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//Universität Leipzig    //BBZ   
//Faculty of Chemistry and Mineralogy    //Institute of Bioanalytical Chemistry

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Zscharnack K, Kreisig T, Prasse AA, Zuchner T. A homogeneous assay principle for universal substrate quantification via hydrogen peroxide producing enzymes. (2014) Anal Chim Acta. Link

Prasse AA, Zauner T, Büttner K, Hoffmann R, Zuchner T
. Improvement of an antibody-enzyme coupling yield by enzyme surface supercharging. (2014) BMC Biotechnol. Link

Dobslaff K, Zuchner T. Application of time-resolved imaging-based multisample and multianalyte detection in single microtitre wells. (2014) Anal Bioanal Chem. Pubmed

Kreisig T, Prasse AA, Zscharnack K
, Volke D, Zuchner T. His-tag protein monitoring by a fast mix-and-measure immunoassay (2014) Scientific Reports (Nature publishing group), Link

Zscharnack K, Kreisig T, Prasse AA, Zuchner T. A luminescence-based probe for sensitive detection of hydrogen peroxide in seconds. (2014) Anal Chim Acta. Link

Sahoo B, Singer D, Kodali R, Zuchner T, Wetzel R. Aggregation behavior of chemically synthesized, full-length huntingtin exon 1. (2014) Biochemistry, Link


Kreisig T
, Hoffmann R, Zuchner T.
Highly efficient Förster resonance energy transfer in a fast, serum-compatible immunoassay. (2013) ChemBioChem, PubMed, Cover picture

D
obslaff K, Kreisig T, Berthold N, Hoffmann R, Zuchner T. Novel peptide-protein assay for identification of antimicrobial peptides by fluorescence quenching. (2012) Anal Bioanal Chem, PubMed


Simeonov P
, Zahn M, Sträter N, Zuchner T. Crystal structure of a supercharged variant of the human enteropeptidase light chain. (2012) Proteins, PubMed

Tschierske C, Nürnberger C, Ebert H, Glettner B, Prehm M, Liu F, Zeng XB, Ungar G. Complex tiling patterns in liquid crystals. (Review) (2012) Interface Focus Link


Zauner T, Berger-Hoffmann R, Müller K
, Hoffmann R, Zuchner T. A novel highly adaptable and sensitive protease assay based on fluorescence resonance energy transfer. (2011) Anal Chem 83, 7356-7363 PubMed

Buettner, K., Hertel, T. C. and Pietzsch, M. Increased thermostability of microbial transglutaminase by combination of several hot spots evolved by random and saturation mutagenesis. (2011) Amino Acids  PubMed

Hagan A, Zuchner T.
Lanthanide-based time-resolved luminescence immunoassays (Review) (2011) Anal Bioanal Chem 400, 2847-2864 PubMed

Kreisig T,
Hoffmann R, Zuchner T. A fluorescence-based homogeneous immunoassay detects antigens within 90 seconds. (2011) Anal Chem 83, 4281-4287 PubMed

Zeng X, Kieffer R, Glettner B, Nürnberger C, Liu F, Pelz K, Prehm M,
Baumeister U, Hahn H, Lang H, Gehring GA, Weber CHM, Hobbs JK,
Tschierske C, Ungar G.  Complex Multicolour Tiling and Critical Phenomena in Tetraphilic Liquid Crystals. (2011) Science 331, 1302-1306. PubMed


Simeonov P, Berger-Hoffmann R
, Hoffmann R, Sträter N, Zuchner T. Surface supercharged human enteropeptidase light chain shows improved solubility and refolding yield. (2010) PEDS 24, 261-268 PubMed

Singer D,  Zauner T, Genz M, Hoffmann R, Zuchner T. Synthesis of pathological and nonpathological human exon 1 huntingtin. (2010) J Pept Sci. 27;16:358-363 PubMed

Büttner K, Marx CK, Hertel TC, Pietzsch M. (2010). Optimierung einer rekombinanten mikrobiellen Transglutaminase. (2010) Chemie Ingenieur Technik, 82;43-44

Zuchner T, Schumer F, Berger-Hoffmann R, Mueller K, Lukas M, Zeckert K, Marx J, Hennig H, Hoffmann R. Highly Sensitive Protein Detection Based on Lanthanide Chelates with Antenna Ligands Providing a Linear Range of Five Orders of Magnitude. (2009) Anal Chem 81, 9449–9453 PubMed

Staflin K, Zuchner T., Lundberg C. Identification of proteins involved in neural progenitor cell targeting of gliomas. (2009), BMC Cancer, 9(1):206 PubMed

Frolov A, Singer D, Zauner T, Hoffmann R. Solid phase synthesis and analysis of Amadori peptides. (2009) Adv Exp Med Biol 611: 423-4 PubMed

Zscharnack K, Kessler R, Bleichert F, Warnke JP, Eschrich K. The PFKFB3 splice variant UBI2K4 is downregulated in high-grade astrocytomas and impredes the growth of U87 glioblastoma cells. (2009) Neuropathol Appl Neurobio. 35:566-578 PubMed

Zuchner T
., Brundin P. Mutant huntingtin can paradoxically protect neurons from death (2008), Cell Death Diff, 15(3):435-42 PubMed

Staflin K., Lindvall M., Zuchner T., Lundberg C. Instructive cross-talk between neural progenitor cells and gliomas.. (2007) J Neurosci Res, 85(10):2147-59 PubMed

Zuchner T., Kazemi AR., Weigelt J., Starikow J., Tanaka S., Rothstein S., Brundin P. Determination of the tertiary structure of exon 1 Huntingtin., (Abstract) (2007) J Neurochem 101 (suppl 1): 65 PubMed

Zuchner T., Schliebe N., Schliebs R. Zinc-uptake is mediated by M1 muscarinic acetylcholine receptors in differentiated SK-SH-SY5Y cells, (2006) Int J Dev Neurosci 24:23-27 PubMed

Zuchner T., Schliebs R. Perez-Polo J.R. Downregulation of muscarinic acetylcholine receptor M2 adversely affects the expression of Alzheimer´s disease relevant genes and proteins. (2005) J Neurochem 95:20-32 PubMed

Zuchner T., Perez-Polo J.R., Schliebs R. Beta-secretase BACE1 is differentially controlled through muscarinic acetylcholine receptor signaling. (2004) J Neurosci Res, 77; 2:250-57 PubMed

Zuchner T., Schliebs R. Expression of beta-secretase BACE is differentially controlled through muscarinic acetylcholine receptor signaling. (Abstract) (2003) J Neurochem 87 (suppl 1): 95 PubMed

Berger, R.G., Hoffmann, R., Zeppezauer, M., Wagner-Redeker, W., Maljers, L., Ingendoh, A. and Hillenkamp, F. 1995. Separation and characterization of bovine histone H1 subtypes by combined ion-exchange and reversed-phase chromatography and mass spectrometry. J. Chromatogr. A, 711: 159-165. PubMed

Hoffmann, R., Wachs, W.O., Berger, R.G., Zeppezauer, M., Kalbitzer, H.R., Waidelich, D. and Bayer, E. 1995. Chemical phosphorylation of the peptides GGXA (X=S,T,Y): An evaluation of different chemical approaches. Int. J. Peptide Protein Res. 45: 26-34. PubMed

R. G. Berger, R. Hoffmann, M. Zeppezauer and E. Bayer 1994 Separation of Histone H1 Subtypes from Calf Thymus Peptides: Chemistry, Structure and Biology ( R.S. Hodges and J.A. Smith eds.) 228-229.

R. Hoffmann, R.G. Berger and M. Zeppezauer 1993. Separation of Histone H1 Subtypes from Calf Thymus by Reversed Phase Chromatography Biol. Chem. Hoppe-Seyler 374: 768-769.

W.O. Wachs, R. Hoffmann, R.G. Berger, S. Kuhn, E. Bayer and M. Zeppezauer 1992. Synthesis of Branched Peptides with Sequences Taken from Ubiquitinated Histones H2A and H2B from Calf Thymus Biol. Chem. Hoppe-Seyler 373: 834-835.


Articles in non peer reviewed  journals:

T. Kreisig, S. Mairif, T. Zuchner. Moderne Proteindiagnostik: das Potential zeitaufgelöster Fluoreszenz. (2011) Laborwelt IV/2011: 29-31 pdf (in German)

R.Muehlbacher, T. Zuchner. Protein detection in gels and on membranes. (2008) Screening -  Trends in drug discovery Vol. 9: 4:30-31 pdf