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Dr. Ute Hempel

Principal Investigator B1

Dr. Ute Hempel
Research Assistant at the Institute of Physiological Chemistry

Technische Universität Dresden
Faculty of Medicine "Carl Gustav Carus"
Institute of Physiological Chemistry
Fiedlerstraße 42
01307 Dresden

Phone: +49 (0)351 458-6430
Fax: +49 (0)351 458-6317

E-Mail: ute.hempel@tu-dresden.de


Curriculum Vitae

1984
Diploma in Chemistry, Universität Leipzig
1984 – 1988
Research assistant at the Institute of Organic Chemistry, Universität Leipzig
1988
Doctorate in Organic Chemistry, Universität Leipzig
since 1988
Research assistant at teh Institute of Physiological Chemistry, Faculty of Medicine, TU Dresden (formerly known as Institute of Medical Diagnostics)
1989 – 1990
Research stay at the Institute of Food Chemistry of the TU Dresden (working group "Peptide Chemistry", Prof. Losse, main research: peptide synthesis)
1990
Research stay at the Institute of Material Research, Berlin (working group "Peptide Chemistry, main research: solid phase peptide synthesis)
1991 – 1997
Cooperative work on projects dealing with "Pathogenesis in the Development of Liver Fibrosis"
1998 – 2006
Principal Investigator in the DFG Priority Programm Gradient Materials
Project "Optimization of the Osseointegration of Bone Implants by Graded Supramolecular Structures on the Basis of Fibronectin and Collagen Type I and III"
since 2007
Principal investigator, DFG project bundle 105 "Understanding of Molecular Mechanisms in the Interaction of Osteoblasts and Soluble and Immobilized Hyaluron Acid Derivatives"

Publications

[1]  
Vogel S, Arnoldini S, Möller S, Schnabelrauch M, Hempel U. Sulfated hyaluronan alters fibron-ectin matrix assembly and promotes osteogenic differentiation of human bone marrow stromal cells. Scientific Reports. 2016;6:36418.
[2]
Schmidt J, Kliemt S, Preissler C, Möller S, von Bergen M, Hempel U*, Kalkhof S*. Osteoblast-released matrix vesicles - Regulation of activity and composition by sulfated and non-sulfated glycosaminoglycans. Mol Cell Proteomics. 2016, 15:558-572. (*shared senior authors)
[3]
Hempel U, Müller K, Preissler C, Noack C, Boxberger S, Dieter P, Bornhäuser M, Wobus M. Human bone marrow stromal cells: A reliable, challenging tool for in vitro osteogenesis and bone engineering approaches. Stem Cells Int. 2016, 2016:7842191.
[4]
Müller M, Torger B, Wehrum D, Vehlow D, Urban B, Woltmann B, Hempel U. Drug delivery and cell interaction of adhesive poly(ethyleneimine)/sulfated polysaccharide complex particle films. Biointerphases. 2015, 10(1):011001.
[5]   Hempel U, Matthäus C, Preissler C, Möller S, Hintze V, Dieter P. Artificial matrices with high-sulfated glycosaminoglycans and collagen are anti-inflammatory and pro-osteogenic for human mesenchymal stromal cells. J Cell Biochem. 2014, 115:1561-1571.
[6] 
Kliemt S*, Lange C*, Otto W, Hintze V, Möller S, von Bergen M, Hempel U**, Kalkhof S**. Sul-fated hyaluronan containing collagen matrices enhance cell-matrix-interaction, endocytosis, and osteogenic differentiation of human mesenchymal stromal cells. J Proteome Res. 2013, 12:378-389. (*shared authorship, **shared senior authors)
[7] 
Büttner M, Möller S, Keller M, Huster D, Schiller J, Schnabelrauch M, Dieter P, Hempel U. Over-sulfated chondroitin sulfate derivatives induce osteogenic differentiation of human mesen-chymal stromal cells independent of bone morphogenetic protein-2 and transforming growth factor-?1 signalling. J Cell Physiol. 2013, 228:330-340.
[8] 
Hempel U, Möller S, Noack C, Hintze V, Scharnweber D, Schnabelrauch M, Dieter P. Sulfated hyaluronan/collagen I-matrices enhance osteogenic differentiation of human mesenchymal stromal cells in vitro even in the absence of dexamethasone. Acta Biomat. 2012, 8:4064-4072.
[9] 
Hempel U, Hintze V, Möller S, Schnabelrauch M, Scharnweber D, Dieter P. Artificial extracellu-lar matrices composed of collagen I and sulfated hyaluronan with adsorbed transforming growth factor ?1 promote collagen synthesis of human mesenchymal stromal cells. Acta Biomat. 2012, 8:659-666.
[10] 
Kalbacova M, Kalbac M, Dunsch L, Hempel U. Influence of single-walled carbon nanotube films on metabolic activity and adherence of human osteoblasts. Carbon. 2007, 45:2266-2272.

Patents

2013
Lutter A-H, Hempel U, Dieter P. Method and means for detecting the activity of osteoclasts. (Europäische Patentanmeldung Nr. 10707908.9, 16.01.2013); EP 2 406 626 B1
2009    
Scheffler A-H, Hempel U, Dieter P. Verfahren und Mittel zum Nachweis der Aktivität von Osteoklasten. (Deutsche Patentanmeldung Nr. 10 2009 013 957.5-41, 13. März 2009), Offenlegung: DE10 209 013 957 A1 2010.09.16