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The role of the ECM during bone regeneration in zebrafish

Prof. Dr. Michael Brand, Dr. Franziska Knopf

Adult zebrafish are able to regenerate various organs and tissues after severe trauma. In particular, they are able to rapidly form bone during the process of fin regeneration. We study fin regeneration in order to better understand the role of the ECM during bone formation. In this context, we aim at improving bone formation with the help of artificial ECM.

Project-related Publications

  1. Geurtzen K*, Knopf F*, Wehner D, Huitema LF, Schulte-Merker S, Weidinger G. Mature steoblasts dedifferentiate in response to traumatic bone injury in the zebrafish fin and kull. Development. 2014;141:2225-34. (*geteilte Erstautorschaft).
  2. Gupta M, Brand M. Identification and Expression Analysis of Zebrafish Glypicans during Embryonic Development. PLoS One. 2013;8:e80824.
    Boekel C, Brand M. Generation and interpretation of FGF morphogen gradients in vertebrates. Curr Opin Gen Dev. 2013;23:415-22.
  3. Knopf F, Hammond C, Chekuru A, Kurth T, Hans S, Weber CW, Mahatma G, Fisher S, Brand M, Schulte-Merker S, Weidinger G. Bone regenerates via dedifferentiation of osteoblastsen the zebrafish fin. Dev Cell. 2011;20:713-24.
  4. Nowak M, Yu SR, Gupta M, Machate A, Brand M. Interpretation of the FGF8 morphogen gradient is regulated by endocytic trafficking. Nat Cell Biol. 2011;13:153-8.
  5. Yu SR, Burkhardt M, Nowak M, Ries J, Petrášek Z, Scholpp S, Schwille P*, Brand M.* FGF8 morphogen gradient is formed by a source-sink mechanism with freely-diffusing molecules. Nature. 2009;461:533-6. (*geteilte Seniorautorschaft).
  6. Ries J, Yu SR, Burkhardt M, Brand M*, Schwille P*. Modular scanning FCS quantifies ligand-receptor interactions in live multicellular organisms. Nat Methods. 2009;6:643-5. (*geteilte Seniorautorschaft).
  7. Raible F, Brand M. Divide et Impera-the midbrain-hindbrain boundary and its organizer. Trends Neurosci. 2004;27:727-34.
    Scholpp S, Brand M. Endocytosis controls spreading and effective signaling range of FGF8. Curr Biol. 2004;14:1834-41.