: 33.801

Kayser C, Lohse MJ, Bock A
Real-Time Measurements of Intracellular cAMP Gradients Using FRET-Based cAMP Nanorulers.
Methods Mol Biol 2022; 2483: 1-13
ISSN 1064-3745
Impact factor: 1.37

Kayser C, Lohse MJ, Bock A
Real-Time Measurements of Intracellular cAMP Gradients Using FRET-Based cAMP Nanorulers
In: Zaccolo M: cAMP signaling. Methods in Molecular Biology
Humana, New York, NY (2022); 1-13
ISBN 978-1-0716-2244-5

Kogel A, Fecher-Trost C, Wissenbach U, Flockerzi V, Schaefer M
Ca(2+) transport via TRPV6 is regulated by rapid internalization of the channel.
Cell Calcium 2022; 106: 102634    ISSN 0143-4160
Impact factor: 4.690

Kogel A, Fikenzer S, Uhlmann L, Opitz L, Kneuer JM, Haeusler KG, Endres M, Kratzsch J, Schwarz V, Werner C, Kalwa H, Gaul S, Laufs U
Extracellular Inflammasome Particles Are Released After Marathon Running and Induce Proinflammatory Effects in Endothelial Cells.
Front Physiol 2022; 13: 866938
ISSN 1664-042X    
Impact factor: 4.755

Li J, Rubini P, Tang Y, Illes P
Astrocyte-derived ATP: A New Etiological Factor for Autism Spectrum Disorder.
Neurosci Bull 2022; 38(1): 104-106
ISSN 1673-7067
Impact factor: 5.271

Lorbeer L, Schwarz S, Franke H, Lachenmeier DW
Toxicological Assessment of Roasted Coffee Silver Skin (Testa of Coffea sp.) as Novel Food Ingredient.
Molecules 2022; 27(20): 6839
ISSN 1420-3049
Impact factor: 4.927

Maier M, Olthoff S, Hill K, Zosel C, Magauer T, Wein LA, Schaefer M
KS0365, a novel activator of the transient receptor potential vanilloid 3 (TRPV3) channel, accelerates keratinocyte migration.
Br J Pharmacol 2022; 179(24): 5290-5304
ISSN 0007-1188
Impact factor: 9.473

Mitgau J, Franke J, Schinner C, Stephan G, Berndt S, Placantonakis DG, Kalwa H, Spindler V, Wilde C, Liebscher I
The N Terminus of Adhesion G Protein-Coupled Receptor GPR126/ADGRG6 as Allosteric Force Integrator.
Front Cell Dev Biol 2022; 10: 873278
ISSN 2296-634X    
Impact factor: 6.081

Mitrach F, Schmid M, Toussaint M, Dukic-Stefanovic S, Deuther-Conrad W, Franke H, Ewe A, Aigner A, Wölk C, Brust P, Hacker MC, Schulz-Siegmund M
Amphiphilic Anionic Oligomer-Stabilized Calcium Phosphate Nanoparticles with Prospects in siRNA Delivery via Convection-Enhanced Delivery.
Pharmaceutics 2022; 14(2): 326
ISSN 1999-4923
Impact factor: 6.525

Morr AS, Nowicki M, Bertalan G, Vieira Silva R, Infante Duarte C, Koch SP, Boehm-Sturm P, Krügel U, Braun J, Steiner B, Käs JA, Fuhs T, Sack I
Mechanical properties of murine hippocampal subregions investigated by atomic force microscopy and in vivo magnetic resonance elastography.
Sci Rep 2022; 12(1): 16723
ISSN 2045-2322
Impact factor: 4.997

Müller M, Niemeyer K, Urban N, Ojha NK, Zufall F, Leinders-Zufall T, Schaefer M, Thorn-Seshold O
BTDAzo: A Photoswitchable TRPC5 Channel Activator.
Angew Chem Int Ed Engl 2022; 61(36): 202201565
ISSN 1433-7851
Impact factor: 16.823

Münzker J, Haase N, Till A, Sucher R, Haange SB, Nemetschke L, Gnad T, Jäger E, Chen J, Riede SJ, Chakaroun R, Massier L, Kovacs P, Ost M, Rolle-Kampczyk U, Jehmlich N, Weiner J, Heiker JT, Klöting N, Seeger G, Morawski M, Keitel V, Pfeifer A, von Bergen M, Heeren J, Krügel U, Fenske WK
Functional changes of the gastric bypass microbiota reactivate thermogenic adipose tissue and systemic glucose control via intestinal FXR-TGR5 crosstalk in diet-induced obesity.
Microbiome 2022; 10(1): 96
ISSN 2049-2618
Impact factor: 16.837

Rahimi MJ,  , Wegler M, Sticht H, Schaefer M, Popp B, Gaunitz F, Morleo M, Nigro V, Maitz S, Mancini GMS, Ruivenkamp C, Suk EK, Bartolomaeus T, Merkenschlager A, Koboldt D, Bartholomew D, Stegmann APA, Sinnema M, Duynisveld I, Salvarinova R, Race S, de Vries BBA, Trimouille A, Naudion S, Marom D, Hamiel U, Henig N, Demurger F, Rahner N, Bartels E, Hamm JA, Putnam AM, Person R, Abou Jamra R, Oppermann H
De novo variants in ATP2B1 lead to neurodevelopmental delay.    Am J Hum Genet 2022; 109(5): 944-952
ISSN 0002-9297
Impact factor: 11.043

Ren WJ, Illes P
Involvement of P2X7 receptors in chronic pain disorders.
Purinergic Signal 2022; 18(1): 83-92
ISSN 1573-9538
Impact factor: 3.950

Rössig A, Hill K, Nörenberg W, Weidenbach S, Zierler S, Schaefer M, Gudermann T, Chubanov V
Pharmacological agents selectively acting on the channel moieties of TRPM6 and TRPM7.
Cell Calcium 2022; 106: 102640
ISSN 0143-4160
Impact factor: 4.690

Schmidt E, Narangoda C, Nörenberg W, Egawa M, Rössig A, Leonhardt M, Schaefer M, Zierler S, Kurnikova MG, Gudermann T, Chubanov V
Structural mechanism of TRPM7 channel regulation by intracellular magnesium.
Cell Mol Life Sci 2022; 79(5): 225
ISSN 1420-682X
Impact factor: 9.234

Tritsch N, Steger MC, Segatz V, Blumenthal P, Rigling M, Schwarz S, Zhang Y, Franke H, Lachenmeier DW
Risk Assessment of Caffeine and Epigallocatechin Gallate in Coffee Leaf Tea.
Foods 2022; 11(3): 263
ISSN 2304-8158
Impact factor: 5.561

Wendt S, Lübbert C, Begemann K, Prasa D, Franke H
Poisoning by Plants.
Dtsch Arztebl Int 2022; 119: 317-324
ISSN 1866-0452
Impact factor: 8.251

Wendt S, Prasa D, Lübbert C, Begemann K, Franke H
Food Poisoning From Fruits in Germany.
Dtsch Arztebl Int 2022; 119(18): 333-334
ISSN 1866-0452
Impact factor: 8.251

Zhang Y, Yin HY, Rubini P, Illes P, Tang Y
ATP indirectly stimulates hippocampal CA1 and CA3 pyramidal neurons via the activation of neighboring P2X7 receptor-bearing astrocytes and NG2 glial cells, respectively.
Front Pharmacol 2022; 13: 944541
ISSN 1663-9812
Impact factor: 5.988

Zhang Y, Yin HY, Rubini P, Tang Y, Illes P
A Possible Causal Involvement of Neuroinflammatory, Purinergic P2X7 Receptors in Psychiatric Disorders.
Curr Neuropharmacol 2022; 20(11): 2142-2155
ISSN 1570-159X
Impact factor: 7.708

Zhao YF, Ren WJ, Zhang Y, He JR, Yin HY, Liao Y, Rubini P, Deussing JM, Verkhratsky A, Yuan ZQ, Illes P, Tang Y
High, in Contrast to Low Levels of Acute Stress Induce Depressive-like Behavior by Involving Astrocytic, in Addition to Microglial P2X7 Receptors in the Rodent Hippocampus.
Int J Mol Sci 2022; 23(3): 1904
ISSN 1422-0067
Impact factor: 6.208

Zheng Z, Tsvetkov D, Bartolomaeus TUP, Erdogan C, Krügel U, Schleifenbaum J, Schaefer M, Nürnberg B, Chai X, Ludwig FA, N´diaye G, Köhler MB, Wu K, Gollasch M, Marko L
Role of TRPC6 in kidney damage after acute ischemic kidney injury.
Sci Rep 2022; 12(1): 3038
ISSN 2045-2322
Impact factor: 4.997

Zheng Z, Xu Y, Krügel U, Schaefer M, Grune T, Nürnberg B, Köhler MB, Gollasch M, Tsvetkov D, Markó L
In Vivo Inhibition of TRPC6 by SH045 Attenuates Renal Fibrosis in a New Zealand Obese (NZO) Mouse Model of Metabolic Syndrome.
Int J Mol Sci 2022; 23(12): 6870
ISSN 1422-0067
Impact factor: 6.208

Zwirner J, Kulakofsky R, Fitzek A, Schröder AS, Bohnert S, Franke H, Renné T, Tse R, Ondruschka B
Forensic biomarkers of lethal traumatic brain injury.
Int J Legal Med 2022; 136(3): 871-886
ISSN 0937-9827
Impact factor: 2.791