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Sulfated glycoaminoglycans as coating for endoprostheses to improve osseointegratione individualized biomaterials

Prof. Dr. Lorenz Hofbauer, Prof. Dr. Stefan Rammelt, Dr. Matthias Schnabelrauch, Dr. Sabine Schulze, Dr. Ulrike Baschant, Heidemarie Allner, Dr. Henriette Bretschneider, Industry partner: Mathys Orthopädie GmbH Mörsdorf

The ongoing demographic changes result in a considerable increase in patients with the need for bone defect filling and joint replacement. Systemic diseases that result in impaired bone healing and osseointegration of implants represent further challenges. These require the development of novel functional biomaterials with improved osseointegrative properties. Within this newly formed transfer project we aim to use our knowledge about the regenerative abilities of extracellular matrix components to significantly improve the osseointegration of orthopaedic implants. Together with Mathys Orthopädie GmbH, Mörsdorf, as an industry partner we will therefore establish coating procedures for existing biomaterial products and optimize the process considering the material shelf life, reproducibility and sterilization process to meet the requirements for medical product approval. The bioactivity will be tested both in vitro and finally validated in a relevant preclinical large animal model. This will serve the long-term goal to identify a novel coating that significantly enhances implant integration and enable the clinical application of these individualized biomaterials.

Industry partner:
Mathys Orthopädie GmbH Mörsdorf
An den Trillers Büschen 2
07646 Mörsdorf

Contact: Dipl.-Ing. Carolin Witt
Phone: 036428 494 610
Fax: 036428 494 220
E-Mail: carolin.witt@mathysmedical.com