Prömel Lab

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All multicellular organisms are highly dependent on the capacity developed by their cells to communicate with each other and with their environment. G protein-coupled receptors (GPCRs) play a central role in controlling this communication. These seven transmembrane receptors regulate numerous physiological mechanisms in health and disease and thus, bear an immense pharmacological potential. One class of to date enigmatic GPCRs are Adhesion GPCRs (aGPCRs). Despite their essential functions in processes such as neurobiology, immunology or development and their unique architecture facilitating cell and matrix interactions, Adhesion GPCRs are by far the most poorly understood receptor class.

Our group is interested in understanding the roles of Adhesion GPCRs in development, metabolic processes and disease. How do Adhesion GPCRs function in a physiological context? Which molecular mechanisms are required? We use the roundworm Caenorhabditis elegans and the mouse as model organisms as well as various cell culture models to address these questions and to link physiological functions with molecular mechanisms.

Contact

Simone Prömel, DPhil (Oxon)
ESF Junior Group Leader

Rudolf Schönheimer
Institute of Biochemistry
Medical Faculty
Johannisallee 30
04103 Leipzig
Germany

☏ +49 341 97-22147
📠 +49 341 97-22159

simone.proemel
(at) medizin.uni-leipzig.de



Curriculum vitae