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Publikationen des Transregio

Im Rahmen des Transregio sind zahlreiche Publikationen entstanden, die Sie im folgenden finden. Die bibliographischen Angaben sind mit Pubmed verlinkt.

2017 2016  |  2015  |  2014  |  2013  |  2012 2011  |  2010  |  2009


PUBLIKATIONEN 2017 


Aliperta R, Welzel PB, Bergmann R, Freudenberg U, Berndt N, Feldmann A, Arndt C, Koristka S, Stanzione M, Cartellieri M, Ehninger A, Ehninger G, Werner C, Pietzsch J, Steinbach J, Bornhäuser M, Bachmann MP. Cryogel-supported stem cell factory for customized sustained release of bispecific antibodies for cancer immunotherapy
. Sci Rep. 2017;7:42855.
 
Becher J, Moeller S, Schnabelrauch M. Building blocks for artificial extracellular matrices bases on cross-linkable polysaccahride and glucosaminoglycan sulfates. Mater Sci Forum. 2017;879:1270-5.
 
Jouy F, Lohmann N, Wandel E, Ruiz-Gómez G, Pisabarro MT, Beck-Sickinger AG, Schnabelrauch M, Moeller S, Simon JC, Kalkhof S, von Bergen M, Franz S. Sulfated hyaluronan attenuates inflammatory signaling pathways in macrophages involving induction of antioxidants. Proteomics. 2017. [Epub ahead of print]

Ferrer RA, Saalbach A, Grünwedel M, Lohmann N, Forstreuter I, Saupe S, Wandel E, Simon JC, Franz S. Dermal Fibroblasts Promote Alternative Macrophage Activation Improving Impaired Wound Healing. J Invest Dermatol. 2017, 137:941-950.

Förster Y, Bernhard R, Hintze V, Möller S, Scharnweber D, Schnabelrauch M, Rammelt S. Collagen/Glycosaminoglycan coatings enhance new bone formation in a critical size bone defect - a pilot study in rats. Mater Sci Eng C. 2017;71:84-92.
 
Friedemann M, Kalbitzer L, Franz S, Moeller S, Schnabelrauch M, Simon JC, Pompe T, Franke K. Instructing human macrophage polarization by stiffness and glycosaminoglycan functionalization in 3D collagen networks. Adv Healthc Mater. 2017, 6.

Huster D. Solid-state NMR techniques to study the molecular dynamics in cartilage. In: Xia Y, Momot K. (Eds.): Biophysics and Biochemistry of Cartilage by NMR and MRI. RSC Publishing, Cambridge, 2017, pp. 279-296. (ISBN 978-1-78262-133-1).
 
Kascholke C, Loth T, Kohn-Polster C, Möller S, Bellstedt P, Schulz-Siegmund M, Schnabelrauch M, Hacker M. Dual-functional hydrazide-reactive and anhydride containing oligomeric hydrogel building blocks. Biomacromolecules. 2017, 18:683-694. 
 
Kohn-Polster C, Bhatmagar D, Woloszyn DJ, Richtmyer M, Strake A, Springwald AH, Franz S, Schulz-Siegmund M, Kaplan HM, Kohn J, Hacker MC. Dual-Component Gelatinous Peptide/Reactive Oligomer Formulations as Conduit Material and Luminal Filler for Peripheral Nerve Regeneration. Int J Mol Sci. 2017 May 21;18(5).
 
Lohmann N, Schirmer L, Atallah P, Wandel E, Ferrer RA, Werner C, Simon JC, Franz S, Freudenberg U. Glycosaminoglycan-based hydrogels capture inflammatory chemokines and rescue wound healing deficiency. Sci Transl Med. 2017, 9(386).  
 
Metzger W, Rother S, Pohlemann T, Möller S, Schnabelrauch M, Hintze V, Scharnweber D. Evaluation of cell-surface interaction using a 3D spheroid cell culture model on artificial extracellular matrices. Mater Sci Eng C. 2017;73:310-8.
 
Müller BM, Loth R, Hoffmeister PG, Zühl F, Kalbitzer L, Hacker MC, Schulz-Siegmund M. Surface modification of copolymerized films from three-armed biodegradable macromers - an analytical platform for modified tissue engineering scaffolds. Acta Biomater. 2017, 51:148-160.

Rother S, Samsonov SA, Möller S, Schnabelrauch M, Rademann J, Blaszkiewicz J, Köhling S, Waltenberger J, Pisabarro MT, Scharnweber D, Hintze V. Sulfate hyaluronan alters endothelial cell activation in vitro by controlling the biological activity of the angiogenic factors vascular endothelial growth factor-A and tissue inhibitor of metalloproteinase-3. CS Appl Mater Interfaces. 2017, 9(11):9539-9550.
 
Sapudom J, Ullm F, Martin S, Kalbitzer L, Naab J, Möller S, Schnabelrauch M, Anderegg U, Schmidt S, Pompe T. Molecular weight specific impact of soluble and immobilized hyaluronan on CD44 expressing melanoma cells in 3D collagen matrices. Acta Biomater. 2017;50:259-70.
 
Thönes S, Kutz LM, Oehmichen S Becher J, Heymann K, Saalbach A, Knolle W, Schnabelrauch M, Reichelt S, Anderegg U. New E-beam-initiated hyaluronan acrylate cryogels support growth and matrix deposition by dermal fibroblasts. Int J Biol Macromol. 2017;611-620.

Sapudom J, Rubner S, Martin S, Pompe T. Mimicking Tissue Boundaries by Sharp Multiparameter Matrix Interfaces. Adv Healthc Mater. 2016 Apr 29.

PUBLIKATIONEN 2016

 
Anders G, Hassiepen U, Theisgen S, Heymann S, Muller L, Panigada T, Huster D, Samsonov SA. The Intrinsic Pepsin Resistance of Interleukin-8 Can be Explained from a Combined Bioinformatical and Experimental Approach. IEEE/ACM Trans Comput Biol Bioinform. 2016. [Epub ahead of print]
 
Ansorge M, Rastig N, Steinborn R, König T, Baumann L, Möller S, Schnabelrauch M, Cross M, Werner C, Beck-Sickinger AG, Pompe T. Short-range cytokine gradients to mimic paracrine cell interactions in vitro. J Control Release. 2016. [Epub ahead of print]

Babik S, Samsonov SA, Pisabarro MT. Computational drill down on FGF1-heparin interactions through methodological evaluation. Glycoconj J. 2016. [Epub ahead of print]

Betz VM, Betz OB, Rosin T, Keller A, Thirion C, Salomon M, Manthey S, Augat P, Jansson V, Müller PE, Rammelt S, Zwipp H. An expedited approach for sustained delivery of bone morphogenetic protein-7 to bone defects using gene activated fragments of subcutaneous fat. J Gene Med. 2016;18: 199-207.

Campbell GM, Tiwari S, Hofbauer C, Picke AK, Rauner M, Huber G, Peña JA, Damm T, Barkmann R, Morlock MM, Hofbauer LC, Glüer CC. Effects of parathyroid hormone on cortical porosity, non-enzymatic glycation and bone tissue mechanics in rats with type 2 diabetes mellitus. Bone. 2016, 82:116-21.

Förster Y, Schmidt JR, Wissenbach DK, Pfeiffer SEM, Baumann S, Hofbauer LC, von Bergen M, Kalkhof S, Rammelt S. Microdialysis sampling from wound fluids enables quantitative assessment of cytokines, proteins, and metabolites reveals bone defect-specific molecular profiles. PLoS One. 2016;11:e0159580. 

Freudenberg U, Liang Y, Kiick KL, Werner C. Glycosaminoglycan-Based Biohybrid Hydrogels: A Sweet and Smart Choice for Multifunctional Biomaterials. Adv Mater. 2016;28:8861-8891.

Gladytz A, John T, Gladytz T, Hassert R, Pagel M, Risselada HJ, Naumov S, Beck-Sickinger AG, Abel B. Peptides@mica: from affinity to adhesion mechanism. Phys Chem Chem Phys. 2016;18:23516-27.

Hammer N, Huster D, Boldt A, Hädrich C, Koch H, Möbius R, Schulze-Tanzil G, Scheidt HA. A preliminary technical study on sodium dodecyl sulfate-induced changes of the nano-structural and macro-mechanical properties in human iliotibial tract specimens. J Mech Behav Biomed Mater. 2016; 61:164-173.

Hempel U, Müller K, Preissler C, Noack C, Boxberger S, Dieter P, Bornhäuser M, Wobus M. Human bone marrow stromal cells: A reliable, challenging tool for in vitro osteogenesis and bone tissue engineering approaches. Stem Cells Int. 2016;2016:7842191.
 
Hendrikx S, Kascholke C, Flath T, Schumann D, Gressenbuch M, Schulze FP, Hacker MC, Schulz-Siegmund M. Indirect rapid prototyping of sol-gel hybrid glass scaffolds for bone regeneration - Effects of organic crosslinker valence, content and molecular weight on mechanical properties. Acta Biomater. 2016;35:318-29.  
 
Kalkhof S, Schildbach S, Blumert C, Horn F, von Bergen M, Labudde D. PIPINO: A Software Package to Facilitate the Identification of Protein-Protein Interactions from Affinity Purification Mass Spectrometry Data. Biomed Res Int. 2016;2016:e2891918.

Köhling S, Exner MP, Nojoumi S, Schiller J, Budisa N, Rademann J. One-pot synthesis of anomeric glycosyl thiols from highly functionalized unprotected sugars in water for use in glycan ligation reactions. Angew Chem Int Ed. 2016;55:15510-4; Angew Chem Int Ed. 2016;55:15736-40.

Köhling S, Künze G, Lemmnitzer K, Bermudez M, Wolber G, Schiller J, Huster D, Rademann J. Chemoenzymatic synthesis of nanosulfated  tetrahyaluronan with a paramagnetic tag for studying its complex with interleukin-10. Chemistry. 2016, 22:5563-5574.

Kohn C, Klemens JM, Kascholke C, Murthy NS, Kohn J, Brandenburger M, Hacker MC. Dual-component collagenous peptide/reactive oligomer hydrogels as potential nerve guidance materials - from characterization to functionalization. Biomater Sci. 2016;4:1605-1621.
 
Künze G, Köhling S, Vogel A, Rademann J, Huster D. Identification of the glycosaminoglycan binding site of interleukin-10 by NMR spectroscopy. J Biol Chem. 2016;291:3100-3113. 

Lemmnitzer K, Riemer T, Groessl M, Süß R, Knochenmuss R, Schiller J. Comparison of ion mobility-mass spectrometry and pulsed-field gradient nuclear magnetic resonance spectroscopy for the differentiation of chondroitin sulfate isomers. Anal Methods. 2016;8:8483-91.

Lutter A-H, Hempel U, Anderer U, Dieter P. Biphasic influence of PGE2 on the resorption activity of osteoclast-like cells derived from human peripheral blood monocytes and mouse RAW264.7 cells. J plefa. 2016;111:1-7.
 
Martin S, Wang H, Rathke T, Anderegg U, Möller S, Schnabelrauch M, Pompe T, Schmidt S. Polymer hydrogel particles as biocompatible AFM probes to study CD44 / hyaluronic acid interactions on cells. Polymer. 2016;102:342-349.
 
Nowald C, Penk A, Chiu H, Bein T, Huster D, Lieleg O. A mucin/methylcellulose hybrid gel for applications in wound treatment. Macromol Biosci. 2016;16:567-579.
 
Pagel M, Beck-Sickinger AG. Multifunctional biomaterial coatings: synthetic challenges and biological activity. Biol Chem. 2016;398:3-22.

Pagel M, Hassert R, John T, Braun K, Wießler M, Abel B, Beck-Sickinger AG. Multifunctional Coating Improves Cell Adhesion on Titanium by using Cooperatively Acting Peptides. Angew Chem Int Ed Engl. 2016;55:4826-4830.

Pagel M, Meier R, Braun K, Wiessler M, Beck-Sickinger AG. On-resin Diels-Alder reaction with inverse electron demand: an efficient ligation method for complex peptides with a varying spacer to optimize cell adhesion. Org Biomol Chem. 2016;14:4809-16.
 
Panitz N, Theisgen S, Samsonov SA, Gehrke JP, Baumann L, Bellmann-Sickert K, Köhling S, Pisabarro MT, Rademann J, Huster D, Beck-Sickinger AG. The structural investigation of glycosaminoglycan binding to CXCL12 displays distinct interaction sites. Glycobiology. 2016;26:1-13
 
Picke AK, Salbach-Hirsch J, Hintze V, Rother S, Rauner M, Kascholke C, Möller S, Bernhardt R, Rammelt S, Pisabarro MT, Ruiz-Gómez G, Schnabelrauch M, Schulz-Siegmund M, Hacker MC, Scharnweber D, Hofbauer C, Hofbauer LC. Sulfated hyaluronan improves bone regeneration of diabetic rats by binding sclerostin and enhancing osteoblast function. Biomaterials. 2016;96:11-23. 
 
Picke AK, Gordaliza Alaguero I, Campbell GM, Glüer CC, Salbach-Hirsch J, Rauner M, Hofbauer LC, Hofbauer C. Bone defect regeneration and cortical bone parameters of type 2 diabetic rats are improved by insulin therapy. Bone. 2016;82:108-115.
 
Rother S, Samsonov SA, Hempel U, Vogel S, Moeller S, Blaszkiewicz J, Köhling S, Schnabelrauch M, Rademann J, Pisabarro MT, Hintze V, Scharnweber D. Sulfated hyaluronan alters the interaction profile of TIMP-3 with the endocytic receptor LRP-1 cluster II and IV and increases the extracellular TIMP-3 level of human bone marrow stromal cells. Biomacromolecules. 2016; 17:3252-3261.

Rother S, Samsonov SA, Hofmann T, Blaszkiewicz J, Köhling S, Moeller S, Schnabelrauch M, Rademann J, Kalkhof S, von Bergen M, Pisabarro MT, Scharnweber D, Hintze V. Structural and functional insights into the interaction of sulfated glycosaminoglycans with tissue inhibitor of metalloproteinase-3 - a possible regulatory role on extracellular matrix homeostasis. Acta Biomater. 2016, 45:143-54

Ruiz-Gómez G, Hawkins JC, Philipp J, Künze G, Wodtke R, Löser R, Fahmy K, Pisabarro MT. Rational structure-based rescaffolding approach to de novo design of interleukin 10 (IL-10) receptor-1 mimetics. PLoS One. 2016; 11: e0154046.

Samsonov SA, Pisabarro MT. Computational analysis of interactions in structurally available protein-glycosaminoglycan complexes. Glycobiology. 2016; 26:850-61.
 
Sapudom J, Rubner S, Martin S, Pompe T. Tissue Boundaries: Mimicking tissue boundaries by discrete multi-parameter matrix interfaces. Adv Healthc Mater. 2016; 5:1860.
 
Savkovic V, Flämig F, Schneider M, Sülflow K, Loth T, Lohrenz A, Hacker MC, Schulz-Siegmund M, Simon JC. Polycaprolactone fiber meshes provide a 3D environment suitable for cultivation and differentiation of melanocytes from the outer root sheath of hair follicle. J Biomed Mater Res A. 2016;104:26-36.

Schirmer L, Atallah P, Werner C, Freudenberg U. StarPEG-heparin hydrogels to protect and sustainably deliver IL-4. Adv Healthc Mater. 2016;5:3154-64.

Schmidt JR, Kliemt S, Preissler C, Möller S, von Bergen M, Hempel U*, Kalkhof S*. Osteoblast-released matrix vesicles - Regulation of activity and composition by sulfated and non-sulfated glycosaminoglycans. Mol Cell Proteomics. 2016;15:558-572. (*shared senior authors)
  
Schneider M, Sülflow K, Loth T, Schulz-Siegmund M, Hacker M, Simon JC, Savkovic V. Melanocytes from the outer root sheath of human hair and epidermal melanocytes display improved melanotic features in the niche provided by cGEL, oligomer-cross-linked gelatin-based hydrogel. J Biomed Mater Res A. 2016;104:3115-26.

Sedaghati B, Jahroomishirazi R, Starke A, Hacker MC, Schulz-Siegmund M. Rat Osteosarcoma Cells as a Therapeutic Target Model for Osteoregeneration via Sclerostin Knockdown. Cells Tissues Organs. 2016;201:366-379.
 
Stelzner K, Herbert D, Popkova Y, Lorz A, Schiller J, Gericke M, Klöting N, Blüher M, Franz S, Simon JC, Saalbach A. Free fatty acids sensitize dendritic cells to amplify TH1/TH17-immune responses. Eur J Immunol. 2016;46:2043-53.
 
Sülflow K, Schneider M, Loth T, Kascholke C, Schulz-Siegmund M, Hacker MC, Simon JC, Savkovic V. Melanocytes from the outer root sheath of human hair and epidermal melanocytes display improved melanotic features in the niche provided by cGEL, oligomer-cross-linked gelatin-based hydrogel. J Biomed Mater Res A. 2016;104:3115-26. 
 
Taubenberger AV, Bray LJ, Haller B, Shaposhnykov A, Binner M, Freudenberg U, Guck J, Werner C. 3D extracellular matrix interactions modulate tumour cell growth, invasion and angiogenesis in engineered tumour microenvironments. Acta Biomater. 2016;36:73-85.
 
Vogel S, Arnoldini S, Möller S, Schnabelrauch M, Hempel U. Sulfated hyaluronan alters fibronectin matrix assembly and promotes osteogenic differentiation of human bone marrow stromal cells. Scientific Reports. 2016; 6:36418. 


Materials in Medicine 09/2015
   

PUBLIKATIONEN 2015

 
Andrault PM, Samsonov SA, Weber G, Coquet L, Nazmi K, Bolscher J,  Lalmanach AC, Jouenne T, Bromme D, Pisabarro MT, Lalmanach G, Lecaille F. The antimicrobial peptide LL-37 is both a substrate of cathepsins S and K and a selective inhibitor of cathepsin L. Biochemistry. 2015;54:2785-98.
 
Altgärde N, Eriksson C, Peerboom N, Phan-Xuan T, Moeller S, Schnabelrauch M, Svedhem S, Trybala E, Bergström T, Bally M. Mucin-like Region of Herpes Simplex Virus Type 1 Attachment Protein Glycoprotein C (gC) Modulates the Virus-Glycosaminoglycan Interaction. J Biol Chem. 2015;290:21473-21485.

Betz VM, Betz OB, Rosin T, Keller A, Thirion C, Salomon M, Manthey S, Augat P, Jansson V, Müller PE, Rammelt S, Zwipp H. The effect of BMP-7 gene activated muscle tissue implants on the repair of large segmental bone defects. Injury. 2015; 46: 2351-8.

Bray LJ, Binner M, Holzheu A, Friedrichs J, Freudenberg U, Hutmacher DW, Werner C. Multi-parametric hydrogels support 3D in vitro bioengineered microenvironment models of tumour angiogenesis. Biomaterials. 2015;53:609-620.

De Barros RRM, Novaes AB, Korn P, Queiroz A, de Almeida ALG, Hintze V, Scharnweber D, Bierbaum S, Stadlinger. Bone Formation in a Local Defect around Dental Implants Coated with Extracellular Matrix Components. Clin Implant Dent Relat Res. 2015;17:742-57.

Elschner C, Noack C, Preißler C, Krause A, Scheler U, Hempel U. In vitro response of human mesenchymal stem cells to titanium coated PEEK films and their suitability for magnetic resonance imaging. Journal of Materials Science & Technology.
2015, 31:427-436. 
 
Franz S, Muñoz LE, Heyder P, Herrmann M, Schiller M. Unconventional apoptosis of polymorphonuclear neutrophils (PMN): staurosporine delays exposure of phosphatidylserine and prevents phagocytosis by M?-2 macrophages of PMN. Clin Exp Immunol. 2015, 179:75-84.
 
Freudenberg U, Zieris A, Chwalek K, Tsurkan MV, Maitz MF, Atallah P, Levental KR, Eming SA, Werner C. Heparin desulfation modulates VEGF release and angiogenesis in diabetic wounds. J Control Release. 2015, 220:79-88. 
 
Gehrcke JP, Pisabarro MT. Identification and characterization of a glycosaminoglycan binding site on interleukin-10 via molecular simulation methods. J Mol Graph Model. 2015;62:97-104.
 
Hacker MC, Nawaz HA. Multi-Functional Macromers for Hydrogel Design in Biomedical Engineering and Regenerative Medicine. Int J Mol Sci. 2015 Nov 19;16:27677-706.
 
Hofmann T, Fischer AW, Meiler J, Kalkhof S. Protein structure prediction guided by crosslinking restraints - A systematic evaluation of the impact of the crosslinking spacer length. Methods. 2015;89:79-90.
  
Hofmann T, Samsonov SA, Pichert A, Lemmnitzer K, Schiller J, Huster D, Pisabarro MT, von Bergen M, Kalkhof S. Structural analysis of the interleukin-8/glycosaminoglycan interactions by amide hydrogen/deuterium exchange mass spectrometry. Methods. 2015, 89:45-53.
 
Jouy F, Müller SA, Wagner J, Otto W, von Bergen M, Tomm JM. Integration of conventional quantitative and phospho-proteomics reveals new elements in activated Jurkat T-cell receptor pathway maintenance. Proteomics. 2015;15:25-33.
 
Kalbitzer L, Franke K, Moeller S, Schnabelrauch M, Pompe T. Glycosaminoglycan functionalization of mechanically and topologically defined collagen  matrices. J Mater Chem B. 2015;3: 8902-8910.
 
Lemmnitzer K, Griesinger H, Süß R, Matheis K, Schulz M, Schiller J. Analysis of glycosaminoglycan oligosaccharides by combined HPTLC/MALDI-TOF MS: reduced silica gel thickness leads to improved spectral qualities and reduced side reactions. Chromatographia. 2015; 78:1409-13.

Lemmnitzer K, Süß R, Schiller J. TLC - MALDI MS of carbohydrates. IN: Kowalska T, Sajewicz M, Sherma J, "Planar Chromatography – Mass Spectrometry", Taylor and Francis Verlag.
 
Loth R, Loth T, Schwabe K, Bernhardt R, Schulz-Siegmund M, Hacker MC. Highly adjustable biomaterial networks from three-armed biodegradable macromers. Acta Biomater. 2015;26:82-96.
 
Matheis K, Fuchs B, Lemmnitzer K, Süß R, Griesinger H, Minarik S, Oberle M, Schulz M, Schiller J. Combining TLC separation with MS detection - A revival of TLC. J Glycom Lipidom 2015;5:e125.
 
Noack C, Hempel U, Preissler C, Dieter P. Prostaglandin E2 impairs osteogenic and facilitates adipogenic differentiation of human mesenchymal stromal cells. Prostaglandins, Leukotrienes & Essential Fatty Acids. 2015;94:91-98.
 
Rother S, Salbach-Hirsch J, Moeller S, Seemann T, Schnabelrauch M, Hofbauer LC, Hintze V, Scharnweber D. Bioinspired Collagen/ Glycosaminoglycan- Based Cellular Microenvironments for Tuning Osteoclastogenesis. CS Appl Mater Interfaces. 2015;7:23787-97.
 
Salbach-Hirsch J, Samsonov SA, Hintze V, Hofbauer C, Picke AK, Rauner M, Gehrcke JP, Moeller S, Schnabelrauch M, Scharnweber D, Pisabarro MT, Hofbauer LC. Structural and functional insights into sclerostin-glycosaminoglycan interactions in bone. Biomaterials. 2015;67:335-345.
 
Samsonov SA, Bichmann L, Pisabarro MT. Coarse-grained model of glycosaminoglycans. J Chem Inf Model, 2015;55:114-24  

Sapudom J, Rubner S, Martin S, Thönes S, Anderegg U, Pompe T. The interplay of fibronectin functionalization and TGF-ß1 presence on fibroblast proliferation, differentiation and migration in 3D matrices. Biomaterials Science. 2015; 3:1291-1301.

 
Scharnweber D, Hübner L, Rother S, Hempel U, Anderegg U, Samsonov SA, Pisabarro MT, Hofbauer L, Schnabelrauch M, Franz S, Simon JC, Hintze V. Glycosaminoglycan derivates: promising candidates for the design of functional biomaterials. J Mater Sci: Mater Med, 2015;26:232.
 
Schiller J, Becher J, Möller S, Lemmnitzer K, Riemer T, Schnabelrauch M. Characterization and chemical Modification of Glycosaminoglycans of the extracellular Matrix. IN: "Sulfated Polysaccharides", Nova Science Publishers, 2015.
 
Thrivikramana G, Poh SL, Hess R, Haenchen V, Basub B, Scharnweber D. Interplay of Substrate Conductivity, Cellular Microenvironment and Pulsatile Electrical Stimulation towards Osteogenesis of Human MSCs in vitro. ACS Appl Mater Interfaces. 2015,41:23015-28.

Tsourdi E, Rijntjes E, Köhrle J, Hofbauer LC, Rauner M. Hyperthyroidism and hypothyroidism in male mice and their effects on bone mass, bone turnover, and the Wnt inhibitors sclerostin and dickkopf-1. Endocrinology. 2015; 156: 3517-27.
 
van der Smissen A, Hoffmeister PG, Friedrich N, Watarai A, Hacker MC, Schulz-Siegmund M, Anderegg U. Artificial extracellular matrices support cell growth and matrix synthesis of human dermal fibroblasts in macroporous 3D scaffolds. J Tissue Eng Regen Med. 2015. [Epub ahead of print]
 
Watarai A, Schirmer L, Thönes S, Freudenberg U, Werner C, Simon JC, Anderegg U. TGFß functionalized starPEG-heparin hydrogels modulate human dermal fibroblast growth and Differentiation. Acta Biomater. 2015;25:65-75.
 
Wodtke R, Ruiz-Gómez G, Kuchar M, Pisabarro MT, Novotná P, Urbanová M, Steinbach J, Pietzsch J, Löser R. Cyclopeptides containing the DEKS motif as conformationally restricted collagen telopeptide analogues: synthesis and conformational analysis. Org Biomol Chem., 2015;13(6):1878-96.

 

PUBLIKATIONEN 2014

 
Anderegg U, Simon J, Averbeck M. More than just a filler - the role of hyaluronan for skin homeostasis. Exp Dermatol. 2014;23:295-303.
 
Beck-Sickinger AG, Panitz N. Semi-synthesis of chemokines. Curr Opin ChemBiol. 2014;22:100-7.
 
Dudeck J, Rehberg S, Bernhardt R, Schneiders W, Zierau O, Manjubala I, Goebbels J, Vollmer G, Fratzl P, Scharnweber D, Rammelt S. Increased bone remodelling around titanium implants coated with chondroitin sulfate in ovariectomized rats. Acta Biomater. 2014;10:2855-2865.

Franke K, Sapudom J, Kalbitzer L, Anderegg U, Pompe T. Topologically defined composites of collagen types I and V as in vitro cell culture scaffolds. Acta Biomater. 2014;10:2693-702.
 
Hamann C, Picke AK, Campbell GM, Balyura M, Rauner M, Bernhardt R, Huber G, Morlock MM, Günther KP, Bornstein SR, Glüer CC, Ludwig B, Hofbauer LC. Effects of parathyroid hormone on bone mass, bone strength and bone regeneration in male rats with type 2 diabetes mellitus. Endocrinology. 2014;155:1197-206.
 
Hempel U, Preissler C, Vogel S, Möller S, Hintze V, Becher J, Schnabelrauch M, Rauner M, Hofbauer LC, Dieter P. Artificial extracellular matrices with oversulfated glycosaminoglycan derivatives promote the differentiation of osteoblast-precursor cells and premature osteoblasts. Biomed Res Int. 2014;2014:938368
 
Hempel U, Matthäus C, Preissler C, Möller S, Hintze V, Dieter P. Artificial matrices with high-sulfated glycosaminoglycans and collagen are anti-inflammatory and pro-osteogenic for human mesenchymal stromal cells. J Cell Biochem. 2014;115:1561-71.

Hintze V, Miron A, Möller S, Schnabelrauch M, Heinemann S, Worch H, Scharnweber D. Artificial extracellular matrices of collagen and sulphated hyaluronan enhance the differentiation of human mesenchymal stem cells in the presence of dexamethasone. J Tissue Eng Regen Med. 2014;8: 314-24.

Hintze V, Samsonov SA, Anselmi M, Möller S, Becher J, Schnabelrauch M, Scharnweber D, Pisabarro MT. Sulfated glycosaminoglycans exploit the conformational plasticity of bone morphogenetic protein-2 (BMP-2) and alter the interaction profile with its receptor. Biomacromolecules, 2014;15:3083-92.
 
Kalkhof S, Förster Y, Schmidt J, Schulz MC, Baumann S, Weißflog A, Gao W, Hempel U, Eckelt U, Rammelt S, von Bergen M. Proteomics and metabolomics for in situ monitoring of wound healing. Biomed Res Int. 2014;2014:934848
 
Korn P, Schulz MC, Hintze V, Range U, Mai R, Eckelt U, Schnabelrauch M, Möller S, Becher J, Scharnweber D, Stadlinger B. Chondroitin sulfate and sulfated hyaluronan containing collagen coatings of titanium implants influence peri-implant bone formation in a minipig model. J Biomed Mater Res A. 2014;102: 2334-44.

Kuenze G, Gehrcke JP, Pisabarro MT, Huster D. NMR characterization of the binding properties and conformation of glycosaminoglycans interacting with interleukin-10. Glycobiology, 2014. [Epub ahead of print]
 
Künze G, Theisgen S, Huster D. Backbone 1H, 15N, 13C and side chain 13Cß NMR chemical shift assignment of murine interleukin-10. Biomol NMR Assign. 2014;8:375-378.
 
Lemmnitzer, K., Schiller, J. The detailed structural characterization of chemically modified glycosaminoglycans is absolutely essential to explain potential biological effects. J Glycom & Lipidom 2014;2014:e122.

Lemmnitzer K, Schiller J, Becher J, Möller, S, Schnabelrauch M. Improvement of the Digestibility of Sulfated Hyaluronans by Bovine Testicular Hyaluronidase: A UV Spectroscopic and Mass Spectrometric Study. Biomed Res Int. 2014;2014:986594.

Loth T, Hötzel R, Kascholke C, Anderegg U, Schulz-Siegmund M, Hacker MC. Gelatin-based biomaterial engineering with anhydride-containing oligomeric cross-linkers. Biomacromoleculares. 2014;15:2104-2118
 
Mai M, Hempel U, Hacker M, Dieter P. Effects of HyStem(TM)-HP hydrogel elasticity on osteogenic differentiation of human mesenchymal stromal cells. Cell Mol Bioeng. 2014;7:155-164.
 
Mattern A, Zellmann T, Beck-Sickinger AG. Processing, signaling, andphysiological function of chemerin. IUBMB Life. 2014;66:19-26
 
Miron A, Rother S, Huebner L, Hempel U, Käppler I, Moeller I, Schnabelrauch M, Scharnweber D, Hintze V. Sulfated Hyaluronan Influences the Formation of Artificial Extracellular Matrices and the Adhesion of Osteogenic Cells. Macromolecular Bioscience 2014;14:1783-94.

Neumann T, Hofbauer LC, Rauner M, Lodes S, Kästner B, Franke S, Kiehntopf M, Lehmann T, Müller UA, Wolf G, Hamann C, Sämann A. Clinical and endocrine correlates of circulating sclerostin levels in patients with type 1 diabetes mellitus. Clin Endocrinol (Oxf). 2014;80:649-55.
 
Novoa-Carballal R, Silva C, Möller S, Schnabelrauch M, Reis RL, Pashkuleva I. Tunable nano-carriers from clicked glycosaminoglycan block copolymers. J Mater ChemB. 2014;2:4177-4184.

Picke A-K, Rauner M, Hofbauer LC, Hamann C. Eine Hyperglykämie hemmt die Osteoblastenfunktionen in vitro. Osteologie. 2014; 23: 79-85.

Reichelt S, Becher J, Weisser J, Prager A, Decker U, Möller S, Berg A, Schnabelrauch M. Biocompatible Polysaccharide-based cryogels. Mater Sci Eng C 2014;C35:164-170 
 
Rentsch C, Schneiders W, Hess R, Rentsch B, Bernhardt R, Spekl K, Schneider K, Scharnweber D, Biewener A, Rammelt S. Healing properties of surface coated polycaprolactone-co-lactide scaffolds – a pilot study in sheep. J Biomater Appl. 2014; 28:654-666.

Rentsch C, Schneiders W, Manthey S, Rentsch B, Rammelt S. Comprehensive histological evaluation of bone implants. Biomatter. 2014; 4: e27993.

Salbach-Hirsch J, Ziegler N, Thiele S, Moeller S, Schnabelrauch M, Hintze V, Scharnweber D, Rauner M, Hofbauer LC. Sulfated glycosaminoglycans support osteoblast fubctions and concurrently suppress osteoclasts. J Cell Biochem. 2014;115:1101-11
 
Samsonov SA, Theisgen S, Riemer T, Huster D, Pisabarro MT. Glycosaminoglycan Monosaccharide Blocks Analysis by Quantum Mechanics, Molecular Dynamics, and Nuclear Magnetic Resonance. BioMed Res Int. 2014;2014:808071
Samsonov S, Gehrcke JP, Pisabarro MT. Flexibility and explicit solvent in molecular dynamics-based docking of protein-glycosaminoglycan systems. J Chem Inf Model. 2014;54:582-92.
 
Savkovic V, Li H, Seon JK, Hacker M, Franz S, Simon JC. Mesenchymal stem cells in cartilage regeneration. Curr Stem Cell Res Ther. 2014;9:469-88.
 
Schneider H, Sedaghati B, Naumann A, Hacker MC, Schulz-Siegmund M. Gene silencing of chordin improves BMP-2 effects on osteogenic differentiation of human adipose tissue-derived stromal cells. Tissue Eng Part A. 2014; 20:335-45.

Schneider M, Dieckmann C, Rabe K, Simon JC, Savkovic V. Differentiating the stem cell pool of human hair follicle outer root sheath into functional melanocytes. Methods Mol Biol. 2014; 1210:203-27.

 
Schulz MC, Korn P,  Stadlinger B, Range U, Moeller S, Becher J, Schnabelrauch M, Mai, R, Scharnweber D, Eckelt U, Hintze V. Coating with artificial matrices from collagen and sulfated hyaluronan influences the osseointegration of dental implants. J Mater Sci Mater Med. 2014;25: 247-258.
 
Steinhagen M, Hoffmeister PG, Nordsieck K, Hötzel R, Baumann L, Hacker MC, Schulz-Siegmund M, Beck-Sickinger AG. Matrix metalloproteinase 9 (MMP-9) mediated release of MMP-9 resistant stromal cell-derived factor 1alpha (SDF-1alpha) from surface modified polymer films. ACS Appl Mater Interfaces. 2014;6:5891-9.
 
Tsourdi E, Salbach-Hirsch J, Rauner M, Rachner TD, Möller S, Schnabelrauch M, Scharnweber D, Hofbauer LC. Glycosaminoglycans and their sulfate derivatives regulate the viability and gene expression of osteocyte-like cell lines. J Bioact Compat Polym. 2014;29:474-85.

Tsurkan MV, Chwalek K, Schoder M, Freudenberg U, Werner C. Chemoselective peptide functionalization of starPEG-GAG hydrogels. Bioconjug Chem. 2014; 25:1942-50.

Zieris A, Dockhorn R, Röhrich A, Zimmermann R, Müller M, Welzel PB, Tsurkan MV, Sommer JU, Freudenberg U, Werner C. Biohybrid Networks of Selectively Desulfated Glycosaminoglycans for Tunable Growth Factor Delivery. Biomacromolecules. 2014; 15:4439-46.




PUBLIKATIONEN 2013


Altgärde N, Nilebäck E, de Battice L, Pashkuleva I, Reis RL, Becher J, Moeller S, Schnabelrauch M, Svedhem S. Probing the biofunctionality of biotinylated hyaluronan and chondroitin sulfate by hyaluronidase degradation and aggrecan interaction. Acta Biomaterialia. 2013;9:8158-8166
 
Altgärde N, Becher J, Möller S, Weber FE, Schnabelrauch M, Svedhem S. Immobilization of chondroitin sulfate to lipid membranes and its interactions with ECm proteins. J Colloid Interface Sci. 2013;390:258-66.
 
Baumann L, Beck-Sickinger AG. Photoactivatable chemokines--controlling proteinactivity by light. Angew Chem Int Ed Engl. 2013;52:9550-3.
 
Becher J, Möller S, Schnabelrauch M. Phase transfer-catalyzed synthesis of highly acrylated hyaluronan. Carbohydr Polym. 2013;93:438-41.
 
Blumert C, Kalkhof S, Brocke-Heidrich K, Kohajda T, von Bergen M, Horn F. Analysis of the STAT3 interactome using in-situ biotinylation and SILAC. J Proteomics. 2013;94:370-86.
 
Büttner M, Möller S, Keller M, Huster D, Schiller J, Schnabelrauch M, Dieter P, Hempel U. Over-sulfated chondroitin sulfate derivatives induce osteogenic differentiation of human mesenchymal stromal cells independent of bone morphogenetic protein-2 and transforming growth factor-b1 signalling. J Cell Physiology. 2013;228:330-40.

Förster Y, Gao W, Demmrich A, Hempel U, Hofbauer LC, Rammelt S. Monitoring the first stages of bone healing with microdialysis. Acta Orthopaedica 2013;84:76-81 

Förster Y, Hintze V, Rentsch C, Rentsch B, Bierbaum S, Wiesmann HP, Scharnweber D, Worch H, Rammelt S. Surface functionalization of biomaterials with tissue-inductive artificial extracellular matrices. BioNanoMat. 2013;14:143–152.

Franz S, Allenstein F, Kajahn J, Forstreuter I, Hintze V, Möller S, Simon JC. Artificial extracellular matrices composed of collagen I and high-sulfated hyaluronan promote phenotypic and functional modulation of human pro-inflammatory M1 macrophages. Acta Biomater. 2013; 9:5621-9.

Hamann C, Rauner M, Höhna Y, Bernhardt R, Mettelsiefen J, Goettsch C, Günther KP, Stolina M, Han CY, Asuncion FJ, Ominsky MS, Hofbauer LC. Sclerostin antibody treatment improves bone mass, bone strength, and bone defect regeneration in rats with type 2 diabetes mellitus. J Bone Miner Res. 2013;28:627-38.

Hassert R, Beck-Sickinger AG. Tuning peptide affinity for biofunctionalizedsurfaces. Eur J Pharm Biopharm. 2013;85:69-77.

Keiler AM, Bernhardt R, Scharnweber D, Jarry H, Vollmer G, Zierau O. Comparison of estrogenic responses in bone and uterus depending on the parity status in Lewis rats. J Steroid Biochem Mol Biol. 2013;133:101-9.

Kliemt S, Lange C, Otto W, Hintze V, Möller S, von Bergen M, Hempel U, Kalkhof S. Sulfated hyaluronan containing collagen matrices enhance cell-matrix-interaction, endocytosis, and osteogenic differentiation of human mesenchymal stromal cells. J Proteome Res. 2013;12:378-89

Loth T, Hennig R, Kascholke C, Hötzel R, Hacker MC. Reactive and stimuli-responsive maleic anhydride containing macromers – multi-functional cross-linkers and building blocks for hydrogel fabrication. React.Func.Polym. 2013;008:002

Möbius K, Nordsieck K, Pichert A, Samsonsov SA, Thomas L, Schiller J, Kalkhof S, Pisabarro MT, Beck-Sickinger AG, Huster D. Investigation of lysine side chain interactions of interleukin-8 with heparin and other glycosaminoglycans studied by a methylation-NMR approach. Glycobiology. 2013;23:1260-9.

Penk A, Förster Y, Scheidt HA, Nimptsch A, Hacker MC, Schulz-Siegmund M, Ahnert P, Schiller J, Rammelt S, Huster D. The pore size of PLGA bone implants determines the de novo formation of bone tissue in tibial head defects in rats. Magn Resonan Med. 2013; 70:925-935.
 
Sage J, Mallevre F, Barbarin-Costes F, Samsonov SA, Gehrcke JP, Pisabarro MT, Perrier E, Schnebert S, Roget A, Livache T, Nizard C, Lalmanach G, Lecaille F. Binding of chondroitin 4-sulfate to cathepsin S regulates its enzymatic activity. Biochemistry. 2013;52:6487-98.
 
Sahoo H, Schwille P. Influence of glycosaminoglycans on lipid dynamics in supported phospholipid bylayers. Soft Matter. 2013;9:3859-65.

Salbach-Hirsch J, Kraemer J, Rauner M, Samsonsov SA, Pisabarro MT, Moeller S, Schnabelrauch M, Scharnweber D, Hofbauer LC, Hintze V. The promotion of osteoclastogenesis by sulfated hyaluronan through interference with osteoprotegerin and receptor activator of NB-?-B ligand/osteoprotegerin complex formation. Biomaterials. 2013;34: 7653-61
 
Samsonov SA, Pisabarro MT. Importance of IdoA and IdoA(2S) ring conformations in computational studies of glycosaminoglycan-protein interactions. Carbohydrate Research. 2013;381:133-137 
 
Schnabelrauch M, Scharnweber D, Schiller J. Sulfated glycosaminoglycans as promising artificial extracellular matrix components to improve the regeneration of tissues. Curr Med Chem. 2013;20:2501-2523 

Schultz S, Saalbach A, Heiker JT, Meier R, Zellmann T, Simon JC, Beck-Sickinger AG. Proteolytic activation of prochemerin by kallikrein 7 breaksan ionic linkage and results in C-terminal rearrangement. Biochem J. 2013;452:271-80
.
 
Stadlinger B, Korn P, Tödtmann N, Eckelt U, Range U, Burki A, Ferguson SJ, Kramer I, Kautz A, Schnabelrauch M, Kneissel M, Schlottig F. Osseointegration of biochemically modified implants in an osteoporosis rodent model. Eur Cell Mater. 2013;25:326-40
 
Steinhagen M, Zunker K, Nordsieck K, Beck-Sickinger AG. Large scalemodification of biomole-cules using immobilized sortase A from Staphylococcusaureus. Bioorg Med Chem. 2013;21:3504-10.

Szulc P, Boutroy S, Vilayphiou N, Schoppet M, Rauner M, Chapurlat R, Hamann C, Hofbauer LC. Correlates of bone microarchitectural parameters and serum sclerostin levels in men: the STRAMBO study. J Bone Miner Res. 2013;28:1760-70.

Tsurkan MV, Chwalek K, Prokoph S, Zieris A, Levental KR, Freu
denberg U, Werner C. Defined polymer-peptide conjugates to form cell-instructive starPEG-heparin matrices in situ. Adv Mater. 2013; 25:2606-10.

Wojak-Cwik IM, Hintze V, Schnabelrauch M, Moeller S, Dobrzynski P, Pamula E, Scharnweber D. Poly(L-lactide-co-glycolide) scaffolds coated with collagen and glycosaminoglycans: impact on proliferation and osteogenic differentiation of human mesenchymal stem cells. J Biomedical Mater Res A. 2013;101:3109-22.

van der Smissen A, Samsonov SA, Hintze V, Scharnweber D, Moeller S, Schnablerauch M, Pisabarro MT, Anderegg U. Artificial extracellular matrix composed of collagen l and high-sulfated hyaluronan interferes with TGFß1 signaling and prevents TGFß1 indiced myofibroblast differentiation. Acta Biomaterialia. 2013;9:7775-86.
 
Wojak-Cwik IM, Hintze V, Schnabelrauch M, Moeller S, Dobrzynski P, Pamula E, Scharnweber D. Poly(L-lactide-co-glycolide) scaffolds coated with collagen and glycosaminoglycans: impact on proliferation and osteogenic differentiation of human mesenchymal stem cells. J Biomed Mater Res A. 2013;101: 3109-22.



 

PUBLIKATIONEN 2012

Abburi R, Kalkhof S, Oehme R, Kiontke A, Birkemeyer C. Artificats in amine analsis from anodic oxidation of organic solvents upon electrospray ionization for mass spectrometry. Eur J Mass Spectrom. 2012;18:301-12.

Ambrosch K, Manhardt M, Loth T, Bernhardt R, Schulz-Siegmund M, Hacker MC. Open porous microscaffolds for cellular and tissue engineering by lipid templating. Acta Biomater. 2012;8:1303-15.

Baumann L, Prokoph S, Gabriel C, Freudenberg U, Werner C, Beck-Sickinger AG. A novel, biased-like SDF-1 derivative acts synergistically with starPEG-based heparin hydrogels and improves eEPC migration in vitro. J Control Release. 2012;162:68-75.

Baumann S, Kalkhof S, Hackermüller J, Otto W, Tomm JM, Wissenbach DK, Rolle-Kampczyk U, von Bergen M. Requirements and perspectives for integrating Metabolomics with other omics data. Current Metabolomics. 2012.

Becher J, Möller S, Riemer T, Schiller J, Hintze V, Bierbaum S, Scharnweber D, Worch H, Schnabelrauch M. Sulfated glycosaminoglycan building blocks for the design of artificial extracellular matrices. Book chapter in: ACS Symposium Series. 2012;Vol.1107:315-28.

Bernhardt R, Kuhlisch E, Schulz MC, Eckelt U, Stadlinger B. Comparison of bone-implant contact and bone-implant volume between 2D-histological sections and 3D-SRmicroCT slices. Eur Cell Mater. 2012;23:237-48.

Bierbaum S, Hintze V, Scharnweber D. Functionalization of biomaterials surfaces using artificial extracellular matrices. Biomatter. 2012;2:132-41.

Böhme J, Anderegg U, Nimptsch A, Nimptsch K, Hacker M, Schulz-Siegmund M, Huster D, Schiller J. De novo biosynthesis of GAG in the extracellular matrix of skin studied by MALDI MS. Anal Biochem. 2012;421:791-3.

Fleddermann J, Pichert A, Arnhold J. Interaction of Serine Proteases from Polymorphonuclear Leucocytes with the Cell Surface and Heparin. Inflammation. 2012;35:81-8.

Förster Y, Gao W, Demmrich A, Hempel U, Hofbauer LC, Rammelt S. Monitoring the first stage of bone healing with microdialysis. Acta Orthop. 2012.

Förster Y, Rentsch C, Schneiders W, Bernhardt R, Simon JC, Huster D, Worch H, Rammelt S. Surface modification of implants in long bone. Biomatter. 2012; http://dx.doi.org/10.4161/biom.21563.

Franz S, Allenstein F, Kajahn J, Forstreuter I, Hintze V, Möller S, Simon JC. Artificial extracellular matrices composed of collagen I and high-sulfated hyaluronan promote phenotypic and functional modulation of human pro-inflammatory M1 macrophages. Acta Biomater. 2012; in press.

Goettsch C, Kliemt S, Sinnigen K, von Bergen M, Hofbauer LC, Kalkhof S. Quantitative proteomics reveals novel functions of osteoclast-associated receptor in STAT signaling and cell adhesion in human endothelial cells. J Mol Cell Cardiol. 2012;53:829-37.

Hamann C, Kirschner S, Günther KP, Hofbauer LC. Bone, sweet bone - osteoporotic fractures in diabetes mellitus. Nat Rev Endocrinol. 2012;8:297-305.

Hamann C, Rauner M, Höhna Y, Bernhardt R, Mettelsiefen J, Goettsch C, Günther KP, Stolina M, Han CJ, Asuncion FJ, Ominsky MS, Hofbauer LC. Sclerostin antibody treatment improves bone mass, bone strength, and bone defect regeneration in rats with type 2 diabetes mellitus. J Bone Miner Res. 2012; in press.

Harms C, Helms K, Taschner T, Stratos I, Ignatius A, Gerber T, Lenz S, Rammelt S, Vollmar B, Mittlmeier T. Osteogenic capacity of a nanocrystalline bone cement in a weight bearing defect at the ovine tibial metaphysis. Int J Nanomed. 2012;7:2883-9.

Hassert R, Pagel M, Ming Z, Häupl T, Abel B, Braun K, Wiessler M, Beck-Sickinger AG. Biocompatible silicon surfaces through orthogonal click chemistries and a high affinity silicon oxide binding peptide. Bioconj Chem. 2012;23:2129-37.

Hassert R, Hoffmeister PG, Pagel M, Hacker M, Schulz-Siegmund M, Beck-Sickinger AG. On-resin synthesis of an acylated and fluorescence-labeled cyclic integrin ligand for modification of poly-(lactid-coglycolic-acid). Chem Biodivers. 2012;9:2648-58.

Hempel U, Möller S, Noack C, Hintze V, Scharnweber S, Schnabelrauch M, Dieter P. Sulfated hyaluronan/collagen I-matrices enhance osteogenic differentiation of human mesenchymal stromal cells in vitro even in the absence of dexamethasone. Acta Biomater. 2012;8:4064-72

Hempel U, Hintze V, Möller S, Schnabelrauch M, Scharnweber D, Dieter P. Artificial extracellular matrices composed of collagen I and sulfated hyaluronan with adsorbed TGF-b1 promote collagen synthesis of human mesenchymal stromal cells. Acta Biomater. 2012;8:659-66.

Hess R, Jeschnke A, Neubert H, Hintze V, Moeller S, Schnabelrauch M, Wiesmann HP, Hart DA, Scharnweber D. Synergistic effect of defined artificial extracellular matrices and pulsed electric fields on osteogenic differentiation of human MSCs. Biomaterials. 2012;33:8975-85.

Hintze V, Miron A, Möller S, Schnabelrauch M, Heinemann S, Worch H, Scharnweber D. Artificial extracellular matrices of collagen and sulfated hyaluronan enhance the differentiation of human mesenchymal stem cells in the presence of dexamethasone. J Tissue Eng Regen Med. 2012;doi 10.1k02/term.1528.

Hintze V, Miron A, Möller S, Schnabelrauch M, Wiesmann HP, Worch H, Scharnweber D. Sulfated hyaluronan and chondroitin sulphate derivatives interact differently with human transforming growth factor-b1 (TGF-B1). Acta Biomater. 2012;8:2144-52.

Hoyer J, Schatzschneider U, Schulz-Siegmund M, Neundorf I. Dimerization of a cell-penetrating peptide leads to enhanced cellular uptake and drug delivery. Beilstein J Org Chem. 2012;8:1788-97.

Kajahn J, Franz S, Rückert E, Forstreuter I, Hintze V, Möller S, Simon JC. Artificial extracellular matrices composed of collagen I and high sulfated hyaluronan modulate monocyte to macrophage differentiation under conditions of sterile inflammation. Biomatter. 2012.

Keiler A, Zierau O, Vollmer G, Scharnweber D, Bernhardt R. Estimation of an early meaningful time point of bone parameter changes in application to an osteoporotic rat model with in vivo microCT measurements. Lab Anim. 2012;46:237-44.

Möller S, Schmidtke M, Weiss D, Schiller J, Pawlik K, Wutzler P, Schnabelrauch M. Synthesis and antiherpetic activity of novel hyaluronan derivatives with varying degrees of carboxymethylation and sulfation. Carbohydrate Polymers. 2012;90:608-15.

Müller SA, van der Smissen A, von Feilitzsch M, Anderegg U, Kalkhof S, von Bergen M. Quantitative proteomics reveals altered expression of extracellular matrix related of proteins of human primary dermal fibroblasts in response to sulphated hyaluronan and collagen applied as artificial extracellular matrix. J Mater Sci Mater Med. 2012;23:3053-65.

Nimptsch K, Süß R, Schnabelrauch M, Nimptsch A, Schiller J. Positive ion MALDI-TOF mass spectra are more suitable than negative ion spectra to characterize suphated glycosaminoglycan oligosaccharides. Int J Mass Spectrom. 2012;310:72-6.

Nordsieck K, Pichert A, Samsonov SA, Thomas L, Berger C, Pisabarro MT, Huster D, Beck-Sickinger AG. Residue 75 of Interleukin-8 is Curicial for the Interaction with Glycosaminoglycans. ChemBioChem. 2012;13:2558-66.

Pichert A, Samsonov SA, Theisgen S, Thomas L, Baumann L, Schiller J, Beck-Sickinger AG, Huster D, Pisabarro MT. Characterization of the interaction of the interaction of Interleukin-8 with hyaluronan, chondroitin sulfate, dermatan sulfate, and their sulfated derivatives by spectroscopy and molecular modelling. Glycobiology. 2012;22:134-45.

Pichert A, Schlorke D, Franz S, Arnhold J. Functional aspects of the interaction between interleukin-8 and sulfated glycosaminoglycans. Biomatter. 2012; http://dx.doi.org/10.4161/biom.21316.

Pompe T, Stamov DR. Structure and function of ECM-inspired composite collagen type I scaffolds. Soft Matter. 2012;8: 10200.

Rauner M, Stein N, Winzer M, Goettsch C, Zwerina J, Schett G, Distler JH, Albers J, Schulze J, Schinke T, Bornhäuser M, Platzbecker U, Hofbauer LC. WNT5a is induced by inflammatory mediators in bone marrow stromal cells and regulates cytokine and chemokine production. J Bone Miner. Res. 2012;27:575-85

Rentsch B, Bernhardt R, Scharnweber D, Schneiders W, Rammelt S, Rentsch C. Embroidered and surface coated polycaprolactone-co-lactide scaffolds: A potential graft for bone tissue engineering. Biomatter. 2012;2:158-65

Rigol S, Xia L, Giannis A. Synthesis of 13C-labeled and functionalized Hyaluronan derivatives for biophysical studies and surface modifications. Bioorg Med Chem. 2012.

Riemer T, Nimptsch A, Nimptsch K, Schiller J. Determination of the glycosaminoglycan and collagen contents in tissue samples by high resolution 1H NMR spectroscopy after DCI-induced hydrolysis. Biomacromolecules. 2012;13:2110-7.

Salbach J, Rachner T, Rauner M, Hempel U, Anderegg U, Franz S, Simon JC, Hofbauer LC. Regenerative potential of glycosaminoglycans for skin and bone. J Mol Med. 2012;90:620-35.

Salbach J, Kliemt S, Rauner M, Rachner TD, Goettsch C, Kalkhof S, von Bergen M, Möller S, Schnabelrauch M, Hintze V, Scharnweber D, Hofbauer LC. The effect of the degree of sulfation of glycosaminoglycans on osteoclast function and signaling pathways. Biomaterials. 2012;33:8418-29.

Savkovic V, Dieckmann C, Milkova L, Simon JC. Improved method of differentiation, selection and amplification of human melanocytes from the hair follicle cell pool. Exp Dermatol. 2012;21:948-76.

Schiller J, Huster D. New methods to study the composition and structure of the extracellular matrix in natural and bioengineered tissues. Biomatter. 2012;2:1-71.

Schlorke D, Thomas L, Samsonov S, Huster D, Arnhold J, Pichert A. The influence of glycosaminoglycans on IL-8 mediated functions of neutrophils. Carbohydr Res. 2012;356:196-203.

Schneiders W, Rehberg S, Rentsch C, Rein S, Zwipp H, Rammelt S. Effect of chondroitin sulphate on osteogenetic differentiation of human mesenchymal stem cells. Mater Sci Eng C. 2012;32:1926-30.
Shroff R, Beringer O, Rao K, Hofbauer LC, Schulz A. Denosumab for post-transplantation hypercalcemia in osteopetrosis. N Engl J Med. 2012;367:1766-7.

Stadlinger B, Hintze V, Bierbaum S, Möller S, Schulz MC, Mai R, Kuhlisch E, Heinemann S, Scharnweber D, Schnabelrauch M, Eckelt U. Biological functionalization of dental implants with collagen and glycosaminoglycans - a comparative study. J Biomed Mater Res B: Appl Biomater. 2012;100:331-41.

Stadlinger B, Terheyden H. Kommunikation der Zellen: Die entzündliche Reaktion. DVD. Quintessenz-Verlag, 2012.

Thiele S, Ziegler N, Tsourdi E, De Bosscher K, Tuckermann JP, Hofbauer LC, Rauner M. Selective glucocorticoid receptor modulation maintains bone mineral density in mice. J Bone Miner Res. 2012; doi:10.1002/jbmr.1668

Vlasova II, Sokolov AV, Arnhold J. The free aminon acid tyrosine enhances the chlorinating activity of human myeloperoxidase. J Inorg Chem. 2012;106:76-83.

Weber F, Böhme J, Scheidt HA, Gründer W, Rammelt S, Hacker M, Schulz-Siegmund M, Huster D. 31P and 13C solid state NMR spectroscopy to study collagen synthesis and biomineralization in polymer-based bone implants. NMR Biomed. 2012;25:464-75.

Willenberg A, Saalbach A, Simon JC, Anderegg U. Melanoma cells control HA synthesis in peritumoral fibroblasts via PDGF-AA und PDGF-CC: impact on melanoma cell proliferation. J Invest Dermatol. 2012;132:385-93.


PUBLIKATIONEN 2011

Bellmann-Sickert K, Beck-Sickinger AG. Palmitoylated SDF1alpha shows increased resistance against proteolytic degradation in liver homogenates. ChemMedChem. 2011;6:193-200.

Flemmig J, Kuchta K, Arnhold J, Rauwald HW. Olea europaea leaf (Ph.eur.) extract as well as several of its isolated phenolics inhibit the gout-related enzyme xanthine oxidase. Phytomedicine. 2011,18:561-66.

Franz S, Rammelt S, Scharnweber D, Simon JC. Immune responses to implants - A review of the implications for the design of immunomodulatory biomaterials. Biomaterials. 2011;32:6692-709

Fuchs B, Süss R, Teuber K, Eibisch M, Schiller J. Lipid analysis by thin-layer chromatography - a review of the current state. J Chromatogr A. 2011;1218:2754-74.

Goettsch C, Rauner M, Pacyna M, Hempel U, Bornstein SR, Hofbauer LC. mi-R-125b regulates calcification of vascular smooth muscle cells. Am J Pathol. 2011;179:1594-600.

Goettsch C, Rauner M, Hamann C, Sinningen K, Hempel U, Bornstein SR, Hofbauer LC. Nuclear factor of activated T cells mediates oxidised LDL-induced calcification of vascular smooth muscle cells. Diabetologia. 2011;54:2690-701.

Goettsch C, Rauner M, Sinnigen K, Helas S, Al-Fakhri N, Nemeth K, Hamann C, Kopprasch S, Aikawa E, Bornstein SR, Schoppet M, Hofbauer LC. The osteoclast-associated receptor (OSCAR) is a novel receptor regulated by oxidized low-density lipoprotein in human endothelial cells. Endocrinology. 2011:152:4915-26.

Hamann C, Göttsch C, Mettelsiefen J, Henkenjohann V, Rauner M, Hempel U, Bernhardt R, Fratzl-Zelman N, Roschger P, Rammelt S, Günther KP, Hofbauer LC. Delayed bone regeneration and low bone mass in a rat model of insulin-resistanz type 2 diabetes mellitus is due to impaired osteoblast function. Am J Physiol Endocrinol Metab. 2011;301:e1220-8.

Hofbauer LC, Rachner TD, Hamann C. From bone to breast and back – the bone cytokine RANKL and breast cancer. Breast Cancer Res. 2011;13:107.

Mörbt N, Tomm J, Feltens R, Mögel I, Kalkhof S, Murugesan K, Wirth H, Vogt C, Binder H, Lehmann I, von Bergen M. Chlorinated benzenes cause concomitantly oxidative stress and induction of apoptotic markers in lung epithelial cells (A549) at nonacute toxic concentrations. J Proteome Res. 2011;10:363-78.

Nemeth K, Schoppet M, Al-Fakhri N, Helas S, Jessberger R, Hofbauer LC, Goettsch C. The role of osteoclast-associated receptor in osteoimmunology. J Immunol. 2011;186:13-18.

Nimptsch A, Schibur S, Ihling C, Sinz A, Riemer T, Huster D, Schiller J. Quantitative analysis of denatured collagen by collagenase digestion and subsequent MALDI-TOF mass spectrometry. Cell Tissue Res. 2011,343:605-17

Rachner TD, Khosia S, Hofbauer LC. Osteoporosis: now and the future. Lancet. 2011;377:1276-87

Rauner M, Goettsch C, Stein N, Thiele S, Bornhaeuser M, De Bosscher K, Haegeman G, Tuckermann J, Hofbauer LC. Dissociation of osteogenic and immunological effects by the selective glucocorticoid receptor agonist, compound a, in human bone marrow stromal cells. Endocrinology. 2011;152:103-112.

Rockstroh M, Müller SA, Jende C, Kerzhner A, von Bergen M, Tomm JM. Cell frationation – an important tool for compartment proteomics. J Integr OMICS. 2011;1:135-43.

Sahoo H, Schwille P. FRET and FCS - Frieds or Foes? ChemPhysChem. 2011;12:532-41.

Samsonov SA, Teyra J, Pisabarro MT. Docking glycosaminoglycans to proteins: analysis of solvent inclusion. J Comput Aided Mol Des. 2011;25:477-89.

Schiller J, Volpi N, Hrabárová E, Šoltés L. Hyaluronic acid: a natural biopolymer, In: Kalia S. (Ed.), Biopolymers: Biomedical and Environmental Applications. Scrivener Publishing LLC, Salem (2011). ISBN: 978-0-470-63923-8, pp. 3-34.   http://onlinelibrary.wiley.com/doi/10.1002/9781118164792.ch1/summary

Steinhagen M, Holland-Nell K, Meldal M, Beck-Sickinger AG. Simultaneous "one pot" expressed protein ligation and CuI-catalyzed azide/alkyne cycloaddition for protein immobilization. ChemBioChem. 2011;12:2426-30.

Teyra J, Samsonov SA, Schreiber S, Pisabarro MT. SCOWLP update: 3D classification of protein-protein, -peptide, -saccaride, and -nucleid acid interactions, and structure-based binding inferences across folds. BMC Bioinformatics. 2011:12:398

Thiele S, Rauner M, Goettsch C, Rachner TD, Benad P, Fuessel S, Erdmann K, Hamann C, Baretton GB, Wirth MP, Jakob F, Hofbauer LC. Expression profile of WNT molecules in prostate cancer and its regulation by aminobisphosphonates. J Cell Biochem. 2011;112:1593-600

Tomczak A, Pisabarro M. Identification of CCR2-binding features in Cytl1 by a CCL2-like chemokine model. Proteins. 2011;79:1277-92.

Tsourdi E, Rachner TD, Rauner M, Hamann C, Hofbauer LC. Denosumab for bone diseases: translating bone biology into targeted therapy. Eur J Endocrinol. 2011;165:833-40.

Van der Smissen A, Hintze V, Scharnweber D, Moeller S, Schnabelrauch M, Majok A, Simon JC, Anderegg U. Growth promoting substrates for human dermal fibroblasts provided by artificial extracellular matrices composed of collagen I and sulfated glycosaminoglycans. Biomaterials. 2011; 32: 8938-46.

Vyalikh A, Simon P, Kollman T, Kniep R, Scheler U. Local environment in biomimetic hydroxyapatite-gelatine nanocomposites as probed by NMR spectroscopy. J Phys Chem C. 2011;115:1513-9.

Washietl S, Findeiss S, Müller SA, Kalkhof S, von Bergen M, Hofacker IL, Stadler PF, Goldman N. RNAcode: robust discrimination of coding and noncoding regions in comparative sequence data. RNA. 2011;17:578-94.

Wu J, Teuber K, Eibisch M, Fuchs B, Schiller J. Chlorinated and brominated phosphatidylcholines are generated under the influence of the Fenton reagent at low pH - a MALDI-TOF MS study. Chem Phys Lipids. 2011;164:1-8.

Yurkova IL, Arnhold J, Fitzl G, Huster D. Fragmentation of mitochondrial cardiolipin by copper ions in the Atp7b-/- mouse model of Wilson's disease. Chem Phys Lipids. 2011;164:393-400.

Zhu H, Pisabarro MT. MSPocket: an orientation-independent algorithm for the detection of ligand binding pockets. Bioinformatics. 2011;27:351-8

 


PUBLIKATIONEN 2010

Arnhold J, Flemmig J. Human myeloperoxidase in innate and acquired immunity. Arch Biochem Biophys. 2010;500:92-106.

Bachmann M, Goede K, Beck-Sickinger AG, Grundmann M, Irbäck A, Janke W. Microscopic mechanism of specific peptide adhesion to semiconductor substrates. Angew Chem Int Ed Engl. 2010;49:9530-33.

Baumann L, Beck-Sickinger AG. Identification of a potential modification site of stromal-derived factor 1. Biopolymers. 2010;94:771-8.

Becher J, Möller S, Weiss D, Schiller J, Schnabelrauch M. Synthesis of new regioselectively sulfated hyaluronans for biomedical applications. Macromol Symp. 2010;296:446-52.

Bellmann-Sickert K, Baumann L, Beck-Sickinger AG. Selective Labelling of Stromal Cell-Derived Factors 1 a with Carboxyfluorescencein to Study Receptor Internalisation. J Pept Sci. 2010;16:568-74.

Bellmann-Sickert K, Beck-Sickinger AG. Peptide drugs to target G protein-coupled receptors. Trends Pharmacol Sci. 2010;31:434-41.

deAzevedo ER, Ayrosa AM, Faria GC, Cervantes HJ, Huster D, Bonagamba TJ, Pitombo RN, Rabbani SR. The effects ot anticalcification treatments and hydration on the molecular dynamics of bovine pericardium collagen as revealed by 13C solid-state NMR. Magn Reson Chem. 2010;48:704-11.

Dieckmann C, Renner R, Milkova L, Simon JC. Regenerative medicine in dermatology: biomaterials, tissue engineering, stem cells, gene transfer and beyond. Exp Dermatol. 2010;19:697-706.

Flemmig J, Arnhold J. Interaction of hyperchlorous acid and myeloperoxidase with phosphatidylserine in the presence of ammonium ions. J Inorg Biochem. 2010;104:759-64.

Fuchs B, Süß R, Schiller J. An Update of MALDI-TOF Mass Spectrometry in Lipid Research. Progr Lipid Res. 2010;49:450-475.

Galle J, Bader A, Grill W, Fuchs B, Käs JA, Krinner A, Müller K, Schiller J, Schulz R, von Butlar M, Löffler M.  Mesenchymal stem cells in cartilage repair: State of the art and methods to monitor cell growth, differentiation and cartilage regeneration. Curr Medic Chem. 2010;17:2274-2291.

Hofbauer LC, Hamann C, Ebeling PR. Approach to the patient with secondary osteoporosis. Eur J Endocrinol. 2010;162:1009-1020.

Kirchner T, Flemmig J, Furtmüller PG, Obinger C, Arnhold J. (-)-Epicatechin enhances the chlorinating activity of human myeloperoxidase. Arch Biochem Biophys. 2010;495:21-27.

Kunze R, Rösler M, Möller S, Schnabelrauch M, Riemer T, Hempel U, Dieter P. Sulfated hyaluronan derivatives reduce the proliferation rate of primary rat calvarial osteoblasts. Glycoconj J. 2010;27:151-158.

Kunze R, Hempel U, Dieter P. Differential Effect of Chondroitin-4-sulfate on the immediate and delayed Prostaglandin E(2) Release from Osteoblasts. Prostaglandins other Lipid Mediat. 2010;92:8-12.

Lutter A-H, Hempel U, Wolf-Brandstetter C, Garbe A, Goettsch C, Hofbauer LC, Jessberger R, Dieter P. A novel resorption assay for osteoclast functionality based on an osteoblast-derived native extracellular matrix. J Cell Biochem. 2010;109:1025-32.

Müller SA, Kohajda T, Findeiß S, Stadler PF, Washietl S, Kellis M, von Bergen M, Kalkhof S. Optimization of parameters for coverage of low molecular weight proteins. Anal Bioanal Chem. 2010;398:2867-81.

Nimptsch K, Süß R, Riemer T, Nimptsch A, Schnabelrauch M, Schiller J.  Differently complex oligosaccharides can be easily identified by matrix-assisted laser desorption and ionization time-of-flight mass spectrometry directly from a standard thin-layer chromatography plate. J Chromatogr A. 2010;1217:3711-3715.

Schiller J, Becher J, Möller S, Nimptsch K, Riemer T, Schnabelrauch M. Synthesis and characterization of chemically modified glycosaminoglycans of the extracellular matrix. Mini-Rev Org Chem. 2010;7:290-299.

Schirmer C, Klein C, von Bergen M, Simon JC, Saalbach A. Human fibroblasts support the expansion of IL-17-producing T cells via up-regulation of IL-23 production by dendritic cells. Blood. 2010;116:1715-25.

Stadlinger B, Terheyden H. Kommunikation der Zellen. Die Osseointegration. DVD (deutsch). Den Trailer für das Video finden Sie hier. Zu beziehen ist die DVD über den Quintessenz-Verlag

Teuber K, Schiller J, Fuchs B, Karas M, Jaskolla T. Significant Sensitivity Improvements by Matrix Optimization: A MALDI-TOF Mass Spectrometric Study of Lipids from Hen Egg Yolk. Chem Phys Lipids. 2010;163:552-560.

Teuber K, Riemer T, Schiller J. Thin-layer chromatography combined with MALDI-TOF-MS and 31P-NMR to study possible selective bindings of phospholipids to silica gel. Anal Bioanal Chem. 2010;398:2833-42.



PUBLIKATIONEN 2009

Fuchs B, Schiller J. Recent developments of useful MALDI matrices for the mass spectrometric characterization of apolar compounds. Curr Org Chem. 2009;13:1664-1681.

Fuchs B, Bischoff A, Süß R, Teuber K, Schürenberg M, Suckau D, Schiller J. Phosphatidylcholines and -ethanolamines can be easily mistaken in phospholipid Mixtures: A negative ion MALDITOF MS study with 9-aminoacridine as matrix and egg yolk as selected example. Anal Bioanal Chem. 2009;395:2479-2487.

Helas S, Goettsch C, Schoppet M, Zeitz U, Hempel U, Morawietz H, Kostenuik PJ, Erben RG, Hofbauer LC. Inhibition of Receptor Activator of NF-kappaB-Ligand by Denosumab Attenuates Vascular Calcium Deposition in Mice. Am J Pathol. 2009;175:473-478.

Hintze V, Moeller S, Schnabelrauch M, Bierbaum S, Viola M, Worch H, Scharnweber D. Modifications of Hyaluronan Influence the Interaction with Human Bone Morphogenetic Protein-4 (hBMP-4). Biomacromolecules. 2009;10:3290-7.

Hofbauer LC, Rauner M. Minireview: Live and let die: Molecular Effects of Glucocorticoids on Bone Cells. Mol Endocrinol. 2009;23:1525-31.

Nimptsch A, Schibur S, Schnabelrauch M, Fuchs B, Huster D, Schiller J. Characterization of the quantitative Relationship between signal-to-noise (S/N) Ratio and Sample Amount on-target by MALDI-TOF MS: Determination of Chondroitin Sulfate subsequent to Enzymatic Digestion. Anal Chim Acta. 2009;635:175-182.

Schneiders W, Reinstorf A, Biewener A, Serra A, Kinscher M, Heineck J, Grass R, Rehberg S, Zwipp H, Rammelt S. In vivo effects of modification of hydroxyapatite/collagen composites with and without chondroitin sulphate on bone remodelling in the sheep tibia. J Orthop Res. 2009;27: 15-21.