Protein-Zustände mit zellbiologischer und medizinischer Relevanz

Sonderforschungsbereich 610

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Aus den Teilprojekten des SFB 610 sind u. a. die untenstehenden Publikationen hervorgegangen:

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Babilon S, Mörl K, Beck-Sickinger AG. Towards improved receptor targeting: anterograde transport, internalization and postendocytic trafficking of neuropeptide Y receptors. Biol Chem. 2013;394:921-36.

Bell J, Mühleck B, Lederer M, Hüttelmaier S. Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs): Post-transcriptional drivers of cancer progression?. Cell Mol Life Sci. 2013;2657-75. 

Berger C, Theisgen S, Pichert A, Berndt S, Huster D. Efficient isotopic tryptophan labeling of membrane proteins by an indole controlled process conduct. Biotechnol Bioeng. 2013;110:1681-90.

Efimov SV, Karataeva FK, Aganov AV, Berger S, Klochkov VV. Spatial structure of cyclosporin A and insight into its flexibility. J Mol Struct. 2013;1036:298-304.

Hofmann S, Frank R, Hey-Hawkins E, Beck-Sickinger AG, Schmidt P. Manipulating Y receptor subtype activation of short neuropeptide Y analogs by introducing carbaboranes. Neuropeptides. 2013;47:59-66.

Keil R, Schulz J, Hatzfeld M. p0071/PKP4, a multifunctional protein coordinating cell adhesion with cytoskeletal organization. Biol Chem. 2013;394:1005-17.

Köhn M, Pazaitis N, Hüttelmaier S. Why Y-RNAs? About forgotten RNAs and their functions. Biomolecules. 2013;in press.

Kovermann M, Balbach J. Dynamic control of the prolyl isomerase function of the dual-domain SlyD protein. Biophys Chem. 2013;171:16-23.

Kovermann M, Schmid FX, Balbach J. Molecular function of the prolyl cis/trans isomerase and metallochaperone SlyD. Biol Chem. 2013;Epub ahead of print.

Krug U, Patzschke R, Zebisch M, Balbach J, Sträter N. Expression and characterization of the N- and C-terminal domains of E. coli 5’-nucleotidase. FEBS Lett. 2013;587:460-6.

Liebscher I, Schöneberg T, Prömel S. Progress in demystification of adhesion GPCR. Biol Chem. 2013;394:937-50.

Lilie H, Richter S, Bergelt S, Frost S, Gehle F. Polyionic and cysteine-containing fusion peptides as versatile protein tags. Biol Chem. 2013;394:995-1004.

Pedragosa-Badia X, Stichel J, Beck-Sickinger AG. Neuropeptide Y receptors: how to get subtype selectivity. Front Endocrinol (Lausanne). 2013; 4:5.

Prell E, Kahlert V, Rücknagel KP, Malešević M, Fischer G. Fine tuning the inhibition profile of cyclosporine A by derivatization of the MeBmt residue. ChemBioChem. 2013;14:63-5.

Rentzsch A, Kahlert V, Jahreis G, Schlott B, Schutkowski M, Malešević M, Fischer G. Identification of prolyl oligopeptidase as a cyclosporine-sensitive protease by screening of mouse liver extracts. Biol Chem. 2013;394:1057-67.

Rudolph T, Beuch S, Reuter G. Lysine-specific histone demethylase LSD1 and the dynamic control of chromatin. Biol Chem. 2013;394:1019-28.

Schmidt P, Ritscher L, Dong EN, Hermsdorf T, Cöster M, Wittkopf D, Meiler J, Schöneberg T. Identification of Determinants Required for Agonistic and Inverse Agonistic Ligand Properties at the ADP Receptor P2Y12. Mol Pharmacol. 2013;83:256-66.

Schöneberg T, Kloos M, Brüser A, Kirchberger J, Sträter N. Structure and allosteric regulation of eukaryotic 6-phosphofructokinases. Biol Chem. 2013;394:977-93.

Simon C, Schaepe S, Breunig KD, Lilie H. Production of Polyomavirus-like particles in a Gal80p knock out strain of the yeast Kuyveromyces lactis. Prep Biochem Biotech. 2013;43:217-35.

Staubert C, Bohnekamp J, Schoneberg T. Determinants Involved in Subtype-specific Functions of Rat Trace Amine-associated Receptors 1 and 4. Br J Pharmacol. 2013;168:1266-78.

Stelter M, Fandrich U, Franzke K, Schierhorn A, Breithaupt C, Parthier C, Stubbs MT. High level expression of the Drosophila Toll receptor ectodomain and crystallization of its complex with the morphogen Spätzle. Biol Chem. 2013;394:1091-6.

Wächter K, Köhn M, Stöhr N, Hüttelmaier S. Subcellular localization and RNP formation of IGF2BPs (IGF2 mRNA binding proteins) is modulated by distinct RNA-binding domains. Biol Chem. 2013;394:1077-90.

Wahle E, Moritz B. Methylation of the nuclear poly(A) binding protein by type I protein arginine methyltransferases - how and why. Biol Chem. 2013;394:1029-43.

Winter R, Liebold J, Schwarz E. The unresolved puzzle why alanine extensions cause disease. Biol Chem. 2013;394:951-63.

Witte K, Kaiser A, Schmidt P, Splith V, Thomas L, Berndt S, Huster D, Beck-Sickinger AG. Oxidative in vitro folding of a cysteine deficient variant of the G protein-coupled neuropeptide Y receptor type 2 improves stability at high concentration. Biol Chem. 2013;394:1045-56.



Berndt H*, Harnisch C*, Rammelt C, Stöhr N, Zirkel A, Dohm JC, Himmelbauer H, Tavanez J-P, Hüttelmaier S, Wahle E. Maturation of mammalian H/ACA box snoRNAs: PAPD5-dependent adenylation and PARN-dependent trimming. RNA. 2012;18:958-72. (*contributed equally)

Brüser A, Kirchberger J, Schöneberg T. Altered allosteric regulation of muscle 6-phosphofructokinase causes Tarui disease. Biochem Biophys Res Commun. 2012;427:133-7.

Brüser A, Kirchberger J, Kloos M, Sträter N, Schöneberg T. Functional linkage of adenine nucleotide binding sites in mammalian muscle 6-phosphofructokinase. J Biol Chem. 2012; 287:17546-53.

Findeisen M, Würker C, Rathmann D, Meier R, Meiler J, Olsson R, Beck-Sickinger AG. Selective mode of action of guanidine-containing non-peptides at human NPFF receptors. J Med Chem. 2012; 55:6124-36. 

Haupt C, Leppert J, Rönicke R, Meinhardt J, Yadav JK, Ramachandran R, Ohlenschläger O, Reymann KG, Görlach M, Fändrich M. Oligomer Structure Provides a Basis for Preventing Aβ-dependent Synaptic Dysfunctions. Angew Chem Int Edt. 2012;51:1576-9.

Kaluarachchi H, Altenstein M, Sugumar SR, Balbach J, Zamble DB, Haupt C. Nickel binding and [NiFe]-hydrogenase maturation by the metallochaperone SlyD with a single metal-binding site in Escherichia coli. J Mol Biol. 2012;417:28-35.

Kölbel K, Ihling C, Kühn U, Neundorf I, Otto S, Stichel J, Robaa D, Beck-Sickinger AG, Sinz A, Wahle E. Peptide backbone conformation affects the substrate preference of protein arginine methyltransferase I. Biochemistry. 2012; 51:5463-75.

Kunz C, Jahreis G, Günther R, Berger S, Fischer G, Hofmann H-J. Influence of lithium cations on prolyl peptide Bonds. J Pept Sci. 2012;18:400-4. 

Lopez del Amo JM, Schmidt M, Fink U, Muralidar Dasari M, Fändrich M, Reif B. An asymmetric dimer is the basic subunit in Alzheimer's disease β-amyloid fibrils. Angew Chem Int Edt. 2012;51:6136-9.

Löw C, Stubbs MT, Haupt C, Balbach J. Metallochaperone SlyD, in: ‘Encyclopedia of Inorganic and Bioinorganic Chemistry’ (A. Scott, ed.), DOI: 10.1002/9781119951438.eibc2061, John Wiley & Sons, Sussex; 2012.

Malesevic M, Schumann M, Jahreis G, Fischer G, Lucke C. Design of Cyclic Peptides Featuring Proline Predominantly in the cis Conformation under Physiological Conditions. ChemBioChem. 2012;13:2122-7.

Morgado I, Wieligmann K, Bereza M, Rönicke R, Meinhardt K, Annamalai K, Baumann M, Wacker J, Hortschansky P, Malešević M, Parthier C, Mawrin C, Schiene-Fischer C, Reymann KG, Stubbs MT, Balbach J, Görlach M, Horn U, Fändrich M. Molecular basis of β-amyloid oligomer recognition with a conformational antibody fragment. Proc Natl Acad Sci U S A. 2012;109:12503-8.

Nahorski MS, Seabra L, Straatman-Iwanowska A, Wingenfeld A, Reiman A, Lu X, Klomp JA, Teh BT, Hatzfeld M, Gissen P, Maher ER. Folliculin interacts with p0071 (plakophilin-4) and deficiency is associated with disordered RhoA signalling, epithelial polarization and cytokinesis. Hum Mol Genet. 2012;21:5268-79. 

Promel S, Frickenhaus M, Hughes S, Mestek L, Staunton D, Woollard A, Vakonakis I, Schöneberg T, Schnabel R, Russ AP, Langenhan T. The GPS motif is a molecular switch for bimodal activities of adhesion class G protein-coupled receptors. Cell Rep. 2012;2:321-31.

Promel S, Waller-Evans H, Dixon J, Zahn D, Colledge WH, Doran J, Carlton MB, Grosse J, Schöneberg T, Russ AP, Langenhan T. Characterization and functional study of a cluster of four highly conserved orphan adhesion-GPCR in mouse. Dev Dyn. 2012;241:1591-602.

Rathmann D, Lindner D, DeLuca SH, Kaufmann KW, Meiler J, Beck-Sickinger AG. Ligand-mimicking receptor variant discloses binding and activation mode of prolactin-releasing peptide. J Biol Chem. 2012; 287:32181-94. 

Räuber C, Berger S. Saturation Transfer Difference NMR studies of the interaction of the Proteinkinase CK2 with Peptides. Protein Pept Lett. 2012;19:934-9.

Seidel D, Krinke D, Jahnke H-G, Hirche A, Kloß D, Mack TGA, Striggow F, Robitzki AA. Induced tauopathy in a novel 3D-culture model mediates neurodegenerative processes: a real-time study on biochips. PLoS One. 2012;7: e49150.

Stöhr N, Köhn M, Lederer M, Glaß M, Reinke C, Singer RH, Hüttelmaier S. IGF2BP1 promotes cell migration by regulating MK5 and PTEN signaling. Genes Dev. 2012;26:176-89.

Stöhr N, Hüttelmaier S. IGF2BP1 - A post-transcriptional ‘driver’ of tumor cell migration. Cell Adh Migr. 2012;6:312-8.

Walther C, Lotze J, Beck-Sickinger AG, Mörl K. The anterograde transport of the human neuropeptide Y2 receptor is regulated by a subtype specific mechanism mediated by the C-terminus. Neuropeptides. 2012;46:335-43.

Willenberg A, Saalbach A, Simon JC, Anderegg U. Melanoma cells control hyaluronan synthesis in peritumoral fibroblasts via PDGF-AA and PDGF-CC: Impact on melanoma cell proliferation. J Invest Dermatol. 2012;132:385-93.

Winter R, Kühn U, Hause G, Schwarz E. Polyalanine-independent Conformational conversion of nuclear poly(A)-binding protein PABPN1. J Biol Chem. 2012;287:22662-71. 



Barbezier N, Chartier A, Bidet Y, Buttstedt A, Voisset C, Galons H, Blondel M, Schwarz E, Simonelig M. Antiprion drugs 6-aminophenanthridine and guanabenz reduce PABPN1 toxicity and aggregation in oculopharyngeal muscular dystrophy. EMBO Mol Med. 2011;3:35-49.

Berger C, Montag C, Berndt S, Huster D. Optimization of Escherichia coli Cultivation Methods for High Yield Neuropeptide Y Receptor Type 2 Production. Protein Expr Purif. 2011;76:25-35.

Bohnekamp J, Schoneberg T. Cell adhesion receptor GPR133 couples to Gs protein. J Biol Chem. 2011;286:41912-6.

Bosse M, Thomas L, Hassert R, Beck-Sickinger AG, Huster D, Schmidt P. Assessment of a Fully Active Class A G Protein-Coupled Receptor Isolated from in vitro Folding. Biochemistry. 2011;50:9817-25.

Drechsler N, Frobel J, Jahreis G, Gopalswamy M, Balbach J, Bosse-Doenecke E, Rudolph R. Binding specificity of the ectodomain of the parathyroid hormone receptor. Biophys Chem. 2011;154:66-72. 

Findeisen M, Rathmann D, Beck-Sickinger AG. RFamide Peptides: Structure, Function, Mechanisms and Pharmaceutical Potential. Pharmaceuticals. 2011;11:1248-1280.

Findeisen M, Rathmann D, Beck-Sickinger AG. Structure-activity studies of RFamide peptides reveal subtype-selective activation of neuropeptide FF1 and FF2- receptors. ChemMedChem. 2011; 6:1081-93.

Fronz K, Güttinger S, Burkert K, Kühn U, Stöhr N, Schierhorn A, Wahle E. () Arginine methylation of the nuclear poly(A) binding protein weakens the interaction with its nuclear import receptor, transportin. J Biol Chem. 2011;286:32986-94.

Garvey M, Tepper K, Haupt C, Knüpfer U, Klement K, Meinhardt J, Horn U, Balbach J, Fändrich M. Phosphate and HEPES buffers potently affect the fibrillation and oligomerization mechanism of Alzheimer’s Aβ peptide. Biochem Biophys Res Comm. 2011;409:385-8.

Haupt C, Morgado I, Kumar ST, Parthier C, Bereza M, Hortschansky P, Stubbs MT, Horn U, Fändrich M. Amyloid fibril recognition with the conformational B10 antibody fragment depends on electrostatic interactions. J Mol Biol. 2011;405:341-8.

Haupt C, Patzschke R, Weininger U, Gröger S, Kovermann M, Balbach J. Transient Enzyme-Substrate Recognition Monitored by Real-Time NMR. J Am Chem Soc. 2011;133:11154-62.

Haupt C, Weininger U, Kovermann M, Balbach J. Local and Coupled Thermodynamic Stability of the Two-Domain and Bifunctional Enzyme SlyD from Escherichia coli. Biochemistry. 2011;50:7321-9.

Jahr N, Fiedler E, Günther R, Hofmann H-J, Berger S. NH exchange in point mutants of human ubiquitin. Int J Biol Macromol. 2011;49:154-60.

Kahra D, Kovermann M, Löw C, Hirschfeld V, Haupt C, Balbach J, Hübner CG. Conformational plasticity and dynamics in the generic protein folding catalyst SlyD unraveled by single-molecule FRET. J Mol Biol. 2011;411:781-90.

Korykaov DE, Walther M, Ebert A, Lein S, Zhimulev IF, Reuter G. The SUUR protein is involved in binding of SU(VAR)3-9 and methylation of H3K9 and H3K27 in chromosomes of Drosophila melanogaster. Chromosome Res. 2011;19:235-49.

Kovermann M, Zierold R, Haupt C, Löw C, Balbach J. NMR relaxation unravels interdomain crosstalk of the two domain prolyl isomerase and chaperone SlyD. Bioche. Biophys Acta. 2011;1814:873-81.

Mathea S, Li S, Schierhorn A, Jahreis G, Schiene-Fischer C. Suppression of EGFR autophosphorylation by FKBP12. Biochemistry. 2011;50:10844-50. 

Mei CG, Jahr N, Singer D, Berger S. Hairpin conformation of an 11-mer peptide. Bioorg Med Chem. 2011;19:3497-501.

Pänke O, Weigel W, Schmidt S, Steude A, Robitzki A. A cell-based impedance assay for monitoring transient receptor potential (TRP) ion channel activity. Biosens Bioelectron. 2011;26:2376-82.

Scheidt HA, Morgado I, Rothemund S, Huster D, Fändrich M. Solid-State NMR of Aβ Protofibrils Implies a β-Sheet Remodelling upon Maturation into Terminal Amyloid Fibrils. Angew Chemie Int Ed. 2011;50:2837-40.

Steude A, Schmidt S, Robitzki A, Pänke O. An electrode array for electrochemical immuno-sensing using the example of impedimetric tenascin C detection. Lab Chip. 2011;11:2884-92.

Sträter N, Marek S, Kuettner EB, Kloos M, Keim A, Brüser A, Kirchberger J, Schöneberg T. Molecular architecture and structural basis of allostericregulation of eukaryotic phosphofructokinases. FASEB J. 2011;25:89-98.

Strotmann R, Schröck K, Böselt I, Stäubert C, Russ A, Schöneberg T. Evolution of GPCR: change and continuity. Mol Cell Endocrinol. 2011;331:170-8.

Theuerkorn M, Fischer G, Schiene-Fischer C. Prolyl cis/trans isomerase signalling pathways in cancer. Curr Opin Pharmacol. 2011;11:281-7.

Walther C, Mörl K, Beck-Sickinger AG. Neuropeptide Y receptors: ligand binding and trafficking suggest novel approaches in drug development. J Pept Sci. 2011;17:233-46. Review.



Angelici G, Castellucci N, Falini G, Huster D, Monari M, Tomasini C. Pseudopeptides designed to form supramolecular helixes: the role of the stereogenic centers. Cryst. Growth Des. 2010;10:923-9.

Averbeck M, Gebhardt C, Anderegg U, Simon JC. Suppression of hyaluronan synthase 2 expression reflects the atrophogenic potential of glucocorticoids. Exp Dermatol. 2010;19:757-9.

Balsley MA, Malesevic M, Stemmy EJ, Gigley J, Jurjus RA, Herzog D, Bukrinsky MI, Fischer G, Constant SL. A cell-impermeable cyclosporine A derivative reduces pathology in a mouse model of allergic lung inflammation. J Immunol. 2010;185:7663-70.

Fodor DB, Shukeir N, Reuter G, Jenuwein T. Mammalian Su(var) genes in chromatin control. Ann Rev Cell Dev Biol. 2010;26:471-501.

Friedrich RP, Tepper K, Rönicke R, Westermann M, Reymann K, Kaether C, Fändrich M. Mechanism of amyloid plaque formation suggests an intracellular basis of Aβ pathogenicity. Proc Natl Acad Sci U S A. 2010;107:1942-7.

Gebhardt C, Averbeck M, Diedenhofen N, Willenberg A, Anderegg U, Sleeman JP, Simon JC. Dermal hyaluronan is rapidly reduced by topical treatment with glucocorticoids. J Invest Dermatol. 2010;130:141-9.

Gebhardt R, Lerche KS, Götschel F, Günther R, Kolander J, Teich L, Zellmer S, Hofmann H-J, Eger K, Hecht A, Gaunitz F. 4-Aminoethylamino-emodin - a novel potent inhibitor of GSK-3 beta - acts as an insulin-sensitizer avoiding downstream effects of activated beta-catenin. J Cell Mol Medicine. 2010;14:1276-93.

Hofreiter M, Schoneberg T. The genetic and evolutionary basis of colour variation in vertebrates. Cell Mol Life Sci. 2010;67:2591-603.

Köhn M, Lederer M, Wächter K, Hüttelmaier S. Near infrared (NIR) dye-labeled RNAs identify binding of ZBP1 to the non-coding Y3-RNA. RNA. 2010;16:1420-8.

Krinke D, Jahnke H-G, Mack TGA, Hirche A, Striggow F, Robitzki AA. A novel organotypic tauopathy model on a new microcavity chip for bioelectronic label-free and real time monitoring. Biosens Bioelectron. 2010;26:162-8.

Löw C, Neumann P, Tidow H, Weininger U, Haupt C, Friedrich-Epler B, Scholz C, Stubbs MT, Balbach J. Crystal structure determination and functional characterization of the metallochaperone SlyD from Thermus thermophilus. J Mol Biol. 2010;398:375-90.

Räuber C, Berger S. 13C-NMR detection of STD spectra. Magn Reson Chem. 2010;48:91-3.

Rosenblum EB, Rompler H, Schoneberg T, Hoekstra HE. Molecular and functional basis of phenotypic convergence in white lizards at White Sands. Proc Natl Acad Sci U S A. 2010;107:2113-7.

Sachse C, Grigorieff N, Fändrich M. Nanoscale flexibility parameters of Alzheimer amyloid fibrils determined using electron cryo-microscopy. Angew Chem Int Edt. 2010;49:1321-23. 

Schiller M, Dennler S, Anderegg U, Kokot A, Simon JC, Luger TA, Mauviel A, Böhm M. Increased cAMP levels modulate TGF-beta /SMAD-induced expression of extracellular matrix components and other key fibroblast effector functions. J Biol Chem. 2010;285:409-21.

Schimmer S, Lindner D, Schmidt P, Montag C, Beck-Sickinger AG, Huster D, Rudolph R. Functional characterization of the in vitro folded human Y1 receptor in lipid environment. Protein Peptide Lett. 2010;17:605-9.

Schmidt P, Berger C, Scheidt HA, Berndt S, Bunge A, Beck-Sickinger AG, Huster D. A Reconstitution Protocol for the in vitro Folded Human G protein-Coupled Y2 Receptor into Lipid Environment. Biophys Chem. 2010;150:29-36.

Schroder-Tittmann K, Bosse-Doenecke E, Reedtz-Runge S, Ihling C, Sinz A, Tittmann K, Rudolph R. Recombinant expression, in vitro refolding, and biophysical characterization of the human glucagon-like peptide-1 receptor. Biochemistry. 2010;49:7956-65.  

Staubert C, Böselt I, Bohnekamp J, Römpler H, Enard W, Schöneberg T. Structural and functional evolution of the trace amine-associated receptors TAAR3, TAAR4 and TAAR5 in primates. PLoS One. 2010;5:e11133.

Turner LM, Young AR, Römpler H, Schöneberg T, Phelps SM, Hoekstra HE. Monogamy evolves through multiple mechanisms: evidence from V1aR in deer mice. Mol Biol Evol. 2010;27:1269-78.

Underwood CR, Garibay P, Knudsen LB, Hastrup S, Peters GH, Rudolph R, Reedtz-Runge S. Crystal structure of glucagon-like peptide-1 in complex with the extracellular domain of the glucagon-like peptide-1 receptor. J Biol Chem. 2010;285:723-30.

Walther C, Nagel S, Gimenez LE, Mörl K, Gurevich VV, Beck-Sickinger AG. Ligand-induced internalization and recycling of the human neuropeptide Y2 receptor is regulated by its carboxyl-terminal tail. J Biol Chem. 2010;285:41578-90.



Anderegg U, Eichenberg T, Parthaune T, Haiduk C, Saalbach A, Milkova L, Ludwig A, Grosche J, Averbeck M, Gebhardt C, Voelcker V, Sleeman JP, Simon JC. ADAM10 is the constitutive functional sheddase of CD44 in human melanoma cells. J Invest Dermatol. 2009;129:1471-82. 

Angelici G, Falini G, Hofmann H-J, Huster D, Monari M, Tomasini C. Nanofibers from Oxazolidi-2-one Containing Hybrid Foldamers: What is the Right Molecular Size?. Chem Eur J. 2009;15:8037-48.

Bauer K, Kretzschmar AK, Cvijic H, Blumert C, Löffler D, Brocke-Heidrich K, Schiene-Fischer C, Fischer G, Sinz A, Clevenger CV, Horn F. Cyclophilins contribute to STAT3 signaling and survival of multiple myeloma cells. Oncogene. 2009;28:2784-95.

Benjamin S, Radermacher M, Kirchberger J, Schöneberg T, Edelmann A, Ruiz T. 3D structure of phosphofructokinase from Pichia pastoris: Localization of the novel gamma-subunits. J Struct Biol. 2009;168:345-51.

Bergelt S, Frost S, Lilie H. Lysteriolysin O as a cytotoxic component of an immunotoxin. Prot Science. 2009;18:1210-20.

Böhme I, Beck-Sickinger AG. Illuminating the life of GPCRs. Cell Commun Signal. 2009;7:16.

Boselt I, Römpler H, Hermsdorf T, Thor D, Busch W, Schulz A, Schöneberg T. Involvement of the V2 vasopressin receptor in adaptation to limited water supply. PLoS One. 2009;4:e5573.

Cvijic H, Bauer K, Löffler D, Pfeifer G, Blumert C, Kretzschmar AK, Henze C, Brocke-Heidrich K, Horn F. Co-activator SRC-1 is dispensable for transcriptional control by STAT3. Biochem J. 2009;420:123-32.

Eissenberg JC, Reuter G. Cellular mechanism for targeting heterochromatin formation in Drosophila. Int Rev Cell Mol Biol. 2009;273:1-47.

Gebhardt C, Averbeck M, Anderegg U, Simon J. Role of Hyaluronan in melanoma progression. In R. Stern (ed). Seminars in Cancer Biology, 2009, Elsevier San Diego ISBN: 978-0-12-374178-3, 329-39. 

Haack M, Beck-Sickinger AG. Towards understanding the free and receptor bound conformation of neuropeptide Y by fluorescence resonance energy transfer studies. Chem Biol Drug Des. 2009;73:573-83. 

Hiller M, Findeiß S, Lein S, Marz M, Nickel C, Rose D, Schulz C, Backofen R, Prohaska SJ, Reuter G, Stadler PF. Conserved introns reveal novel transcripts in Drosophila melanogaster. Genome Res. 2009;19:1289-300.

Keil R, Kiessling C, Hatzfeld M. Targeting of p0071 to the midbody depends on KIF3. J Cell Sci. 2009;122:1174-83.

Klochkov VV, Baikeev RF, Skirda VD, Klochkov AV, Muhamadiev FR, Baskyr I, Berger S. Spatial structure of peptides determined by residual dipolar couplings analysis. Magn Reson Chem. 2009;47:57-62. 

Kölbel K, Ihling C, Bellmann-Sickert K, Neundorf I, Beck-Sickinger AG, Sinz A, Kühn U, Wahle E. Type I Arginine Methyltransferases PRMT1 and PRMT-3 Act Distributively. J Biol Chem. 2009;284:8274-82. 

Lindner D, Walther C, Tennemann A, Beck-Sickinger AG. Functional role of the extracellular N-terminal domain of Neuropeptide Y subfamily receptors in membrane integration and agonist-stimulated internalization. Cell Signal. 2009;21:61-8.

Malesevic M, Kuhling J, Erdmann F, Balsley MA, Bukrinsky MI, Constant SL, Fischer G. A cyclosporin derivative discriminates between extracellular and intracellular cyclophilins. Angew Chem Int Ed. 2009;49:213-5. 

Parthier C, Reedtz-Runge S, Rudolph R, Stubbs MT. Passing the baton in class B GPCRs: peptide hormone activation via helix induction? Trends Biochem Sci. 2009;34:303-10.

Phalke S, Nickel O, Walluscheck D, Hortig F, Onorati MC, Reuter G. Retrotransposon silencing and telomere integrity in somatic cells of Drosophila depends on the cytosine-5 methyltransferase DNMT2. Nat Genet. 2009;41:696-702.

Reuter G, Lein S. Coordinated demethylation and methylation of histones controls heterochromatin formation and gene silencing in Drosophila. Review, in: Chromosomes to Genome, IK International Publishing House Pvt. Ltd., New Delhi, 2009;41-59.

Schmidt M, Sachse C, Richer W, Xu C, Fändrich M, Grigorieff N. Comparison between Alzheimer's Ab(1-40) and Ab(1-42) amyloid fibrils reveals similar protofilament structures. Proc Natl Acad Sci U S A. 2009;106:19813-8.

Schmidt P, Lindner D, Montag C, Sandra Berndt, Beck-Sickinger AG, Rudolph R, Huster D. Prokaryotic Expression, in vitro Folding, and Molecular Pharmacological Characterization of the Neuropeptide Y Receptor Type 2. Biotechnol Progr. 2009;25:1732-39.

Thomas L, Scheidt HA, Bettio A, Beck-Sickinger AG, Huster D, Zschörnig O. The interaction of neuropeptide Y with negatively charged and zwitterionic phospholipid membranes. Eur Biophys J. 2009;38:663-77.

Thor D, Le Duc D, Strotmann R, Schoneberg T. Luciferase activity under direct ligand-dependent control of a muscarinic acetylcholine receptor. BMC Biotechnol. 2009;9:46.

Vogel A, Reuther G,  Weise K, Triola G, Nikolaus J, Tan K-T, Nowak C, Herrmann A, Waldmann H, Winter R, Huster D. Lipid Modifications of Ras Sense the Membrane Environment and Induce Local Enrichment. Angew Chem Int Ed. 2009;48:8784-87.

Weidensdorfer D, Stöhr N, Baude A, Lederer M, Köhn M, Schierhorn A, Buchmeier S, Wahle E, Hüttelmaier S. Control of c-myc mRNA stability by IGF2BP1-associated cytoplasmic RNPs. RNA. 2009;15:104-15.

Weininger U, Haupt C, Schweimer K, Graubner W, Kovermann M, Brüser T, Scholz C, Schaarschmidt P, Zoldak G, Schmid FX, Balbach J. NMR solution structure of SlyD from Escherichia coli: Spatial separation of prolyl isomerase and chaperone function. J Mol Biol. 2009;387:295-305.

Zhang YX, Erdmann F, Fischer G. Augmented photoswitching modulates immune signaling. Nat Chem Biol. 2009;5:724-6. 



Angelici G, Falini G, Hofmann H-J, Huster D, Monari M, Tomasini C. A Fiber-like Peptide Material Stabilized by Single Intermolecular Hydrogen Bonds. Angew Chem Int Ed. 2008;47:8075-8.

Aumüller T, Fischer G. Bioactivity of Folding Intermediates Studied by the Recovery of Enzymatic Activity during Refolding. J Mol Biol. 2008;376:1478-92.

Bhat RK, Berger S. The 5S Subunit of Transcarboxylase interacts with free Biotin as studied by transferred-NOESY and Saturation Transfer Difference NMR. Protein Pept Lett. 2008;15:624-9.

Fronz K, Otto S, Kölbel K, Kühn U, Friedrich H, Schierhorn A, Beck-Sickinger AG, Ostareck-Lederer A, Wahle E. Promiscuous modification of the nuclear poly(A) binding protein by multiple protein arginine methyl transferases does not affect the aggregation behavior. J Biol Chem. 2008;283:20408-20.

Haack M, Enck S, Seger H, Geyer A, Beck-Sickinger AG. Novel Backbone Scan to Elucidate Structural Properties of a Flexible Peptide Segment. J Am Chem Soc. 2008, 130:8326-36.

Hoffmann A, Funkner A, Neumann P, Juhnke S, Walther M, Weininger U, Schierhorn A, Balbach J, Reuter G, Stubbs MT. Biophysical characterisation of refolded Drosophila Spätzle, a cystine knot protein, reveals distinct properties of three isoforms. J Biol Chem. 2008;283:32598-609.

Hoffmann A, Neumann P, Schierhorn A, Stubbs MT. Crystallisation of Spätzle, a cystine-knot protein involved in embryonic development and innate immunity in Drosophila melanogaster. Acta Cryst. 2008;F64:707-10.

Kloss D, Fischer M, Rothermel A, Simon JC, Robitzki AA. Drug testing on 3D in vitro tissues trapped on a microcavity chip. Lab Chip. 2008; 8:879-84.

Kloss D, Kurz RG, Jahnke HG, Fischer M, Rothermel A, Anderegg U, Simon JC, Robitzki AA. Micro cavity array (MCA)-based biosensor chip for functional drug screening of 3D tissue model. Biosens Bioelectron. 2008;23:1473-80.

Lindner D, Günther R, van Dieck J, Merten N, Mörl K, Hofmann HJ, Beck-Sickinger AG. Receptor, not ligand decides on binding mode in multi-receptor/multi-ligand systems. Biochemistry. 2008;47:5905-14.

Lodderstedt G, Sachs R, Faust J, Bordusa F, Kühn U, Golbik R, Kerth A, Wahle E, Balbach J, Schwarz E. Hofmeister salts and potential therapeutic compounds accelerate in vitro fibril formation of the N-terminal domain of PABPN1 containing a disease-causing alanine extension. Biochemistry. 2008;47:2181-9.

Rennert R, Neundorf I, Jahnke HG, Suchowerskyj P, Dournaud P, Robitzki A, Beck-Sickinger AG. Novel generation of carrier peptides for the delivery of nucleic acid drugs in primary cells. ChemMedChem. 2008;3:241-53.

Rohrberg J, Sachs R, Lodderstedt G, Sackewitz M, Balbach J, Schwarz E. Monitoring fibril formation of the N-terminal domain of PABPN1 carrying an alanine repeat by tryptophan fluorescence and real-time NMR. FEBS Letters. 2008;582:1587-92. 

Sackewitz M, Scheidt HA, Lodderstedt G, Schwarz E, Huster D. Structural and dynamical characterization of fibrils from a disease-associated alanine expansion domain using proteolysis and solid-state NMR spectroscopy. J Am Chem Soc. 2008;130:7172-3.

Sackewitz M, von Einem S, Hause G, Wunderlich M, Schmid F-X, Schwarz E. A folded and functional protein domain in an amyloid-like fibril. Prot Sci. 2008;17:1-11.

Schilling S, Zeitschel U, Hoffmann T, Heiser U, Francke M, Kehlen A, Holzer M, Hutter-Paier B, Prokesch M, Windisch M, Jagla W, Schlenzig D, Lindner C, Rudolph T, Reuter G, Cynis H, Montag D, Demuth HU, Rossner S. Glutaminyl cyclase inhibition attenuates pyroglutamate Abeta and Alzheimer's disease-like pathology. Nat Med. 2008;14:1106-11.

Shoji A, Souma H, Ozaki T, Kurosu H, Ando I, Berger S. Precise Structural Analysis of α-Helical Poly(L-alanine) by Quantum Chemical Calculation. J Mol Structure. 2008;889:104-1.

Thor D, Schulz A, Hermsdorf T, Schöneberg T. Generation of an agonistic binding site for blockers of the M3 muscarinic acetylcholine receptor. Biochem J. 2008;416:103-12.

Voelcker V, Gebhardt C, Averbeck M, Saalbach A, Wolf V, Weih F, Sleeman J, Anderegg U, Simon J. Hyaluronan Fragments Induce Cytokine and Metalloprotease Upregulation in Human Melanoma Cells in part by signalling via TLR4. Exp Dermatol. 2008;17:100-7.

Wolf P, Rothermel A, Beck-Sickinger AG, Robitzki AA. Microelectrode chip based real time monitoring of vital MCF-7 mamma carcinoma cells by impedance spectroscopy. Biosens Bioelectronics. 2008;24:253-9. 



Barcena M, Radermacher M, Bär J, Kopperschläger G, Ruiz T. The structure of the ATP-bound state of S. cerevisiae phosphofructokinase determined by cryo-electron microscopy. J Struct Biol. 2007;159:135-43.

Benjamin S, Radermacher M, Bär J, Edelmann A, Ruiz T. Structures of S. pombe phosphofructokinase in the F6P-bound and ATP-bound states. J Struct Biol. 2007;159:498-506.

Bhat RK, Berger S. New and easy strategy for cloning, expression, purification, and characterization of the 5S subunit of transcarboxylase from Propionibacterium f. shermanii. Prep Biochem Biotechnol. 2007;37:13-26. 

Böhme I, Mörl K, Bamming D, Meyer C, Beck-Sickinger AG. Tracking of human Y receptors in living cells-a fluorescence approach. Peptides. 2007;28:226-34.

Brand T, Cabrita EJ, Morris GA, Günther R, Hofmann H-J, Berger S. Residue-specific NH exchange rates studied by NMR diffusion experiments. J Magn Reson. 2007;187:97-104.

Daum S, Lücke C, Wildemann D, Schiene-Fischer C. On the benefit of bivalency in peptide ligand/Pin1 interactions. J Mol Biol. 2007;374:147-61.

Findeisen M, Brand T, Berger S. A 1H NMR thermometer suitable for cryoprobes. Magn Reson Chem. 2007;45:175-178.

Haack M, Beck-Sickinger AG. Multiple Peptide Synthesis to Identify Bioactive Hormone Structures. Top Curr Chem. 2007;278:243-88.

Holst B, Mokrosinski J, Lang M, Brandt E, Nygaard R, Frimurer TM, Beck-Sickinger AG, Schwartz TW. Identification of an efficacy switch region in the ghrelin receptor responsible for interchange between agonism and inverse agonism. J Biol Chem. 2007;282:15799-811.

Keil R, Wolf A, Huttelmaier S, Hatzfeld M. Beyond Regulation of Cell Adhesion: Local Control of RhoA at the Cleavage Furrow by the p0071 Catenin. Cell Cycle. 2007;6:122-7. 

Lalueza-Fox C, Römpler H, Caramelli D, Stäubert C, Catalano G, Hughes D, Rohland N, Pilli E, Longo L, Condemi S, de la Rasilla M, Fortea J, Rosas A, Stoneking M, Schöneberg T, Bertranpetit J, Hofreiter M. A melanocortin 1 receptor allele suggests varying pigmentation among Neanderthals. Science. 2007;318:1453-5.

Lodderstedt G, Hess S, Hause G, Scheibel T, Scheuermann T, Schwarz E. The number of alanines in the N-terminal domain of the poly (A) binding protein PABPN1 dictates fibril growth, morphology and stability. FEBS J. 2007;274:346-55.

Merten N, Lindner D, Rabe N, Römpler H, Mörl K, Schöneberg T, Beck-Sickinger AG. Receptor subtype-specific docking of Asp6.59 with C-terminal arginine residues in Y receptor ligands. J Biol Chem. 2007;282:7543-51.

Morris MJ, Gannan E, Stroud LM, Beck-Sickinger AG, O'Brien TJ. Neuropeptide Y suppresses absence seizures in a genetic rat model primarily through effects on Y receptors. Eur J Neurosci. 2007;25:1136-43.

Namasivayam V, Günther R. PSO@AUTODOCK: A fast flexible molecular docking program based on swarm intelligence. Chem Biol & Drug Design. 2007;70:475-84.

Peikert C, Seeger K, Bhat RK, Berger S. Determination of the binding specificity of the 12S subunit of the transcarboxylase by saturation transfer difference NMR. Org Biomol Chem. 2004;2:1777-81.

Raeck C, Berger S. A 2D NMR method to study peptide phosphorylation. Anal Bioanal Chem. 2007;389:2161-5.

Römpler H, Stäubert C, Thor D, Schulz A, Hofreiter M, Schöneberg T. G protein-coupled time travel: evolutionary aspects of GPCR research. Mol Interv. 2007;7:17-25.

Rudolph T, Yonezawa M, Lein S, Heidrich K, Kubicek S, Schäfer C, Phalke S, Walther M, Schmidt A, Jenuwein T, Reuter G. Heterochromatin formation in Drosophila is initiated through active removal of H3K4 methylation by the LSD1 homolog SU(VAR)3-3. Mol Cell. 2007;26:103-15.

Schöneberg T, Hofreiter M, Schulz A, Römpler H. Learning from the past: evolution of GPCR functions. Trends Pharmacol Sci. 2007;28:117-21.

Stäubert C, Tarnow P, Brumm H, Pitra C, Gudermann T, Grüters A, Schöneberg T, Biebermann H, Römpler H. Evolutionary aspects in evaluating mutations in the melanocortin 4 receptor. Endocrinology. 2007;148: 4642-8.

Tanneberger K, Kirchberger J, Bär J, Schellenberger W, Rothemund S, Kamprad M, Otto H, Schöneberg T, Edelmann A. A novel form of 6-Phosphofructokinase: Identification and functional relevance of a third type of subunit in Pichia pastoris. J Biol Chem. 2007;282:23687-97.

Ziemek R, Schneider E, Kraus A, Cabrele C, Beck-Sickinger AG, Bernhardt G, Buschauer A. Determination of affinity and activity of ligands at the human neuropeptide Y Y4 receptor by flow cytometry and aequorin luminescence. J Recept Signal Transduct Res. 2007;27:217-33. 



Ebert A, Lein S, Schotta G, Reuter G. Histone modification and the control of heterochromatic gene silencing in Drosophila. Chromosome Research. 2006;14:377-92.

Koryakov DE, Reuter G, Patrizio D, Zhimuliev I. Heterochromatic proteins HP1, SU(VAR)3-9 and SUUR are distributed differently in chromosomes of germ-line and somatic cells of Drosophila melanogaster. Chromosoma. 2006;115:296-310.

Merten N, Beck-Sickinger AG. Molecular ligand-receptor interaction of the NPY/PP peptide family. EXS. 2006;95:35-62. Review.

Ostareck-Lederer A, Ostareck DH, Rücknagel KP, Schierhorn A, Moritz B, Hüttelmaier S, Flach N, Handoko L, Wahle E. Asymmetric arginine dimethylation of hnRNP K by PRMT1 inhibits its interaction with c-Src. J Biol Chem. 2006;281:11115-25. 

Pluder F, Mörl K, Beck-Sickinger AG. Proteome analysis to study signal transduction of G protein-coupled receptors. Pharmacol Ther. 2006;112:1-11.

Römpler H, Yu HT, Arnold A, Orth A, Schöneberg T. Functional consequences of naturally occurring DRY motif variants in the mammalian chemoattractant receptor GPR33. Genomics. 2006;87:724-32.

Römpler H, Rohland N, Lalueza-Fox C, Willerslev E, Kuznetsova T, Rabeder G, Bertranpetit J, Schöneberg T, Hofreiter M. Nuclear gene indicates coat-color polymorphism in mammoths. Science. 2006;313:62.

Rosenkilde MM, David R, Oerlecke I, Benned-Jensen T, Geumann U, Beck-Sickinger AG, Schwartz TW. Conformational constraining of inactive and active States of a seven transmembrane receptor by metal ion site engineering in the extracellular end of transmembrane segment V. Mol Pharmacol. 2006;70:1892-901.

Scholz C, Eckert B, Hagn F, Schaarschmidt P, Balbach J, Schmid FX. (2006), SlyD Proteins from Different Species Exhibit High Prolyl Isomerase and Chaperone Activities. Biochemistry. 2006;45:20-33.

Uckermann O, Wolf A, Kutzera F, Kalisch F, Beck-Sickinger AG, Wiedemann P, Reichen­bach A, Bringmann A. Glutamate release by neurons evokes a purinergic inhibitory mechanism of osmotic glial cell swelling in the rat retina: activation by neuropeptide Y. J Neurosci Res. 2006;83:538-50.

Weiwad M, Edlich F, Kilka S, Erdmann F, Jarczowski F, Dorn M, Moutty M-C, Fischer G. Comparative analysis of calcineurin inhibition by complexes of immunosuppressive drugs with human FK506 binding proteins. Biochemistry. 2006;45:15776-184.

Wolf A, Keil R, Götzl O, Mun A, Schwarze K, Lederer M, Hüttelmaier S, Hatzfeld M. The armadillo-protein p0071 regulates Rho-signalling during cytokinesis. Nat Cell Biol. 2006;8:1432-40.

Ziemek R, Brennauer A, Schneider E, Cabrele C, Beck-Sickinger AG, Bernhardt G, Buschauer A. Fluorescence- and luminescence-based methods for the determination of affinity and activity of neuropeptide Y2 receptor ligands. Eur J Pharmacol. 2006;551:10-8.



Benmaamar R, Richichi C, Gobbi M, Daniels AJ, Beck-Sickinger AG, Vezzani A. Neuropeptide Y Y5 receptors inhibit kindling acquisition in rats. Regul Pept. 2005;125:79-83.

Dammann R, Strunnikova M, Schadgarsurengin U, Rastetter M, Papritz M, Hattenhorst UE, Hofmann HS, Silber RE, Burdach S, Hansen G. CpG island methylation and expression of tumour-associated genes in lung carcinoma. Eur J Cancer. 2005;41:1223-36.

El Bahh B, Balosso S, Hamilton T, Herzog H, Beck-Sickinger AG, Sperk G, Gehlert DR, Vezzani A, Colmers WF. The anti-epileptic actions of neuropeptide Y in the hippocampus are mediated by Y and not Y receptors. Eur J Neurosci. 2005;22:1417-30.

Ewers H, Smith AE, Sbalzarini IF, Lilie H, Koumoutsakos P, Helenius A. Single-particle tracking of murine polyoma virus-like particles on live cells and ar-tificial membranes. Proc Natl Acad Sci USA. 2005;102:15110-5. (* contributed equally)

Hatzfeld M. The p120 family of cell adhesion molecules. Eur J Cell Biol. 2005;84:205-14.  

Howell OW, Doyle K, Goodman JH, Scharfman HE, Herzog H, Pringle A, Beck-Sickinger AG, Gray WP. Neuropeptide Y stimulates neuronal precursor proliferation in the post-natal and adult dentate gyrus. J Neurochem. 2005;93:560-70.

Lerch M, Kamimori H, Folkers G, Aguilar MI, Beck-Sickinger AG, Zerbe O. Strongly altered receptor binding properties in PP and NPY chimeras are accompanied by changes in structure and membrane binding. Biochemistry. 2005;44:9255-64.

Pagel K, Seeger K, Seiwert B, Villac A, Mark AE, Berger S, Koksch B. Advanced approaches for the characterization of a de novo designed antiparallel coiled coil peptide. Org Biomol Chem. 2005;3:1189-94.

Römpler H, Schulz A, Pitra C, Coop G, Przeworski M, Pääbo S, Schöneberg T. The rise and fall of the chemoattractant receptor GPR33. J Biol Chem. 2005;280:31068-75.

Scholz C, Schaarschmidt P, Engel AM, Andres H, Schmitt U, Faatz E, Balbach J, Schmid FX. (2005), The functional solubilization of aggregation-prone HIV envelope proteins by covalent fusion with chaperone modules. J Mol Biol. 2005;345:1229-41. 

Seeger K, Lein S, Reuter G, Berger S. Saturation Transfer Difference Measurements with SU(VAR)3-9 and S-adenosyl-L-methionine. Biochemistry. 2005;44:6208-13.

Thomas L, Scheidt HA, Bettio A, Huster D, Beck-Sickinger AG, Arnold K, Zschörnig O. Membrane interaction of neuropeptide Y detected by EPR and NMR spectroscopy. Biochim Biophys Acta. 2005;1714:103-13.

Yu C, Malesevic M, Jahreis G, Schutkowski M, Fischer G, Schiene-Fischer C. The architecture of protein-ligand binding sites revealed through template-assisted intramolecular peptide-peptide interactions. Angew Chem Int Ed. 2005;44:1408-12.



Bader JE, Beck-Sickinger AG. Fluorescence resonance energy transfer to study receptor dimerization in living cells. Methods Mol Biol. 2004;259:335-52.

Baldauf C, Günther R, Hofmann H-J. Mixed helices - a general folding pattern in homologous peptides? Angew Chem Int Ed. 2004;43:1594-7.

Baldauf C, Günther R, Hofmann H-J. Conformational properties of sulfonamido peptides. J Mol Struct (Theochem). 2004;675:19-28.

Brocke-Heidrich K, Kretzschmar AK, Pfeifer G, Henze C, Löffler D, Koczan D, Thiesen HJ, Burger R, Gramatzki M, Horn F. Interleukin-6 dependent gene expression profiles in multiple myeloma INA-6 cells reveal a Bcl-2 family-independent survival pathway closely associated with Stat3 activation. Blood. 2004;103:242-51.

David R, Richter MPO, Beck-Sickinger AG. Expressed protein ligation: methods and application. Eur J Biochem. 2004;271:663-77.

Ebert A, Schotta G, Lein S, Kubiced S, Krauss V, Jenuwein T, Reuter G. Su(var) genes regulate the balance between eurochromatin and heterochromatin in Drosophila. Genes Dev. 2004;18:2973-83.

Ende C, Gebhardt R. Inhibition of matrix metalloproteinase-2 and -9 activities by selected flavonoids. Planta Med. 2004;70:1006-8.

Gaunitz F, Heise K, Gebhardt R. A silencer element in the first intron of the glutamine synthetase gene represses induction by glucocorticoids. Mol Endocrinol. 2004;18:63-9.

Günther C, Hause B, Heinz D, Krauzewicz N, Rudolph R, Lilie H. Combination of Listeriolysin O and a tumor-specific antibody facilitates efficient cell-type specific gene delivery of conjugated DNA. Cancer Gene Ther. 2004.

Günther R, Elsner C, Schmidt S, Hofmann H-J, Bordusa F. on the rational design of substrate mimetics: The function of docking approaches for the prediction of protease specifities. Org Biomol Chem. 2004;2:1442-6.

Hofmann HS, Hansen G, Burdach S, Bartling B, Silber RE, Simm A. Discrimination of human lung neoplasm from normal lung by two target genes. Am J Respir Crit Care Med. 2004;170:516-9.

Kretzschmar AK, Dinger MC, Henze C, Brocke-Heidrich K, Horn F. Analysis of Stat3 (signal transducer and activator of transcription 3) dimerization by fluorescence resonance energy transfer in living cells. Biochem J. 2004;377:289-97.

Kurschus FC*, Kleinschmidt M*, Fellows E, Dornmair K, Rudolph R, Lilie H, Jenne DE. Killing of target cells by re-directed granzyme B in the absence of perforin. FEBS Lett. 2004;562:87-92. (*contributed equally)

Mörl K, Beck-Sickinger AG. Structure-activity relationship of peptide-derived ligands at at Y-receptors. Exp Pharmacol. 2004;162:480-503. Review.

Nissler L, Gebhardt R, Berger S. Flavonoid binding t a multi-drug-resistance transporter protein: a STD-NMR study. Anal Bioanal Chem. 2004;379:1045-9.

Peikert C, Seeger K, Bhat RK, Berger S. Determination of the Binding Specificity of the 12S Subunit of the Transcarboxylase by Saturation Transfer Difference NMR. Org Biomol Chem. 2004;2:1777-81.

Rakwalska M, Rospert S. The ribosome-bound chaperones RAC and Ssb1/2p are required for accurate translation in Saccharomyses cerevisiae. Mol Cell Biol. 2004;24:9186-97.

Raue R, Islam MR, Islam MN, Islam KM, Badhy SC, Das PM, Müller H. Reversion of molecularly engineered, partially attenuated very virulent infectious bursal disease virus during infenction of commercial chicken. Avian Pathol. 2004;33:41-50.

Rospert S. Ribosome function: How to govern the fate of a nascent polypeptide. Curr Biol. 2004;14:R386-8.

Scheidt HA, Pampel A, Nissler R, Gebhardt R, Huster D. Investigation of the membrane localization of flavonoids by high-resolution magic angle spinning NMR spectroscopy. Biochim Biophys Acta. 2004;1663:97-107.

Schotta G, Lachner M, Sarma K, Ebert A, Sengupta R, Reuter G, Reinberg D, Jenuwein T. A silencing pathway to induce H3-K9 and H4-K20 tri-methylation at constitutive heterochromatin. Genes Dev. 2004;18:1251-62.

Staege MS, Hutter C, Neumann I, Foja S, Hattenhorst UE, Hansen G, Afar D, Burdach SE. DNA microarrays reveal relationship of Ewing family tumors to both endothelial and fetal neural crest-derived cells and define novel targets. Cancer Res. 2004;64:8213-21.

Tovote P, Meyer M, Beck-Sickinger AG, von Hörsten S, Ove Ogren S, Spiess J, Stiedl O. Central NPY receptor-mediated alteration of heart rate dynamics in mice during expression of fear conditioned to an auditory cue. Regul Pept. 2004;120:205-14.

Tschöp M, Castañeda TR, Joost HG, Thöne-Reineke C, Ortmann S, Klaus S, Hagan MM, Chandler PC, Oswald KD, Benoit SC, Seeley RJ, Kinzig KP, Moran TH, Beck-Sickinger AG, Koglin N, Rodgers RJ, Blundell JE, Ishii Y, Beattie AH, Holch, P, Allison DB, Raun K, Madsen K, Wulff BS, Stidsen CE, Birringer M, Kreuzer OJ, Schindler M, Arndt K, Rudolf K, Mark M, Deng XY, Whitcomb DC, Halem H, Taylor J, Dong J, Datta R, Culler M, Craney S, Flora D, Smiley D, Heiman ML. Does gut hormone PYY3-36 decrease food intake in rodents? Nature. 2004;430:165.

Ueberham E, Arendt E, Starke M, Bittner R, Gebhardt R. Reduction and expansion of the glutamine synthetase expressing zone in livers from tetracycline controlled TGF-β1 transgenic mice and multiple starved mice. J Hepatol. 2004;41:75-81.

van den Berg TP, Morales D, Eterradossi N, Rivallan G, Toquin D, Müller H, Raue R, Zierenberg K, Zhang MF, Zhu YP, Wang CQ, Zheng HJ, Wang X, Lim BL. Comparison of selected criteria for the classification of IBDV strains as pathotypes: a collaborative study. Avian Pathol. 2004;33:470-6.

Zierenberg K, Raue R, Nieper H, Islam MR, Eterradossi N, Toquin D, Müller H. Generation of serotype 1/serotype 2 reassortant viruses of the infectious bursal disease virus and their investigation in vitro and in vivo. Virus Res. 2004;105:23-34.



Angulo M, Hawat C, Hofmann H-J, Berger S. Site-specific solvation determined by intermolecular nuclear Overhauser effect-measurements and molecular dynamics. Org Biomol Chem. 2003;1:1049-52.

Baldauf C, Günther R, Hofmann H-J. Helix formation and folding in γ-peptides and their vinylogues. Helv Chim Acta. 2003;86:2573-88.

Bonne S, Gilbert B, Hatzfeld M, Chen X, Green K, VanRoy F. Defining Desmosomal-Plakophilin 3 interactions. J Cell Biol. 2003;161:403-16.

Brecht S, Schwarze K, Waetzig V, Christner C, Heiland S, Fischer G, Sartor K, Herdegen T. Changes in the peptidyl-prolyl cis/trans isomerase activity and FK506 binding protein expression following neuroprotection by FK506 in the ischemic rat brain. Neuroscience. 2003;120:1037-48.

Calkiens CC, Hoepner BL, Law CM, Novak MR, Hatzfeld M, Kowalczyk AP. The armadillo family protein p0071 is a VE-cadherin and desmoplakin binding protein: implications for vascular endothelial intercellular junction assembly. J Biol Chem. 2003;278:1774-83.

Dinger MC, Bader JE, Kobor AD, Kretzschmar AK, Beck-Sickinger AG. Homodimerization of NPY receptors investigated by fluorescence resonance energy transfer in living cells. J Biol Chem. 2003;278:10562-71.

Gautschi M, Just S, Mun A, Ross S, Rücknagel P, Dubaquie Y, Ehrenhofer-Murray A, Rospert S. The yeast Nα-acetyltransferase NatA is quantitatively anchored to the ribosome and interacts with nascent polypeptides. Mol Cell Biol. 2003;23:7403-14.

Hatzfeld M, Green , Sauter H.Targeting of p0071 to desmosomes and adherens junctions is mediated by different protein domains. J Cell Sci. 2003;116:1220-33.

Kerwitz Y, Kühn U, Lilie H, Knoth A, Scheuermann T, Friedrich H, Schwarz E, Wahle E. Stimulation of poly(A) polymerase through a direct interaction with the nuclear poly(A) binding protein allosterically regulated by RNA. EMBO J. 2003;22:3705-14.

Kleinschmidt M, Rudolph R, Lilie H. Design of a modular immunotoxin connected by polyionic adapter peptides. J Mol Biol. 2003;327:445-52.

Koglin N, Lang M, Rennert R, Beck-Sickinger AG. Facile and selective nanoscale labeling of peptides in solution using photolabile protecting groups. J Med Chem. 2003;46:4369-72.

Kühn U, Nemeth A, Meyer S, Wahle E. The RNA binding domains of the nuclear poly(A)binding protein. J Biol Chem. 2003;278:16196-25.

Machova Z, von Eggelkraut-Gottanka R, Wehofsky N, Bordusa F, Beck-Sickinger AG. Expressed enzymatic ligation: a new approach for the synthesis of chemically modified proteins. Angew Chem Int Ed. 2003:42:4916-8.

Meyer-Wentrup F, Burdach S. Efficacy of dendritic cell generation for clinical use: recovery and purity of monocytes and mature dendritic cells after bimmunomagnetic sorting or adherence selection of CD14+ starting populations. J Hematother Stem Cell Res. 2003;12:289-99.

Müller H, Islam MR, Raue R. Review: Research on infectious bursal disease - the past, the present and the future. Vet Microbiol. 2003;97:153-65.

Niedernberg A, Blaukat A, Schöneberg T, Kostenis E. Resolution of constitutive activity of the human S1P5 receptor in various biochemical and cellular assays. Brit J Pharmacol. 2003;128:481-93.

Raile K, Berthold A, Banning U, Horn F, Pfeiffer G, Kiess W. IGFs, basic FGF, and glucose modulate proliferation and apoptosis induced by IFNγ but not by IL-1β in rat INS-1E βcells. Horm Metab Res. 2003;35:407-14.

Raile K, Hille R, Laue S, Schulz A, Pfeifer G, Horn F, Kiess W. Insulin-like growth factor I (IGF-I) stimulates proliferation but also increases caspase-3 activity, Annexin-V binding, and DNA-fragmentation in human MG63 osteosarcoma cells: co-activation of pro- and anti-apoptotic pathways by IGF-I. Horm Metab Res. 2003;35:786-93.

Scheuermann T, Schulz B, Blume A, Wahle E, Rudolph R, Schwarz E. Trinucleotide expansions leading to an extended poly-L-alanine segment in the poly (A) binding protein PABPN1 cause fibril formation. Prot Sci. 2003;12:2685-92. 

Schotta G, Ebert A, Reuter G. SU(VAR)3-9 a conserved key function in heterochromatic gene silencing. Genetica. 2003;117:149-58.

Schotta G, Ebert A, Reuter G. Position-effect variegation and the genetic dissection of chromatin regulation in Drosophila. Sem Cel Dev Biol. 2003;14:67-75.

Schulz A, Schöneberg T. The structural evolution of a P2Y-like G-protein coupled receptor. J Biol Chem. 2003;278:34998-5015.

Smith AE, Lilie H, Helenius A. Ganglioside-dependent cell attachment and endocytosis of murine polyomavirus-like particles. FEBS Lett. 2003;555:199-203.

Staege MS, Hattenhorst UE, Neumann UE, Hutter C, Foja S, Burdach S. DNA-microarrays as tools for the identification of tumor specific gene expression profiles: applications in tumor biology, diagnosis and therapy. Klin Pädiatr. 2003;21:135-9.

Straub BK, Boda J, Kuhn C, Schnoelzer M, Korf U, Kempf T, Spring H, Hatzfeld M, Franke WW. A novel cell-cell junction system: The cortex adhaerens mosaic of lens fiber cells. J Cell Sci. 2003;16:4985-95.

Tarnow P, Schöneberg T, Krude H, Grüters A, Biebermann H. Mutationally induced sulfide bond formation within the third extracellular loop causes melanocortin 4 receptor inactivation in patients with obesity. J Biol Chem. 2003;278:48666-73.

Thum A, Oertel M, Hansen G, Hofmann S, Burdach S, Posch S. Differentially co-regulated groups of genes in microarray experiments. Bioinformatics. 2004.

Ueberham E, Loew R, Ueberham U, Schoenig K, Bujard H, Gebhardt R. Conditional tetracycline-regulated expression of TGF-β1 in liver of transgenic mice leads to reversible intermediary fibrosis. Hepatology. 2003;37:1067-78.

von Eggelkraut-Gottanka R, Klose A, Beck-Sickinger AG, Beyermann M. Peptide alpha-thioester formation using standard Fmoc-chemistry. Tetrahydron Lett. 2003;44:3551-4.

von Eggelkraut-Gottanka R, Machova Z, Grouzmann E, Beck-Sickinger AG. Semisynthesis and characterisation of the first analogues of pro-neuropeptide Y. Chembiochem. 2003;4:425-33.

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