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Research Area B: Biological active profiles in cells systems and aECM-backed tissue regeneration

The Research Area B – Biological active profiles in cells systems and aECM-backed tissue regeneration – combine projects with cell biological and clinical orientation. The main focus here is the systematic cell and molecular biological characterisation of matrix/cell interactions in complex systems. We investigate mainly cell types that have intensive matrix contacts in skin and bones.

The following subprojects are part of the Research Area B:

B1 Influence of artificial and native extracellular matrices on adhesion and differentiation of mesenchymal stem cells and osteoblats (Hempel)

B2  Effects of sulfated glycosaminoglycans on bone regeneration (Hofbauer/Hofbauer)

B3 Immune responses to native and artificial extracellular matrices (Simon/Franz)

B4 Impact of artificial extracellular matrix on fibroblast functions (Anderegg/Saalbach)

B5 In vivo- and ex vivo-investigation of the effects of artificial matrices on implant surfaces in long bones (Rammelt/Pietzsch)

B10 In situ characterization of mediator controlled immune cell interaction in GAG-modified aECM (Pompe)

B11 Die Rolle der EZM für die Knochenregeneration im Zebrafisch (Brand/Knopf)