Publications
Publications in Peer-reviewed Journals
| Janine Kutzsche, Gustavo A. Guzman, Antje Willuweit, Olaf Kletke, Esther Wollert, Ian Gering, Dagmar Jürgens, Jörg Breitkreutz, Holger Stark, Annette G. Beck-Sickinger, Nikolaj Klöcker, Patricia Hidalgo, Dieter Willbold (2024) An orally available Cav2.2 calcium channel inhibitor for the treatment of neuropathic pain. BritJPharmacol., doi: 10.1111/bph.16309 | Abstract | |
| Xuan Zhang, Tina Weiß, Mary Hongying Cheng, Siqi Chen, Carla Katharina Ambrosius, Anne Sophie Czerniak, Kunpeng Li, Mingye Feng, Ivet Bahar, Annette G Beck-Sickinger, Cheng Zhang (2023) Structural basis of G protein-Coupled receptor CMKLR1 activation and signaling induced by a chemerin-derived agonist. PLoS Biol., doi: 10.1371/journal.pbio.3002188 | Abstract | |
| Catherine A Tindall, Kevin Möhlis, Inka Rapöhn, Sebastian Dommel, Veronika Riedl, Michael Schneekönig, Corinna Höfling, Steffen Roßner, Jan Stichel, Annette G Beck-Sickinger, Juliane Weiner, John T Heiker (2023) LRP1 is the cell-surface endocytosis receptor for vaspin in adipocytes. FEBS J., doi: 10.1111/febs.16991 | Abstract | |
| Sacha Bodin, Lisa C. Peuker, Emmanuelle Jestin, Isabel D. Alves, Valérie Velasco, Imade Ait-Arsa, Romain Schollhammer, Frédéric Lamare, Delphine Vimont, Gaétan MacGrogan, Elif Hindié, Annette G. Beck-Sickinger, and Clément Morgat (2023) Development of Radiopharmaceuticals for NPY Receptor‑5 (Y5) Nuclear Imaging in Tumors by Synthesis of Specific Agonists and Investigation of Their Binding Mode. Bioconjugate Chem., doi: 10.1021/acs.bioconjchem.3c00313 | Abstract | |
| Eva-Maria Jülke, Jan-Patrick Fischer, Sylvia Els-Heindl, Donald Bierer, Ingo Flamme, Johannes Köbberling, Bernd Riedl, Annette G Beck-Sickinger (2023) Rational design of highly stabilized and selective adrenomedullin analogs. J. Peptide Science, doi: 10.1002/psc.3530 | Abstract | |
| Anca Constantina Parau , Mihaela Dinu, Cosmin Mihai Cotrut, Iulian Pana, Diana Maria Vranceanu, Lidia Ruxandra Constantin, Giuseppe Serratore, Ioana M. Marinescu, Catalin Vitelaru, Giuseppina Ambrogio, Dennis A. Böhner, Annette G. Beck-Sickinger and Alina Vladescu (Dragomir) (2023) Effect of Deposition Temperature on the Structure, Mechanical, Electrochemical Evaluation, Degradation Rate and Peptides Adhesion of Mg and Si-Doped Hydroxyapatite Deposited on AZ31B Alloy. Coatings, doi: 10.3390/coatings13030591 | Abstract | |
| Iulian Pana, Anca Constantina Parau, Cosmin Mihai Cotrut, Mihaela Dinu, Diana Maria Vranceanu, Adrian Kiss, Giuseppe Serratore, Dennis Böhner, Catalin Vitelaru, Giuseppina Ambrogio, Annette G. Beck-Sickinger, Alina Vladescu (Dragomir) (2023) Influence of deposition temperature on the structure and functional properties of Mg doped hydroxyapatite coatings deposited on manufactured AZ31B alloy substrates by RF magnetron sputtering. Ceramics International, doi: 10.1016/j.ceramint.2023.04.064 | Abstract | |
| Corinna Schüß, Oanh Vu, Nigam M Mishra, Iain R Tough, Yu Du, Jan Stichel, Helen M Cox, C David Weaver, Jens Meiler, Kyle A Emmitte, Annette G Beck-Sickinger. (2023) Structure-Activity Relationship Study of the High-Affinity Neuropeptide Y4 Receptor Positive Allosteric Modulator VU0506013. J Med Chem., doi: 10.1021/acs.jmedchem.3c00383 | Abstract | |
| Kevin Kretschmer, Tristan Zellmann, Karin Mörl, Annette G Beck-Sickinger. (2023) Stable Binding of Full-Length Chemerin is Driven by Negative Charges in the CMKLR1 N-terminus. Chembiochem., e202300280. doi: 10.1002/cbic.202300280 | Abstract | |
| Kevin Kretschmer, Jan Stichel, Kathrin Bellmann-Sickert, Lars Baumann, Donald Bierer, Bernd Riedl, Annette G Beck-Sickinger. (2023) Pinpointing the interaction site between semaphorin-3A and its inhibitory peptide J. Pept. Sci. e3460, doi: 10.1002/psc.3460 | Abstract |
| Anne Sophie Czerniak, Kevin Kretschmer, Tina Weiß, Annette G Beck-Sickinger. (2022) The Chemerin Receptor CMKLR1 Requires Full-Length Chemerin for High Affinity in Contrast to GPR1 as Demonstrated by a New Nanoluciferase-Based Binding Assay Chem. Med. Chem. e202200413 doi: 10.1002/cmdc.202200413 | Abstract | |
| Tingting Tang, Qiuxiang Tan, Shuo Han, Anne Diemar, Kristin Löbner, Hongyu Wang, Corinna Schüß, Victoria Behr, Karin Mörl, Mu Wang, Xiaojing Chu, Cuiying Yi, Max Keller, Jacob Kofoed, Steffen Reedtz-Runge, Anette Kaiser, Annette G Beck-Sickinger, Qiang Zhao, Beili Wu (2022) Receptor-specific recognition of NPY peptides revealed by structures of NPY receptors Sc Adv. 8(18):eabm1232. doi: 10.1126/sciadv.abm1232 | Abstract | |
| Sarina Rudolf, Kerstin Kaempf, Oanh Vu, Jens Meiler, Annette G Beck-Sickinger, Irene Coin (2022) Binding of Natural Peptide Ligands to the Neuropeptide Y 5 Receptor Angew Chem Int Ed Engl. 61(5):e202108738. doi: 10.1002/anie.202108738. | Abstract | |
| Philipp Wolf, Alexander Mohr, Georgina Gavins, Victoria Behr, Karin Mörl, Oliver Seitz, Annette G Beck-Sickinger (2022) Orthogonal Peptide-Templated Labeling Elucidates Lateral ET A R/ET B R Proximity and Reveals Altered Downstream Signaling ChemBioChem 23(6):e202100340 DOI:10.1093/ndt/gfab284 | Abstract | |
| Carmine Zoccali, Alberto Ortiz, Inga Arune Blumbyte, Sarina Rudolf, Annette G. Beck-Sickinger, Jolanta Malyszko, Goce Spasovski, Sol Carriazo, Davide Viggiano, Justina Kurganaite, Vaiva Sarkeviciene, Daiva Rastenyte, Andreja Figurek, Merita Rroji, Christopher Mayer, Mustapha Arici, Gianvito Martino, Gioacchino Tedeschi, Annette Bruchfeld, Belinda Spoto, Ivan Rychlik, Andrzej Wieçek, Mark Okusa, Giuseppe Remuzzi and Francesca Mallamaci (2022) Neuropeptide Y as a risk factor for cardiorenal disease and cognitive dysfunction in chronic kidney disease: translational opportunities and challenges Nephrol Dial Transplant DOI:10.1093/ndt/gfab284 | Abstract |
| Nicolas A Heyder, Gunnar Kleinau, David Speck, Andrea Schmidt, Sarah Paisdzior, Michal Szczepek, Brian Bauer, Anja Koch, Monique Gallandi, Dennis Kwiatkowski, Jörg Bürger, Thorsten Mielke, Annette G Beck-Sickinger, Peter W Hildebrand, Christian M T Spahn, Daniel Hilger, Magdalena Schacherl, Heike Biebermann, Tarek Hilal, Peter Kühnen, Brian K Kobilka, Patrick Scheerer (2021) Structures of active melanocortin-4 receptor-Gs-protein complexes with NDP-α-MSH and setmelanotide Cell Res. DOI:10.1038/s41422-021-00569-8 | Abstract | |
| Sabrina Spiller, Tom Wippold, Kathrin Bellmann-Sickert, Sandra Franz, Anja Saalbach, Ulf Anderegg and Annette G. Beck-Sickinger (2021) Protease-Triggered Release of Stabilized CXCL12 from Coated Scaffolds in an Ex Vivo Wound Model Pharmaceutics. DOI:10.3390/pharmaceutics13101597 | Abstract | |
| Tobias F. Fischer, Anne S. Czerniak, Tina Weiß, Tristan Zellmann, Lina Zielke, Sylvia Els-Heindl and Annette G. Beck-Sickinger (2021) Cyclic Derivatives of the Chemerin C-Terminus as Metabolically Stable Agonists at the Chemokine-Like Receptor 1 for Cancer Treatment Cancers. DOI:10.3390/cancers13153788 | Abstract | |
| Catherine A Tindall, Estelle Erkner, Jan Stichel, Annette G Beck-Sickinger, Anne Hoffmann, Juliane Weiner, John T Heiker (2021) Cleavage of the vaspin N-terminus releases cell-penetrating peptides that affect early stages of adipogenesis and inhibit lipolysis in mature adipocytes. Adipocyte. DOI: 10.1080/21623945.2021.1910154 | Abstract | |
| Tobias F. Fischer, Anne S. Czerniak, Tina Weiß, Clara T. Schoeder, Philipp Wolf, Oliver Seitz, Jens Meiler, Annette G. Beck‑Sickinger (2021) Ligand‑binding and ‑scavenging of the chemerin receptor GPR1. CMLS. DOI:10.1007/s00018-021-03894-8 | Abstract | |
| Annette G Beck-Sickinger, Neville Compton, Wolfram Koch, Theresa Kueckmann, Katharina Landfester, Frank Maaß, Peter R Schreiner, Xin Su, Suzanne Tobey, Nathalie Weickgenannt (2021) Introducing… Advisory Editors and New Author Profiles at Angewandte Chemie. Angewandte Chemie. DOI: 10.1002/anie.202107455 | Abstract | |
| Nayara Braga Emidio, Rajeshwari Meli, Hue N T Tran, Hayeon Baik, Séverine Morisset-Lopez, Alysha G Elliott, Mark A T Blaskovich, Sabrina Spiller, Annette G Beck-Sickinger, Christina I Schroeder, Markus Muttenthaler (2021) Chemical Synthesis of TFF3 Reveals Novel Mechanistic Insights and a Gut-Stable Metabolite. J Med Chem. DOI: 10.1021/acs.jmedchem.1c00767 | Abstract | |
| Philipp Wolf, Annette G. Beck-Sickinger (2021) The ring size of monocyclic ET-1 controls selectivity andsignaling efficiency at both endothelin receptor subtypes. JPepScience. DOI: 10.1002/psc.3325 | Abstract | |
| Tobias F Fischer, Clara T Schoeder, Tristan Zellmann, Jan Stichel, Jens Meiler, Annette G Beck-Sickinger (2021) Cyclic Analogues of the Chemerin C-Terminus Mimic a Loop Conformation Essential for Activating the Chemokine-like Receptor 1. JMedChem. DOI: 10.1021/acs.jmedchem.0c01804 | Abstract | |
| Corinna Schüß, Oanh Vu, Mario Schubert, Yu Du, Nigam M Mishra, Iain R Tough, Jan Stichel, C David Weaver, Kyle A Emmitte, Helen M Cox, Jens Meiler, Annette G Beck-Sickinger (2021) Highly Selective Y 4 Receptor Antagonist Binds in an Allosteric Binding Pocket. JMedChem. doi:10.1021/acs.jmedchem.0c02000 Online ahead of print. | Abstract | |
| M Florencia Sánchez , Sylvia Els-Heindl , Annette G Beck-Sickinger , Ralph Wieneke , Robert Tampé (2021) Photo-induced receptor confinement drives ligand-independent GPCR signaling. Science. doi: 10.1126/science.abb7657 Online ahead of print. | Abstract | |
| Ali Işbilir, Robert Serfling, Jan Möller, Romy Thomas, Chiara De Faveri, Ulrike Zabel, Marco Scarselli, Annette G. Beck-Sickinger, Andreas Bock, Irene Coin, Martin J. Lohse and Paolo Annibale. (2021) Determination of G-protein–coupled receptor oligomerization by molecular brightness analyses in single cells. Nature Protocols. doi: 10.1038/s41596-020-00458-1 | Abstract | |
| Tingting Tang, Christin Hartig, Qiuru Chen, Wenli Zhao, Anette Kaiser, Xuefeng Zhang, Hui Zhang, Honge Qu, Cuiying Yi, Limin Ma, Shuo Han, Qiang Zhao, Annette G. Beck-Sickinger and Beili Wu. (2021) Structural basis for ligand recognition of the neuropeptide Y Y2 receptor. Nature Communications. doi:10.1038/s41467-021-21030-9 | Abstract | |
| Philipp Wolf, Georgina Gavins, Annette G Beck-Sickinger, Oliver Seitz. (2021) Strategies for site-specific labeling of receptor proteins on surfaces of living cells using genetically encoded peptide tags. Chembiochem. doi: 10.1002/cbic.202000797 | Abstract | |
| Georgina C Gavins, Katharina Gröger, Michael D Bartoschek, Philipp Wolf, Annette G Beck-Sickinger, Sebastian Bultmann, Oliver Seitz. (2021) Live cell PNA labelling enables erasable fluorescence imaging of membrane proteins. Nat Chem. doi: 10.1038/s41557-020-00584-z Epub 2020 Dec 7 | Abstract |
| Alexander Vogel, Mathias Bosse, Marcel Gauglitz, Sarah Wistuba, Peter Schmidt, Anette Kaiser, Vsevolod V Gurevich, Annette G Beck-Sickinger, Peter W Hildebrand, Daniel Huster. (2020) The Dynamics of the Neuropeptide Y Receptor Type 1 Investigated by Solid-State NMR and Molecular Dynamics Simulation. Molecules. doi: 10.3390/molecules25235489 | Abstract | |
| Franziska Voigtmann, Philipp Wolf, Kathrin Landgraf, Robert Stein, Jürgen Kratzsch, Samuel Schmitz, Rami Abou Jamra, Matthias Blüher, Jens Meiler, Annette G Beck-Sickinger, Wieland Kiess, Antje Körner. (2020) Identification of a novel leptin receptor (LEPR) variant and proof of functional relevance directing treatment decisions in patients with morbid obesity. Metabolism. doi: 10.1016/j.metabol.2020.154438 | Abstract | |
| Paul Hoppenz, Sylvia Els-Heindl, Annette G. Beck-Sickinger. (2020) Peptide-Drug Conjugates and Their Targets in Advanced Cancer Therapies. Front Chem. doi: 10.3389/fchem.2020.00571. eCollection 2020. | Abstract | |
| Anette Kaiser, Lizzy Wanka, Isabelle Ziffert, Annette G. Beck-Sickinger. (2020) Biased agonists at the human Y(1) receptor lead to prolonged membrane residency and extended receptor G protein interaction. Cell Mol Life Sci. doi: 10.1007/s00018-019-03432-7 | Abstract | |
| Jeannette M Laugwitz, Haleh H Haeri, Anette Kaiser, Ulrike Krug, Dariush Hinderberger, Annette G Beck-Sickinger, Peter Schmidt. Probing the Y 2 Receptor on Transmembrane, Intra- and Extra-Cellular Sites for EPR Measurements. Molecules. doi: 10.3390/molecules25184143 | Abstract | |
| Franziska Clauder, Stephanie Möller, Sebastian Köhling, Kathrin Bellmann-Sickert, Jörg Rademann, Matthias Schnabelrauch, Annette G Beck-Sickinger. Peptide-mediated surface coatings for the release of wound-healing cytokine. J Tissue Eng Regen Med. doi: 10.3390/molecules25184143 | Abstract | |
| Ulrike Krug, Anika Gloge, Peter Schmidt, Johanna Becker-Baldus, Frank Bernhard, Anette Kaiser, Cindy Montag, Marcel Gauglitz, Sergey A Vishnivetskiy, Vsevolod V Gurevich, Annette G Beck-Sickinger, Clemens Glaubitz, Daniel Huster (2020) The Conformational Equilibrium of the Neuropeptide Y2 Receptor in Bilayer Membranes. Angew Chem Int Ed Engl. doi: 10.1002/anie.202006075 | Abstract | |
| Isabelle Ziffert, Anette Kaiser, Paul Hoppenz, Karin Mörl, Annette G Beck-Sickinger (2020) Shuttling of Peptide-Drug Conjugates by G Protein-coupled Receptors is Significantly Improved by Pulsed Application. ChemMedChem. doi: 10.1002/cmdc.202000490. | Abstract | |
| Steve Reynaud, Justyna Ciolek, Michel Degueldre, Natalie J. Saez, Ana Filipa Sequeira, Yoan Duhoo, Joana L. A. Brás, Hervé Meudal, Miguel Cabo Díez, Victoria Fernández Pedrosa, Marion Verdenaud, Julia Boeri, Oscar Pereira Ramos, Frédéric Ducancel, Margot Vanden Driessche, Rudy Fourmy, Aude Violette, Grégory Upert, Gilles Mourier, Annette G. Beck-Sickinger, Karin Mörl, Céline Landon, Carlos M. G. A. Fontes, Rebeca Miñambres Herráiz, Ricardo C. Rodríguez de la Vega, Steve Peigneur, Jan Tytgat, Loïc Quinton, Edwin De Pauw, Renaud Vincentelli, Denis Servent, and Nicolas Gilles (2020) A Venomics Approach Coupled to High-Throughput Toxin Production Strategies Identifies the First Venom-Derived Melanocortin Receptor Agonists. J Med Chem. doi:10.1021/acs.jmedchem.0c00485 | Abstract | |
| Annette G Beck-Sickinger, Thomas Carell, Stefanie Dehnen, Walter Leitner, Peter R Schreiner, Helma Wennemers. (2020) From Scientists to Scientists-Moving Angewandte into the Future. Angew Chem Int Ed Engl. doi: 10.1002/anie.202008469 | Abstract | |
| Franziska Clauder, Franziska D. Zitzmann, Sabrina Friebe, Stefan G. Mayr, Andrea A. Robitzki, Annette G. Beck-Sickinger Multifunctional coatings combining bioactive peptides and affinity-based cytokine delivery for enhanced integration of degradable vascular grafts. Biomater Sci. doi:10.1039/c9bm01801h | Abstract | |
| Dennis J. Worm, Sylvia Els-Heindl und Annette G. Beck-Sickinger (2020) Targeting of peptide‐binding receptors on cancer cells with peptide‐drug conjugates. PeptideScience. doi:10.1002/pep2.24171 | Abstract | |
| Isabelle Ziffert, Anette Kaiser, Stefanie Babilon, Karin Mörl and Annette G. Beck-Sickinger (2020) Unusually persistent Gαi-signaling of the neuropeptide Y2 receptor depletes cellular Gi/o pools and leads to a Gi-refractory state. Cell Communication and Signaling. doi:10.1186/s12964-020-00537-6 | Abstract | |
| Ronny Frank, Christoph Prönnecke, Ronny Azendorf, Heinz-Georg Jahnke, Annette G. Beck-Sickinger and Andrea A. Robitzki (2020) Advanced 96-microtiter plate based bioelectrochemical platform reveals molecular short cut of electron flow in cytochrome P450 enzyme. Lab Chip. doi: 10.1039/c9lc01220f | Abstract | |
| Adrien Chastel, Dennis J. Worm, Isabel D. Alves, Delphine Vimont, Melina Petrel, Samantha Fernandez, Philippe Garrigue, Philippe Fernandez, Elif Hindié, Annette G. Beck-Sickinger and Clément Morgat (2020) Design, synthesis, and biological evaluation of a multifunctional neuropeptide-Y conjugate for selective nuclear delivery of radiolanthanides. EJNMMI Res doi: 10.1186/s13550-020-0612-8 | Abstract | |
| Laura Krieg, Alexandra Schaffert, Matthias Kern, Kathrin Landgraf, Martin Wabitsch, Annette G. Beck-Sickinger, Antje Körner Matthias Blüher, Martin von Bergen and Kristin Schubert (2020) An MRM-Based Multiplexed Quantification Assayfor Human Adipokines and Apolipoproteins. Molecules. doi:10.3390/molecules25040775 | Abstract | |
| Franziska Clauder, Franziska Zitzmann, Sabrina Friebe, Stefan Mayr, Andrea Robitzki and Annette G. Beck-Sickinger (2020) Multifunctional Peptide Coatings for Biodegradable Scaffolds in Cardiovascular Applications. Biomater Sci. doi: 10.1039/c9bm01801h | Abstract | |
| Lisa Marie Kögler, Jan Stichel and Annette G. Beck-Sickinger. (2020) Structural investigations of cell-free expressed G protein-coupled receptors. Biol Chem. doi: 10.1515/hsz-2019-0292 | Abstract | |
| Stefanie Wittrisch, Nora Klöting, Karin Mörl, Rima Chakaroun, Matthias Blüher and Annette G. Beck-Sickinger. (2020) NPY(1)R-targeted peptide-mediated delivery of a dual PPARα/γ agonist to adipocytes enhances adipogenesis and prevents diabetes progression. Mol Metab. doi: 10.1016/j.molmet.2019.11.009 | Abstract | |
| Dennis J Worm, Paul Hoppenz, Sylvia Els-Heindl, Martin Kellert, Robert Kuhnert, Stefan Saretz, Johannes Köbberling, Bernd Riedl, Evamarie Hey-Hawkins and Annette G. Beck-Sickinger. (2020) Selective Neuropeptide Y Conjugates with Maximized Carborane Loading as Promising Boron Delivery Agents for Boron Neutron Capture Therapy. J Med Chem. doi: 10.1021/acs.jmedchem.9b01136 | Abstract | |
| Paul Hoppenz, Sylvia Els-Heindl, Martin Kellert, Robert Kuhnert, Stefan Saretz, Hans-Georg Lerchen, Johannes Köbberling, Bernd Riedl, Evamarie Hey-Hawkins and Annette G. Beck-Sickinger (2020) A Selective Carborane-Functionalized Gastrin-Releasing Peptide Receptor Agonist as Boron Delivery Agent for Boron Neutron Capture Therapy. J. Org. Chem. doi: 10.1021/acs.joc.9b02406 | Abstract | |
| Martin Kellert, Paul Hoppenz, Peter Lönnecke, Dennis J. Worm, Bernd Riedl, Johannes Koebberling, Annette G. Beck-Sickinger and Evamarie Hey-Hawkins. (2020) Tuning a modular system – synthesis and characterisation of a boron-rich s-triazine-based carboxylic acid and amine bearing a galactopyranosyl moiety. Dalton Trans. doi: 10.1039/c9dt04031e | Abstract |
| Paul Hoppenz, Sylvia Els-Heindl, Annette G. Beck-Sickinger. (2019) Identification and stabilization of a highly selective gastrin-releasing peptide receptor agonist. J Pept Sci. doi: 10.1002/psc.3224 | Abstract | |
| Franziska Clauder, Anne Sophie Czerniak, Sabrina Friebe, Stefan G. Mayr, Dierk Scheinert, and Annette G. Beck-Sickinger (2019) Endothelialization of Titanium Surfaces by Bioinspired Cell Adhesion Peptide Coatings. Bioconjug. Chem. doi: 10.1021/acs.bioconjchem.9b00573 | Abstract | |
| Sabrina Spiller, Nydia Panitz, Lucas Schirmer, Passant Morsi Atallah, Yanuar Dwi Putra Limasale, Kathrin Bellmann-Sickert, Joanna Blaszkiewicz, Sebastian Köhling, Uwe Freudenberg, Jörg Rademann, Carsten Werner and Annette G. Beck-Sickinger (2019) Modulation of Human CXCL12 Binding Properties to Glycosaminoglycans to Improve the Chemotactic Gradient. ACS Biomater. Sci. Eng. doi: 10.1021/acsbiomaterials.9b01139 | Abstract | |
| Nils Wilharm, Tony Fischer, Florian Ott, Robert Konieczny, Mareike Zink, Annette G. Beck-Sickinger, and Stefan G. Mayr (2019) Energetic Electron Assisted Synthesis of Highly Tunable Temperature-Responsive Collagen/Elastin Gels for Cyclic Actuation: Macroscopic Switching and Molecular Origins. Sci. Rep., 9, 12363, doi: 10.1038/s41598-019-48830-w. | Abstract | |
| Martin Kellert, Dennis J. Worm, Paul Hoppenz, Menyhárt B. Sárosi, Peter Lönnecke, Bernd Riedl, Johannes Koebberling, Annette G. Beck-Sickinger, and Evamarie Hey-Hawkins (2019) Modular Triazine-Based Carbaborane-Containing Carboxylic Acids – Synthesis and Characterisation of Potential Boron Neutron Capture Therapy Agents Made of Readily Accessible Building Blocks. Dalton Trans., 48, 10834-44, doi: 10.1039/c9dt02130b | Abstract | |
| Esben M. Bech, Anette Kaiser, Kathrin Bellmann-Sickert, Søren S.-R. Nielsen, Kasper K. Sørensen, Lisbeth Elster, Nikos Hatzakis, Søren L. Pedersen, Annette G. Beck-Sickinger, and Knud J. Jensen (2019) Half-Life Extending Modification of Peptide YY(3-36) Direct Receptor-Mediated Internalization. Mol. Pharm., 16, 3665-77, | Abstract | |
| Lisa Maria Kögler, Jan Stichel, Anette Kaiser, Annette G. Beck-Sickinger (2019) Cell-Free Expression and Photo-Crosslinking of the Human Neuropeptide Y2 Receptor. Front. Pharmacol., 10, 176, doi: 10.3389/fphar.2019.00176. | Abstract | |
| Jan-Patrick Fischer, Ria Schönauer, Sylvia Els-Heindl, Donald Bierer, Johannes Koebberling, Bernd Riedl, Annette G. Beck-Sickinger (2019) Adrenomedullin Disulfide Bond Mimetics Uncover Structural Requirements for AM1 Receptor Activation. J. Pept. Sci., 25, e3147, doi:10.1002/psc.3147. | Abstract | |
| Brian J. Bender, Gerrit Vortmeier, Stefan Ernicke, Mathias Bosse, Anette Kaiser, Sylvia Els-Heindl, Ulrike Krug, Annette G. Beck-Sickinger, Jens Meiler, Daniel Huster (2019) Structural Model of Ghrelin Bound to its G Protein-Coupled Receptor. Structure, 27, 537-544, doi:10.1016/j.str.2018.12.004. | Abstract |
| Sebastian Köhling, Joanna Blaszkiewicz, Gloria Ruiz-Gómez, María Isabel Fernández-Bachiller, Katharina Lemmnitzer, Annette G. Beck-Sickinger, Daniel Huster, Jürgen Schiller, M. Teresa Pisabarro, Jörg Rademann (2018) Evaluating the GAG binding diversity on ECM target proteins using defined sulfated oligohyaluronans. Chem. Sci. 10, 866-878. | Abstract | |
| Valeria Castelleto, Ian W. Hamley, Jani Seitsonen, Janne Ruokolainen, Gemma Harris, Kathrin Bellmann-Sickert, Annette G. Beck-Sickinger (2018) Conformation and Aggregation of Selectively PEGylated and Lipidated Gastric Peptide Hormone Human PYY3-36. Biomacromolecules, 19, 4320-4332. | Abstract | |
| Dennis Worm, Sylvia Els-Heindl, Martin Kellert, Robert Kuhnert, Stefan Saretz, Johannes Koebberling, Bernd Riedl, Evamarie Hey-Hawkins, Annette G. Beck-Sickinger (2018) A Stable meta-Carborane Enables the Generation of Boron-Rich Peptide Agonists Targeting the Ghrelin Receptor. J. Pept. Sci., 10, e3119, doi: 10.1002/psc.3119 | Abstract | |
| Sven Hofmann, Josephin Lindner, Annette G. Beck-Sickinger, Evamarie Hey-Hawkins, Kathrin Bellmann-Sickert (2018) Carbaboranylation of truncated C-terminal neuropeptide Y analogue leads to full hY1 receptor agonism. ChemBioChem., 19, 2300–2306. | Abstract | |
| Jan-Patrick Fischer, Sylvia Els-Heindl, Ria Schönauer, Donald Bierer, Johannes Köbberling, Bernd Riedl, Annette G. Beck-Sickinger (2018) The Impact of Adrenomedullin Thr22 on Selectivity within the Calcitonin Receptor-like Receptor/Receptor Activity-Modifying Protein System. ChemMedChem., 13, 1797-1805. | Abstract | |
| Lizzy Wanka, Stefanie Babilon, Anette Kaiser, Karin Mörl, Annette G. Beck-Sickinger (2018) Different mode of arrestin-3 binding at the human Y1 and Y2 receptor. Cell. Signal., 50, 58-71. | Abstract | |
| Zhenlin Yang, Shuo Han, Max Keller, Anette Kaiser, Brian J. Bender, Mathias Bosse, Kerstin Burkert, Lisa M. Kögler, David Wifling, Guenther Berndhardt, Nicole Plank, Timo Littmann, Peter Schmidt, Cuiying Yi, Beibei Li, Sheng Ye, Rongguang Zhang, Bo Xu, Dan Larhammar, Raymond C. Stevens, Daniel Huster, Jens Meiler, Qiang Zhao, Annette G. Beck-Sickinger, Armin Buschauer, Beili Wu (2018) Structural basis of ligand binding modes at the nuropeptide Y Y1 Receptor. Nature, 556, 520-524. | Abstract | |
| Anette Kaiser, Caroline Hempel, Lizzy Wanka, Mario Schubert, Heidi E. Hamm, Annette G. Beck-Sickinger (2018) G protein pre-assembly rescues efficacy of W6.48 toggle mutations in neuropeptide Y2 receptors. Mol. Pharm., 93, 387-401. | Abstract | |
| Milos Erak, Kathrin Bellmann-Sickert, Sylvia Els-Heindl, Annette G. Beck-Sickinger (2018) Peptide chemistry toolbox – Transforming natural peptides into peptide therapeutics. Bioorg. Med. Chem., 26, 2759-2765. | Abstract | |
| Karoline Nordsieck, Lars Baumann, Vera Hintze, M. Teresa Pisabarro, Matthias Schnabelrauch, Annette G. Beck-Sickinger, Sergey A. Samsonov (2018) The effect of interleukin-8 truncations on its interactions with glycosaminoglycans. Biopolymers, 109, e23103. | Abstract | |
| Peter Schmidt, Brian J. Bender, Anette Kaiser, Khushboo Gulati, Holger A. Scheidt, Heidi E. Hamm, Jens Meiler, Annette G. Beck-Sickinger, Daniel Huster (2018) Improved In Vitro Folding of the Y2 G Protein-Coupled Receptor into Bicelles. Front. Mol. Biosci., 4:100 doi:10.3389/fmolb.2017.00100. eCollection 2017. | Abstract | |
| Jonathan Lotze, Philipp Wolf, Ulrike Reinhardt, Oliver Seitz, Karin Mörl, Annette G. Beck-Sickinger (2018) Time-resolved tracking of separately internalized Neuropeptide Y2 Receptors by two-color pulse-chase. ACS Chem., 13, 618-627. | Abstract | |
| Sarah Zernia, Ronny Frank, Renato H.-J. Weiße, Heinz-Georg Jahnke, Kathrin Bellmann-Sickert, Andrea Prager, Bernd Abel, Norbert Sträter, Andrea Robitzki, Annette G. Beck-Sickinger (2018) Surface-Binding Peptide Facilitates Electricity-Driven NADPH-Free Cytochrome P450 Catalysis. ChemCatChem., 10, 525-530. | Abstract |
| Franziska D. Zitzmann, Heinz-Georg Jahnke, Felix Nitschke, Annette G. Beck-Sickinger, Bernd Abel, Detlev Belder and Andrea A. Robitzki (2017) A novel microfluidic microelectrode chip for a significantly enhanced monitoring of NPY-receptor activation in live mode. Lab Chip. 17, 4294-4302. | Abstract | |
| Mario Schubert, Jan Stichel, Yu Du, Iain R. Tough, Gregory Sliwoski, Jens Meiler, Helen M. Cox, C. David Weaver and Annette G. Beck-Sickinger (2017) Identification and Characterization of the First Selective Y4 Receptor Positive Allosteric Modulator. J Med Chem. 60, 7605-7612. | Abstract | |
| Stefanie Schrottke, Anette Kaiser, Gerrit Vortmeier, Sylvia Els-Heindl, Dennis Worm, Mathias Bosse, Peter Schmidt, Holger A. Scheidt, Annette G. Beck-Sickinger and Daniel Huster (2017) Expression, Functional Characterization, and Solid-State NMR Investigation of the G Protein-Coupled GHS Receptors in Bilayer Membranes. Sci Rep. 7, 46128. | Abstract | |
| Rares-Petru Moldovan, Sylvia Els-Heindl, Dennis J. Worm, Torsten Kniess, Michael Kluge, Annette G. Beck-Sickinger, Winnie Deuther-Conrad, Ute Krügel and Peter Brust (2017) Development of Fluorinated Non-Peptidic Ghrelin Receptor Ligands for Potential Use in Molecular Imaging. Int J Mol Sci. 5, 786-802. | Abstract | |
| Florent Jouy, Nadine Lohmann, Elke Wandel, Gloria Ruiz-Gómez, M. Teresa Pisabarro, Annette G. Beck-Sickinger, Matthias Schnabelrauch, Stephanie Möller, Jan C. Simon, Stefan Kalkhof, Martin von Bergen and Sandra Franz (2017) Sulfated hyaluronan attenuates inflammatory signaling pathways in macrophages involving induction of antioxidants. Proteomics. 17, e1700082. | Abstract | |
| Cathleen Juhl, Sylvia Els-Heindl, Ria Schönauer, Gordon Redlich, Erik Haaf, Frank Wunder, Bernd Riedl, Nils Burkhardt, Annette G. Beck-Sickinger and Donald Bierer (2017) Development of Potent and Metabolically Stable APJ Ligands with High Therapeutic Potential. ChemMedChem, 11, 2378-2384. | Abstract | |
| Kerstin Burkert, Tristan Zellmann, Rene Meier, Anette Kaiser, Jan Stichel, Jens Meiler, Gopi K. Mittapalli, Edward Roberts and Annette G. Beck-Sickinger (2017) A Deep Hydrophobic Binding Cavity is the Main Interaction for Different Y2R Antagonists. ChemMedChem. 12, 75-85. | Abstract | |
| Lizzy Wanka, Stefanie Babilon, Karin Mörl, Vsevolod V. Gurevich and Annette G. Beck-Sickinger (2017) C-terminal motif of human neuropeptide Y4 receptor determines internalization and arrestin recruitment. Cell Signal. 29, 233-239. | Abstract |
| Veronika Thieme, Navjeet Jolly, Andreas N. Madsen, Kathrin Bellmann-Sickert, Thue Schwartz, Birgitte Holst, Helen M. Cox and Annette G. Beck-Sickinger (2016) High molecular weight PEGylation of human pancreatic polypeptide at position 22 improves stability and reduces food intake in mice. Br. J. Pharmacol. 173, 3208-3221. | Abstract | |
| Nydia Panitz, Stephan Theisgen, Sergey A. Samsonov, Jan-Philip Gehrcke, Lars Baumann, Kathrin Bellmann-Sickert, Sebastian Köhling, M Teresa Pisabarro, Jörg Rademann, Daniel Huster and Annette G. Beck-Sickinger (2016) The structural investigation of glycosaminoglycan binding to CXCL12 displays distinct interaction sites. Glycobiology. 26, 1209-1221. | Abstract | |
| Cecilia Ratner, Louise J. Skov, Zindy Raida, Thomas Bächler, Kathrin Bellmann-Sickert, Christelle Le Foll, Bjørn Sivertsen, Louise S. Dalbøge, Bolette Hartmann, Annette G. Beck-Sickinger, Andreas N. Madsen, Jacob Jelsing, Jens J. Holst, Thomas A. Lutz, Zane B. Andrews and Birgitte Holst (2016) Effects of Peripheral Neurotensin on Appetite Regulation and Its Role in Gastric Bypass Surgery. Endocrinology. 157, 3482-3492. | Abstract | |
| Anika Gladytz, Torsten John, Thomas Gladytz, Rayk Hassert, Mareen Pagel, H. Jelger Risselada, Sergej Naumov, Annette G. Beck-Sickinger and Bernd Abel (2016) Peptides@mica: from affinity to adhesion mechanism. Phys. Chem. Chem. Phys. 18, 23516-23527. | Abstract | |
| Ria Schönauer, Sylvia Els-Heindl, Jan-Patrick Fischer, Johannes Köbberling, Bernd Riedl and Annette G. Beck-Sickinger (2016) Adrenomedullin 2.0: Adjusting key levers for metabolic stability. J. Med. Chem. 12, 5695-5705. | Abstract | |
| Gregory Sliwoski, Mario Schubert, Jan Stichel, David Weaver, Annette G. Beck-Sickinger and Jens Meiler (2016) Discovery of Small-Molecule Modulators of the Human Y4 Receptor. PLoS ONE, 11, e0157146. | Abstract | |
| Mareen Pagel, Rene Meier, Klaus Braun, Manfred Wiessler and Annette G. Beck-Sickinger (2016) On-resin Diels-Alder reaction with inverse electron demand: an efficient ligation method for complex peptides with a varying spacer to optimize cell adhesion. Org. Biomol. Chem. 14, 4809-4816. | Abstract | |
| David Böhme, Jan Krieghoff and Annette G. Beck-Sickinger (2016) Double Methotrexate-modified Neuropeptide Y analogues express increased toxicity and overcome drug resistance in breast cancer cells. J. Med. Chem. 59, 3409-3417. | Abstract | |
| Dilip Verma, B. Hörmer, Kathrin Bellmann-Sickert, Veronika Theime, Annette G. Beck-Sickinger, Herbert Herzog, Günther Sperk and Ramon O Tasan (2016) Pancreatic polypeptide and its central Y4 receptors are essential for cued fear extinction and permanent suppression. Br. J. Pharmacol. 173, 1925-1938. | Abstract | |
| Sarah Zernia, Florian Ott, Kathrin Bellmann-Sickert, René Frank, Marcus Klenner, Heinz-Georg Jahnke, Andrea Prager, Bernd Abel, Andrea Robitzki and Annette G. Beck-Sickinger (2016) Peptide-mediated specific immobilization of catalytically active Cytochrome P450 BM3 variant. Bioconjug. Chem. 27, 1090-1097. | Abstract | |
| Michael Ansorge, Nadine Rastig, Ralph Steinborn, Tina König, Lars Baumann, Staphanie Möller, Matthias Schnabelrauch, Michael Cross, Carsten Werner, Annette G. Beck-Sickinger and Tilo Pompe (2016) Short-range cytokine gradients to mimic paracrine cell interactions in vitro. J. Contr. Release 224, 59-68. | Abstract | |
| Mareen Pagel, Rayk Hassert, Torsten John, Klaus Braun, Manfred Wiessler and Annette G. Beck-Sickinger (2016) Multifunctional coating improves cell adhesion on titanium by using cooperatively acting peptides. Angew. Chem. Int. Ed. 55, 4826-4830. | Abstract | |
| René Frank, Verena M. Ahrens, Solveig Boehnke, Annette G. Beck-Sickinger and Evamarie Hey-Hawkins (2016) Charge-compensated metallacarborane building blocks for conjugation with peptides. Chembiochem. 17, 308-317. | Abstract | |
| Jianxin Hu, Matthew Stern, Luis E. Diaz Gimenez, Lizzy Wanka, Lu Zhu, Mario Rossi, Annette G. Beck-Sickinger, Vsevolod V. Gurevich and Jürgen Wess (2016) A G-protein biased designer G-protein coupled receptor useful for studying the physiological relevance of Gq/11-dependent signaling pathways. J. Biol. Chem. 291, 7809-7820. | Abstract | |
| Anja Saalbach, Jenny Tremel, Diana Herbert, Katharina Schwede, Elke Wandel, Christine Schirmer, Ulf Anderegg, Annette Beck-Sickinger, John T. Heiker, Stephan Schultz, Thomas MAgin, Jan C. Simon (2016) Anti-inflammatory action of keratinocyte-derived Vaspin: Relevance for the pathogenesis of psoriasis. Am. J. Pathol. 186, 639-651 | Abstract | |
| Sylvia Els-Heindl, Kathrin Bellmann-Sickert and Annette G. Beck-Sickinger (2016) C-terminus of a hexapeptidic ghrelin receptor inverse agonist can switch peptide behaviour from inverse agonism to agonism. Biopolymers, 106, 101-108. | Abstract | |
| Cathleen Jendrny and Annette G. Beck-Sickinger (2016) Inhibition of kallikrein-related peptidases 7 and 5 by grafting serpin reactive center loop sequences onto sunflower trypsin inhibitor-1 (SFTI-1). Chembiochem. 17, 719-726. | Abstract | |
| Tom Marten Kilian, Nora Klöting, Matthias Blüher and Annette G. Beck-Sickinger (2016) Prenatal notch1 receptor blockade by protein delta homolog 1 (DLK1) modulates adipocyte size in vivo. Int. J. Obes. 40, 698-705. | Abstract | |
| Xuanzhi Zhan, Henriette Stoy, Tamer S. Kaoud, Niclos A. Perry, Qiuyan Chen, Alejandro Perez, Sylvia Els-Heindl, Jack V. Slagis, Tina M. Iverson, Annette G. Beck-Sickinger, Eugenia V. Gurevich, Kevin N. Dalby, Vsevolod V. Gurevich (2016) Peptide mini-scaffold facilitates JNK3 activation in cells. Sci. Rep. 6, 21025. | Abstract |
| René Frank, Verena Ahrens, Solveig Boehnke, Sven Hofmann, Martin Kellert, Stefan Saretz, Souvik Pandey, Menyhárt Sárosi, Ágota Bartók, Annette G. Beck-Sickinger and Evamarie Hey-Hawkins (2015). Carbaboranes – more than just phenyl mimetics. Pure Appl. Chem. 87, 163-171. | Abstract | |
| Ria Schönauer, Anette Kaiser, Cathleen Holze, Stefanie Babilon, Johannes Koebberling, Bernd Riedl and Annette G. Beck-Sickinger (2015) Flourescently labeled adrenomedullin allows realtime monitoring of adrenomedullin receptor trafficking in living cells. J. Pept. Sci. 21, 905-912. | Abstract | |
| Minyoung Park, Bjørn B. Sivertsen, Sylvia Els-Heindl, Thomas Huber, Brigitte Holst, Annette G. Beck-Sickinger, Thue W. Schwartz and Thomas P. Sakmar (2015) Bioorthogonal labeling of ghrelin receptor to facilitate studies of ligand-dependent conformational dynamics. Chem. Biol. 22, 1431-1436. | Abstract | |
| Ulrike Reinhard, Jonathan Lotze, Karin Mörl, Annette G. Beck-Sickinger and Oliver Seitz (2015) Rapid covalent fluorescence labeling of membrane proteins on live cells via coiled-coil templated acyl-transfer. Bioconjug Chem. 26, 2106-2117. | Abstract | |
| Florian Job, Florian Settele, Susan Lorey, Chris Rundfeld, Lars Baumann, Annette G. Beck-Sickinger, Ulrich Haupts, Hauke Lilie and Eva Bosse-Doenecke (2015) Ubiquitin is a versatile scaffold protein for the generation of molecules with de novo binding and advantageous drug-like properties. FEBS Open Bio. 5, 579-593. | Abstract | |
| Tom M. Kilian, Nora Klöting, Ralf Bergmann, Sylvia Els-Heindl, Stefanie Babilon, Mathieu Clement-Ziza, Yixin Zhang, Annette G. Beck-Sickinger and Constance Chollet (2015) Rational design of dual peptides targeting Ghrelin and Y2 receptors to regulate food intake and body weight.J. Med. Chem. 58, 4180-4193. | Abstract | |
| Verena M. Ahrens, Katja B. Kostelnik, Robert Rennert, David Böhme, Stefan Kalkhof, David Kosel, Lutz Weber, Martin von Bergen and Annette G. Beck-Sickinger (2015) A cleavable cytolysin-neuropeptide Y bioconjugate enables specific drug delivery and demonstrates intracellular mode of action. J. Control Release 209, 170-178. | Abstract | |
| Anette Kaiser, Paul Müller, Tristan Zellmann, Holger A. Scheidt, Lars Thomas, Mathias Bosse, Rene Meier, Jens Meiler, Daniel Huster, Annette G. Beck-Sickinger and Peter Schmidt (2015) Unwinding of the C-Terminal Residues of Neuropeptide Y is critical for Y2 Receptor Binding and Activation. Angew. Chemie Int. Ed. 54, 7446-7449. | Abstract | |
| David Böhme and Annette G. Beck-Sickinger (2015) Controlling toxicity in peptide-drug conjugates by different chemical linker structures. ChemMedChem 10, 804-814. | Abstract | |
| Gerrit Vortmeier, Stephanie H. DeLuca, Sylvia Els-Heindl, Constance Chollet, Holger A. Scheidt, Annette G. Beck-Sickinger, Jens Meiler and Daniel Huster (2015) Integrating Solid State NMR and Computational Modeling to Investigate the Structure and Dynamics of Membrane-Associated Ghrelin. PloS One 10, e0122444. | Abstract | |
| Sven Hofmann, Simone Maschauer, Torsten Kuwert, Annette Beck-Sickinger and Olaf Prante (2015) Synthesis, in vitro and in vivo evaluation of an 18F-labeled neuropeptide Y analog for imaging of breast cancer by PET. Mol. Pharmaceutics. 12, 1121-1130. | Abstract | |
| Tom-Marten Kilian and Annette G. Beck-Sickinger (2015) Recombinant Expression and Characterization of Biologically Active Protein Delta Homolog 1. Protein Expr. Purif. 110C, 72-78. | Abstract | |
| Katja B. Kostelnik, Sylvia Els-Heindl, Nora Klöting, Sven Baumann, Martin von Bergen and Annette G. Beck-Sickinger (2015) High metabolic in vivo stability and bioavailability of a palmitoylated ghrelin receptor ligand assessed by mass spectrometry. Bioorg. Med. Chem. 23, 3925-3932. | Abstract | |
| Verena M. Ahrens, Rene Frank, Solveig Boehnke, Christian L. Schütz, Gabriele Hampel, Dorothée S. Iffland, Nicolas H. Bings, Eva Hey-Hawkins and Annette G. Beck-Sickinger (2015) Receptor-mediated uptake of boron-rich neuropeptide Y analogs for boron neutron capture therapy. ChemMedChem 10, 164-172. | Abstract | |
| Jennifer M. Rojas, Eveline Bruinstroop, Richard L. Printz,Maxine K. Turney, Leena George, Annette G. Beck-Sickinger, Andries Kalsbeek and Kevin D. Niswender (2015) Central nervous system neuropeptide Y regulates mediators of hepatic phospholipid remodeling and very low density lipoprotein secretion via sympathetic innervation. Mol. Metab. 4, 210-221. | Abstract | |
| Verena te Kamp, Heinz-Georg Jahnke, Dana Krinke, Katja Kostelnik, Annette G. Beck-Sickinger and Andrea A. Robitzki (2015) Quantitative impedimetric NPY-receptor activation monitoring and signal pathway profiling in living cells. Biosens. Bioelectronics. 67, 386-393. | Abstract |
| Veronika Mäde, Kathrin Bellmann-Sickert, Anette Kaiser, Jens Meiler and Annette G. Beck-Sickinger (2014) Position and length of fatty acids strongly affect receptor selectivity pattern of human pancreatic polypeptide analogues. ChemMedChem 9, 2463-74 | Abstract | |
| Ulrike Reinhardt, Jonathan Lotze, Sarah Zernia, Karin Mörl, Annette G. Beck-Sickinger and Oliver Seitz (2014) Peptide-templated acyl transfer: a chemical method for the labeling of membrane proteins. Angew. Chem. Int. Ed. 53,10237-41 | Abstract | |
| Veronika Mäde, Stefanie Babilon, Navjeet Jolly, Lizzy Wanka, Kathrin Bellmann-Sickert, Luis E. Diaz Gimenez, Karin Mörl, Helen M. Cox, Vsevolod V. Gurevich and Annette G. Beck-Sickinger (2014) Peptide modifications differentially alter G protein-coupled receptor internalization and signaling bias. Angew. Chem. Int. Ed. 53, 10067-71 | Abstract | |
| Alexander Baer, Ivo de Sena Oliveira, Max Steinhagen, Annette G. Beck-Sickinger and Georg Mayer (2014) Slime protein profiling: a non-invasive tool for species identification in Onychophora (velvet worms). J. Zool. Syst. Evol. Res. 52, 265-272. | Abstract | |
| Luiz E. Diaz Gimenez, Stefanie Babilon, Lizzy Wanka, Annette G. Beck-Sickinger and Vsevolod V. Gurevich (2014) Mutations in arrestin-3 differentially affect binding to neuropeptide Y receptor subtypes. Cell Signal. 26, 1523-31. | Abstract | |
| Max Steinhagen, Peter-Georg Hoffmeister, Karoline Nordsieck, Rudi Hötzel, Lars Baumann, Michael Hacker, Michaela Schulz-Siegmund and Annette G. Beck-Sickinger (2014) Matrix metalloproteinase 9 (MMP-9) mediated release of MMP-9 resistant stromal cell-derived factor 1α (SDF-1α) from surface modified polymer films. ACS Appl. Mater. Interfaces. 6, 5891-99. | Abstract | |
| Xavier Pedragosa-Badia, Gregory R. Sliwoski, Elizabeth Dong Nguyen, Diana Lindner, Jan Stichel, Kristian W. Kaufmann, Jens Meiler and Annette G. Beck-Sickinger (2014) Pancreatic polypeptide is recognized by two hydrophobic domains of the human Y4 receptor binding pocket. J. Biol. Chem. 289, 5846-59. | Abstract | |
| Markus Gyger, Roland Stange, Tobias R. Kießling, Anatol Fritsch, Katja B. Kostelnik, Annette G. Beck-Sickinger, Mareike Zink and Josef A. Käs (2014) Active contractions in single suspended epithelial cells. Eur. Biophys. J. 43, 11-23. | Abstract |
| Kristin Möbius, Karoline Nordsieck, Annelie Pichert, Sergey A. Samsonov, Lars Thomas, Jürgen Schiller, Stefan Kalkhof, M. Teresa Pisabarro, Annette G. Beck-Sickinger and Daniel Huster (2013) Investigation of Lysine Side Chain Interactions of Interleukin-8 with Heparin and Other Glycosaminoglycans Studied by a Methylation-NMR Approach. Glycobiology 23,1260-9. | Abstract | |
| Jana Breitfeld, John T. Heiker, Yvonne Böttcher, Dorit Schleinitz, Anke Tönjes, Kerstin Weidle, Kerstin Krause, E. Bartholomeus Kuettner, Markus Scholz, Wieland Kiess, Norbert Sträter, Annette G. Beck-Sickinger, Michael Stumvoll, Antje Körner, Matthias Blüher, Peter Kovacs (2013) Analysis of a Rare Functional Truncating Mutation rs61757459 in Vaspin (SERPINA12) on Circulating Vaspin Levels. J. Mol. Med. (Berl.) 91, 1285-92. | Abstract | |
| Lars Baumann and Annette G. Beck-Sickinger (2013) Photoactivatable Chemokines – Controlling Protein Activity by Light. Angew. Chem. Int. Ed. Engl. 52, 9550-53. | Abstract | |
| Kristina Witte, Anette Kaiser, Peter Schmidt, Victoria Splith, Lars Thomas, Sandra Berndt, Daniel Huster and Annette G. Beck-Sickinger (2013) Oxidative In Vitro Folding of a Cysteine Deficient Variant of the G Protein-coupled Neuropeptide Y Receptor Type 2 Improves Stability at High Concentration. Biol. Chem. 394, 1045-56. | Abstract | |
| Daniel Rathmann, Xavier Pedragosa-Badia and Annette G. Beck-Sickinger (2013) In Vitro Modification of Substituted Cysteines as Tool to Study Receptor Functionality and Structure-activity Relationships. Anal. Biochem. 439, 173-83. | Abstract | |
| Max Steinhagen, Katja Zunker, Karoline Nordsieck and Annette G. Beck-Sickinger (2013) Large Scale Modification of Biomolecules Using Immobilized Sortase A from Staphylococcus Aureus. Bioorg. Med. Chem. 21, 3504-10. | Abstract | |
| Stephan Schultz, Anja Saalbach, John T. Heiker, René Meier, Tristan Zellmann, Jan C. Simon and Annette G. Beck-Sickinger (2013) Proteolytic Activation of Prochemerin by Kallikrein 7 Breaks an Ionic Linkage and Results in C-terminal Rearrangement. Biochem. J. 452, 271-80. | Abstract | |
| John T. Heiker, Nora Klöting, Peter Kovacs, E. Bartholomeus Küttner, Norbert Sträter, Stephan Schultz, Matthias Kern, Michael Stumvoll, Matthias Blüher and Annette G. Beck-Sickinger (2013) Vaspin inhibits kallikrein 7 by serpin mechanism. Cell. Mol. Life Sci. 70, 2569-83. | Abstract | |
| Sven Hofmann, Rene Frank, Eva Hey-Hawkins, Annette G. Beck-Sickinger, Peter Schmidt (2013) Manipulating Y Receptor Subtype Activation of Short Neuropeptide Y Analogs by Introducing Carbaboranes. Neuropeptides 47, 59-66. | Abstract | |
| Volker Adams, John T. Heiker, Robert Höllriegel, Ephraim B. Beck, Felix J. Woitek, Sandra Erbs, Matthias Blüher, Michael Stumvoll , Annette G. Beck-Sickinger, Gerhard Schuler, Axel Linke (2013) Adiponectin Promotes the Migration of Circulating Angiogenic Cells Through p38-mediated Induction of the CXCR4 Receptor. Int. J. Cardiol. 167, 2039-46. | Abstract | |
| Stephanie H. DeLuca, Daniel Rathmann, Annette G. Beck-Sickinger, Jens Meiler (2013) The Activity of Prolactin Releasing Peptide Correlates with its Helicity. Biopolymers 99, 314-325. | Abstract | |
| Robert Spinnler, Theresa Gorski, Katharina Stolz, Susanne Schuster, Antje Garten, Annette G. Beck-Sickinger, Marten A. Engelse, Eelco J.P. de Koning, Antje Körner, Wieland Kiess and Kathrin Maedler (2013) The Adipocytokine Nampt and its Product NMN Have No Effect on Beta-Cell Survival but Potentiate Glucose Stimulated Insulin Secretion. PLoS ONE 8, e54106. | Abstract | |
| Annelie Pichert, Sergey A. Samsonov, Stephan Theisgen, Lars Thomas, Lars Baumann, Jürgen Schiller, Annette G. Beck-Sickinger, Daniel Huster and M. Teresa Pisabarro (2012) Characterization of the Interaction of Interleukin-8 with Hyaluronan, Chondroitin Sulfate, Dermatan Sulfate, and their Sulfated Derivatives by Spectroscopy and Molecular Modelling, Glycobiology 22, 134-145. | Abstract | |
| Anja Saalbach, Katharina Vester, Kathrin Rall, Jenny Tremel, Ulf Anderegg, Annette G. Beck-Sickinger, Matthias Blüher and Jan Simon (2012) Vaspin – a Link of Obesity and Psoriasis? Exp. Dermatol. 21, 309-312. | Abstract | |
| Constance Chollet, Ralf Bergmann, Jens Pietzsch and Annette G. Beck-Sickinger (2012) Design, Evaluation, and Comparison of Ghrelin Receptor Agonists and Inverse Agonists as Suitable Radiotracers for PET Imaging Bioconjug. Chem. 23, 771-784. | Abstract | |
| Lars Baumann, Silvana Prokoph, Christian Gabriel, Uwe Freudenberg, Carsten Werner and Annette G. Beck-Sickinger (2012) A Novel, Biased-like SDF-1 Derivative acts Synergistically with starPEG-based Heparin Hydrogels and improves eEPC Migration in vitro, J. Control. Release 162, 68-75. | Abstract | |
| Cathleen Juhl, David Kosel and Annette G. Beck-Sickinger (2012) Two Motifs with Different Function Regulate the Anterograde Transport of the Adiponectin Receptor 1, Cell. Sign. 24, 1762-1769. | Abstract | |
| J.C. Morales-Medina, S. Dominguez-Lopez, G. Gobbi, A.G. Beck-Sickinger and R. Quirion (2012) The Selective Neuropeptide Y Y5 agonist [cPP(1-7),NPY(19-23),Ala31,Aib32,Gln34]hPP Differently Modulates Emotional Processes and Body Weight in the Rat, Behav. Brain Res. 233, 298-304. | Abstract | |
| Maria Findeisen, Cäcilia Würker, Daniel Rathmann, René Meier, Jens Meiler, Roger Olsson and Annette G. Beck-Sickinger (2012) Selective Mode of Action of Guanidine-Containing Non-Peptides at Human NPFF Receptors, J. Med. Chem. 55, 6124-6136 | Abstract | |
| Knut Kölbel, Christian Ihling, Uwe Kühn, Ines Neundorf, Silke Otto, Jan Stichel, Dina Robaa, Annette G. Beck-Sickinger, Andrea Sinz and Elmar Wahle (2012) Peptide Backbone Conformation Affects the Substrate Preference of Protein Arginine Methyltransferase I,Biochemistry 51, 5463-5475. | Abstract | |
| Daniel Rathmann, Diana Lindner, Stephanie H. DeLuca, Kristian W. Kaufmann, Jens Meiler and Annette G. Beck-Sickinger (2012) Ligand Mimicking Receptor Variant Discloses Binding and Activation Mode of Prolactin Releasing Peptide, J. Biol. Chem. 287, 32181-32194. | Abstract | |
| Sylvia Els, Enrico Schild, Pia Steen Petersen, Tom-Marten Kilian, Jacek Mokrosinski, Thomas M. Frimurer, Constance Chollet, Thue W. Schwartz, Birgitte Holst and Annette G. Beck-Sickinger (2012) An Aromatic Region to Induce a Switch between Agonism and Inverse Agonism at the Ghrelin Receptor, J. Med. Chem. 55, 7437-7449. | Abstract | |
| Sven Stadlbauer, René Frank, Matthias Scholz, Solveig Boehnke, Verena M. Ahrens, Annette G. Beck-Sickinger and Evamarie Hey-Hawkins (2012) Imitation and Modification of Bioactive Lead Structures via Integration of Boron Clusters, J. Pure Appl. Chem. 84, 2289-2298. | Abstract | |
| Rayk Hassert, Mareen Pagel, Zhou Ming, Tilmann Häupl, Bernd Abel, Klaus Braun, Manfred Wiessler and Annette G. Beck-Sickinger (2012) Biocompatible Silicon Surfaces through Orthogonal Click Chemistries and a High Affinity Silicon Oxide Binding Peptide. Bioconj. Chem. 23, 2129-2137. | Abstract | |
| Karoline Nordsieck, Annelie Pichert, Sergey A. Samsonov, Lars Thomas, Christian Berger, M. Teresa Pisabarro, Daniel Huster and Annette G. Beck-Sickinger (2012) Residue 75 of Interleukin 8 is Crucial for its Interaction with Glucosaminoglycans. ChemBioChem 13, 2558-2566. | Abstract | |
| Jennifer M. Rojas, John M. Stafford , Sanaz Saadat, Richard L. Printz, Annette G. Beck-Sickinger and Kevin D. Niswender (2012) Central Nervous System Neuropeptide Y Signaling via the Y1 receptor Partially Dissociates Feeding Behavior from Lipoprotein Metabolism in Lean Rats. Amer. J. Physiol. Endocrin. Metabol. 303, E1479-1488. | Abstract | |
| Rayk Hassert, Peter-Georg Hoffmann, Mareen Pagel, Michael Hacker, Michaela Schulz-Siegmund and Annette Beck-Sickinger (2012) On-Resin Synthesis of An Acylated and Fluorescence-Labeled Cyclic Integrin Ligand for Modification of Poly(lactic-co-glycolic acid). Chem. Biodivers. 9, 2648-2658. | Abstract | |
| Cornelia Walther, Jonathan Lotze, Annette G. Beck-Sickinger and Karin Mörl (2012) The Anterograde Transport of the Human Neuropeptide Y2 Receptor is regulated by a Subtype Specific Mechanism Mediated by the C-Terminus. Neuropeptides 46, 335-343. | Abstract |
| Matthias Scholz, Max Steinhagen, John T. Heiker, Annette G. Beck-Sickinger, Evamarie Hey-Hawkins (2011) Asborin inibits Aldo/Keto Reductase 1A1, ChemMedChem.6, 89-93. | Abstract | |
| Kathrin Bellmann-Sickert and Annette G. Beck-Sickinger (2011) Palmitoylated SDF1α Shows Increased Resistance Against Proteolytic Degradation in Liver Homogenates, ChemMedChem.6, 193-200. | Abstract | |
| Verena M. Ahrens, René Frank, Sven Stadlbauer, Annette G. Beck-Sickinger, Evamarie Hey-Hawkins (2011) Incorporation of ortho-Carbaboranyl-Nε-modified L-Lysine into Neuropeptide Y Receptor Y1- and Y2-Selective Analogues, J. Med. Chem. 54, 2368-2377. | Abstract | |
| Kathrin Bellmann-Sickert, Christian Elling, Andreas Nygaard Madsen, Paul B. Little, Karsten Lundgren, Lars-Ole Gerlach, Ralf Bergmann, Birgitte Holst, Thue W. Schwartz, Annette G. Beck Beck-Sickinger (2011) Long-acting Lipidated Analogue of Human Pancreatic Polypeptide is Slowly Released into Circulation, J. Med. Chem. 54, 2658-67 | Abstract | |
| Maria Findeisen, Daniel Rathmann, Annette G. Beck-Sickinger (2011) Structure/Activity Studies of RFamides Reveal a Subtype Specific Activation of Neuropeptide FF1 and FF2 Receptors, ChemMedChem. 6, 1081-1093. | Abstract | |
| Bjørn Sivertsen, Manja Lang, Thomas M.Frimurer, Anders Bach, Sylvia Els, Maja S.Engelstoft, Thue W. Schwartz, Annette G. Beck-Sickinger and Birgitte Holst (2011) Unique Interaction Pattern for a Functionally Biased Ghrelin Receptor Agonist, J. Biol. Chem. 286, 20845-60 | Abstract | |
| Nora Klöting, Peter Kovacs, Matthias Kern, John T. Heiker, Jana Breitfeld, Joanna Kosacka, Michael Stumvoll, Annette G. Beck-Sickinger , Matthias Blüher (2011) Central Vaspin Administration Acutely Reduces Food Intake and has Sustained Blood Glucose-lowering Effects, Diabetiologica 54, 1819-23 | Abstract | |
| Cathleen Juhl, Karin Mörl, Annette G. Beck-Sickinger (2011) Adiponectin Receptor 1 Interacts with Both Subunits of Protein Kinase CK2, Mol. Cell. Biochem. 356, 185-189 | Abstract | |
| Claire Jones, Jonas Denecke, Ronald Sträter, Torsten Stölting, Yvonne Schunicht, Dagmar Zeuschner, Judith Klumperman, Dirk J. Lefeber, Oliver Spelten, Alexander Zarbock, Sørge kelm, Karen Strenge, Stuart M. Haslam, Kerstin Lühn, Dorothea Stahl, Luca Gentile, Thomas Schreiter, Philip Hilgard, Annette G. Beck-Sickinger, Thorsten Marquart and Martin K. Wild (2011) A Novel Type of Macrothrombocytopenia Associated with a Defect in α2,3-Sialylation, Am. J. Path. 179, 1969-77 | Abstract | |
| Max Steinhagen, Kai Holland-Nell, Morten Meldal and Annette G. Beck-Sickinger (2011) Simultaneous “One Pot” Expressed Protein Ligation and CuI-Catalyzed Azide/Alkyne Cycloaddition for Protein Immobilization, ChemBioChem. 12, 2426-30 | Abstract | |
| Mathias Bosse, Lars Thomas, Rayk Hassert, Annette G. Beck-Sickinger, Daniel Huster and Peter Schmidt (2011) Assessment of a Fully Active Class A G Protein-Coupled Receptor Isolated from in Vitro Folding, Biochemistry 50, 9817-25. | Abstract | |
| Irfan U. Khan, Denise Zwanziger, Ilka Böhme, Muhammad Javed, Hamid Naseer, Syed W. Hyder, Annette G. Beck-Sickinger (2010) Breast cancer diagnosis by neuropeptide Y analogues – first clinical approach, Angew. Chem. Int. Ed. 49, 1155-1158. (VIP-Paper). | Abstract | |
| Susann Schimmer, Diana Lindner, Peter Schmidt, Annette G. Beck-Sickinger, Daniel Huster, Rainer Rudolph (2010) Functional characterization of the in vitro folded human Y1 receptor in lipid environment, Protein Pept. Lett. 17, 605-609. | Abstract | |
| David Kosel, John Heiker, Cathleen Juhl, Cornelia Deckert, Matthias Blüher, Karin Mörl, Annette G. Beck-Sickinger (2010) Adiponectin receptor 1 dimerisation is inhibited by adiponectin, J. Cell. Sci. 123, 1320-1328. | Abstract | |
| Peter Schmidt, Christian Berger, Holger A. Scheidt, Sandra Berndt, Andreas Bunge, Annette G. Beck-Sickinger, and Daniel Huster (2010), A Reconstitution Protocol for the in vitro Folded Human G Protein-Coupled Y2 Receptor into Lipid Environment, Biophys. Chem. 150, 29-36. | Abstract | |
| John T. Heiker, Nora Klöting, Matthias Blüher, Annette G. Beck-Sickinger (2010) Access to gram scale amounts of functional globular adiponectin from E. coli inclusion bodies by alkaline-shock solubilization, Biophys. Biochem. Res. Comm. 398, 32-37. | Abstract | |
| Kathrin Bellmann-Sickert, Lars Baumann, Annette G. Beck-Sickinger (2010) Selective labelling of stromal cell-derived factor 1α with carboxyfluorescein to study receptor internalisation, J. Pept. Sci. 16, 568-574. | Abstract | |
| Michael Bachmann, Karsten Goede, Annette G. Beck-Sickinger, Marius Grundmann, Anders Irbäck, Wolfhard Janke (2010) Microscopic Mechanism of Specific Peptide Adhesion to Semiconductor Substrates, Angew. Chem, Int. Ed. 49, 9530-9533. | Abstract | |
| Lars Baumann, Annette G. Beck-Sickinger (2010) Identification of a potential modification site of stromal-derived factor 1, Biopolymers 94, 771-778. | Abstract | |
| Cornelia Walther, Stefanie Nagel, Luis E. Gimenez, Karin Mörl, Vsevolod V. Gurevich, Annette G. Beck-Sickinger (2010) Ligand induced internalization and recycling of the human neuropeptide Y2 receptor is regulated by its C-terminal tail, J. Biol. Chem. 285, 41578-41590. | Abstract |
| Diana Lindner, Cornelia Walther, Anja Tennemann and Annette G. Beck-Sickinger (2009) Functional role of the extracellular N-terminal domain of Neuropeptide Y subfamily receptors in membrane integration and agonist-stimulated internalisation, Cell. Signal. 21, 61–68. | Abstract | |
| Knut Kölbel, Christian Ihling, Kathrin Bellmann-Sickert, Ines Neundorf, Annette G. Beck-Sickinger, Andrea Sinz, Uwe Kühn and Elmar Wahle (2009) Type I arginine methyl transferases PRMT1 and 3 act distributively, J. Biol. Chem. 284, 8274-8282. | Abstract | |
| John T. Heiker, Cornelia M. Wottawah, Cathleen Juhl, David Kosel, Karin Mörl and Annette G. Beck-Sickinger (2009) Protein kinase CK2 interacts with adiponectin receptor 1 and participates in adiponectin signalling, Cell. Signal. 21, 936-942. | Abstract | |
| Lars Thomas, Holger A. Scheidt, Andrea Bettio, Annette G. Beck- Sickinger, Daniel Huster and Olaf Zschörnig (2009) The Interaction of Neuropeptide Y with Negatively Charged and Zwitterionic Phospholipid Membrane, Eur. Biophys. J. 38, 663-77. | Abstract | |
| Michael Haack, Annette G. Beck-Sickinger (2009) Towards understanding the free and receptor bound conformation of neuropeptide Y by fluorescence resonance energy transfer studies, Chem. Biol. Drug Design 73, 573-583. | Abstract | |
| Pia Steen Petersen, David P.D. Woldbye, Andreas Nygaard Madsen, Kristoffer L Egerod, Chunyu Jin, Manja Lang, Annette G.Beck-Sickinger, and Birgitte Holst (2009) In Vivo Characterization of High Basal Signaling from the Ghrelin Receptor, Endocrinology 150,4920-30. | Abstract | |
| Denise Zwanziger, Ilka Böhme, Diana Lindner and Annette G. Beck-Sickinger (2009) The First Selective Agonist of the Neuropeptide Y1-Receptor with Reduced Size, J. Pept. Sci. 15, 856-866. | Abstract | |
| Peter Schmidt, Diana Lindner, Cindy Montag, Sandra Bertsch, Annette G. Beck-Sickinger; Rainer Rudolph, Daniel Huster (2009) Prokaryotic expression, in vitro folding, and molecular pharmacological characterisation of the neuropeptide Y receptor type 2, Biotechnol. Progr. 25, 1732-1739. | Abstract |
| Keller M, Pop N, Hutzler C, Beck-Sickinger AG, Bernhardt G, Buschauer A. (2008) Guanidine-acylguanidine bioisosteric approach in the design of radioligands: synthesis of a tritium-labeled N(G)-propionylargininamide ([3H]-UR-MK114) as a highly potent and selective neuropeptide Y Y1 receptor antagonist. J. Med. Chem. 51, 8168-72. | Abstract | |
| David R, Günther R, Baumann L, Lühmann T, Seebach D, Hofmann HJ, Beck-Sickinger AG. (2008) Artificial chemokines: combining chemistry and molecular biology for the elucidation of interleukin-8 functionality. J. Am. Chem. Soc. 130, 15311-7. | Abstract | |
| Chee MJ, Mörl K, Lindner D, Merten N, Zamponi GW, Light PE, Beck-Sickinger AG, Colmers WF. (2008) The third intracellular loop stabilizes the inactive state of the neuropeptide Y1 receptor. J. Biol. Chem. 283, 33337-46. | Abstract | |
| Böhme I, Stichel J, Walther C, Mörl K, Beck-Sickinger AG. (2008) Agonist induced receptor internalization of neuropeptide Y receptor subtypes depends on third intracellular loop and C-terminus. Cell. Signal. 20, 1740-9. | Abstract | |
| Lindner D, Günther R, van Dieck J, Merten N, Mörl K, Hofmann HJ, Beck-Sickinger AG. (2008) GPC-Receptors, not Ligands decide on binding mode in neuropeptide Y multi-receptor/multi-ligand system, Biochemistry, 47, 5905-14. | Abstract | |
| Fronz K, Otto S, Kölbel K, Kühn U, Friedrich H, Schierhorn A, Beck-Sickinger AG, Ostareck-Lederer A, Wahle E (2008) Promiscuous modification of the nuclear poly(A)-binding protein by multiple protein-arginine methyltransferases does not affect the aggregation behavior. J. Biol. Chem. 283, 20408-20. | Abstract | |
| Wolf P, Rothermel A, Beck-Sickinger AG, Robitzki AA (2008) Microelectrode chip based real time monitoring of vital MCF-7 mamma carcinoma cells by impedance spectroscopy. Biosens. Bioelectron. 24, 253-9. | Abstract | |
| Zwanziger D, Khan IU, Neundorf I, Sieger S, Lehmann L, Friebe M, Dinkelborg L, Beck-Sickinger AG (2008) Novel chemically modified analogues of neuropeptide Y for tumor targeting. Bioconjug. Chem. 19, 1430-8. | Abstract | |
| Haack M, Enck S, Seger H, Geyer A, Beck-Sickinger AG. (2008) Pyridone dipeptide backbone scan to elucidate structural properties of a flexible peptide segment. J. Am. Chem. Soc. 130, 8326-36. | Abstract | |
| David Frommhold, Andreas Ludwig, M. Gabriele Bixel, Alexander Zarbock, Inna Babushkina, Melitta Weissinger, Sandra Cauwenberghs, Bärbel Lange-Sperandio, Lesley G. Ellies, Jamey D. Marth, Annette G. Beck-Sickinger, Alma Zernecke, Christian Weber, Dietmar Vestweber, Klaus Ley, and Markus Sperandio (2008) Sialyltransferase ST3Gal-IV controls CXCR2-mediated firm leukocyte arrest during inflammation, J. Exp. Med. 205, 1435-46. | Abstract | |
| Löw C, Weininger U, Lee H, Schweimer K, Neundorf I, Beck-Sickinger AG, Pastor RW, Balbach J (2008) Structure and dynamics of Helix-0 of the N-BAR domain in Lipid Micelles and Bilayers. Biophys. J. 95, 4315-23. | Abstract | |
| Rennert R, Neundorf I, Jahnke HG, Suchowerskyj P, Dournaud P, Robitzki A, Beck-Sickinger AG (2008) Generation of carrier peptides for the delivery of nucleic acid drugs in primary cells. ChemMedChem. 3, 241-53. | Abstract | |
| Singer D, Herth N, Kuhlmann J, Holland-Nell K, Beck-Sickinger AG, Hoffmann R (2008) Mapping of phosphorylation-dependent anti-Tau monoclonal antibodies in immunoblots using human tau-constructs synthesized by native chemical ligation, Biochem. Biophys. Res. Comm. 367, 318-22 | Abstract |
| Birgitte Holst, Kristoffer Egerod, Enrico Schild, Lars-Ole Gerlach, Carsten E. Stiedsen, Annette G. Beck-Sickinger & Thue W. Schwartz (2007) GPR39 Signaling is stimulated by Zinc ions but not by Obestatin. Endocrinology 148, 13-20. | Abstract | |
| Ralf David and Annette G. Beck-Sickinger (2007) Identification of the dimerisation interface of human interleukin-8 by IL-8-variants containing the photoactivatable amino acid benzoyl-phenylalanine. Eur. Biophys. J. 36, 385-91. | Abstract | |
| Elisa García Garayoa, Dominique Rüegg, Peter Bläuenstein, Martin Zwimpfer, Irfan Ullah Khan, Veronique Maes, Alain Blanc, Annette G. Beck-Sickinger, Dirk A. Tourwé and P. August Schubiger (2007) Chemical and biological characterization of new Re(CO)3/[99mTc](CO)3 bombesin analogues. Nucl. Med. Biol. 34, 17-28. | Abstract | |
| Nicole Merten, Diana Lindner, Nadine Rabe, Holger Römpler, Karin Mörl, Torsten Schöneberg, Annette G. Beck-Sickinger (2007) Receptor Subtype Specific Docking of Asp6.59 with C-terminal Arginine Residues in Y-Receptor Ligands. J. Biol. Chem. 282, 7543-51. | Abstract | |
| Ilka Böhme, Karin Mörl, Darja Bamming, Cindy Meyer, Annette G. Beck-Sickinger (2007) Tracking of human Y receptors in living cells – a fluorescence approach. Peptides 28, 226-34. | Abstract | |
| Franka Pluder, Annette G. Beck-Sickinger (2007) One step procedure for staining of 2D-gels with ruthenium II tris (bathophenanthroline disulfonate). Anal. Biochem. 361, 299-301. | Abstract | |
| Margaret J. Morris, Emma Gannan, Leanne M Stroud, Annette G. Beck-Sickinger and Terence J O’Brien, (2007) Neuropeptide Y suppresses absence of seizures in a genetic rat model primarily through effects on Y2 receptors, Eur. J. Neurosci. 25, 1136-43. | Abstract | |
| Franka Pluder, Andrea Sinz and Annette G. Beck-Sickinger (2007) Proliferative effect of calcitonin gene-related peptide is induced by at least five proteins as identified by proteome profiling. Chem. Biol. Drug Des. 69, 14-22. | Abstract | |
| Elisa García Garayoa, G. Schweinsberg, Veronique Maes, Dominique Rüegg, Alain Blanc, Peter Bläuenstein, Dirk A. Tourwé, Annette G. Beck-Sickinger, and P. August Schubiger (2007) New [99mTc] bombesin analogues with improved biodistribution for targeting gastrin releasing-peptide receptor-positive tumors. Q. J. Nucl. Med. Mol. Imaging 51, 42-50. | Abstract | |
| Irfan U. Khan, Regina Reppich, Annette G. Beck-Sickinger (2007) Identification of Neuropeptide Y Cleavage Products in Human Blood tom Improve Metabolic Stability. Biopolymers 88, 182-9. | Abstract | |
| Birgitte Holst, Jacek Mokrosinski, Manja Lang, Erik Brandt, Annette G. Beck-Sickinger, Thue W. Schwartz (2007) Identification of an efficacy switch region in the ghrelin receptor responsible for interchange between agonism and inverse agonism. J. Biol. Chem. 282, 15799-15811. | Abstract | |
| Kai Holland-Nell, Annette G. Beck-Sickinger (2007) Specifically immobilised aldo/keto reductase AKR1A1 shows dramatic increase in activity compared to randomly immobilized enzyme, Chembiochem. 8, 1071-6. | Abstract | |
| Ralf Ziemek, Erich Schneider, Anja Kraus, Chiara Cabrele, Annette G. Beck-Sickinger, Günther Bernhardt, Armin Buschauer (2007) Determination of Affinity and Activity of Ligands at the Human Neuropeptide Y Y4 Receptor by Flow Cytometry and Aequorin Luminescence, J. Recept. Signal. Transduct. Res. 27, 217–233. | Abstract |
| Manja Lang, Silvia De Pol, Carsten Baldauf, Hans-Jörg Hofmann, Oliver Reiser and Annette G. Beck-Sickinger (2006) Identification of the key residue of calcitonin gene related peptide (CGRP) 27-37 to obtain antagonists with picomolar affinity at the CGRP receptor, J. Med. Chem. 49, 616-24. | Abstract | |
| Manja Lang, Bernd Bufe, Silvia de Pol, Oliver Reiser, Wolfgang Meyerhof and Annette G. Beck-Sickinger (2006) Structural properties of orexins for activation of their receptors, J. Pept. Sci. 12, 258-66. | Abstract | |
| Paulus, T., Riemer, C., Beck-Sickinger, A. G., Henle, T., Klostermeyer, H. (2006), Protein-backbone-modifications: Formation of imidazolines. Eur. Food Res. & Techn. 222, 242-9 | Abstract | |
| Ortrud Uckermann, Antje Wolf, Franziska Kutzera, Folke Kalisch, Annette G. Beck-Sickinger, Peter Wiedemann, Andreas Reichenbach and Andreas Bringmann (2006) Glutamate Release by Neurons Evokes a Purinergic Inhibitory Mechanism of Osmotic Glial Cell Swelling in the Rat Retina. Activation by Neuropeptide Y, J. Neurosci. Res., 83, 538-50. | Abstract | |
| Robert Rennert, Christian Wespe, Annette G. Beck-Sickinger, Ines Neundorf (2006) Developing novel hCT derived cell-penetrating peptides with improved metabolic stability, Biochim. Biophys. Acta, 1758, 347-54. | Abstract | |
| Christian Ihling, Andreas Schmidt, Stefan Kalkhof, Christoph Stingl, Karl Mechtler, Michael Haack, Daniela M. Schulz, Dermot M. F. Cooper, Annette G. Beck-Sickinger and Andrea Sinz (2006) Isotope-Labeled Cross-Linkers and Fourier Transform Ion Cyclotron Resonance Mass Spectrometry for Structural Analysis of a Protein / Peptide Complex, J. Am. Soc. Mass Spectrom. 17, 1100-13. | Abstract | |
| K. Goede, M. Grundmann, K. Holland-Nell, A. G. Beck-Sickinger (2006) Cluster properties of peptides on (100) semiconductor surfaces, Langmuir 22, 8104-8. | Abstract | |
| Birgitte Holst, Manja Lang, Erik Brandt, Anders Bach, Andrew Howard, Thomas M. Frimurer, Annette Beck-Sickinger, Thue W. Schwartz (2006) Ghrelin Receptor Inverse Agonists – Identification of an Active Peptide Core and its Interaction Epitopes on the Receptor, Mol. Pharmacol. 70, 936-46. | Abstract | |
| Mette M. Rosenkilde, Ralf David, Ilka Oerlecke, Ulf Geumann, Annette G. Beck-Sickinger and Thue W. Schwartz (2006) Conformational constraining of inactive and active states of a 7TM receptor by metal-ion site engineering in the top of TM 5. Mol. Pharmacology 70, 1892-1901 | Abstract | |
| Ralf Ziemek, Albert Brennauer, Erich Schneider, Chiara Cabrele, Annette G. Beck-Sickinger, Günther Bernhardt, Armin Buschauer (2006) Fluorescence- and luminescence-based methods for the determination of affinity and activity of neuropeptide Y Y2 receptor ligands. Eur. J. Pharmacol. 551, 10-18. | Abstract | |
| Krause K, Schierhorn A, Sinz A, Wissmann JD, Beck-Sickinger AG, Paschke R, Fuhrer D. (2006) Toward the application of proteomics to human thyroid tissue, Thyroid 16, 1131-43 | Abstract | |
| Cornelia M. Deckert, John T. Heiker, Annette G. Beck-Sickinger (2006) Localization of Novel Adiponectin Receptor Constructs. J. Recept. Signal. Transduct. Res. 26, 647-57. | Abstract |
| Dimitrijevic M, Stanojevic S, Vujic V, Beck-Sickinger A, von Horsten S (2005) Neuropeptide Y and its receptor subtypes specifically modulate rat peritoneal macrophage functions in vitro: counter regulation through Y1 and Y2/5 receptors. Regul. Pept. 124, 163-72. | Abstract | |
| R. Benmaamar, C. Richichi, M. Gobbi, A. J. Daniels, A. G. Beck-Sickinger, A. Vezzani (2005) Neuropeptide Y Y5 receptors mediate inhibition of kindling acquisition in rats, Regul. Pept. 125, 79-83. | Abstract | |
| Klammt J., Garten A., Barnikol-Oettler A., Beck-Sickinger A. G., Kiess. W. (2005) Comparative analysis of the signalling capabilities of the insulin receptor related receptor, Biochem. Biophys. Res. Commun. 327, 557-64. | Abstract | |
| Christina Foerg, Urs Ziegler, Jimena Fernandez-Carneado, Ernest Giralt, Robert Rennert, Annette G. Beck-Sickinger, Hans P. Merkle (2005) Decoding the entry of two novel cell penetrating peptides in HeLa cells: lipid-raft mediated endocytosis and endosomal escape, Biochemistry 44, 72-81. | Abstract | |
| Howell O. W., Doyle K., Goodman J. H., Scharfman H. E., Herzog H., Pringle A., Beck-Sickinger A. G., Gray W. P. (2005) Neuropeptide Y stimulates neuronal precursor proliferation in the post-natal and adult dentate gyrus, J. Neurochem. 93, 560-70. | Abstract | |
| Michael E. Herbig, Ursina Fromm, Jeannine Leuenberger, Ulrike Krauss, Annette G. Beck-Sickinger, and Hans P. Merkle (2005) Bilayer interaction and localization of cell penetrating peptides with model membranes: A comparative study of a human calcitonin (hCT) derived peptide with pVEC and pAntp(43-58), Biochim. Biophys. Acta. 1712, 197-211. | Abstract | |
| Mirjam Lerch, Hiroshi Kamimori, Gerd Folkers, Marie-Isabel Aguilar, Annette G. Beck-Sickinger, and Oliver Zerbe (2005) Strongly Altered Receptor Binding Properties in PP and NPY Chimeras Are Accompanied by Changes in Structure and Membrane Binding, Biochemistry 44, 9255-64. | Abstract | |
| Michael P. O. Richter, Annette G. Beck-Sickinger (2005) Expressed Protein Ligation for the Semisynthesis of Modified Aldo/ketoreductases, Pept. Prot. Lett. 12, 777-81. | Abstract | |
| Bouchaïb El Bahh, Silvia Balosso, Trevor Hamilton, Herbert Herzog, Annette G. Beck-Sickinger, Günther Sperk, Donald R. Gehlert, Annamaria Vezzani and William F. Colmers (2005) The antiepileptic actions of neuropeptide Y in the hippocampus are mediated by the Y2 receptor; Eur. J. Neuroscience 22, 1417-30. | Abstract | |
| Lars Thomas, Holger A. Scheidt, Andrea Bettio, Daniel Huster, Annette G. Beck-Sickinger, Klaus Arnold, Olaf Zschörnig (2005), Membrane interaction of neuropeptide Y detected by EPR and NMR spectroscopy, Biochim. Biophys. Acta 1714, 103-13. | Abstract | |
| Michael E. Herbig, Kathrin Weller, Ulrike Krauss, Annette G. Beck-Sickinger, Hans P. Merkle, and Oliver Zerbe (2005) Membrane surface associated helices promote lipid interactions and cellular uptake of human calcitonin-derived cell penetrating peptides, Biophysical J. 89, 4056-66. | Abstract | |
| Manja Lang, Richard M. Söll, Franz Dürenberger, Frank Dautzenberg and Annette G. Beck-Sickinger (2004) Structure-activity studies of orexin A and orexin B at the human orexin 1 and orexin 2 receptors led to orexin 2 receptor selective and orexin 1 receptor preferring ligands, J. Med. Chem. 47, 1153-60 | Abstract | |
| Ulrike Krauss, Martin Müller, Annette G. Beck-Sickinger (2004) In Vitro Gene Delivery by a Novel Human Calcitonin (hCT) derived Carrier Peptide, Bioorg. Med. Chem. Lett. 14, 51-4 | Abstract | |
| Rahel Tréhin, Ulrike Krauss, R. Muff, Martina Meinecke, Annette G. Beck-Sickinger, Hans P. Merkle (2004) Cellular internalization of human calcitonin derived peptides in MDCK monolayers: A comparative study with tat(47-57) and penetratin(43-58), Pharm. Res. 21, 33-42 | Abstract | |
| O. Della-Zuana, L. Revereault, A. G. Beck-Sickinger, A. Monge, D.-H. Caignard, J.-L. Fauchere, J.-M. Henlin, V. Audinot, J. A. Boutin, S. Chamorro, M. Feletou, N. Levens (2004) A potent and selective NPY Y5 antagonist reduces food intake but not through blockade of the NPY Y5 receptor, Int. J. Obes. Relat. Metab. Disord. 28, 628-39 | Abstract | |
| Philip Tovote, Michael Meyer, Annette G. Beck-Sickinger, Stephan von Hörsten, Sven Ove Ögren, Joachim Spiess and Oliver Stiedl (2004) Central NPY receptor-mediated alteration of heart rate dynamics in mice during expression of fear conditioned to an auditory cue, Reg. Peptides 120, 205-14 | Abstract | |
| P. Bläuenstein, E. G. Garayoa, D. Ruegg, A. Blanc, D. Tourwe, A. G. Beck-Sickinger, P. A. Schubiger (2004) Improving the tumor uptake of (99m)Tc-labelled neuropeptides using stabilized peptide analogues, Cancer Biother. Radiopharm. 19, 181-8 | Abstract | |
| Kerstin Wagner, Nicole van Mau, Sylvie Boichot, Andrey V. Kajava, Ulrike Krauss, Christian Le Grimmellec, Annette Beck-Sickinger and Frédéric Heitz (2004) Interactions of human calcitonin-fragment 9-32 with phospholipids: a monolayer study, Biophysical J. 87, 386-95 | Abstract | |
| Michael P. O. Richter, Kai Holland-Nell, and Annette G. Beck-Sickinger (2004) Site specific biotinylation and immobilization of the human aldo/keto reductase AKR1A1, Tetrahedron 60, 7507-13 | Abstract | |
| M. Tschöp, T. R. Castañeda, H. G. Joost, C. Thöne-Reineke, S. Ortmann, S. Klaus, M. M. Hagen, P. C. Chandler, K. D. Oswald, S. C. Benoit, R. J. Seeley, K. P. Kinzig, T. H. Moran, A. G. Beck-Sickinger, N. Koglin, R. J. Rodgers, J. E. Blundell, Y. Ishii, A. H. Beattie, P. Holch, D. B. Allison, K. Raun, K. Madsen, B. S. Wulff, C. E. Stidsen, M. Birringer, O. J. Kreuzer, M. Schindler, K. Arndt, K. Rudolf, M. Mark, X. Y. Deng, D. C. Withcomb, H. Halem, J. Taylor, J. Dong, R. Datta, M. Culler, S. Craney, D. Flora, D. Smiley, M. L. Heimann (2004) Does gut hormone PYY3-36 decrease food intake in rodents? Nature 430, 165 f. | Abstract | |
| Rachel Tréhin, Ulrike Krauss, Annette G. Beck-Sickinger, Hans P. Merkle (2004) Cellular Uptake but low Permeation of Human Calcitonin Derived Cell Penetrating Peptides and Tat(47-57) through Well-Differentiated Epithelial Models, Pharm. Res. 21, 1248-56 | Abstract | |
| Sylvie Boichot, Ulrike Krauss, Thomas Plénat, Piere-Emmanuel Milhiet, Annette G. Beck-Sickinger, Christian Le Grimellec (2004) Calcitonin derived carrier peptides play a major role in the membrane localisation of a peptide cargo complex, FEBS Lett. 569, 346-50 | Abstract | |
| Kerstin Wagner, Annette G. Beck-Sickinger, and Daniel Huster (2004) Structural investigations of a human calcitonin-derived carrier peptide in membrane environment by solid-state NMR, Biochemistry 43, 12459-68 | Abstract | |
| Jürgen Bader, Cornelia M. Deckert, Franka Pluder, Karin Mörl, Norman Koglin, Dirk Koczan, Hans-Jürgen Thiesen, Annette G. Beck-Sickinger (2004) From transcription profile to expression: the signaling repertoire of the SK-N-MC neuroepithelioma cell-line, J. Recept. Signal Transduct. Res. 24, 257-82 | Abstract | |
| K. Berger, D. Wissmann, C. Ihling, S. Kalkhof, A. Beck-Sickinger, A. Sinz, R. Paschke, D. Führer (2004) Quantitative proteome analysis in benign thyroid nodular disease using the fluorescent ruthenium II tris(bathophenanthroline disulfonate) stain, Mol. Cel.. Endocrinology 227, 21-30 | Abstract | |
| Dumont Y, Thakur M, Beck-Sickinger A, Fournier A, Quirion R (2004) Characterization of a new neuropeptide Y Y5 agonist radioligand: [125I][cPP(1-7),NPY(19-23),Ala31,Aib32,Gln34]hPP. Neuropeptides 38, 163-74 | Abstract | |
| Rachel Tréhin, Hanne M. Nielsen, Hans-Georg Jahnke, Ulrike Krauss, Annette G. Beck-Sickinger, Hans P. Merkle (2004) Metabolic Cleavage of Cell-penetrating Peptides with Epithelial Models: Human Calcitonin (hCT) Derived Peptides, Tat(47-57) and Penetratin(43-58), Biochem. J. 382, 945-56 | Abstract | |
| Norman Koglin, Chiara Zorn, Raphael Beumer, Christian Bubert, Norbert Sewald, Oliver Reiser, Annette G. Beck-Sickinger (2003) Analogues of Neuropeptide Y Containing b-Aminocyclopropane-carboxylic Acids are the Shortest Linear Peptides Selective for the Y1-Receptor, Angew. Chem. Int. Ed. 42, 202-5 | Abstract | |
| Norman Koglin, Chiara Zorn, Raphael Beumer, Christian Bubert, Norbert Sewald, Oliver Reiser, Annette G. Beck-Sickinger (2003) Neuropeptid Y Analoga mit b-Aminocyclopropan-carbonsäure Derivaten sind die kürzesten linearen und selektiven Peptide am Y1 Rezeptor, Angew. Chem. 115, 212-5 | Abstract | |
| Michaela C. Dinger, Jürgen E. Bader, Andreas D. Kóbor, Antje K. Kretzschmar and Annette G. Beck-Sickinger (2003) Homodimerization of NPY Receptors Investigated by Fluorescence Resonance Energy Transfer in Living Cells, J. Biol. Chem. 278, 10562-71 | Abstract | |
| Danielle Jacques, Sawsan Sader, Claudine Perreault, Alain Fournier, Georges Pelletier, Annette G. Beck-Sickinger, and Magda Descorbeth (2003) Presence of neuropeptide Y and the Y1 receptor in the plasma membrane and nuclear envelope of human endocardial endothelial cells: modulation of intracellular calcium. Can. J. Physiol. Pharmacol. 81, 288-300 | Abstract | |
| Regula von Eggelkraut-Gottanka, Annerose Klose, Annette G. Beck-Sickinger, Michael Beyermann (2003) Peptide a-thioester formation using standard Fmoc-chemistry, Tetrahedron Lett. 44, 3551-4 | Abstract | |
| Regula von Eggelkraut-Gottanka, Zuzana Machova, Eric Grouzmann, Annette G. Beck-Sickinger (2003) Semisynthesis and characterisation of the first analogues of pro-neuropeptide Y, ChemBioChem. 4, 425-33 | Abstract | |
| Christian Ihling, Kerstin Berger, Martin M. Höfliger, Dagmer Führer, Annette G. Beck-Sickinger, Andrea Sinz (2003) Nano-high performance liquid chromatography in combination with nano-electrospray ionization fourier transform ion-cyclotron resonance mass spectrometry for proteome analysis, Rapid Comm. Mass Spectrom. 17, 1240-6 | Abstract | |
| Yvan Dumont, Mira Thakur, Annette Beck-Sickinger, Alain Fournier and Rémi Qurion (2003) Development and characterization of a highly selective neuropeptide Y5 receptor agonist radioligand: [125I][hPP1-17, Ala31, Aib32]-NPY, Br. J. Pharm. 139, 1360-8 | Abstract | |
| Anne Lecklin, Ingrid Lundell, Suvi Salmela, Pekka T. Männistö, Annette G. Beck-Sickinger and Dan Larhammar (2003) Agonists for neuropeptide Y receptors Y1 and Y5 stimulate different phases of feeding in guinea pigs, Br. J. Pharmacol. 139, 1433-40 | Abstract | |
| Owain W. Howell, Helen E. Scharfman, Herbert Herzog, Lars E. Sundstrom, Annette G. Beck-Sickinger and William P. Gray (2003) Neuropeptide Y is neuroproliferative for post-natal hippocampal precursor cells, J. Neurochemistry 86, 646-59 | Abstract | |
| Norman Koglin, Manja Lang, Robert Rennert, Annette G. Beck-Sickinger (2003) Facile and selective nanoscale labeling of peptides in solution using photolabile protecting groups, J. Med. Chem. 46, 4369-72 | Abstract | |
| Martin M. Höfliger, Gloria López Castejón, Wieland Kiess, Annette G. Beck-Sickinger (2003) Novel Cell Line Selectively Expressing Neuropeptide Y Y2 Receptors, J. Recept. Signal Transduct. Res. 23, 351-60 | Abstract | |
| Ulrike Krauss, Felix Kratz, Annette G. Beck-Sickinger (2003) Novel Daunorubicin-Carrier Peptide Conjugates Derived from Human Calcitonin Segments, J. Mol. Recogn. 16, 280-7 | Abstract | |
| Zuzana Machova, Regula von Eggelkraut-Gottanka, Nicole Wehofsky, Frank Bordusa and Annette G. Beck-Sickinger (2003) Expressed enzymatic ligation: a new approach for the synthesis of chemically modified proteins, Angew. Chem. Int. Ed., 42, 4916-8 (VIP-Paper) | Abstract | |
| Zuzana Machova, Regula von Eggelkraut-Gottanka, Nicole Wehofsky, Frank Bordusa and Annette G. Beck-Sickinger (2003) Exprimierte enzymatische Ligation: ein neuer Ansatz für die Synthese chemisch modifizierter Proteine, Angew. Chem. 115, 5065-7 | Abstract | |
| Ralf David, Zuzana Machova and Annette G. Beck-Sickinger (2003) Semisynthesis and application of carboxyfluorescein-labeled biologically active human interleukin-8, Biol. Chem. 384, 1619-30 | Abstract | |
| S. Bedoui, S. Miyake, Y. Lin, K. Miyamoto, S. Oki, N. Kawamura, A. Beck-Sickinger, S. von Horsten, T. Yamamura (2003) Neuropeptide Y (NPY) suppresses experimental autoimmune encephalomyelitis: NPY1 receptor-specific inhibition of autoreactive Th1 responses in vivo, J. Immunol. 171, 3451-8 | Abstract |
| Heike A. Wieland, Richard M. Söll, Henri N. Doods, Dirk Stenkamp, Rudolf Hurnaus, B. Lämmle and Annette G. Beck-Sickinger (2002) The SK-N-MC cell line expresses an orexin binding site different from recombinant orexin1 type receptor, Eur. J. Biochem. 269, 1128-35 | Abstract | |
| Nina Pronchuk, Annette G. Beck-Sickinger and William F. Colmers (2002) Multiple NPY receptors Inhibit GABA(A) synaptic responses of rat medial parvocellular effector neurons in the hypothalamic paraventricular nucleus, Endocrinology 143, 535-43 | Abstract | |
| Daniela Proske, Martin Höfliger, Richard M. Söll, Annette G. Beck-Sickinger, Michael Famulok (2002) First Y2 receptor mimicking anti-NPY-aptamer, J. Biol. Chem. 277, 11416-22 | Abstract | |
| Michaela Dinger and Annette G- Beck-Sickinger (2002) The first reporter gene assay on living cells, Mol. Biotechn. 21, 9-18 | Abstract | |
| Bouchaib El Bahh, Jeffrey Q. Cao, Annette G. Beck-Sickinger, William F. Colmers (2002) Blockade of Neuropeptide Y2 Receptors and Suppression of NPY’s Antiepileptic Actions in the Rat Hippocampal Slice by BIIE 0246, Br. J. Pharmacol. 136, 502-9 | Abstract | |
| Reto Bader, Gabriela Ryth, Mirjam Lerch, Annette Beck-Sickinger, Oliver Zerbe, (2002) The Key Motif to Gain Selectivity at the Neuropeptide Y5-Receptor II: Solution Structure and Dynamics of [Ala31, Pro32]-NPY, Biochemistry 41, 8031-42 | Abstract | |
| Chiara Cabrele, Heike A. Wieland, Norman Koglin, Carsten Stidsen, Annette Beck-Sickinger (2002) Ala31-Aib32: Identification of the Key Motif for High Affinity and Selectivity of Neuropeptide Y at the Y5-Receptor, Biochemistry 41, 8043-9 | Abstract | |
| Zuzana Machova, Christiane Mühle, Ulrike Krauss, Rahel Trébin, Annette Koch, Hans-Peter Merkle, Annette G. Beck-Sickinger (2002) Cellular Internalization of Enhanced Green Fluorescent Protein Ligated to Human Calcitonin-based Carrier Peptide, Chem. Biochem. 3, 672-7 | Abstract | |
| Mohammed Daghish, Lothar Hennig, Matthias Findeisen, Sabine Giesa, Frank Schumer, Horst Hennig, Annette G. Beck-Sickinger and Peter Welzel (2002) Tetrafunctional photoaffinity labels based on Nakanishi’s m-nitro-alkoxy-substituted phenyl-trifluoromethyl diazirine, Angew. Chem. Int Ed. 41, 2293-7 | Abstract | |
| Mohammed Daghish, Lothar Hennig, Matthias Findeisen, Sabine Giesa, Frank Schumer, Horst Hennig, Annette G. Beck-Sickinger and Peter Welzel (2002) Tetrafunktionelle Reagentien für die Affinitätschromatographie, die sich von Nakanishis m-Nitroalkoxy-substituiertem Phenyltrifluormethyldiazirin ableiten, Angew. Chem. 114, 2404-8 | Abstract | |
| Roberto La Bella, Elisa Garcia-Garayoa, Michael Langer, Peter Bläuenstein, Annette G. Beck-Sickinger & Pius A. Schubiger (2002) In vitro and in vivo evaluation of a 99mTC(I)-tricarbonyl labeled high affinity bombesin analogue for imaging of gastrin releasing peptide receptor-positive tumors, Nucl. Med. Biol. 29, 553-60 | Abstract | |
| Daili Jacqueline Aguilar Netz, Regula Pohl, Annette G. Beck-Sickinger, Antonio J. Pierik, Thorsten Selmer, Maria do Carmo de Freire Bastos and Hans-Georg Sahl (2002) Biochemical characterization and genetic analysis of aureocin A53, a new, atypical bacteriocin from Staphylococcus aureus, J. Mol. Biol. 319, 745-56 | Abstract | |
| Andrea Bettio, Michaela C. Dinger and Annette G. Beck-Sickinger (2002) The Neuropeptide Y Monomer in Solution is Not Folded in the PP-Fold, Protein Sci. 11, 1834-44 | Abstract | |
| Mirjana Dimitrijevic, Stanislava Stanojevic, Vesna Vujic, Vesna Kovacevic-Jovanovic, Annette G. Beck-Sickinger, Hans-Ulrich Demuth, Stephan von Hörsten (2002) Effect of neuropeptide Y (NPY) on inflammatory paw edema in the rat: involvement of peripheral NPY Y1 and Y5 receptors and interaction with dipeptidyl-peptidase IV (CD26), J. Neuroimmunol. 129, 35-42 | Abstract | |
| Sammy Bedoui, Sandra Lechner, Thomas Gebhardt, Heike Nave, Annette G. Beck-Sickinger, Rainer H. Straub, Reinhard Pabst, Stephan von Hörsten (2002) NPY modulates epinephrine-induced leukocytosis via Y-1 and Y-5 receptor activation in vivo: sympathetic co-transmission during leukocyte mobilization, J. Neuroimmunol. 132, 25-33 | Abstract | |
| Andrea Bettio, Volker Gutewort, Andreas Pöppl, Michaela C. Dinger, Olaf Zschörnig, Klaus Arnold, Claudio Toniolo, Annette G. Beck-Sickinger (2002) Backbone Dynamics Studies on Spin-Labelled Neuropeptide Y Analogues by Electron Paramagnetic Resonance Spectroscopy, J. Pept. Sci. 8, 671-82 | Abstract | |
| Csaba Fekete, Sumit Sarkar, William M. Rand, John W. Harney, Charles H. Emerson, Antonio C. Bianco, Annette G. Beck-Sickinger, Ronald M. Lechan (2002) Neuropeptide Y1 and Y5 receptors mediate the effects of neuropeptide Y on the hypothalamic-pituitary-thyroid axis, Endocrinology 143, 4513-9 | Abstract | |
| Reto Bader, Andrea Bettio, Gerd Folkers, Annette G. Beck-Sickinger, and Oliver Zerbe (2001) Structure and Dynamics of Micelle-bound Neuropeptide Y: Comparison with unligated NPY and Implications for Receptor Selection, J. Mol. Biol. 305, 307-29 | Abstract | |
| Katharina Hoffmann, Richard M. Söll, Annette G. Beck-Sickinger, Manfred Jung (2001) Fluorescence-labeled octapeptides as substrates for histone deacetylase, Bioconj. Chem. 12, 51-5 | Abstract | |
| Magnus M. Berglund, Ingrid Lundell, Hendrik Eriksson, Richard Söll, Annette G. Beck-Sickinger, Dan Larhammar (2001) Studies of the Human, Rat, and Guinea Pig Y4 Receptors Using Neuropeptide Y Analogues and Two Distinct Radioligands, Peptides 22, 351-6 | Abstract | |
| Chiara Cabrele, Heike A. Wieland, Michael Langer, Carsten Stidsen and Annette G. Beck-Sickinger (2001) Y-Receptor Affinity Modulation by the Design of Pancreatic Polypeptide/Neuropeptide Y Chimera Led to Y5-Receptor Ligands with Picomolar Affinity, Peptides 22, 365-78 | Abstract | |
| Christophe Eckard, Chiara Cabrele, Heike Wieland, Annette G. Beck-Sickinger (2001) Molecular characterisation of NPY receptors using synthetic peptides and anti-receptor antibodies, Molecules 6, 448-67 | ||
| Michael Langer, Felix Kratz, Barbara Rothen-Rutishauser, Heidi Wunderli-Allenspach and Annette G. Beck-Sickinger (2001) Novel peptide conjugates for tumor specific chemotherapy, J. Med. Chem. 44, 1341-8 | Abstract | |
| Richard M. Söll, Michaela Dinger, Ingrid Lundell; Dan Larhammar and Annette G. Beck-Sickinger (2001) The first analogue of neuropeptide Y with preference for the Y1 receptor, Eur. J. Biochem. 268, 2828-37 | Abstract | |
| Didier-David Malis, Beate Rist, Keyvan Nicoucar, Annette G. Beck-Sickinger, Denis Morel, Jean-Silvain Lacroix (2001) Modulatory effect of 2 novel CGRP1-receptor antagonists on nasal vasodilatory response to exogenous CGRP, histamine, bradykinin and capsaicin in anaesthetised pigs, Reg. Peptides 101, 101-8 | Abstract | |
| N. Frei, J. Weissenberger, M. Höfliger, A. G. Beck-Sickinger, J. Weis and H. Imboden (2001) Immunocytochemical localization of angiotensin II receptor subtypes and angiotensin II with monoclonal antibodies in the rat adrenal gland, Reg. Peptides 101, 149-55 | Abstract | |
| Caspar Demuth, Oliver Zerbe, Didier Rognan, Richard Söll, Annette G. Beck-Sickinger, Gerd Folkers & Ursula Spichiger (2001) A rationally designed oligopeptide shows significant conformational changes upon binding to sulfate ions, Biosens. Bioelectron. 16, 783-9 | Abstract | |
| Michael Langer, Roberto La Bella, Pius A. Schubiger & Annette G. Beck-Sickinger (2001) 99mTc-labelled neuropeptide Y analogues as potential tumor imaging agents, Bioconj. Chem. 12, 1028-34 | Abstract | |
| Melisa W.Y. Ho, Annette G. Beck-Sickinger, William F. Colmers (2000) Neuropeptide Y5 Receptor-Mediated Inhibition of Synaptic Excitation In Proximal Subiculum Declines With Age and Does Not Affect Epileptiform Bursting in Rat Hippocampal Slice, J. Neurophysiol. 83, 723-34 | Abstract | |
| Karen McCrea, Todd Wisialowski, Chiara Cabrele, Bret Church, Annette G. Beck-Sickinger, Edward Kraegen, Herbert Herzog (2000) 2-36[K4,RYYSA19-23]PP a novel Y5-receptor preferring ligand with strong stimulatory effect on food intake, Reg. Peptides 87, 47-58 | Abstract | |
| Chiara Cabrele, Annette G. Beck-Sickinger (2000) Molecular characterisation of the ligand receptor interactions of the NPY/PP peptide family, J. Peptide Sci. 6, 97-122 | Abstract | |
| Richard Söll, Annette G. Beck-Sickinger (2000) On the synthesis of orexin A: A novel protocol to obtain peptides with two intramolecular disulfide bonds, J. Peptide Sci. 6, 387-97 | Abstract | |
| Marlies Fabry, Michael Langer, Barbara Rothen-Rutishauser, Heidi Wunderli-Allenspach, Hartwig Höcker, Annette G. Beck-Sickinger (2000) Monitoring of the Internalization of Neuropeptide Y on Neuroblastoma Cell Line SK-N-MC, Eur. J. Biochem. 267, 5631-7 | Abstract | |
| Magnus M. Berglund, Ingrid Lundell, Chiara Cabrele, Claudine Serradeil-Le Gal, Annette G. Beck-Sickinger and Dan Larhammar (2000) Structure-activity studies of three neuropeptide Y receptor subtypes from zebrafish, Biochem. Pharmacol. 60, 1815-22 | Abstract | |
| Chiara Cabrele, Michael Langer, Reto Bader, Heike Wieland, Henry N. Doods, Oliver Zerbe, Annette G. Beck-Sickinger (2000) The first selective agonist at the neuropeptide Y Y5-receptor increases food intake in rats, J. Biol. Chem. 275, 46, 36043-8 | Abstract | |
| Marlies Fabry, Chiara Cabrele, Hartwig Höcker, Annette G. Beck-Sickinger (2000) Differently labelled ligands for rapid investigation of receptor expression on a new human glioblastoma cell line, Peptides 21, 1885-93 | Abstract | |
| S. Gonser, N. E. A. Crompton, P. J. A. Weber, A. G. Beck-Sickinger, G. Folkers (1999) TP5 triggers signal transduction involving mitogen activated protein kinases in monocytes, J. Recept. Signal Transduct. Res. 19, 155-66 | Abstract | |
| Christophe P. Eckard, Annette G. Beck-Sickinger, Heike A. Wieland (1999) Comparison of antibodies directed against receptor segments of NPY-receptors, J. Recept. Signal Transduct. Res. 19, 379-94 | Abstract | |
| Beate Rist, Silvain Lacroix, Michael Enzeroth, Henry N. Doods, Annette Beck-Sickinger (1999) CGRP27-37 analogues with high affinity to the CGRP1 receptor show antagonistic properties in a rat blood flow assay, Regul. Pept. 79, 153-8 | Abstract | |
| Nikolaus Ingenhoven, Christophe Eckard, Donald Gehlert, Annette G. Beck-Sickinger (1999) Molecular characterisation of the human Y2 receptor, Biochemistry 38, 6897-902 | Abstract | |
| Chiara Cabrele, Michael Langer & Annette G. Beck-Sickinger (1999) Amino acid side chain attachment approach and its application to the synthesis of tyrosine-containing cyclic peptides, J. Org. Chem. 64, 4353-61 | Abstract | |
| P. Sharma, A. K. Arvidsson, A. Wraith, A. G. Beck-Sickinger, A.-C. Jönsson-Rylander, D. Larhammar (1999) Characterization of the cloned atlantic cod neuropeptide Y-Yb receptor: peptide-binding requirements distinct from known mammalian receptors, Gen. Comp. Endocrinol. 115, 422-8 | Abstract | |
| Peter J. A. Weber, Christophe P. Eckard, Susanne Gonser, Heike Otto, Gerd Folkers, Annette G. Beck-Sickinger (1999) On the role of thymopoietins in cell proliferation. Immunochemical evidence for new members of the human thymopoietin family, Biol. Chem. 380, 653-60 | Abstract |
| Beate Rist, Michael Enzeroth & Annette G. Beck-Sickinger (1998) From micromolar to nanomolar affinity: A systematic approach to identify the binding site of CGRP at the hCGRP1 receptor, J. Med. Chem. 41, 117-23 | Abstract | |
| Peter J. A. Weber, Jürgen E. Bader, Gerd Folkers and Annette G. Beck-Sickinger (1998) A fast and inexpensive method for N-terminal fluorescein-labeling of peptides, Bioorg. Med. Chem. Lett. 8, 597-600 | Abstract | |
| Virginia Pickel, Annette G. Beck-Sickinger, June Chan & Heike A. Wieland (1998) Y1 Receptors in the Nucleus Accumbens: Ultrastructural Localization and Association with Neuropeptide Y, J. Neurosci. Res. 52, 54-68 | Abstract | |
| Heike A Wieland, Christophe Eckard, Henry N. Doods, Annette G. Beck-Sickinger (1998) Probing of the Neuropeptide Y -Y1 receptor interaction with anti-receptor antibodies, Eur. J. Biochem. 255, 595-603 | Abstract | |
| Maria Christiane Schmidt, Barbara Rothen-Rutishauser, Beate Rist, Annette G. Beck-Sickinger, Heidi Wunderli-Allenspach, Werner Rubas, Wolfgang Sadée, Hans Peter Merkle (1998) Translocation of human calcitonin in respiratory nasal epithelium is associated with self-assembly in lipid membrane, Biochemistry 37, 16582-90 | Abstract | |
| Helen Cox, Iain R. Tough, Nikolaus Ingenhoven and Annette G. Beck-Sickinger (1998) Structure-activity relationships with neuropeptide Y analogues: a comparison of human Y1-, Y2- and rat Y2-like systems, Regul. Pept. 75-76, 3-8 | Abstract | |
| Parul Sharma, Sara K. Holmberg, Henrik Eriksson, Annette G. Beck-Sickinger, Lars Grundemar, and Dan Larhammar (1998) Cloning and functional expression of the guinea pig neuropeptide Y Y2 receptor, Regul. Pept. 75-76, 23-28 | Abstract | |
| Henrik Behrends, Gerd Folkers, Annette G. Beck-Sickinger (1997) A new approach to secondary structure evaluation: Secondary structure prediction of porcine adenylate kinase and yeast guanylate kinase by circular dichroism spectroscopy of overlapping synthetic peptide segments, Biopolymers 41, 213-31 | Abstract | |
| Nikolaus Ingenhoven and Annette G. Beck-Sickinger (1997) Fluorescence labelled analogues of neuropeptide Y for the characterisation of cells expressing NPY receptor subtypes, J. Recept. Signal Transduct. Res. 17, 407-18 | Abstract | |
| Peter A. J. Weber & Annette G. Beck-Sickinger (1997) Comparison of the photochemical behavior of four different photoactivatable probes, J. Peptide Res. 49, 375-83 | Abstract | |
| Herbert Herzog, Karen Darby, Helen Ball, Yvonne Hort, Annette G. Beck-Sickinger, & John Shine (1997) The human neuropeptide Y receptor subtypes Y1 and Y5 form an overlapping gene cluster on chromosome 4q31-32, Genomics 41, 315-9 | Abstract | |
| Beate Rist, Nikolaus Ingenhoven, Leonardo Scapozza, Gerd Schnorrenberg, Wolfram Gaida, Heike A. Wieland & Annette G. Beck-Sickinger (1997) The bioactive conformation of neuropeptide Y at the human Y2 receptor, Eur. J. Biochem. 247, 1019-28 | Abstract | |
| Stephan Uebel, Titia Plantinga, Peter J. A. Weber, Annette G. Beck-Sickinger and Robert Tampé (1997) Peptide binding and photo-crosslinking to detergent solubilized and to lipid-reconstituted transporter associated with antigen processing (TAP), FEBS Lett. 416, 359-63 | Abstract | |
| Noureddine Brakch, Beate Rist, Annette G Beck-Sickinger, Jaqueline Goenaga, Riccardo Wittek, Erich Bürger, Hans R Brunner & Eric Grouzmann (1997) Role of prohormone convertases in pro-neuropeptide Y processing: coexpression and in vitro kinetic investigations, Biochemistry 36, 16309-20 | Abstract | |
| L. J. Mark Cross, Annette G. Beck-Sickinger, Michael Bienert, Wolfram Gaida, Günther Jung, Eberhard Krause, Madeleine Ennis (1996) Structure activity studies of mast cell activation and hypotension induced by neuropeptide Y (NPY), centrally truncated and C-terminal NPY analogues, Br. J. Pharm. 117, 325-32 | Abstract | |
| Martine Sautel, Klaus Rudolf, Helmut Wittneben, Herbert Herzog, Raquel Martinez, Miguel Munoz, Wolfgang Eberlein, Wolfhard Engel, Philippe Walker & Annette G. Beck-Sickinger (1996) Neuropeptide Y and the non peptide antagonist BIBP 3226 share a large overlapping binding site at the human Y1 receptor, Mol. Pharmacol. 50, 285-92 | Abstract | |
| Susanne Hoffmann, Beate Rist, Klaus Rudolf, Heike A. Wieland, Georgi Videnov, Klaus-Dieter Willim, Wolfgang Eberlein, Wolfhard Engel, Günther Jung & Annette G. Beck-Sickinger (1996) Structure-affinity studies of C-terminally modified analogs of neuropeptide Y led to a novel class of peptidic Y1 receptor antagonists, Regul. Pept. 65, 61-70 | Abstract | |
| Beate Rist, Oliver Zerbe, Nikolaus Ingenhoven, Leonardo Scapozza, Chris Peers, Peter F. T. Vaughan, Ruth L. Mc Donald, Heike Wieland and Annette G. Beck-Sickinger (1996) Modified, cyclic dodeca-peptide analog of neuropeptide Y is the smallest full agonist at the human Y2 receptor, FEBS Lett. 394, 169-73 | Abstract | |
| Henrik Behrends, Annette G. Beck-Sickinger, Gerd Folkers (1996) Evaluation of the secondary structure of vaccinia-virus thymidine kinase by circular dichroism spectroscopy of overlapping synthetic peptides, Eur. J. Biochem. 241, 126-32 | Abstract | |
| Annette G. Beck-Sickinger, Heike A. Wieland & Josef Brunner (1995) Synthesis, affinity and photocrosslinking of photoactive analogues of neuropeptide Y, J. Recept. Signal Transduct. Res. 15, 473-85 | Abstract | |
| Annette G. Beck-Sickinger, Matthias Kiess, Petra Kern & Gerd Folkers (1995) Secondary structure prediction of adenylate kinase by circular dichroism spectroscopy of synthetic peptides, Pharm. Acta Helv. 70, 33-41 | Abstract | |
| Jörg W. Metzger, Annette G. Beck-Sickinger, Manuel Loleit, Marianne Eckert, Wolfgang G. Bessler & Günther Jung (1995) Synthetic S-[2,3-dihydroxypropyl]-cysteinyl peptides derived from the N-terminus of the cytochrom-subunit of the photoreaction centre of Rhodopseudomonas viridis enhance murine splenocyte proliferation, J. Pept. Sci. 1, 184-90 | Abstract | |
| Insa Flechsler, Annette G. Beck-Sickinger, Holger Stephan, Robert Sheppard & Günther Jung (1995) Anchor-linked intermediates in peptide amide synthesis are caused by dimeric anchors on solid supports, J. Pept. Sci. 1, 191-200 | Abstract | |
| R. L. McDonald, A. G. Beck-Sickinger, B. Rist, P. F. T. Vaughan and C. Peers (1995) Low potency inhibition of Ca2+ channel currents in human neuroblastoma (SH-SY5Y) cells by [Ala31] NPY, an L-alanine substituted analogue of neuropeptide Y, Neurosci. Lett. 190, 179-82 | Abstract | |
| Martine Sautel, Raquel Martinez, Miquel Munoz, Manual C. Peitsch, Annette G. Beck-Sickinger & Philippe Walker (1995) Role of a hydrophobic pocket of the human Y1 neuropeptide Y receptor in ligand binding, Mol. Cell. Endocrinol. 112, 215-22 | Abstract | |
| R. L. McDonald, P. F. T. Vaughan, A. G. Beck-Sickinger & C. Peers (1995) Inhibition of Ca2+ channel currents in human neuroblastoma (SH-SY5Y) cells by neuropeptide Y and a novel cyclic neuropeptide Y analogue, Neuropharmacology 34, 1507-14 | Abstract | |
| Beate Rist, Heike A. Wieland, Klaus-Dieter Willim & Annette G. Beck-Sickinger (1995) A rational approach for the development of reduced-size analogues of neuropeptide Y with high affinity to the Y1 receptor, J. Pept. Sci. 1, 341-8 | Abstract | |
| Annette G. Beck-Sickinger, Eike Hoffmann, Klaus Paulini, Hans-Ulrich Reissig, Klaus-Dieter Willim, Günther Jung (1994) High affinity analogues of neuropeptide Y containing conformationally restricted non-proteinogenic amino acids, Biochem. Soc. Trans. 22, 145-9 | Abstract | |
| L. J. Mark Cross, Annette G. Beck-Sickinger, Michael Beyermann, Eberhard Krause, Michael Bienert, Madeleine Ennis (1994) Neuropeptide Y-induced mast cell activation, Biochem. Soc. Trans. 22, 75 | Abstract | |
| Annette G. Beck-Sickinger, Heinz Rothering, Karl-Heinz Wiesmüller, Friedrich Dorner & Günther Jung (1994) Mapping of antigenic and immunogenic sites of Haemophilus influenzae outer membrane protein P6 using synthetic lipopeptides, Biol. Chem. Hoppe Seyler 375, 173-82 | Abstract | |
| Dietmar Steverding, York-Dieter Stierhof, Maliha Chaudhri, Marjolijn Ligtenberg, Dietmar Schell, Annette G. Beck-Sickinger & Peter Overath (1994) ESAG 6 and 7 products of Trypanosoma brucei form a transferrin binding protein complex, Eur. J. Cell Biol. 64, 78-87 | Abstract | |
| D. Evéquoz, E. Grouzmann, A. G. Beck-Sickinger, H.-R. Brunner & B. Waeber (1994) Differential vascular effects of neuropeptide Y (NPY) selective receptor agonists, Experientia 50, 936-8 | Abstract | |
| Annette G. Beck-Sickinger, Heike A. Wieland, Helmut Wittneben, Klaus-Dieter Willim, Klaus Rudolf & Günther Jung (1994) Complete L-alanine scan of neuropeptide Y reveals ligands binding to Y1 and Y2 receptors with distinguished conformations, Eur. J. Biochem. 225, 947-58 | Abstract | |
| Klaus Rudolf, Wolfgang Eberlein, Wolfhard Engel, Heike A. Wieland, Klaus D. Willim, Michael Enzeroth, Wolfgang Wienen, Annette G. Beck-Sickinger & Henri N. Doods (1994) The first highly potent and selective non-peptide neuropeptide Y Y1 receptor antagonist: BIBP 3226, Eur. J. Pharmacol. 271, R11-3 | Abstract | |
| Annette G. Beck-Sickinger, Herbert Köppen, Eike Hoffmann, Wolfram Gaida, Günther Jung (1993) Cyclopeptide analogs for characterization of the neuropeptide Y Y2-receptor, J. Recept. Res. 13, 215-28 | Abstract | |
| Stefan Stevanovic, Karl-Heinz Wiesmüller, Jörg Metzger, Annette G. Beck-Sickinger, Günther Jung (1993) Natural and synthetic peptide pools: Characterization by sequencing and electrospray mass spectrometry, Bioorg. Med. Chem. Letts. 3, 431-6 | Abstract | |
| Annette G. Beck-Sickinger, Eike Hoffmann, Wolfram Gaida, Eric Grouzmann, Hansjörg Dürr, Günther Jung (1993) Novel Y2-selective reduced-size agonists of neuropeptide Y, Bioorg. Med. Chem. Letts. 3, 937-42 | Abstract | |
| Elisabeth G. Pollerberg & Annette G. Beck-Sickinger (1993) A functional role for the middle extracellular region of the neutral cell adhesion molecule (NCAM) in axonal fasciculation and orientation, Dev. Biol. 156, 324-40 | Abstract | |
| Hans-Joachim Gaus, Annette G. Beck-Sickinger, Ernst Bayer (1993) Optimization of capillary electrophoresis of mixtures of basic peptides and comparison with HPLC, Anal. Chem. 65, 1399-1405 | Abstract | |
| E. Weber, H. P. Lehmann, A. G. Beck-Sickinger, E. J. Wawrzynczak, R. Waibel, G. Folkers & R. A. Stahel (1993) Antibodies to the protein core of the small cell lung cancer workshop antigen cluster-w4 and to the leukocyte workshop antigen CD24 recognize the same short protein sequence leucyl-alanyl-proline, Clin. Exp. Immunol. 93, 279-85 | Abstract | |
| Annette G. Beck-Sickinger & Günther Jung (1993) Synthesis and conformational analysis by circular dichroism of lantibiotic leader, pre- and propeptides, Liebigs Ann. Chem. 1993, 1125-31 | ||
| Dietmar Ochs, Cortina Kaletta, Karl-Dieter Entian, Annette G. Beck-Sickinger, Karl Poralla (1992) Cloning, expression and sequencing of squalene-hopene cyclase, a key enzyme in triterpenoid metabolism, J. Bacteriol. 174, 298-302 | Abstract | |
| Harald Burkhardt, Tan Yan, Barbara Bröker, Annette Beck-Sickinger, Rikard Holmdahl, Klaus Von der Mark & Frank Emmrich (1992) Peptide protection provides a novel way of inhibiting autoreactive T-cells, Eur. J. Immunol. 22, 1063-7 | Abstract | |
| Annette G. Beck-Sickinger, Eric Grouzmann, Eike Hoffmann, Wolfram Gaida, Erwin G. Van Meier, Bernard Waeber, Günther Jung (1992) A novel cyclic analog of neuropeptide Y specific for the Y2 receptor, Eur. J. Biochem. 206, 957-64 | Abstract | |
| Yoshiaki Sudo, Dario Valenzuela, Annette G. Beck-Sickinger, Mark C. Fishman, Stephen M. Strittmatter (1992) Palmitoylation alters protein activity: Blockade of Go stimulation by GAP-43, EMBO J. 11, 2095-102 | Abstract | |
| S. Becker, E. Prusak-Sochaczwski, G. Zamponi, A. G. Beck-Sickinger, R. D. Gordon & R. J. French (1992) Action of derivatives of m-conotoxin GIIIA (m-CTX) on sodium channels. Single amino acid substitutions in the toxin separately affect association and dissociation rates, Biochemistry 31, 8229-38 | Abstract | |
| Annette G. Beck-Sickinger, Hansjörg Dürr, Wolfram Gaida, Günther Jung (1992) Characterization of the binding site of neuropeptide Y to the rabbit kidney receptor using multiple peptide synthesis, Biochem. Soc. Trans. 20, 847-50 | Abstract | |
| Martin C. Michel, Wolfram Gaida, Annette G. Beck-Sickinger, Heike A. Wieland, Henry Doods, Hansjörg Dürr, Günther Jung, Gerd Schnorrenberg (1992) Further characterization of Neuropeptide Y receptor subtypes using centrally truncated analogs of neuropeptide Y: Evidence for subtype differentiating effects on affinity and intrinsic efficacy, Mol. Pharmacology 42, 642-48 | Abstract | |
| Günther Jung, Annette G. Beck-Sickinger, Hansjörg Dürr, Wolfram Gaida & Gerd Schnorrenberg (1991) a-Helical, small molecular size analogues of Neuropeptide Y: Structure-activity-relationships, Biopolymers 31, 613-9 | Abstract | |
| Annette G. Beck-Sickinger, Gerd Schnorrenberg, Jörg Metzger & Günther Jung (1991) Sulfonation of arginine residues as side reaction in peptide synthesis, Int. J. Pept. Protein Res. 38, 25-31 | Abstract | |
| Hansjörg Dürr, Annette G. Beck-Sickinger, Gerd Schnorrenberg, Wolfgang Rapp & Günther Jung (1991) Cleavage kinetics and anchor linked intermediates in solid phase peptide amide synthesis, Int. J. Pept. Protein Res. 38, 146-53 | Abstract | |
| Annette G. Beck-Sickinger, Hansjörg Dürr & Günther Jung (1991) Semiautomated T-bag peptide synthesis using 9-fluorenyl-methoxycarbonyl strategy and benzotriazol-1-yl-tetramethyl-uronium tetrafluoroborate activation, Pept. Res. 4, 88-94 | Abstract | |
| Eike Hoffmann, Annette G. Beck-Sickinger & Günther Jung (1991) Investigations on different coupling agents for synthesis of a cyclopeptide analogue of neuropeptide Y, Liebigs Ann. Chem. 1991, 585-90 | ||
| Norbert Zimmermann, Annette G. Beck-Sickinger, Gerd Folkers, Sabine Krickl, Ingrid Müller & Günther Jung (1991) Conformational and epitope mapping of Herpes simplex virus type 1 thymidinekinase using synthetic peptide segments, Eur. J. Biochem. 200, 519-28 | Abstract | |
| Harald Burkhardt, Tan Yan, Annette Beck-Sickinger, Rikard Holmdahl, Klaus von der Mark & Frank Emmrich (1991) An autoantibody to collagen type II interferes with processing of the antigen thus generating an inhibitory peptide for autoreactive human T-cells, Journal of Cellular Biochemistry O204, Suppl. 15E, 162 | ||
| Wim van’t Hof, Peter C. Driedijk, Marjan van den Berg, Annette G. Beck-Sickinger, Günther Jung, Rob. C. Aalberse (1991) Epitope mapping of the Dermatophagoides pteronyssinus house dust mite major allergen Der p II using overlapping synthesis peptides, Mol. Immunol. 28, 1225-32 | Abstract | |
| Hans-Peter Weil, Annette G. Beck-Sickinger, Jörg Metzger, Stefan Stevanovic, Günther Jung, Michaela Josten & Hans-Georg Sahl (1990) Biosynthesis of the Lantibiotic Pep5: Isolation and characterisation of a prepeptide containing dehydroamino acids, Eur. J. Biochem. 194, 217-23 | Abstract | |
| Annnette G. Beck-Sickinger, Wolfram Gaida, Gerd Schnorrenberg, Rudolph Lang & Günther Jung (1990) Neuropeptide Y: Identification of the binding site, Int. J. Pept. Protein Res. 36, 522-30 | Abstract | |
| Annette G. Beck-Sickinger, Günther Jung, Wolfram Gaida, Herbert Köppen, Gerd Schnorrenberg & Rudolph Lang (1990) Structure/activity relationships of C-terminal neuropeptide Y segments and analogues composed of sequence 1-4 linked to 25-36, Eur. J. Biochem. 194, 449-56 | Abstract | |
| Annette Beck, Günther Jung, Wolfram Gaida, Herbert Köppen, Rudolph Lang & Gerd Schnorrenberg (1989) Highly potent and small Neuropeptide Y agonist obtained by linking NPY 1-4 via spacer to a-helical NPY 25-36, FEBS Lett. 244, 119-22 | Abstract | |
| Wolfram Gaida, Gerd Schnorrenberg, Herbert Köppen, Annette Beck, Günther Jung, Ursula Mauss & Rudolph Lang (1988) Structure activity studies on NPY and NPY-fragments: Effects on blood pressure, presynaptic action and receptor binding, Neurochem. Int. 13, 114 | ||
| Lothar Seik, Annette Beck & Claude P. Muller (1988) High-sensitivity isoelectric focusing of biotinylated peptides: A new method, Anal. Biochem. 171, 96-103 | Abstract |
Reviews
| Corinna Schüß, Victoria Behr, Annette G. Beck-Sickinger (2024) Illuminating the neuropeptide Y4 receptor and its ligand pancreatic polypeptide from a structural, functional, and therapeutic perspective. Neuropeptides., doi: 10.1016/j.npep.2024.102416 | Abstract | |
| Annette G. Beck-Sickinger, Daniel P. Becker, Oksana Chepurna, Bhaskar Das, Sebastian Flieger, Evamarie Hey-Hawkins, Narayan Hosmane, Satish S. Jalisatgi, Hiroyuki Nakamura, Rameshwar Patil, Maria da Graça H. Vicente, and Clara Viñas. (2023) New Boron Delivery Agents. Biol. Chem. doi: 10.1089/cbr.2022.0060 | Abstract | |
| Tobias Fischer, Annette G Beck-Sickinger. (2022) Chemerin – Exploring a versatile adipokine. Biol. Chem. doi: 10.1515/hsz-2021-0409 | Abstract | |
| Lizzy Wanka, Victoria Behr, Annette G Beck-Sickinger. (2021) Arrestin-dependent internalization of rhodopsin-like G protein-coupled receptors. Biol. Chem. doi: 10.1515/hsz-2021-0128 | Abstract | |
| Oanh Vu, Brian Joseph Bender, Lisa Pankewitz, Daniel Huster, Annette G Beck-Sickinger, Jens Meiler (2021) The Structural Basis of Peptide Binding at Class A G Protein-Coupled Receptors. Molecules. Dec 30;27(1):210. doi: 10.3390/molecules27010210 | Abstract | |
| Sabrina Spiller, Franziska Clauder, Kathrin Bellmann-Sickert, Annette G Beck-Sickinger (2021) Improvement of wound healing by the development of ECM-inspired biomaterial coatings and controlled protein release Biol Chem. Aug 16;402(11):1271-1288. doi: 10.1515/hsz-2021-0144 | Abstract | |
| Oanh Vu, Brian J Bender, Lisa Pankewitz, Daniel Huster, Annette G Beck-Sickinger, Jens Meiler. (2020) Peptide-Drug Conjugates and Their Targets in Advanced Cancer Therapies. Front. Chem. doi:10.3389/fchem.2020.00571. | Abstract | |
| Paul Hoppenz, Sylvia Els-Heindl, Annette G Beck-Sickinger. (2020) Peptide-Drug Conjugates and Their Targets in Advanced Cancer Therapies. Front. Chem. doi:10.3389/fchem.2020.00571. | Abstract | |
| Jan-Patrick Fischer, Sylvia Els-Heindl, Annette G. Beck-Sickinger. Adrenomedullin – Current perspective on a peptide hormone with significant therapeutic potential. Peptides. doi:10.1016/j.peptides.2020.170347 | Abstract | |
| Lisa Maria Kögler, Jan Stichel, and Annette G. Beck-Sickinger (2019) Structural Investigations of Cell-Free Expressed G Protein-Coupled Receptors. Biol. Chem. doi:10.1515/hsz-2019-0292 [Epub ahead of print]. | Abstract | |
| Sven Hofmann, Kathin Bellmann-Sickert, Annette G. Beck-Sickinger (2019) Chemical Modification of Neuropeptide Y for Human Y1 Receptor Targeting in Health and Disease. Biol. Chem. 400, 299-311, doi:10.1515/hsz-2018-0364. | Abstract | |
| Milos Erak, Kathrin Bellmann-Sickert, Sylvia Els-Heindl and Annette G. Beck-Sickinger (2018) Peptide chemistry toolbox – transforming natural peptides into peptide therapeutics, Bioorg. Med. Chem. 26, 2759-65, doi:10.1016/j.bmc.2018.01.012. | Abstract | |
| Ria Schönauer, Sylvia Els-Heindl and Annette G. Beck-Sickinger (2017). Adrenomedullin – new perspectives of a potent peptide hormone, J. Pept. Sci. 23, 473-485. | Abstract | |
| Mareen Pagel and Annette G. Beck-Sickinger (2017). Multifunctional biomaterial coatings: synthetic challenges and biological activity. Biol. Chem. 398, 3-22. | Abstract | |
| Jonathan Lotze, Ulrike Reinhardt, Oliver Seitz and Annette G. Beck-Sickinger (2016). Peptide tags for site-specific protein labeling in vitro and in vivo. Mol. Biosyst. 12, 1731-45. | Abstract | |
| David Böhme and Annette G. Beck-Sickinger (2015) Drug delivery and release systems for targeted tumor therapy. J Pept Sci. 21, 186-200. | Abstract | |
| Annette G. Beck-Sickinger and Nydia Panitz (2014) Semi synthesis of chemokines. Curr. Opin. Chem. Biol. 22C, 100-107. | Abstract | |
| Veronika Mäde, Sylvia Els-Heindl and Annette G. Beck-Sickinger (2014) Automated solid-phase peptide synthesis to obtain therapeutic peptides. Beilstein J. Org. Chem. 10, 1197-212. | Abstract | |
| Andreas Mattern, Tristan Zellmann and Annette G. Beck-Sickinger (2014) Processing, Signaling, and Physiological Function of Chemerine. IUBMB Life. 66, 19-26. | Abstract | |
| Annette G. Beck-Sickinger (2013) Highlight: Protein states with cell biological and medicinal relevance. Biol. Chem. 394, 919-920. | ||
| Lars Baumann, Max Steinhagen und and Annette G. Beck-Sickinger (2013) Preparation of C-terminally Modified Chemokines by Expressed Protein Ligation. Methods Mol. Biol. 1047, 103-18. | Abstract | |
| Rayk Hassert and Annette G. Beck-Sickinger (2013) Tuning Peptide Affinity for Biofunctionalized Surfaces. Eur. J. Pharm. Biopharm. 85, 69-77. | Abstract | |
| Stefanie Babilon, Karin Mörl and Annette G. Beck-Sickinger (2013) Towards Improved Receptor Targeting: Anterograde Transport, Internalization and Postendocytic Trafficking of Neuropeptide Y Receptors. Biol. Chem. 394, 921-936. | Abstract | |
| Xavier Pedragosa Badia, Jan Stichel, Annette G. Beck-Sickinger (2013) Neuropeptide Y Receptors: How to get subtype selectivity. Front. Neuroendo. Sci. 4, 5. | Abstract | |
| Stephan Schultz and Annette G. Beck-Sickinger (2013) Chemerin and Vaspin: Possible Targets to Treat Obesity? Chem Med. Chem. 8, 549-59. | Abstract | |
| Verena Ahrens, Kathrin Bellmann-Sickert and Annette G. Beck-Sickinger (2012) Peptides and Peptide Conjugates: Therapeutics on the Upward Path. Future Med. Chem. 4, 1567-1586. | Abstract | |
| Annette G. Beck-Sickinger and Nediljko Budisa (2012) Genetically encoded Photocrosslinkers as Molecular Probes to Study G-Protein-Coupled Receptors (GPCRs). Angew. Chem. Int. Ed. 51, 310-312. | Abstract | |
| Maria Findeisen, Daniel Rathmann and Annette G. Beck-Sickinger (2011) RFamide Peptides: Structure, Function, Mechanisms and Pharmaceutical Potential. Pharmaceuticals 11, 1248-1280. | ||
| Cornelia Walther, Karin Mörl, Annette G. Beck-Sickinger (2011) Neuropeptide Y receptors: Ligand Binding and Trafficking Suggest Novel Approaches in Drug Development. J. Pept. Sci. 4, 233-46. | Abstract | |
| John T. Heiker, David Kosel and Annette G. Beck-Sickinger (2010) Molecular Mechanisms of Signal Transduction via Adiponectin and Adiponectin Receptors. Biol. Chemistry 39, 1005-1018. | Abstract | |
| Kathrin Bellmann-Sickert, Annette G. Beck-Sickinger (2010) Peptide Drugs to Target G-Protein Coupled Receptors. Trends Pharm. Sci. 31, 434-441. | Abstract | |
| Els S, Beck-Sickinger AG, Chollet C. (2010) Ghrelin receptor: High Constitutive Activity and Methods for Developing Inverse Agonists. Methods Enzymol. 485,103-21. | Abstract | |
| Rennert R, Neundorf I, Beck-Sickinger AG. (2009) Synthesis and Application of Peptides as Drug Carriers. Methods Mol. Biol. 535, 389-403. | Abstract | |
| Ilka Böhme, Annette G. Beck-Sickinger (2009) Illuminating the life of GPCRs – a Review. Cell. Comm. Signaling, 7,16-38. | Abstract | |
| Constance Chollet, Karoline Meyer, Annette G. Beck-Sickinger (2009) Ghrelin – a Novel Generation of Anti-Obesity Drugs: Design, Pharmacomodulation and Biological Activity of Ghrelin Analogues. J. Pept. Sci. 15, 711-730. | Abstract | |
| Sommer G, Garten A, Petzold S, Beck-Sickinger AG, Blüher M, Stumvoll M, Fasshauer M. (2008) Visfatin/PBEF/Nampt: structure, regulation and potential function of a novel adipokine. Clin. Sci. (Lond.) 115(1),13-23. | Abstract | |
| Zwanziger D, Beck-Sickinger AG. (2008) Radiometal targeted tumor diagnosis and therapy with peptide hormones. Curr. Pharm. Des. 14(24), 2385-400. | Abstract | |
| Diana Lindner, Jan Stichel and Annette G. Beck-Sickinger (2008) Molecular recognition of the NPY hormone family by their receptors. Nutrition 24, 907-917. | Abstract | |
| Khan IU, Beck-Sickinger AG. (2008) Targeted tumor diagnosis and therapy with peptide hormones asradiopharmaceuticals. Anticancer Agents Med. Chem. 8(2):1 86-99. | Abstract | |
| Robert Rennert, Ines Neundorf, Annette G. Beck-Sickinger (2008) Calcitonin-derived Peptide Carriers: Mechanism and Application. Adv. Drug Deliv. Rev. 60, 485-98. | Abstract | |
| Michael Haack and Annette G. Beck-Sickinger (2007) Multiple Peptide Synthesis to Identify Bioactive Hormone Structures, Top. Curr. Chem. 278, 243-88. | ||
| Franka Pluder, Karin Mörl, Annette G. Beck-Sickinger (2006) Proteome analysis to study signal transduction of G protein-coupled receptors, Pharmacol Ther. 112, 1-11. | Abstract | |
| Manja Lang, Annette Beck-Sickinger (2006) Structure-activity-relationship studies: Methods and ligand design for G-protein coupled peptide receptors. Curr. Protein Pept. Sci. 7, 335-53. | Abstract | |
| M. M. Boggiano, P. C. Chandler, K. D. Oswald, R. J. Rodgers, J. E. Blundell, Y. Ishii, A. H. Beattie, P. Holch, D. B. Allison, M. Schindler, K. Arndt, K. Rudolf, M. Mark, C. Schoelch, H. G. Joost, S. Klaus, C. Thöne-Reineke, S. C. Benoit, R. J. Seeley, A. G. Beck-Sickinger, N. Koglin, K. Raun, K. Madsen, B. S. Wulff, C. E. Stidsen, M. Birringer, O. J. Kreuzer, X. Y. Deng, D. C. Whitcomb, H. Halem, J. Taylor, J. Dong, R. Datta, M. Culler, S. Ortmann, T. R. Castañeda and M. Tschöp (2005) PYY3-36 as an anti-obesity drug target, Obes. Rev. 6, 307-22. | Abstract | |
| Ines Neundorf, Annette G. Beck-Sickinger (2005) Calcitonin-Derived Carrier Peptides, Curr. Pharm. Des. 11, 3661-3669. | Abstract | |
| Norman Koglin, Annette G. Beck-Sickinger (2004) Novel modified and radiolabelled analogues of the PP/NPY system to study Y-receptor subtypes, Neuropeptides 38, 153-61. | Abstract | |
| Regula von Eggelkraut-Gottanka, Annette G. Beck-Sickinger (2004) Biosynthesis of Peptide Hormones Derived from Precursor Sequences, Curr. Med. Chem. 11, 2651-67. | Abstract | |
| Ralf David, Michael P. O. Richter, Annette G. Beck-Sickinger (2004) Expressed protein ligation: methods and application, Eur. J. Biochem. 271, 663-77. | Abstract | |
| Andrea Bettio and Annette G. Beck-Sickinger (2002) Biophysical methods to study ligand-receptor interactions of neuropeptide Y, Biopolymers 60, 420-37. | Abstract | |
| D. Merkel, N. Koglin, A. G. Beck-Sickinger, B. Hamilton, H. A. Wieland (2002) Recent Advances in Proteome Research, Curr. Topics in Pept. Protein Res. 4, 124-37. | ||
| Richard M. Söll and Annette G. Beck-Sickinger (2001) On the Role of Neuropeptides in Hypothalamic Regulation of Food Intake, Curr. Med. Chem. – Immunol. Endocrinol. 1, 151-64. | ||
| Michael Langer and Annette G. Beck-Sickinger (2001) Peptides as carrier for tumor diagnosis and treatment, Curr. Med. Chem. Anticancer Agents 1, 71-93. | Abstract | |
| Christophe P. Eckard & Annette G. Beck-Sickinger (2000) Characterisation of G-Protein-coupled Receptors by Antibodies, Curr. Med. Chem. 7, 897-910. | Abstract | |
| Nikolaus Ingenhoven & Annette G. Beck-Sickinger (1999) Molecular charaterization of the ligand-receptor interaction of neuropeptide Y, Curr. Med. Chem. 6, 1055-66. | Abstract | |
| Michel, M. C. , Beck-Sickinger, A. G., Cox, H., Doods, H. N., Herzog, H., Larhammar, D., Quirion, R., Schwartz, T. W. & Westfall, T. (1998) XVI. International union of pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors (review), Pharmacol. Rev. 50, 143-50. | Abstract | |
| Annette G. Beck-Sickinger (1996) Structural characterization and binding sites of G-protein coupled receptors (review), Drug Discovery Today 1, 502-13. | ||
| Annette G. Beck-Sickinger & Günther Jung (1995) Structure-activity relationship of neuropeptide Y with respect to Y1 and Y2 receptors (review), Biopolymers (Peptide Science) 37, 123-42. | Abstract | |
| Annette G. Beck-Sickinger & Günther Jung (1993) Epitope mapping: Synthetic approaches to the understanding of molecular recognition in the immune system (review), Acta Pharm. Helv. 68, 3-20. | Abstract | |
| Günther Jung & Annette G. Beck-Sickinger (1992) Multiple peptide synthesis and applications (review), Angew. Chem. Int. Ed. 31, 367-83. | ||
| Günther Jung & Annette G. Beck-Sickinger (1992) Multiple peptide synthesis and applications (review), Angew. Chem. 104, 375-91. |