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Ronny Schulz
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Dr. rer nat. Dipl.-Ing. (FH) Ronny Schulz
Contact
Current activity
Research projects
Ronny Schulz’s research interests are mainly related to cartilage
tissue and its unique biomechanical and mechano-biological
properties as well as the conception of novel strategies for GMP-compliant
bioreactor systems for the manufacture of three-dimensional
artificial cartilage grafts.
His interest in cartilage tissue began in the year 2000 when he
sustained a focal cartilage lesion in his left knee and discovered
that no adequate therapy existed. He then did an internship at
Co.don AG, the first commercial manufacturer of ACT (autologous
chondrocyte transplantation) therapy in Germany, where his research
focus included the evaluation of beneficial effects of
electromagnetic fields on human periosteal cells. Ronny Schulz
received the Diploma degree in Chemical Engineering and a focus in
Biotechnology with the thesis "Development of a bioreactor system
for an in vitro cultivation and stimulation of human
chondrocytes", which was funded by 5th FP - Project “IMBIOTOR – a
machine to process tissue engineered implants”. For his Ph.D. thesis
with the topic “Advanced Tools for Articular Cartilage Tissue
Engineering: Bioreactors, Monitoring, Scaffolds, and Defect Model”,
he performed his research at the University of Leipzig with multiple
interdisciplinary projects.
Since 2006 he has led “Cartilage / Bone Group” in a cooperative
(funded by
Federal Ministry of Education and Research of Germany) project with
a focus on the
“Multiparametric Monitoring and Steering of Mesenchymal Stem
Cell-derived Cartilage Formation in 3D Production Systems“.
His
research focus also includes the monitoring of extracellular matrix
components in autologous cartilage implants with novel and
established techniques and methodologies,
namely 13C-NMR-MAS spectroscopy, MALDI-TOF mass spectrometry and
ultrasound biomicroscopy.
In parallel he established, together with surgeons of the Medical
Faculty of Leipzig, a
large animal model on merino sheep. This model uses a chronic,
focal osteochondral defect in stifle joints to represent the similar
aetiology and pathogenesis as seen at the human femoral condyle.
Randomised preclinical studies using this model for matrix-coupled
ACT have shown similar outcomes to human cases.
Since 2009 and 2011 he has been the principal investigator and study
director
in
the
TRM
(Translational Centre for Regenerative Medicine Leipzig) funded
projects
“Evaluation of tissue engineered MSC-based MACT in a GLP-study”
and
“Establishing the human MSC-based MACT as an Advanced Therapy
Medicinal Product (ATMP)”, respectively.
The aim of these preclinical studies is the development and
evaluation of autologous MSC-based cartilage grafts as a cell-based
medicinal product for the repair of focal osteochondral defects.
Curriculum vitae
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July, 1996 |
School Leaving Examination ("Abitur") |
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09/96-07/97 |
Military service; Electrical Engineering – Instructor at the
Repair Instruction Company in Weißenfels |
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01/98-08/98 |
CNC– Technician |
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09/98-02/02 |
Undergraduate student of Chemistry engineering, University
of applied sciences Lausitz, Senftenberg |
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03/02-03/03
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Diploma thesis, Institute of Anatomy, Medical Faculty of the
Eberhard Karls University Tuebingen and German Research
Center for Biotechnology, Braunschweig
Diploma thesis: "Development of a bioreactor system for an
in-vitro cultivation and stimulation of human chondrocytes"
University of applied sciences Lausitz, Senftenberg, 2003 |
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04/03-05/03 |
Scientific Employee in the
5th FP-Project “IMBIOTOR – a
machine to process tissue engineered implants”,
Institute of Anatomy, Medical Faculty of the Eberhard Karls
University Tuebingen |
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06/03-01/04 |
Scientific Employee in the
5th FP-Project “IMBIOTOR – a
machine to process tissue engineered implants”,
Professorship `Cell Techniques and Applied Stem Cell
Biology´, Medical Faculty of the University of Leipzig
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01/04-12/06 |
Scientific Employee in the
Project “NMR quality control / quality assurance (QC/QA)-Analysis
for autologous cartilage implants”, Professorship `Cell
Techniques and Applied Stem Cell Biology´,
Medical Faculty of the University of Leipzig |
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01/05-12/05 |
Scientific Employee in the `Formel
1´-Project “In vitro - Regeneration of articular cartilage
in a bio-reactor and Re-implantation into animal model for
the reconstruction of traumatic focal cartilage defects”,
Professorship `Cell Techniques and Applied Stem Cell
Biology´,
Medical Faculty of the University of Leipzig |
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since
08/06 |
Leader
of the bioreactor group in the BMBF project „Multiparametric
Monitoring and Steering of Mesenchymal Stem Cell derived
Cartilage Formation in 3D Production Systems”,
Professorship `Cell Techniques and Applied Stem Cell
Biology´,
Medical Faculty of the University of Leipzig |
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since 11/07 |
Scientific
co-investigator in the DFG Project “Analysis of
extracellular matrix in artificial cartilage” at the
Professorship `Cell Techniques and Applied Stem Cell
Biology´, Medical Faculty of the University of Leipzig |
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05/06-10/08 |
PhD thesis at
the Professorship `Cell Techniques and Applied Stem Cell
Biology´, Medical Faculty of the University of Leipzig with
the topic “Advanced Tools for Articular Cartilage Tissue
Engineering: Bioreactors, Monitoring, Scaffolds, and Defect
Model” |
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01/09-12/09 |
Overseas
visiting scientist of the Royal Society-funded
Project “Effects of the collagen fragments and mechanical
loading in chondrocytes" of Dr. T. T. Chowdhury, Queen Mary
University of
London.
Professorship `Cell
Techniques and Applied Stem Cell Biology´, Medical Faculty
of the University of Leipzig. |
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01/09-03/11 |
Principal
Investigator in a TRM-(Translational Centre for Regenerative
Medicine Leipzig) funded
Project
„Evaluation of
tissue engineered mesenchymal stem cells-based autologous
cartilage transplants in a GLP-study”.
Professorship `Cell
Techniques and Applied Stem Cell Biology´, Medical Faculty
of the University of Leipzig. |
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since 04/11 |
Principal
Investigator in a TRM-(Translational Centre for Regenerative
Medicine Leipzig) funded
Project
„Establishing
the human MSC-based MACT as an Advanced Therapy Medicinal
Product (ATMP)”.
Professorship `Cell
Techniques and Applied Stem Cell Biology´, Medical Faculty
of the University of Leipzig. |
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since 07/12 |
Principal Investigator
in a ERDF (European Regional Development Fund)-funded
Projekt „Development and validation of a platform technology
for intraoperative sorting and application of CD271+
mesenchymal stromal cells (MSCs) using the example of the
treatment of hyaline cartilage lesions“. |
Thesis supervisor
“Tissue Engineering of
articular cartilage substitutes in whole blood and blood plasma
constructs”, Doctoral thesis Marcus J. Haberhauer
"Determination of the role of
integrin α5β1
in ECM gene expression by chondrocytes embedded in agarose gel, in
response to dynamic compression", Master thesis Linda M. Kock
"Techniques to stimulate and
measure cartilaginous material in a bioreactor", Diploma thesis Nico
Wüstneck
"Design and
implementation of an automated mini-bioreactor", Diploma thesis
Christian Müller
"Automation and process visualization of a
biotechnological plant", Master thesis Nico Wüstneck
„Development of an
Embedded System based on an ARM9-Processor of Atmel",
Master thesis
Christian Müller
"Design of an embedded control system for a bioreactor",
Master thesis Matthias Stark
Publications
Zscharnack M,
Hepp
P, Richter R, Aigner T, Schulz R, Somerson J, Josten
C, Bader
A, Marquass B. Repair of Chronic Osteochondral Defects Using
Predifferentiated Mesenchymal Stem Cells in an Ovine Model.
Am J Sports Med. 2010 Sep;38(9):1857-69. Epub 2010 May 27
Marquass B, Schulz RM, Hepp P, Zscharnack M, Aigner T, Schmidt S,
Stein F, Richter R, Osterhoff G, Aust G, Josten C, Bader A.
Matrix-associated implantation of predifferentiated mesenchymal stem
cells versus articular chondrocytes: in-vivo results of cartilage
repair after one year. American Journal of Sports Medicine,
doi:10.1177/0363546511398646.
Galle J, Bader A, Hepp, P, Grill W, Fuchs B, Käs JA, Krinner A,
Marquaß B, Müller K, Schiller J, Schulz RM, von Buttlar M, von der
Burg E, Zscharnack M, Löffler M. Mesenchymal Stem Cells in Cartilage
Repair: State of the Art and Methods to monitor Cell Growth,
Differentiation and Cartilage Regeneration. Current Medicinal
Chemistry, 17 (21), 2274-2291, (2010).
Zscharnack M, Hepp P., Richter R, Aigner T, Schulz RM, Somerson JS,
Josten C, Bader A, and Marquass B. Repair of chronic osteochondral
defects using pre-differentiated mesenchymal stem cells in an ovine
model. American Journal of Sports Medicine, 38 (9), 1857-1869,
(2010).
Marquass B, Somerson JS, Hepp P, Aigner T, Schwan S, Bader A, Josten
C., Zscharnack M, Schulz RM. A novel MSC-seeded triphasic construct
for the repair of osteochondral defects. Journal of Orthopaedic
Research, 28(12), 1586-99, (2010).
Chowdhury TT, Schulz RM, Rai SS, Thuemmler C, Bader A, Homandberg
GA. Biomechanical modulation of collagen fragment induced anabolic
and catabolic activities in chondrocyte / agarose constructs.
Arthritis Research & Therapy, 12 (3), R82, (2010).
Scheidt HA, Schibur S, Magalhäes A, de Azevedo ER, Bonagamba TJ,
Pascui O, Schulz RM, Reichert D, Huster D. The mobility of
chondroitin sulfate in articular and artificial cartilage
characterized by 13C magic-angle spinning NMR spectroscopy.
Biopolymers, 93 (6), 520-532, (2010).
Kock LM; Schulz RM; van Donkelaar CC; Thümmler CB; Bader A; Ito K.
RGD-dependent integrins are mechanotransducers in dynamically
compressed tissue-engineered cartilage constructs. Journal of
Biomechanics, 42(13), 2177-82, (2009).
Hepp P, Osterhoff G, Niederhagen M, Marquass B, Aigner T, Bader A,
Josten C, Schulz RM. Perilesional changes of focal osteochondral
defects in an ovine model and their relevance to human osteochondral
injuries. Journal of Bone and Joint Surgery - British Volume, 91(8),
1110-1119, (2009).
Schulz RM, Wüstneck N, van Donkelaar CC, Shelton J, Bader A.
Development and validation of a novel bioreactor system for load-
and perfusion-controlled tissue engineering of
chondrocyte-constructs. Biotechnology and Bioengineering, 101(4),
714-728, (2008).
Haberhauer M, Zernia G, Deiwick A, Pösel C, Bader A, Huster D,
Schulz RM. Cartilage Tissue Engineering in Plasma and Whole Blood
Scaffolds. Advanced Materials, 20(11), 2061-67, (2008).
Schulz RM, Zscharnack M, Hanisch I, Geiling M, Hepp P, Bader A.
Cartilage Tissue Engineering by Collagen Matrix Associated Bone
Marrow Derived Mesenchymal Stem Cells. Bio-Medical Materials and
Engineering, 18(1), 55-70, (2008).
van Donkelaar CC and Schulz RM. Review on Patents for Mechanical
Stimulation of Articular Cartilage Tissue Engineering. Recent
Patents on Biomedical Engineering, 1(1), 1-12, (2008).
Schulz RM and Bader A. Cartilage tissue engineering and bioreactor
systems for the cultivation and stimulation of chondrocytes.
European Biophysics Journal, 36(4-5), 539-68 (2007).
Schulz RM, Höhle S, Zernia G, Zscharnack M., Schiller J., Bader A,
Arnold K, Huster D. Analysis of the production of extracellular
matrix in artificial cartilage constructs by histology,
immuncytochemistry, mass spectrometry, and NMR spectroscopy. Journal
of Nanoscience and Nanotechnology, 6(8), 2368-2381, (2006).
Hepp P, Bader A, Josten C, Rose T, Schulz RM. Tissue engineering von
Knorpelzellen. Arthroskopie, 18(3), 233–238, (2005).
Patents
DE10349484A1: „Verfahren und Bioreaktor zum Kultivieren und
Stimulieren von dreidimensionalen, vitalen und mechanisch
widerstandsfähigen Zelltransplantaten “,
25.05.2005
WO2005040332A3: “Method
and bioreactor for the cultivation and stimulation of
three-dimensional vital and mechanically resistant cell transplants”,
06.05.2005
Conference Proceedings
B
Marquaß, P Hepp, S Schmidt, F Stein, A Bader, C Josten, M
Zscharnack, RM Schulz. Chondrogenic predifferentiation of ovine
mesenchymal stem cells leads to a better histological repair of
chronic osteochondral defects after one year in a sheep model.
Langenbeck's Archives of Surgery, 394(5), 915-970, (2009).
Marquass B, Hepp P, Richter R, Schmidt S, Stein F, Bader A, Josten
C, Zscharnack M, Schulz RM. “Regeneration of chronic focal cartilage
defects using autologous mesenchymal stem cells”. Saxon
Biotechnology Symposium 2009, 26th May 2009. ISBN 978-3-00-027884-6.
p.179
Schulz RM,
Wuestneck N, Bader A (2008).
Bioreactor system for
bioengineered cartilage grafts. Tissue Engineering. Volume 14(5):
815
Schulz RM, Proceedings of 3rd World Congress on Regenerative
Medicine.
18th-20th October, 2007, Leipzig, Germany. ISSN 1746-0751.
Regenerative Medicine (2007). Volume 2, No. 5, p.600, 625, 629,
631, 642, 682, 683.
Schulz RM. 6th Leipzig Research Festival for Life Sciences. 14th
December 2007.
ISBN: 3-9810760-2-8. p.77, 285.
Schulz RM. 5th Leipzig Research Festival for Life Sciences. 15th
December 2006.
ISBN: 3-9810760-1-X. p.13, 63, 68.
Schulz RM, Bioreaktorsystem für die Generierung von
Knorpeltransplantaten.
13. Heiligenstädter Symposium « Technische Systeme für
Biotechnologie und Umwelt ».
25-27. September 2006.
ISBN
978-3-00-018621-9. p.57-59.
Schulz RM. 5th Biotechnology Symposium of the University of Leipzig.
18th-19th May 2006. p.223, 233.
Schulz RM, Zscharnack M, Hepp P, Josten C, Bader A. Chondrogenesis
of ovine
chondrocytes in a collagen gel for the regeneration of an
osteochondral defect in femur condyles of Merino sheep. ISSN
1465-3249. Cytotherapy (2006). Volume 8, Suppl. 2, p.55.
M.
Zscharnack, RM. Schulz, P. Hepp, I. Hanisch, A. Bader (2006)
Chondrogenic differentiation of
ovine mesenchymal stem cells in a collagen gel for the regeneration
of a focal articular cartilage defect in an ovine model. ISSN
1465-3249. Cytotherapy (2006). Volume 8, Suppl. 2, p.57.
Schulz RM. 4th Leipzig Research Festival for Life Sciences. 16th
December 2005.
ISBN: 3-9810760-0-1. p.71, 78, 80, 219.
Schulz RM, Zscharnack M, Haberhauer M, Deiwick A, Bader A. Novel
bioreactor for
simultaneous stimulation and cultivation of 3-dimensional cell
constructs. Journal of Artificial Organs (2005). Volume 28,
No. 4/2005.
Schulz RM. 4th Biotechnology Symposium of the University of Leipzig.
3rd June 2005. p.182, 187.
Schulz RM. 3rd Leipzig Research Festival for Life Sciences. 10th
December 2004.
ISBN: 3-00-015269-5. p136.
Schulz RM. 3rd Biotechnology Symposium of the University of Leipzig.
19th May 2004. p.42, 206, 207.
Schulz RM, Deiwick A, Bader A. CFD-analysis of a flow perfusion
bioreactor model for the regeneration of 3D-cartilage implants.
Journal of Artificial Organs (2003). Volume 26, No. 9/2003.
Invited Presentations
“Mechanical stimulation to mimic the in vivo environment: biological
view”. Conference on Biophysical stimuli and mass transport for
tissue development; implications for in vitro model systems. Lattrop,
The Netherlands. 18th and 19th November 2010.
“Preclinical safety requirements for the approval of cell-based
medicinal products – Demonstration of the safety testing concept at
Fraunhofer IZI and TRM Leipzig”.
Fraunhofer Life Science Symposium. Leipzig. 29th and 30th October
2010.
„Evaluierung einer MSC-basierten MACT zur Knorpelregeneration in
einer randomisierten, doppelverblindeten GLP-Studie am Großtier“.
Deutscher Kongress für Orthopädie und Unfallchirurgie; Berlin.
26.–29. Oktober 2010.
„Synoviale Veränderungen nach osteochondraler Defektsetzung und
deren Verlauf unter dem Einfluss unterschiedlicher
Behandlungsstrategien“. Deutscher Kongress für Orthopädie und
Unfallchirurgie; Berlin. 26.–29. Oktober 2010.
“Evaluation of a MSC-based MACT for cartilage repair in a large
animal model by a randomized double blinded GLP-study”. 27th AGA
Congress. German Speaking Association of Arthroscopy (AGA). Wien,
Austria. 9th-11th September 2010.
“Bioreactor strategies for Skeletal Tissue Engineering” Graduate
School BuildMoNa. Scientific and method module “Hybrid Systems”.
Leipzig, Germany. 03rd February 2009
"Comparative in vitro study on the behavior of ovine chondrocytes
and bmMSCs in a clinical approved MACT scaffold“.
26th AGA Congress. German Speaking Association of Arthroscopy (AGA).
Leipzig, Germany. 17th-19th September 2009
”Ergebnisse zur Therapie von fokalen osteochondralen
Gelenkknorpeldefekten am Großtiermodell”. Tissue Engineering –
Knorpel II, Experimentelles Forum. Deutscher Kongress für Orthopädie
und Unfallchirurgie. Berlin. 02.-06. Oktober 2006
”Bioreaktorsystem für die Generierung von Knorpeltransplantaten”.
13. Heiligenstädter Symposium « Technische Systeme für
Biotechnologie und Umwelt ». Institut für Bioprozess- und
Analysenmesstechnik e.V.. Heiligenstadt. 25.-27. September 2006
”Membranen und Materialen für Zellkultursysteme für
regenerativ-therapeutische Anwendungen an ausgewählten Beispielen”.
150 Jahre VDI - Arnold Sommerfeld Schule, Symposium des VDI Leipzig,
der ASG und der HTWK Leipzig.
Leipzig. 29.09.2006
”Regeneration of Bone: From bench to bed-side, Potential of stem
cells”.
Deutsche Gesellschaft für Implantologie / Arbeitskreis Implantologie
Sachsen. Mortka.
06. September 2006
”Bioreactor systems for the regeneration of cartilage-grafts”.
3rd international meeting on medical engineering and therapy,
Université Henri Poincaré, Faculté de Médecine. Nancy. 15th-16th May
2006
“Biomechanic Aspects of Cartilage Tissue Engineering“.
Fraunhofer-Institut für Werkstoffmechanik IWM. Halle. 02. Mai 2006
„Möglichkeiten und Perspektiven von Bioreaktoren zur Regeneration
autologer Chondrozytentransplantate“. 22. Workshop & Symposium für
Experimentelle Osteologie „Die Zukunft des Knochentransplantates:
Klinische und rechtliche Aspekte“. Deutsche Gesellschaft für
Osteologie e.V. / Arbeitskreis Experimentelle Osteologie. Halle.
03.-05. Juni 2005
Vorstellung der Projektes "Kooperationsverbund von Wissenschaft,
Wirtschaft (KMU) und Anwendern in der Wirtschaftsregion Leipzig,
Sachsen zur industriellen Umsetzung von Ergebnissen der
biotechnologischen Grundlagen- und angewandten Forschung".
„Entwicklung und Prozessautomation eines modularen
Bioreaktor-systemes zur autologen Knorpelregeneration“. Mechatronik
in der Automatisierungstechnik. Leipzig. 28. April 2005
„Entwicklung eines modularen Bioreaktorsystemes zur autologen
Knorpelregeneration“.
Doktoranden-Kolloquium, BBZ. Leipzig. 11. Mai 2005
“Aspects of design in an intelligent mini bioreactor with perfusion
and mechanical stimulation” 1st World Congress on Regenerative
Medicine, Leipzig. 22nd October 2003
Poster award
”Etablierung eines Großtiermodells chronischer focaler
osteochondraler Defekte am Kniegelenk zur Evaluierung
matrixgekoppelter autologer Transplantationsverfahren”
P. Hepp,
M. Niederhagen, G. Osterhoff, B. Marquass, T. Rose, C. Josten, R.
Schulz
23. AGA
Kongress, Salzburg,
29th
September 2006
Posters
“Outcomes of Pre-differentiated Mesenchymal Stem Cell-seeded
Hydrogel Implants in Cartilage Lesions”
Schulz RM, Somerson JS, Zscharnack M, Hepp P, Richter R, Josten C,
Bader A, Marquass B.
2010 Biomedical Engineering Society. Austin, Texas.
6th-9th October 2010.
“Pre-differentiation of mesenchymal stem cells improves cartilage
regeneration for treatment of chronic osteochondral lesions”.
Somerson JS, Marquass B, Hepp P, Richter R, Aigner T, Josten C,
Bader A, Zscharnack M, Schulz RM.
2010 International Cartilage Repair Society. Sitges/Barcelona,
Spain.
26th-29th September 2010.
"Biomechanical modulation of collagen fragment induced anabolic and
catabolic activities in chondrocyte / agarose constructs".
Chowdhury TT, Schulz RM, Rai SS, Thuemmler C, Wuestneck N, Bader A,
Homandberg GA.
2010 World Congress on Osteoarthritis. Brussels, Belgium.
23rd-26th September 2010.
“Tissue
Engineering of Artificial Cartilage in Plasma and Whole Blood based
Scaffolds”.
Haberhauer M, Schulz RM, Zernia G, Huster D, Bader A.
26th AGA Congress. German Speaking Association of Arthroscopy (AGA).
Leipzig, Germany.
17th-19th September 2009
“Regeneration of chronic focal cartilage defects using autologous
mesenchymal stem cells”
Marquass B, Hepp P, Richter R, Schmidt S, Stein F, Bader A, Josten
C, Zscharnack M, Schulz RM
Saxon Biotechnology Symposium 2009, Leipzig, Germany,
26th May 2009
"Bioreactor for combinatory studies of perfusion and mechanical
loading on 3D cartilage-grafts"
Schulz RM, Wuestneck N, Bader A.
16th Congress of the European Society of Biomechanics, Lucerne,
Switzerland,
06-09 October 2008
"Bioreactor system for bioengineered cartilage grafts"
RM. Schulz, N. Wuestneck, A. Bader
TERMIS-EU 2008 Annual Meeting,
Porto, Portugal,
22-26
June 2008
"Development of a bioreactor system for the regeneration of 3D
cartilage-grafts”
R. Schulz, N. Wuestneck, M. Zscharnack, A. Bader
3rd World
Congress on Regenerative Medicine, Leipzig,
17-20 October 2007
"Determination of the role of Integrin α5β1 in cartilaginous ECM
gene expression by chondrocytes embedded in agarose gel, in response
to dynamic compression"
L.M. Kock, C. Thümmler, R. Schulz, C.C. van Donkelaar, A. Bader
3rd World
Congress on Regenerative Medicine, Leipzig,
17-20 October 2007
"In-vitro comparison of collagen based MACTs produced from ovine
chondrocytes and bmMSCs"
R. Schulz, M. Zscharnack, P. Hepp, A. Bader
2nd Congress of the German Society for Stem
Cell Research, Würzburg
4-6 October 2007
”Chondrogenic
differentiation of ovine mesenchymal stem cells in a collagen gel
for the regeneration of a focal articular cartilage defect in an
ovine model”
M. Zscharnack,
R. Schulz, P. Hepp,
I. Hanisch, A. Bader
Strategies in Tissue
Engineering, Würzburg,
31.05-02.06.2006
”Chondrogenesis of
ovine chondrocytes in a collagen gel for the regeneration of an
osteochondral defect in femur condyles of Merino sheeps”
R.
Schulz, M. Zscharnack, P. Hepp, C. Josten, A. Bader
Strategies in Tissue
Engineering, Würzburg,
31.05-02.06.2006
"Effect of initial seeding density of mesenchymal stem cells
in collagen gel on contraction, proliferation and chondrogenic
differentiation”
M. Zscharnack, R.
Schulz, P. Hepp P, A. Bader
5th
Biotechnology Symposium of the University of Leipzig; Leipzig,
18th
May 2006
"Chondrogenesis
and proliferative behaviour of ovine chondrocytes in matrix-induced
autologous chondrocyte transplantats and their clinical outcome"
R. Schulz, M.
Zscharnack, I. Hanisch, M. Geiling, P. Hepp, A. Bader,
5th Biotechnology
Symposium of the University of Leipzig; Leipzig,
18th May 2006
"Investigation of the Dynamics of the Macromolecules in Articular
and Tissue Engineered Cartilage by NMR Spectroscopy "
G.
Zernia, S. Höhle, R. Schulz, M. Zscharnack, A. Bader, J. Schiller,
K. Arnold, and D. Huster
49th
Meeting of the American Biophysical Society, Long Beach, USA,
February 2005
“Investigation of the Dynamics of the Macromolecules in
Articular and Tissue Engineered Cartilage by NMR Spectroscopy”
G. Zernia, S. Höhle, R. Schulz, M. Zscharnack, A. Bader, J.
Schiller, K. Arnold, D. Huster
4th
Leipzig Research Festival for Life Sciences, Leipzig,
16th December 2005
“Chondrogenic differentiation of mesenchymal stem cells in
three-dimensional collagen gel cultures for the application in
tissue engineering”
M. Zscharnack, R. Schulz, I. Hanisch, P. Hepp, M. Geiling, A.
Bader
4th
Leipzig Research Festival for Life Sciences, Leipzig,
16th December 2005
„Etablierung eines Großtiermodells fokaler osteochondraler
Defekte am Kniegelenk zur Therapie mittels tissue engineertem
Knorpel“
P. Hepp P, G. Osterhoff G, S. Öllers, A. Van Linden, M.
Niederhagen, M. Marquass, R. Schulz, A. Bader, C. Josten
4th
Leipzig Research Festival for Life Sciences, Leipzig,
16th December 2005
“Bioreactor system for the cultivation of MACT-grafts”
R. Schulz, M. Zscharnack, N. Wüstneck, C. Müller, A. Bader
4th
Leipzig Research Festival for Life Sciences, Leipzig,
16th December 2005
“Novel bioreactor for simultaneous stimulation and
cultivation of 3-dimensional cell constructs”.
R. Schulz, A. Deiwick, N. Wüstneck, C. Müller, A. Bader
4th Biotechnology Symposium of the University of Leipzig;
Leipzig, 3rd June 2005
“Investigation of the dynamics of the macromolecules in
articular and tissue engineered cartilage by NMR spectroscopy”.
G. Zernia, S. Höhle, R. Schulz, M. Zscharnack, A. Bader, J.
Schiller, K. Arnold, D. Huster
4th Biotechnology Symposium of the University of Leipzig;
Leipzig,
3rd June 2005
“Novel bioreactor for simultaneous stimulation and
cultivation of 3-dimensional cell constructs”.
R. Schulz, M. Zscharnack, M. Haberhauer, A. Deiwick, A. Bader
2nd World
Congress on Regenerative Medicine, Leipzig,
18-20 May 2005
”Novel bioreactor for simultaneous stimulation and
cultivation of 3-dimensional cell constructs”.
R. Schulz, M. Zscharnack, M. Haberhauer, A. Deiwick, A. Bader
Bioperspectives 2005, Wiesbaden, 10-11th May 2005
“CFD-analysis of a flow perfusion bioreactor for the
regeneration of 3D-cartilage implants”.
R. Schulz, A. Deiwick, A.Bader
3rd Biotechnology Symposium of the University of Leipzig,
Leipzig, 19th May 2004
“Development of an intelligent bioreactor (Imbiotor)”.
R.
Schulz, A. Bader, J. Shelton, P. Netti, C. Oomens, V. Kunert
3rd Biotechnology Symposium of the University of Leipzig, Leipzig,
19th May 2004
“Investigation of the dynamics of the macromolecules in
articular and tissue engineered cartilage by NMR spectroscopy”.
D. Huster, S. Höhle, G. Zernia, R.Schulz, A.Bader, J.
Schiller, K. Arnold
3rd Biotechnology Symposium of the University of Leipzig,
Leipzig, 19th May 2004
“CFD-analysis of a flow perfusion bioreactor model for the
regeneration of 3D-cartilage implants”.
R. Schulz, A. Deiwick, A., Bader
1st World Congress on Regenerative Medicine, Leipzig,
22.10.2003
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