|
Shibashish Giri
|
|
Dr. rer.
nat. Shibashish Giri
Contact
Current activity
|
Creating human
induced pluripotent stem cells using
chemical compounds, minicircle DNA,
Sendai
virus,
Disease modelling
|
|
Bioartificial liver
support, hepatic differentiation, drug metabolism,
hepatotoxicity assessments. Scar less healing mechanism,
Generation of insulin producing cells,
Cardiac differentiation. 2D and 3D image analysis. |
Education
1995 -1998 |
B.Sc (Zoology Hons), Botany, Chemistry. Best Graduate Award for
Rairangpur, College (Autonomous), Utkal University, India |
1999 - 2001
|
M.Sc in Zoology with specialization in Cytogenetics from North
Orissa University, India |
2002 - 2003 |
M. Phil in Zoology form University of Delhi, India |
2013 |
PhD thesis with the topic "Bioreactor
development for hepatocyte culture model, stem cell expansion
and efficient hepatic differentiation using self assembling
peptides" |
Research Experiences and Professional
Memberships
since 2008 |
Member of
the Biomedical-Biotechnological Center,
Professorship of Cell Technology and Applied Stem Cell Biology,
Medical Faculty, Universität Leipzig |
Dec.
2004 -
Oct. 2007 |
Researcher in Applied Microbiology Lab, Center for Rural
Development and Technology, IIT, Delhi, India |
May
2004 -
May 2006 |
Part
Time as a Team leader (India) for
Tico Tours™
a U.S. based birding tour company. |
May 2004 -June
2004 |
Short Term training Programme in “Genetics and Molecular
techniques in Fisheries” from Central
Institute of
Fisheries
Education, Mumbai |
Nov
2002 -
May 2004 |
Senior research fellow (SRF) on ICAR research project titled
“Molecular mechanisms of egg hardening and egg organization in
fish” from Department of Zoology, University of Delhi, Delhi.
India |
2003 |
Senior Research fellowship (ICAR, Govt of India) in University
of Delh |
2003 |
Certificate of appreciation for assistance CPDHE sponsored
Refresher course on current trends in Physiology from Department
of zoology, University of Delhi |
1998 |
Best
graduate student award in in Rairangpur College (Autonomous),
Rairangpur, Orissa, India) |
Publications
Temnov A, Rogov K, Zhalimov V, Popov
I, Pekov S, Bader A, Skifas A, Giri S. The
effect of mesenchimal stem cell conditioned medium fraction on
morphological characteristics of hepatocytes in
acetamonophen-induced acute liver failure - a preliminari study.
Hepat Med. 2019 Jul 19;11:89-96
Tsepkolenko A, Tsepkolenko V, Mishra
A, Bader A, Melerzanov A, Giri S. The
Regenerative Potential of Skin and the Immune System. Clin
Cosmet Investig Dermatol. 2019 Jul 15;12:519-532
Giri S, Machens HG, Bader
A. Therapeutic potential of
endogenous stem cells and cellular factors for scar-free skin
regeneration. Drug discovery today.
2019 Jan;24(1):69-84. Epub 2018 Nov 5.
Review
Temnov AA, Astrelina TA, Rogov
KA, Moroz BB, Lebedev VG, Nasonova TA, Lyrshchikova AV,
Dobrynina OA, Deshevoy YU.B, Melerzanov AV, Bader A,
Mishra A, Giri S, Boyarintsev VV, Trofimenko AV,
Bushmanov AYu, Samoylov AS. Use Of Paracrine Factors From Stem Cells
To Treat Local Radiation Burns In Rats. Stem Cells and Cloning:
Advances and application. Stem Cells Cloning. 2018 Oct 26;11:69-76
Giri S, Machens HG,
Bader
A. Therapeutic potential of
endogenous stem cells and cellular factors for scar-free skin
regeneration. Drug discovery today.
2019 Jan;24(1):69-84. Epub 2018 Nov 5.
Review
Günter Ch, Machens HG, Ilg F,
Hapfelmeier A, Jelkmann W, Egert-Schwender S, Giri S,
Bader A. A Randomized Controlled
Trial: Regenerative Effects, Efficacy and Safety of
Erythropoietin in Burn and Scalding Injuries". Frontiers in
Pharmacology, section Pharmaceutical Medicine and Outcomes
Research. Volume 9, 18 Oct 31
Skrzypczyk A, Kehr S, Krystel I,
Bernhart S, Giri S, Bader A,
Stadler P. Non-coding RNA transcripts during differentiation of
induced pluripotent stem cells into hepatocytes.
Stem Cells Int. 2018 Aug
19;2018:5692840
Gerisch M, Smettan J, Ebert S,
Athelogou M, Brand-Saberi B, Spindler N, Mueller WC,
Giri S,
Bader A. Qualitative and
quantitative analysis of cardiac progenitor cells in cases of
myocarditis and cardiomyopathy. Front Genet. 2018 Mar 6;9:72
Bader A, Reinhardt M, Beuthe A,
Röhl K, Giri S. Therapy of an Spinal cord injury by intrathecal
injection of erythropoietin and subcutaneous injection of EPO,
vitamin C and GCSF. Ther Clin Risk Manag. 2017 Nov
27;13:1183-1188
Zeidler R, Freitas Soarez LB, Bader A,
Giri S. Molecular
epigenetic targets for livers diseases: Current challenges and
future prospects. Drug discovery today 2017 Jul 25
Skrzypczyk A, Giri S,
Bader A. Generation of induced
pluripotent stem cell line from foreskin fibroblasts. Stem Cell
Res. 2016 Sep 15;17(3):572-575
Bader A, Hollmann HJ, Storm GR,
Kern L, Giri S, Machens HG. 3-D scar-free regeneration of a
gangrenous heel in a diabetic patient and complete reversal of
neuropathy instead of upper limb amputation with in vivo and in
situ cell therapy. Four year follow-up.itted Stem Cells
Translational Medicine. Accepted 18.09.14
Bader A, Giri S. Personalized and
regenerative medicine for liver diseases. Curr Stem Cell Res
Ther. 2016, 11, 692-705, Epub 2015 Oct 26
Guenter IC,
Kern L, Giri S,
Machens HG , Bader A. First
Results on Three Patients Treated with Topical Recombinant Human
Erythropoietin (rhEPO) to Improve Wound Healing in Diabetic Foot
Ulcers. Journal of Transplantation & Stem Cell Biology, ISSN
2374-9326, Jan 2015, Volume: 2, Issue: 1
Giri S,
Acikgöz A, Bader A. Isolation and Expansion of Hepatic Stem-like
Cells from a Healthy Rat Liver and their Efficient Hepatic
Differentiation of under Well-defined Vivo Hepatic like
Microenvironment in a Multiwell Bioreactor. Journal of Clinical and
Experimental Hepatoligy. June 2015, Vo. 5, No. 2, 107-122
Giri P, Ebert S,
Braumann DU, Kremer M,
Giri S,
Machens HG, Bader A.
Skin Regeneration of Deep Second-degree Scalding Injuries either
by Infusion Pumping of rHuEPO or Topical Application of rHuEPO
Gel. Drug Design, Development and Therapy. 2015: 9, 2565-2579
Wegener M, Bader A,
Giri S. Regenerate hearts using adult stem cells and induced
pluripotent stem cells: New challenges on new targets on heart
for safer drug development for heart diseases. Drug Discov Today.
2015 Jun;20(6):667-685. Epub 2015 Feb 23. Review.
Heublein H, Bader A,
Giri S. Preclinical and clinical evidence of stem cell therapies
for diabetic wounds: Therapeutic targets for regenerating
diabetic wounds. Drug Discov Today. 2015 Jun;20(6):703-717. Epub
2015 Jan 17. Review.
Reinhardt M,
Giri S, Bader
A. Preclinical challenges and
clinical target of nanomaterials in regenerative medicine. (Under
revision). Book Chapter. Book chapter. Diverse Applications of
Nanotechnology in Biomedicine, Chemistry, and Engineering.
Advances in Chemical and Materials Engineering. IGI Global Book
Series ACME. Hershey, USA 2015, 350-371
Reinhardt M, Bader A,
Giri S. Devices for stem cell isolation and delivery: Current
need for drug discovery and cell therapy. Review. Expert Review
of Medical Devices. 2015 May;12(3):353-64. Epub 2014 Dec 25
Giri S, Bader A.
Immortalization of human fetal hepatocyte by ectopic expression
of human telomerase reverse transcriptage, human papilloma virus
(E7) and simian virus 40 large T (SV40 T) antigen is an
important milestone towards bioartificial liver support. J Clin
Exp Hepatol. 2014 Sep;4(3):191-201. Epub 2014 Sep 18.
Giri S, Bader A.
Low cost and high quality new drug discovery process using
patient-derived induced pluripotent stem cells. Drug Discov
Today. 2015 Jan;20(1):37-49. Epub 2014 Nov 15.
Giri P, Ebert S, Braumann DU,
Kremer M, Giri S, Machens HG, Bader A.
Skin Regeneration of Deep Second-degree Scalding Injuries either
by Infusion Pumping of rHuEPO or Topical Application of rHuEPO
Gel. Cell Regeneration journal, accepted
Acikgöz A, Langsch A,
Bader A, Giri S. Potential Interactions of Herbal Extracts of St. John´s Wort with
Metabolites of Diazepam in an Organotypical Sandwich Culture of
Primary Porcine Hepatocytes. British Journal of Phamaceutical
research 4 (15), 1840-1860, 2014
Giri S, Bader A.
Shortcut route for generation of functional hepatocyte cells
from human skin allogenically for autologous treatment of
chronic liver diseases. Journal of Clinical and
Experimental Hepatology, Volume 4, Issue 1, March 2014, Pages
74-78
Giri S, Bader A.
Preclinical liver bud engineering towards clinical target for
liver diseases. Journal of Clinical and Experimental Hepatology,
Volume 4, Issue 1, March 2014, Pages 71-74
Giri S, Bader A.
Chemistry, biology and therapeutic potential of bio-molecules
for activation, proliferation and commitment of endogenous
resident stem cells for cell/tissue/organ repair: A holistic
approach to regenerative medicine. Chemical Reviews. Accepted on
19 April 2012
Acikgöz A,
Giri S, Cho MG,
Bader A. Morphological and
Functional Analysis of Hepatocyte Spheroids Generated on
Poly-HEMA-Treated Surfaces under the Influence of Fetal Calf
Serum and Nonparenchymal Cells. Biomolecules 2013, 3(1), 242-269
Giri S,
Braumann UD, Giri P, Acikgöz A, Scheibe P, Nieber K, Bader A. Nanostructured self-assembling peptides as a defined
extracellular matrix for long-term functional maintenance of
primary hepatocytes in a bioartificial liver modular device.
Int J Nanomedicine. 2013;8:1525-39. Epub 2013 Apr 18
Giri S, Bader A. Engineering biomimetic microenvironment using biomaterials, soluble signals
for ex vivo expansion and differentiation of stem cells:
Strategic challenges for creation of clinical grades for stem
cell therapy. In: Biomaterials for Stem Cell Therapy: State of
Art and Vision for the Future. CRC Press. Taylor & Francis
Group, January 15, 2013. 279-316, Editor DeBartolo L, Bader A.
Bader A, Ebert S,
Giri S,
Kremer M, Liu S, Nerlich A, Guenter C, Smith D, Machens H-G.
Skin regeneration with conical and hair follicle structure of
deep second degree scalding injuries via combined expression of
EPO receptor and beta common receptor by local subcutaneous
injection of nanosized rhEPO. Int J Nanomedicine.
2012;7:1227-37. Epub 2012 Mar 6
Giri S,
Acikgöz A, Pathak P, Gutschker S, Krusten A, Nieber K, Bader A.
Three Dimensional Cultures of Rat Liver Cells Using a Natural
Self-assembling Nanoscaffold in a Clinically Relevant Bioreactor
for Bioartificial Liver Construction: J Cell Physiol. 2012
Jan;227(1):313-27.
Giri S, Bader A. Improved Preclinical
Safety Assessment using Micro-BAL Devices: The Potential Impact
on Human Discovery and Drug Attrition. Drug Discov Today. 2011
May;16(9-10):382-97. Epub 2011 Feb 24
Bader A,
Lorenz K, Richter A, Scheffler K, Kern L, Ebert S,
Giri S,
Behrens M, Dornseifer U, Macciarini P, Machens HG.
Role of trauma cytokines and erythropoietin and
its therapeutic potential for acute and chronic wounds.
Rejuvenation
Research, 2011 Feb;14(1):57-66.
Giri S, Nieber
K, Bader A.
Hepatotoxicity and hepatic metabolism of available drugs and
xenobiotics: current problems and possible solutions in
preclinical stages. Expert Opin Drug Metab Toxicol. 2010
Aug;6(8):895-917
Maringka M,
Giri S, Nieber K, Açikgöz A, Bader A.
Biotransformation of
diazepam in a clinical relevant flat membrane bioreactor model using
primary porcine hepatocytes.
Fundam Clin Pharmacol. 2011 Jun;25(3):343-53. doi:
10.1111/j.1472-8206.2010.00857.x.
Giri S, Nieber K,
Bader A.
Hepatotoxicity and
hepatic metabolism of available drugs and xenobiotics: current
problems and possible solutions in preclinical stages.
Expert Opin Drug Metab Toxicol. 2010 Aug;6(8):895-917.
Giri S, Weingartz U,
Nieber K, Acikgöz A, Bader A. Cryopresvation of primary
porcine hepatocyte in organotypical sandwich culture model in a
clinical relevent flat membrane bioreactor.
Biotechnol Lett. 2010 Jun;32(6):765-71. Epub 2010 Mar 7
Maringka M,
Giri S, Bader A.
(2009)
Preclinical
characterization of primary porcine hepatocyte in a clinical
relevant flat membrane bioreactor.
Biomaterials.
2010 Jan; 31(1):156-72.
Epub 2009 Oct 8.
Giri S, Nieber
K, Acikgöz A, Pavlica S, Keller M, Bader A. Telomerase activity and
hepatic functions of rat embryonic liver progenitor cell in
nanoscaffold coated model bioreactor.
Mol Cell Biochem. 2009 Oct 9. [Epub
ahead of print]
Frühauf JH, Mertsching H;
Giri S; Frühauf NR, Bader A.
Porcine endogenous retrovirus (PERV)
released by a bioartificial liver infects primary human cells
(2009) .
Liver Int. 2009
Nov;29(10):1553-61. Epub 2009 Aug 14
Langsch A, Giri
S, Acikgöz A, Jasmund I, Frericks B, Bader A.
Interspecies
difference in liver-specific functions and biotransformation of
testosterone of primary rat, porcine and human hepatocyte in an
organotypical sandwich culture. Toxicology Letters. 2009
Aug 10;188(3):173-9. Epub 2009 Apr 2.
Acikgöz A, Karim
N, Giri S, Schmidt-Heck W, Bader A.
Two
compartment model of diazepam biotransformation in an organotypical
culture of primary human hepatocytes. Toxicololgy and
Applied Pharmacology. 2009 Jan 15;234(2):179-91. Epub 2008 Oct 15.Priya
Pathak, V. K katiyar and Shibashish Giri. Cancer research -
Nanoparticle, Nanobiosensor and their role in Cancer research,
Journal of Nanotechnology Online, Vol 3, 1-14, 2007.
|
|