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Recent Publications
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Giri S, Braumann UD, Giri P,
Acikgöz A, Scheibe P, Nieber K, Bader A. Nanostructured self-assembling peptides as a defined
extracellular matrix for long-term functional maintenance of
primary hepatocytes in a bioartificial liver modular device.
Int J Nanomedicine. 2013;8:1525-39. Epub 2013 Apr 18
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Elliot M, DeCoppi P, Speffiorin S, Roebuck D, Butler C, Samuel
E, Clowly C, McLarenC, FierensA, Vondrys D, Cochrane L, Jephson
C, Janes S, Beaumont NJ, Cogan T, Bader A,
Seifalian A, , Hsuan J, Lowdell M, P, Birchall M. Two-year
follow up of a stem cell based, tissue engineered organ
replacement in a child. Lancet. 2012 Sep
15;380(9846):994-1000. Epub 2012 Jul 26
Acikgöz A, Giri S, Bader A.
Nannolevel drug metabolites detection in an organotypical
culture of primary human hepatocytes and porcine hepatocytes
with special reference to two compartment model. International
Journal of Nanomedicine. International Journal of Nanomedicine
2012: 7, 5859-5872
Leal-Egaña A, Frisch A,
Heidebrecht F, Díaz-Cuencac A, Nowicki M, Bader A,
Käs J. Tuning liver stiffness against tumours: An in vitro study
using entrapped cells in tumour-like microcapsules. J of the
Mechanical Behavior of Biomedical Materials. J Mech Behav Biomed
Mater. 2012 May;9:113-21. Epub 2012 Jan 31
Pavlica S, Milosevic J, Keller M,
Schulze M, Piscioneri A, DeBartolo L, Darsow K, Bartel S, Lange
H, Bader A. Erythropoietin
enhances cell proliferation and survival of human fetal neuronal
progenitors in normoxia. Brain Res. 2012 May 3;1452:18-28. Epub
2012 Feb 25
Jungebluth P, Bader A,
Baiguera S, Möller S, Jaus M, Mei Ling Lim, Fried K,
Kjartansdóttir KR, Go T, Nave H, Harringer W, Lundin V, Teixeira
AI, Macchiarini P. The concept of in vivo airway tissue
engineering. Biomaterials. 2012 Jun;33(17):4319-26. Epub 2012
Mar 21
Bader A, Ebert S, Giri S,
Kremer M, Liu S, Nerlich A, Guenter C, Smith D, Machens H-G.
Skin regeneration with conical and hair follicle structure of
deep second degree scalding injuries via combined expression of
EPO receptor and beta common receptor by local subcutaneous
injection of nanosized rhEPO. Int J Nanomedicine.
2012;7:1227-37. Epub 2012 Mar 6
Bader A, Peters O, Keller M,
Pavlica S. (2011) Paracetamol treatment increases telomerase
activity in rat embryonic liver cells (short communication).
Pharmacol Rep. 2011 Nov;63(6):1435-41
DeBartolo L, Bader A,
Lendlein A, DeGrey A, Cucio E, Drioli E. Bio-Hybrid Organs and
Tissues for Patient Therapy: a Future Vision for 2030. Chemical
Engineering and Processing. 51 (2012) 79-87
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Bader A, Pavlica S, Deiwick A,
Lotkova H, Kucera O, Darsow K, Bartel S, Schulze M, Lange HA,
Cervinkova Z. Proteomic analysis to display the effect of low
doses of Erythropoietin on rat liver regeneration. Life Sci.
2011 Dec 5;89(23-24):827-33. Epub 2011 Aug 18.
Mofidi A, Bader A, Pavlica
S. (2011) The use of Erythropoietin and ist Derivatives to Treat
Spinal Cord Injury. Mini Rev Med Chem. 2011 Aug 1;11(9):763-70.
Pavlica S., Schmitmeier S, Gloeckner P, Piscioneri A, Peinemann
F, Krohn K, Siegmud-Schulz M, Laera S, DeBartolo L, Bader
A. Effects of native and NH3
plasma functionalized polimeric membranes on the gene expression
profiles of primary hepatocytes. J Tissue Eng Regen Med. 2012
Jun;6(6):486-96. Epub 2011 Jul 13
Leal-Egaña A, Dietrich-Braumann U, Díaz-Cuenca A, Nowicki M,
Bader A. Determination of
Pore Size Distribution at the Cell-Hydrogel Interface. J
Nanobiotechnology. 2011 May 27;9(1):24.
Marquass B, Schulz R, Hepp P, Zscharnack M, Aigner T, Schmidt S,
Stein F, Richter R, Osterhoff G, Aust G, Josten C, Bader
A. Matrix-Associated Implantation
of Predifferentiated Mesenchymal Stem Cells Versus Articular
Chondrocytes: In Vivo Results of Cartilage Repair After 1 Year.
Am J Sports Med. 2011 Jul;39(7):1401-12. Epub 2011 Apr 28
Giri S, Acikgöz
A, Pathak P, Gutschker S, Krusten A, Nieber K, Bader A.
Three Dimensional Cultures of Rat Liver Cells Using a Natural
Self-assembling Nanoscaffold in a Clinically Relevant Bioreactor
for Bioartificial Liver Construction: J Cell Physiol. 2012
Jan;227(1):313-27.
Jungebluth P,
Luedde M, Ferrer E, Luedde T, Vucur M, Peinado VI, Go T,
Schreiber C, Richthofen MV, Bader A,
Haag J, Darsow KH, Bartel SJ, Lange HA, Furlani D, Steinhoff G,
Macchiarini P. Mesenchymal stem cells restore lung function by
recruiting resident and non-resident proteins. Cell Transplant.
2011;20(10):1561-74. Epub 2011 Mar 7.
Giri S, Bader A. Improved Preclinical
Safety Assessment using Micro-BAL Devices: The Potential Impact
on Human Discovery and Drug Attrition. Drug Discov Today. 2011
May;16(9-10):382-97. Epub 2011 Feb 24
Bader A,
Lorenz K, Richter A, Scheffler K, Kern L, Ebert S, Giri S,
Behrens M, Dornseifer U, Macciarini P, Machens HG.
Role of trauma cytokines and erythropoietin and
its therapeutic potential for acute and chronic wounds.
Rejuvenation
Research, 2011 Feb;14(1):57-66. |
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2010
Muller D, Chim H,
Bader A,
Whiteman M, Schantz JT. Vascular guidance: Microstructural
scaffold patterning for inductive neovascularisation. Stem Cells
Int. 2010 Dec 1; 2011:547247
Marquass B, Somerson JS, Hepp P, Aigner T, Schwan S,
Bader A,
Josten C, Zscharnack M, Schulz RM. A novel MSC-seeded triphasic
construct for the repair of osteochondral defects. J Orthop Res.
2010 Dec;28(12):1586-99
Glaser V. Interview with Prof. Dr. Augustinus
Bader. Rejuvenation
Research. August 2010, 13(4): 489-492.
doi:10.1089/rej.2010.1087, Volume: 13 Issue 4: August 24, 2010, Epub August 9, 2010
Giri S, Nieber K,
Bader A.
Hepatotoxicity and hepatic metabolism of available drugs and
xenobiotics: current problems and possible solutions in
preclinical stages. Expert Opin Drug Metab Toxicol. 2010
Aug;6(8):895-917
Bader A,
Machens HG. rhErythropoietin plays a
pivotal role as a topical stem cell activator to reverse effects
of damage to the skin in aging and trauma.
Rejuvenation Research,
Aug;13(4):499-500
Piscioneri A,
Campana C, Salerno S, Morelli S, Bader
A, Giordano
F, Drioli E, De Bartolo L. Biodegradable and synthetic membranes
for the expansion functional differentiation of rat embryonic
liver cells. (2010) Acta Biomater. 2011 Jan;7(1):171-9. Epub
2010 Aug 4.
Rupf T, Ebert S, Lorenz K, Salvetter J,
Bader A.
Cryopreservation of organotypical cultures based on 3D scaffolds
Comparison of cryopreservation methods of skin substitutes
composed of polymere matrices. Cryo Letters. 2010
Mar-Apr;31(2):157-68
Mauth
C, Deiwick A, Steffen A, Pavlica S, Bader A.
The influence of oxygen supply on metabolism of neural cells
cultured on gas-permeable PTFE foil. (2010)
Biotechnol Prog.
2010 Nov-Dec;26(6):1724-32. doi: 10.1002/btpr.478.
Maringka M, Giri S, Nieber K, Açikgöz A,
Bader A.
Biotransformation of diazepam in a clinical relevant flat
membrane bioreactor model using primary porcine hepatocytes.
Fundam Clin Pharmacol. 2011 Jun;25(3):343-53. doi:
10.1111/j.1472-8206.2010.00857.x.]
Zscharnack M,
Hepp
P, Richter R, Aigner T, Schulz R, Somerson J, Josten C, Bader
A, Marquass B. Repair of Chronic Osteochondral Defects Using
Predifferentiated Mesenchymal Stem Cells in an Ovine Model.
Am J Sports Med. 2010 Sep;38(9):1857-69. Epub 2010 May 27
Chowdhury TT,
Schulz RM, Rai SS, Thuemmler CB, Wuestneck N, Bader A, Homandberg GA.
Biomechanical modulation of collagen fragment induced anabolic
and catabolic activities in chondrocyte /agarose constructs.
Arthritis Res Ther.
2010 May 12;12(3):R82. Epub 2010 May 12
Galle J, Bader A, Hepp P, Grill W, Fuchs B, Käs JA,
Krinner A, Marquaß B, Müller K, Schiller J, Schulz RM, von
Buttlar M, von der Burg E, Zscharnack M, Löffler M. Mesenchymal
Stem Cells in Cartilage Repair: State of the Art and Methods to
monitor Cell Growth, Differentiation and Cartilage Regenration.
Curr Med Chem. 2010;17(21):2274-91. Review
Bader A.,
Macchiarini P. Moving towards in situ tracheal regeneration: the
bionic tissue engineered transplantation approach.
J Cell Mol Med. 2010 Jul;14 (7):1877-89. Epub 2010 Apr 19
Giri S, Nieber K,
Bader A. Hepatotoxicity and
hepatic metabolism of available drugs and xenobiotics: current
problems and possible solutions in preclinical stages.
Expert Opin Drug Metab Toxicol. 2010 Aug;6(8):895-917.
Giri S, Weingartz U,
Nieber K, Acikgöz A, Bader A. Cryopresvation of primary
porcine hepatocyte in organotypical sandwich culture model in a
clinical relevent flat membrane bioreactor.
Biotechnol Lett. 2010 Jun;32(6):765-71. Epub 2010 Mar 7.
Go T, Jungebluth P, Baiguera S, Asnaghi A, Martorell J, Ostertag
H, Mantero S, Teresa C M, Birchall M, Bader A,
Macchiarini P. (2009) Both epithelial cells and mesenchymal stem
cell-derived chondrocytes contribute to the survival of
tissue-engineered airway transplants in pigs.
J
Thorac Cardiovasc Surg.
2010 Feb;139(2):437-43. Epub 2009 Dec 7
Maringka M, Giri S, Bader A. (2009)
Preclinical
characterization of primary porcine hepatocyte in a clinical
relevant flat membrane bioreactor.
Biomaterials. 2010 Jan; 31(1):156-72.
Epub 2009 Oct 8.
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2009
Genové
E, Schmitmeier S, Sala A, Borrós S, Bader A, Griffith LG,
Semino CE. (2009) Functionalized self-assembling peptide
hydrogel enhance maintenance of hepatocyte
activity in vitro.
J Cell Mol Med.
2009 Sep;13(9B):3387-97. Epub 2009 Nov 13.
Giri S,
Nieber K, Acikgöz A,
Pavlica S, Keller M, Bader A. (2009) Telomerase activity
and hepatic functions of rat embryonic liver progenitor cell in
nanoscaffold coated small scale bioreactor.
Mol Cell
Biochem. 2010 Mar;336(1-2):137-49. Epub
2009 Oct 9.
Pavlica S, Piscioneri A, Peinemann F, Keller
M, Milosevic J, Staeudte A, Heilmann A, Schulz-Siegmund M, Laera
S, Favia P, DeBartolo L., Bader A. (2009) Rat embryonic
liver expansion and differentiation on NH3
plasma-grafted PEEK-WC-PU membranes.
Biomaterials 30, 6514-6521, Epub 2009 Sep 1
Frühauf JH, Mertsching H; Giri S; Frühauf NR, Bader A.
Porcine endogenous retrovirus (PERV)
released by a bioartificial liver infects primary human cells
(2009) .
Liver Int. 2009
Nov;29(10):1553-61. Epub 2009 Aug 14.
Krinner A, Zscharnack M, Bader A, Drasdo D, Galle J.
Impact of oxygen environment on mesenchymal stem cell expansion
and chondrogenic differentiation. Cell
Prolif. 2009 Aug;42(4):471-84
Kock LM, Schulz RM,
van Donkelaar CC, Thümmler CB, Bader A, Ito K. RGD-dependent
integrins are mechanotransducers in dynamically compressed
tissue-engineered cartilage construct.
J
Biomech. 2009 Sep
18;42(13):2177-82. Epub 2009 Aug 5
Hepp P, Osterhoff G, Marquass B, Niederhagen M, Aigner T,
Bader A, Josten C, Schulz RM.
Perilesional changes of focal osteochondral
defects in an ovine model and their relevance to human osteo
chondral injuries. Journal of Bone and Joint Surgery - British
Volume, 91(8), 1110-1119, (2009)
Heidebrecht F, Schulz I, Keller M,
Behrens SE, Bader A.
Improved Protocols for Protein and RNA
Isolation from 3D Collagen Sandwich Cultures of Primary
Hepatocytes.
Anal Biochem.
2009 Oct 1;393(1):141-4. Epub 2009 Jun 17
Leal-Egaña A, Díaz-Cuenca A,
Bader A.
Determination of the decay rate constant for
hepatocytes immobilized in alginate microcapsules.
(2009)
J Microencapsul.
2010; 27 (1) 86-93. Epub 2009 Jun 19
Salerno S, Piscioneri A, Laera S, Morelli S, Favia P, Bader A,
Drioli E, De Bartolo L. Improved functions of human hepatocytes
on NH(3) plasma-grafted PEEK-WC-PU membranes. (2009)
Biomaterials 30, 4348-434356.
Epub 2009 Jun 3
Shen
C, Meng Q, Schmelzer E, Bader A. Gel entrapment culture
of rat hepatocytes for investigation of tetracycline-induced
toxicity. Toxicol Appl Pharmacol.
2009
Jul 15;238(2):178-87. Epub 2009 May 19.
Heidebrecht F,
Heidebrecht A, Schulz I, Behrens SE, Bader A. (2009)
Improved semiquantitative Western blot technique with increased
quantification range.
Journal of
Immunological Methods. I2009
Jun 30; 345(1-2):40-8. Epub 2009 Apr 5
Langsch A, Giri S, Acikgöz A, Jasmund I, Frericks B, Bader A.
Interspecies difference in liver specific functions and
biotransformation of testosterone of primary rat, porcine and
human hepatocyte in an organotypical sandwich culture. (2009)
Toxikology
letters. 2009 Aug
10;188(3):173-9. Epub 2009 Apr 2
Acikgöz A, Karim N, Giri S, Schmidt-Heck W, Bader A. (2008) Two compartment
model of diazepam biotransformation in an organotypical culture
of primary human hepatocytes. Toxicol
Appl Pharmacol. 234 (2009) 179-91
Spanholtz T, Maichle A, Niedworok C, Stoeckelhuber BM,
Krüger S, Wedel T, Aach T, Middeler G, Hellwig-Bürgel T,
Bader A, Krengel S, Müller OJ, Franz WM, Lindenmaier W,
Machens HG. Timing and targeting of
cell-based VEGF165 gene expression in ischemic tissue.
J Surg Res. 2009
Jan;151(1):153-62. Epub 2008 Mar 13
De Bartolo L, Salerno S, Curcio E,
Piscioneri A, Rende M, Morelli S, Tasselli F, Bader A, Drioli E:
Humanhepatocyte functions in a crossed hollow fiber membrane
bioreactor. Biomaterials. 30 (2009)
2531-2543 |
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2008
Acikgöz
A, Bader A. (2008) Von der Gewebezüchtung zur
individuellen Geweberegeneration – Der Mensch als Bioreaktor.
Journal für Verbraucherschutz und Lebensmittelsicherheit 3 2008
Supplement 1, 64-72
Vozzi
F, Heinrich JM, Bader A, (2008) Ahluwalia AD.
Connected Culture of Murine Hepatocytes and HUVEC in a
Multicompartmental Bioreactor.
Tissue Eng Part A.
2009 Jun; 15(6):1291-9
Zscharnak M, Poesel C, Bader A and Galle J. (2008) Low oxygen improves expansion
and subsequent chondrogenic differentiation of ovine mesenchymal
stem cells.
Cells Tissues Organs. 2008 Nov
25
Schulz
RM, Wüstneck N, van Donkelaar C, Shelton J, Bader A
(2008) Development and validation of a novel bioreactor system
for load- and perfusion-controlled tissue engineering of
chondrocyte-constructs. Biotechnology and Bioengineering, Volume
101, Issue 4, 1 November 2008, Pages 714-728, published online 2
May 2008
Lorenz K, Sicker M, Schmelzer E, Rupf T, Salvetter J, Schulz-Siegmund
M,
Bader A; Multilineage Differentiation Potential of
Human Dermal Skin Derived Fibroblasts, original article accepted
28.02.08 in ExpDerm, 2008 Nov.; 17(11): 925-32. Epub Jun.14
Lorenz K, Rupf T, Salvetter J, Bader
A.
Enrichment of human β1bri/α6bri/CD71dim
keratinocytes after culture in Defined Media,
Cells Tissues
Organs. 2009;189(6):382-90. Epub 2008 Aug 11
Fuchs B, Schiller
J, Süß R, Zscharnack M,
Bader A,
Müller P,
Schürenberg M, Becker M, Suckau D. Analysis of Stem Cell
Lipids by Offline HPTLC-MALDI-TOF MS. Analytical and
Bioanalytical Chemistry. 2008 Nov; 392 (5): 849-60. Epub 2008
Aug 5
Haberhauer
M, Zernia G, Deiwick A, Pösel C, Bader
A, Huster D, Schulz R. Cartilage Tissue
Engineering in Plasma and Whole Blood
Scaffolds. Advances Materials 2008;
Volume 20 Issue 11, June 4, 2008, 2061-2067.
Schulz R, Zscharnack M,
Hanisch I, Geiling M, Hepp P, Bader A. Cartilage Tissue Engineering by Collagen
Matrix Associated Bone Marrow Derived Mesenchymal Stem Cells.
Biomed Mater Eng. 2008;18(1):55-70.
van Donkelaar CC, Schulz R.
Review on patents for
mechanical stimulation of articular cartilage tissue
engineering. Recent Patents on Biomedical Engineering.
Volume 1(1):1-12.
Schmelzer E, Deiwick A, Bader A.
Thrombopoietin is a growth factor for hepatic progenitors. Eur J
Gastroenterol Hepatol. 2008 Mar;20(3):209-16.
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2007
Jasmund I, Schwientek S, Acikgöz A, Langsch
A, Machens HG, Bader A (2007). The Influence of Medium
Composition and Matrix on Long-term Cultivation of Primary
Porcine and Human Hepatocytes. Biomolecular Engineering
24:59-69.
Meng Q, Ru J, Zhang G, Shen C,
Schmitmeier S, Bader A.
(2007) Re-evaluation of
tacrine hepatotoxicity using gel entrapped hepatocytes.
Toxicology Letters 168:140-147.
Schulz R, Bader A. Cartilage tissue engineering and
bioreactor systems for the cultivation and simulation of
chondrocytes. Eur Biophys J. 2007 Apr;36(4-5):539-68. Epub 2007
Feb 23. Review.
Diekmann S, Glockner
P, Bader A.
(2007) The Influence of different cultivation
conditions on the metabolic functionality of encapsulated
primary hepatocytes. International Journal of Artificial Organs
30:192-198.
Schulz J, Pretzsch M, Khalafi
I, Deiwick A, Scheidt HA, von Salis-Soglio G, Bader A,
Huster D. (2007) Quantitative Monitoring of Extracellular Matrix
Production in Bone Implants by 13C and 31P Solid-State NMR
Spectroscopy. Calcif Tissue International,
2007 Apr;80(4):275-85. Epub 2007 Apr 1.
Hauschild G, Bader A, Uhr G., Meyer-Lindberg A,
Fehr M (2007)Klinischer Einsatz von
b-Tricalciumphosphat –
Erfahrungen mit einem matrixorientierten Ansatz zur
Osteoregenation, Tierärztliche Prax 2007; 35 (K) 5-13.
Schmitmeier S, Langsch A, Schmidt-Heck W,
Jasmund I, Bader A. (2007)
Improvement of metabolic performance of primary hepatocytes in
hyperoxic cultures by vitamin C in a novel small-scale
bioreactor. Journal of Membrane Science 298, 2007, 30-40.
Curcio
E, Salerno S, Barbieri G, De Bartolo L, Drioli E, Bader A.
(2007) Mass
transfer and metabolic reactions in hepatocyte spheroids
cultured in rotating wall gas-permeable membrane system.
Biomaterials. 2007 Dec;28(36):5487-97.
Epub 2007 Sep 18.
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Leal-Egana A,
Heinrich JM, Smith MD, Nowicki M, Bader A.
(2006). A simple,
non-destructive method for the fixation and immunostaining of
cultured cells encapsulated in alginate. Biotechnology and
Applied biochemistry 44:143-150.
Schulz
R, Hohle S, Zernia G, Zscharnack M, Schiller J, Bader A,
Huster D.
(2006) Analysis of
extracellular matrix Production in Artificial Cartilage
Constructs by Histology, Immunocytochemistry, Mass Spectrometry,
and NMR Spectroscopy. Journal of Nanoscience and Nanotechnology
6:2368-2381.
Diekmann S, Bader A, Schmitmeier S.
(2006) Present and future developments in hepatic
tissue engineering for liver support systems. Cytotechnology.
50:163-179.
DeBartolo L, Salerno S, Morelli S, Giorno L, Rende M, Memoli B,
Procino A, Andreucci V, Bader A, Drioli E.
(2006) Long-term
maintenance of human hepatocytes in oxygen-permeable membrane
bioreactor. Biomaterials 27:4794–4803.
Just L, Kürsten A, Borth-Bruhns T, Lindenmaier W, Rohde M,
Dittmar K, Bader A.
(2006) Formation of
three-dimensional fetal myocardial tissue cultures from rat for
long-term cultivation. Developmental dynamics 235:2200-2209.
Schmitmeier S, Langsch A,
Jasmund I, Bader A. (2006).
Development and characterization of a
small-scale bioreactor based on a bioartificial hepatic culture
model for predictive pharmacological in vitro screenings.
Biotechnolology & Bioengineering 95:1198-1206.
Schmitmeier S, Langsch A, Bader A. (2006) A membrane-based small scale bioreactor for
accelerated in vitro drug screening with primary hepatocytes.
Desalination 199:258-260.
Rocker D, Hesse F, Bader A, Wagner R.
(2006) Intracellular Nucleotide Pools and Ratios
as Tools for Monitoring Dedifferentiation of Primary Porcine
Hepatocytes in Culture. Cytotechnology 51:119-132.
Karim N, Golz K, Bader A. (2006) The cardiovascular tissue-reactor: a novel
device for the engineering of heart valves. Artificial
Organs 30:809-814.
Klingmüller
U, Bauer A, Bohl S, Breitkopf K, Dooley S, Zellmer S, Kern C,
Merfort I, Sparna T, Donauer J, Walz G, Geyer M, Kreutz C,
Hermes M, Walter D, Egger L, Neubert K, Borner C, Brulport M,
Schormann W, Sauer C, Baumann F, Preiss R, Illes P, Nickel PJ,
MacNelly S, Godoy P, Wiercinska E, Ciuclan L, Zeilinger K,
Heinrich M, Zanger UM, Reuss M, Gebhardt R, Maiwald T, Timmer J,
von Weizsäcker F, Hengstler JG.
(2005)
Primary mouse hepatocytes for systems biology approaches: a
standardized in vitro system for modelling of signal
transduction pathways. IEE Proceedings- Systems Biology
153:433-447.
Schmelzer, E., Acikgoez,A., Fruehauf, N.R., Crome, O.,
Klempnauer, J., Christians, U., Bader, A. .
Biotransformation of cyclosporin in matrix overlaid primary
rat, porcine, and human hepatocytes.
Xenobiotica. 36:693-708.
Seleverstov, O., Bader, A. (2005)
Evaluation of
liver support systems for pre-clinical animal trials. Artificial
Organs
30:815-821.
Seleverstov O, Zabirnyk O, Zscharnack M, Bulawina L, Heinrich JM,
Yezhelyev M, Emmrich F, O’Regan R, Bader A.
(2006)
Quantum dots for human mesenchymal stem cells labelling, a
size-dependent autophagy activation. Nano Letters 6:2826-2832.
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2005
K. Prank, M. Waring, U. Ahlvers, A. Bader, E.
Penner, M. Möller, G. Brabant and C. Schöfl (2005) The
precision of intracellular calcium spike timing in primary rat
hepatocytes. Sys. Biol. 2:31-34.
Hauschild G., Merten H.-A., Bader A., Uhr G., Deiwick
A., Meyer-Lindenberg A. (2005) Bioartificial bone grafting:
Tarsal joint fusion in a dog using a bioartificial composite
bone graft consisting of β-tricalciumphosphate and platelet
rich plasma – A case report. Vet Comp Orthop Traumatol,
1/2005: 52-54.
Bader, A., Brückenschlag zwischen der präventiven und
regenerativen Medizin. (2005) Anti Aging for professionals.
Journal of preventive, regenerative and aesthetic medicine.
1/2005: 23-27.
Bader, A., Langsch, A., Jasmund, I. (2005) Perspectives
for regenerative medicine: Alternatives to liver
transplantation. Proceedings of the international school on
advanced material science and technology: Advanced
biomaterials, biomimetics, tissue engineering: 2004: 7-16.
Bader, A., Langsch, A., Jasmund, I.(2005). Use of a
hollow fibre membrane oxygenator as a bioartificial liver
device. Proceedings of the international school on advanced
material science and technology: Advanced biomaterials,
biomimetics, tissue engineering: 125- 141.
Hepp P, Bader
A, Josten C, Rose T, Schulz R. (2005). Tissue engineering von Knorpelzellen.
Arthroskopie. 18:233–238.
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Wilkening S, Bader A Quantitative real-time
polymerase chain reaction: methodical analysis and
mathematical model. JBiomol Tech. 2004 Jun;15(2):107-11.
Fruhauf NR, Oldhafer KJ, Holtje M, Kaiser GM, Fruhauf JH,
Stavrou GA, Bader A, Broelsch CE., A bioartificial
liver support system using primary hepatocytes: A preclinical
study in a new porcine hepatectomy model., Surgery. 2004
Jul;136(1):47-56.
Hauschild G, Bader A, Vor- und Nachteile synthetischer
versus xenogener Knochenersatzmaterialien, Tierärztliche
Praxis 2004, 32 (K): 67-70.
Schlesinger F, Meywirth J, Krampfl K, Grosskreutz J, Petri S,
Mauth C, Just L, Bader A, Bufler J., Ligand-gated
channels in early mesencephalic neuronal precursors:
immunocytochemical and electrophysiological analysis. European
Journal of Neuroscience. 2004;19(9):2371-6.
Wilkening S. and Bader A. Differential regulation of
CYP3A4 and CYP3A7 by dimethylsulfoxide. Basic & Clinical
Pharmacology & Toxicology 2004, 95(2), 92–93.
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Wilkening S, Bader A., Influence of culture time on
the expression of drug-metabolizing enzymes in primary human
hepatocytes and hepatoma cell line HepG2., J Biochem Mol
Toxicol. 2003;17(4):207-13.
Just L, Timmer M, Tinius J, Stahl F, Deiwick A, Nikkhah G,
Bader A., Identification of human cells in brain
xenografts and in neural co-cultures of rat by in situ
hybridisation with Alu probe., J Neurosci Methods. 2003 Jun
15;126(1):69-77.
Wilkening S, Stahl F, Bader A., Comparison of primary
human hepatocytes and hepatoma cell line Hepg2 with regard to
their biotransformation properties., Drug Metab Dispos. 2003
Aug;31(8):1035-42.
Schmelzer E., Langsch A. and Bader A. (2003). 24- and
96- Well Bioreactors. In: New Hepatocyte In vitro Systems for
Drug Metabolism: Metabolic Capacity and Recommendations for
Application in Basic Research and Drug Development, Standard
Operation Procedures. Gebhardt R.*, Hengstler J.G.*, Mueller
D.*, Gloeckner R.*, Buenning P.*, Laube B.*, Schmelzer E.*,
Ullrich M., Utesch D., Hewitt N., Ringel M., Reder Hilz B.,
Bader A., Langsch A., Koose T., Burger H.-J., Maas J., and
Oesch F. (*contributed equally to this manuscript). Drug
Metabolism Reviews, 35(2, 3):145-213.
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De Bartolo L, Bader A, Morelli S, Drioli
E, (2001) Evaluation of cell behaviour related to physico-chemical
properties of polymeric membranes to be used in bioartificial
organs, Biomaterials 23 (2002), 2485-2497.
Jasmund I, Bader A, (2002) Bioreactor developments
for Tissue Engineering Applications by the example of the
bioartificial liver. Advances in Biochemcial Éngineering
/ Biotechnology 74, 100-108.
Schmitmeier S, Thole H, Bader A, Bauer K,
(2002) Purification and characterization of the thyrotropin-releasing
hormone (TRH)-degrading serum enzyme and ist identification
as a product of liver origin. E.J. Biochem. 269, 1278-1286,
FEBS.
Jasmund I, Simmoteit R, Bader A, (2002)
Cultivation of primary porcine hepatocytes in an OXY-HFB for
use as Bioartificial Liver. Biotechnology Progress 2002:18,839-46.
Ringel M, Oesch F, Bader A, Gerl M, Klebach
M, Quint M, Tanner B, Dillenburg W, Böttger T, Hengstler
JG, (2002) Permissive and suppressive effects of dexamethasone
on enzyme induction in hepatocyte cultures, Xenobiotica.
Bader A, Schnittmengen der rekonstruktiven
Chirurgie im Bereich der Regenerativen Medizin. Chirurg 2002
73:428 - 434.
De Bartolo L, Bader A, Development of a
hybrid liver-support device. MITAT Journal 2002:11(3)
123-134.
Langsch A, Jasmund I, Bader A.
(2002) Potentials of tissue engineering as an
alternative to organ transplantation. Tx Med 14
(2002): 146-150.
DeBartolo L, Bader A.
(2002)
Flat membrane bioreactor for the
replacement of liver functions. Ernst Schering Res Found
Workshop. 2002;
(35):89-104. Review .
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Moza, AK, Mertsching H, Herden T, Bader A,
Haverich A, (2001) Heart valves from pigs and the porcine
endogenous retrovirus: Experimental and clinical data to assess
the probability of porcine endogenous retrovirus infection
in human subjects. J Thorac Cardiovasc Surg. Apr; 121(4):697-701.
Langsch A, Bader A, (2001) Longterm stability
of phase I and phase II enzymes of porcine liver cells in
flat membrane bioreactors. Biotechnology and Bioengineering
76 (No. 2): 115-125.
Fruhauf NR, Kaiser GM, Nosser SA, Bader A,
Oldhafer KJ, (2001) Large animal models for testing bioartificial
liver support systems. Biomed Sci Instrum;37:511-6.
Hauschild G, Uhr G, Bader A, Meyer-Lindenberg
A, Fehr M, (2001) Einsatz des bioartifiziellen Knochenersatzstoffes
ß-Trikalziumphosphat zur chirurgishen Konsolidierung
einer Pseudarthrose. Kleintierpraxis 46 (8):461-582.
De Bartolo L, Morelli S, Bader A, Drioli
E, (2001) The influence of polymeric membrane surface free
energy on cell metabolic functions, Journal of Materials Science:
Materials in Medicine, 12:959-963.
De Bartolo L, Bader A, Morelli S, Drioli
E, (2001) Membrane Bioartificial Organs: Requirements and
Experimental Approaches La Chimica e l’Industria, Maggio:
1-6.
De Bartolo L, Bader A, Review of a flat
membrane bioreactor as a bioartificial liver. Ann Transplant.
2001; 6 (3):40-6.
Hauschild G, Fehr M, Uhr G, Bader A. (2001) Die zukünftige Bedeutung von tissue Engineering
für die Onkologie. Der Onkologe 7
(10): 1089-1096.
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Bader A, Hansen T, Kirchner G, Allmeling
C, Haverich A, Borlak JT, (2000) Primary porcine enterocyte
spheroidal cultures to study drug oxidation. Brit. J. Pharmacology
129 331-342.
DeBartolo L, Jarosch v. Schweder G, Haverich A, Bader
A, (2000) A novel full-scale flat membrane bioreactor
utilizing porcine hepatocytes: Cell viability and tissue-specific
functions. Biotechnology Progress 16, 102-108.
Hansen T, Borlak J, Bader A, (2000) Cytochrome
P450 activity and protein expression in primary porcine enterocyte
and hepatocyte cultures. Xenobiotica 30:27-46.
Bader A, DeBartolo L, Haverich A, (2000)
High level benzodiazepine and ammonia clearance by flat membrane
bioreactors with porcine liver cells. J Biotechnol 25:95-105.
Bader A, Steinhoff G, Strobl K, Schilling
T, Brandes G, Mertsching H, Tsikas D, Froelich J, Haverich
A, (2000) Engineering of human vascular aortic tissue based on a xenogeneic
starter matrix. Transplantation 70:7-14.
Mertsching H, Karim N, Haverich A, Bader A,
(2000) Investigations on biological saftey and immunologic
aspects of chimeric bioartificial vessels in xenotransplantation.
Transplant Proc 32:1165.
Högemann D, Baumann A, Rocker D, Bader A,
(2000) In vitro model of the human liver parenchyma to study
hepatotoxic side effects of Dy-EOB-DTPA. Investigative Radiology
25:373-379.
Karim N, Allmeling C, Hengstler J-G, Haverich A, Bader
A, (2000) Diazepam metabolism and albumin secretion
of porcine hepatocytes in collagen-sandwich after cryopreservation.
Biotechnol Letters 22:1647-1652.
Teebken OE, Bader A, Steinhoff G, Haverich
A, (2000) Tissue engineering of vascular grafts: Human cell
seeding of decellularised porcine matrix. Eur J Vasc Endovasc
Surg 19:381-386.
Shen, Z-L, Lassner F, Bader A, Becker M,
Walter GF, Berger A, (2000) Cellular activity of resident
macrophages during wallerian degeneration. Microsurgery 20:255-261.
Steinhoff G, Stock U, Karim N, Mertsching H, Timke A, Meliss
R, Pethig K, Haverich A, Bader A, (2000)
Tissue Engineering of pulmonary heart valves on allogeneic
acellular matrix conduits in vivo restoration of valve tissue.
Circulation 102 (19,3):III50-55.
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Shen ZL, Lassner F, Becker M, Walter GF, Bader A,
Berger A, (2000) Viabillity of cultured nerve grafts: An assessment
of proliferation of Schwann cells and fibroblasts. Microsurgery
19:356-363.
pdf
Bader A, Frühauf N, Tiedge M, Drinkgern
M, Zech K, Borlak J, Steinhoff G, Haverich A, (1 0999) Enhanced
oxygen delivery reverses anaerobic metabolic states in prolonged
sandwich rat hepatocyte culture. Exp Cell Res. 246, 221-232.
pdf
Hildebrand H, Schmidt U, Kempka G, Jacob H, Ahr HJ, Ebener
C, Goretzki PE, Bader A, (1999) An in vitro
model for peroxisome proliferation utilizing primary hepatocytes
in sandwich culture. Tox In Vitro 13, 265-273.
pdf
Karim N, Mertsching H, Haverich A, Bader A,
(1999) Human vascular cells create new matrix when seeded
into acellularized porcine aorta. Medical and Biological Engineering
and Computing 37(2):596.
pdf
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Jura H, Bader A, Frosch M, In-vitro activity
of benzimidazoles against Echinococcus multilocularis metacestodes.
(1998) Antimicrobial Agents and Chemotherapy 42, 1052-1056.
pdf
Bader A, Schilling T, Teebken O, Brandes
G, Steinhoff G, Haverich A, (1998) Tissue engineering of heart
valves - human endothelial cell seeding of detergent acellularized
porcine valves. EJ Cardiovasc Surg 14, 279-284.
pdf
Bader A, Frühauf N, Zech K, Haverich
A, Borlak J, (1998) Development of a small scale bioreactor
for drug metabolism studies maintaining hepatospecific functions.
Xenbiotica 28, 815-825.
pdf
Fahrig R, Rupp M, Steinkamp-Zucht A, Bader A,
(1998) Use of primary rat and human hepatocyte sandwich cultures
for activation of indirect carcinogens: Monitoring of DNA
strand breaks and gene mutations in co-cultured cells. Tox
in vitro. 12, 431-444.
pdf
Lampen A, Bader A, Bestmann T, Winkler M,
Witte L, Sewing K-F, Borlak JT, (1998) Catalytic activities,
protein- and mRNA-expression of cytochrome P450 isoenzymes
in intestinal cell lines. Xenobiotica 28, 429-441.
pdf
McCully S, Cameron GA, Bader A, Hawksworth
G, Borlak J, (1998) In vitro investigations of the interaction
between terfenadine and tedisamil in human liver microsomes.
Xenobiotica 28, 219-223.
pdf
Reimer P, Bader A, Weissleder, (1998) Preclinical
assessment of hepatocyte-targeted MR contrast agents in stable
human liver cell cultures. JMRI. 3, 687-689.
pdf
Teebken OE, Bader A, Steinhoff G, Haverich
A, A new concept for substitutes in vascular surgery. (1998)
Langenbecks Arch Chir Suppl Kongressbd 115, 1256-9.
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Kern A, Bader A, Pichlmayr R, Sewing K-F,
(1997) Drug metabolism in hepatocyte sandwich cultures of
rats and humans. Biochem Pharmacol. 54, 761-772. Felix-Wankel
Forschungspreis 1996.
pdf
Reimer P, Bader A, Weissleder R, (1997)
Application of a stable cell culture assay for the functional
assessment of novel MR contrast agents. Eur Radiol. 7, 527-531.
pdf
Weinhold B, Bader A, Poli V, Rüther
U, (1997) Interleukin-6 is necessary but not sufficient, for
the induction of the human C-reactive protein in vivo. Biochem
J. 325, 617-621.
pdf
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Bader A, Knop E, Böker KHW, Crome
O, Frühauf N, Gonschior A, Christians U, Esselman H,
Pichlmayr R, Sewing KF, (1996) Tacrolimus (FK 506) metabolism
in primary rat hepatocytes depends on extracellular matrix
geometry. NS Arch Pharm. 353, 461-473. Felix-Wankel Forschungspreis
1996.
pdf
Bader A, Knop E, Kern A, Boker K, Frühauf
N, Crome O, Esselmann H, Pape C, Kempka G, Sewing K-F, (1996)
3-D coculture of hepatic sinusoidal cells with primary hepatocytes-Design
of an organotypical model. Exp Cell Res. 226, 223-33. Felix-Wankel
Forschungspreis 1996.
pdf
Christians U, Bleck JS, Lampen A, Bader A,
Thiesemann C, Kliem V, Repp H, Westhoff BM, Manns M, Sewing
KF, (1996) Are cytochrome P450 3A enzymes in the small intestine
responsible for different cyclosporine metabolite patterns
in stable male and female renal allograft recipients after
co-administration of diltiazem? Transplant Proc. 28, 2159-61.
pdf
Christians U, Schmidt G, Bader A, Lampen
A, Schottmann R, Linck A, Sewing K-F, (1996) Identification
of drugs inhibiting the in vitro metabolism of tacrolimus
by human liver microsomes. Br J Clin Pharmacol. 41, 187-196.
pdf
Frühauf N, Bader A, Crome O, Steinhoff
G, Haverich A, Pichlmayr R, (1996) Rapamycin biotransformation
in primary rat sandwich hepatocytes. Exp Toxic Pathol. 48,
137-142.
pdf
Jura H, Bader A, Hartmann M, Maschek H.
Frosch M, (1996) Hepatic tissue culture model for study of
host-parasite interactions in alveolar echinococcosis. Infect
Immun. 64, 3484-90.
pdf
Lampen A, Christians U, Bader A, Hackbarth
I, Sewing K-F, (1996) Drug interactions and interindividual
variability fo the small intestinal metabolism of ciclosporin.
Pharmacology. 52, 159-168.
pdf
Lampen A, Christians U, Gonschior AK, Bader A,
Hackbarth I, Engelhardt W, Sewing K-F, (1996) Metabolism of
the macrolide immunosuppressant tacrolimus in the pig gut
mucosa in the ussing chamber. Br J Pharmacology. 117, 1730-1734.
pdf
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Bader A, Knop E, Böker K, Frühauf
N, Schüttler W, Oldhafer K, Pichlmayr R, Sewing K-F,
(1995) A novel bioreactor design for in vitro reconstruction
of in vivo liver characteristics. Artif Organs. 19, 368-374.
pdf
Bader A, Knop E, Fruhauf N, Crome O, Boker
K, Christians U, Oldhafer K, Ringe B, Pichlmayr R, Sewing
K-F, (1995) Reconstruction of liver tissue in vitro: geometry
of characteristic flat bed, hollow fiber, and spouted bed
bioreactors with reference to the in vivo liver. Artif Organs.
19, 941-50.
pdf
Bader A, Reimer P, Knop E, Christians U,
Weissleder R, Sewing K-F, (1995) An organotypical in vitro
model of the liver parenchyma for uptake studies of diagnostic
MR receptor agents. Magn Res Imaging. 13, 991-996.
pdf
Bader A, Reimer P, Knop E, Weissleder R,
Sewing K-F, (1995) Receptor mediated endocytosis in matrix
overlaid primary hepatocytes. J Exp Clin Cancer Res. 14, 185-7.
pdf
Christians U, Kohlhaw K, Surig T, Bader A,
Schottmann R, Linck A, Ringe B, Sewing K-F, (1995) Parallel
blood concentrations of second-generation cyclosporine metabolites
and bilirubin in liver graft recipients. Ther Drug Monit.
17, 487-98.
pdf
Knop E, Bader A, Böker K, Pichlmayr
R, Sewing K-F, (1995) Ultrastructural and functional differentiation
of hepatocytes under long-term culture conditions. Anatomical
Record. 242, 337-349.
pdf
Lampen A, Christians U, Guengerich FP, Watkins PB, Kolars
JC, Bader A, Gonschior AK, Dralle H, Hackbarth
I, Sewing K-F, (1995) Metabolism of the immunosuppressant
tacrolimus in the small intestine: cytochrome P450, drug interactions,
and interindividual variability. Drug Metab Dispos. 23, 1315-24.
Best Paper Award of the American Society for Pharmacology
and Experimental Therapeutics 1995.
pdf
Melzig MF, Wobus AM, Muller KW. Breitkreutz D, Werner S,
Boukamp P, Bader A, Niehrs C, Fusenig NE,
(1995) International conference on cell interactions in malignancy,
development and differentiation. J Cancer Res Clin Oncol.
121, 757-63.
pdf
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Bader A, Zech K, Crome O, Christians U,
Pichlmayr R, Sewing K-F, (1994) Use of organotypical cultures
of primary hepatocytes to analyze drug biotransformation in
man and animals. Xenobiotica. 24, 623-633. Forschungspreis
des Bundesgesundheitsministers 1993 für die Entwicklung
von Alternativmethoden für Tierversuche.
pdf
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Christians U, Spiekermann K, Bader A, Schottmann
R, Linck A, Wonigeit K, Sewing K-F, Link, H. (1993) Cyclosporine
metabolite pattern in blood from patients with acute GVHD
after BMT. Bone Marrow Transplant. 12, 27-33.
Closs EI, Rinkes IH, Bader A, Yarmush ML,
Cunningham JM, (1993) Retroviral infection and expression
of cationic amino acid transporters in rodent hepatocytes.
J Virol. 67, 2097-102.
Bader A, (1993) Leberzellkulturen: Anspruch
und Wirklichkeit. In-vitro-Systeme. 9-10.
Bader A, Böker K, Christians U, Crome
O, Frühauf N, Manns M, Pichlmayr R, Sewing K-F, (1994)
Organotypical culture conditions for primary hepatocytes.
Transplantationsmedizin. 6, 11-13.
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Bader A, Rinkes IHB, Closs IE, Ryan CM,
Toner M, Cunningham JM, Tompkins GR, Yarmush ML, (1992) A
stable long-term hepatocyte culture system for studies of
physiologic processes: Cytokine stimulation of the acute phase
response in rat and human hepatocytes. Biotechnol Prog. 8,
219-225. Renate and Hans Lettre Fortbildungsstipendium der
Deutschen Sektion der European Tissue Culture Society.
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Bader A, Carrigan T, Gopalswamy N, Truelzsch
DV, (1989) Reversible hematologic suppression during ranitidine
treatment. Drugs Int Clin Pharm. 23, 507-508.
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