Drug Safety in Critical PatientsClinical pharmacokinetics of drugs in critical patients
The pharmacokinetics
of drugs in special critical patient populations varies considerably.
In collaboration with clinical units of the University Hospital of
Leipzig (UKL) and other hospitals, we are project partners in clinical
observational studies. Currently, we investigate concentrations and
pharmacokinetics of the echinocandine antimycotic drug posaconazol in
immune-compromised patients, and of the opioid meptazinol in mothers
and newborns during the perinatal period. The results are correlated
with pharmacodynamics and/or adverse drug effects in order to derive
recommendations for the safer use of such drugs in practical medicine.
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