Cell Techniques and Applied Stem Cell Biology



Recent Publications




















Temnov A, Rogov K, Zhalimov V, Popov I, Pekov S, Bader A, Skifas A, Giri S. The effect of mesenchimal stem cell conditioned medium fraction on morphological characteristics of hepatocytes in acetamonophen-induced acute liver failure - a preliminari study. Hepat Med. 2019 Jul 19;11:89-96

Tsepkolenko A, Tsepkolenko V, Mishra A, Bader A, Melerzanov A, Giri S. The Regenerative Potential of Skin and the Immune System. Clin Cosmet Investig Dermatol. 2019 Jul 15;12:519-532

Giri S, Machens HG, Bader A. Therapeutic potential of endogenous stem cells and cellular factors for scar-free skin regeneration. Drug discovery today. 2019 Jan;24(1):69-84. Epub 2018 Nov 5. Review



De Wilde RL, Leicher L, Torres-de la Roche LA, Cezar C, Bader A. Adhesion in Patients by Defective Programming of Stem Cells? Geburtsh Frauenheilk. Volume 78, issue 3, Mar 2018, 225-225

Temnov AA, Astrelina TA, Rogov KA, Moroz BB, Lebedev VG, Nasonova TA, Lyrshchikova AV, Dobrynina OA, Deshevoy YU.B, Melerzanov AV, Bader A, Mishra A, Giri S, Boyarintsev VV, Trofimenko AV, Bushmanov AYu, Samoylov AS. Use Of Paracrine Factors From Stem Cells To Treat Local Radiation Burns In Rats. Stem Cells and Cloning: Advances and application. Stem Cells Cloning. 2018 Oct 26;11:69-76

Giri S, Machens HG, Bader A. Therapeutic potential of endogenous stem cells and cellular factors for scar-free skin regeneration. Drug discovery today. 2019 Jan;24(1):69-84. Epub 2018 Nov 5. Review

Günter Ch, Machens HG, Ilg F, Hapfelmeier A, Jelkmann W, Egert-Schwender S, Giri S, Bader A. A Randomized Controlled Trial: Regenerative Effects, Efficacy and Safety of Erythropoietin in Burn and Scalding Injuries&quot. Frontiers in Pharmacology, section Pharmaceutical Medicine and Outcomes Research. Volume 9, 18 Oct 31

Skrzypczyk A, Kehr S, Krystel I, Bernhart S, Giri S, Bader A, Stadler P. Non-coding RNA transcripts during differentiation of induced pluripotent stem cells into hepatocytes. Stem Cells Int. 2018 Aug 19;2018:5692840

Gerisch M, Smettan J, Ebert S, Athelogou M, Brand-Saberi B, Spindler N, Mueller WC, Giri S, Bader A. Qualitative and quantitative analysis of cardiac progenitor cells in cases of myocarditis and cardiomyopathy. Front Genet. 2018 Mar 6;9:72



Bader A, Reinhardt M, Beuthe A, Röhl K, Giri S. Therapy of an Spinal cord injury by intrathecal injection of erythropoietin and subcutaneous injection of EPO, vitamin C and GCSF. Ther Clin Risk Manag. 2017 Nov 27;13:1183-1188

Zeidler R, Freitas Soarez LB, Bader A, Giri S. Molecular epigenetic targets for livers diseases: Current challenges and future prospects. Drug discovery today. 2017 Nov;22(11):1620-1636

Salerno S, Messina A, Giordano F, Bader A, Drioli E, De Bartolo L. Dermal-epidermal membrane systems by using human keratinocytes and mesenchymal stem cells isolated from dermis. Mater Sci Eng C Mater Biol Appl. 2017 Feb 1;71:943-953



Skrzypczyk A, Giri S, Bader A. Generation of induced pluripotent stem cell line from foreskin fibroblasts. Stem Cell Res. 2016 Sep 15;17(3):572-575

Bader A, Giri S. Personalized and regenerative medicine for liver diseases. Curr Stem Cell Res Ther. 2016, 11, 692-705, Epub 2015 Oct 26



Guenter IC, Kern L, Giri S, Machens HG , Bader A. First Results on Three Patients Treated with Topical Recombinant Human Erythropoietin (rhEPO) to Improve Wound Healing in Diabetic Foot Ulcers. Journal of Transplantation & Stem Cell Biology, ISSN 2374-9326, Jan 2015, Volume: 2, Issue: 1

Giri S, Acikgöz A, Bader A. Isolation and Expansion of Hepatic Stem-like Cells from a Healthy Rat Liver and their Efficient Hepatic Differentiation of under Well-defined Vivo Hepatic like Microenvironment in a Multiwell Bioreactor. Journal of Clinical and Experimental Hepatoligy. June 2015, Vo. 5, No. 2, 107-122

Giri P, Ebert S, Braumann DU, Kremer M, Giri S, Machens HG, Bader A. Skin Regeneration of Deep Second-degree Scalding Injuries either by Infusion Pumping of rHuEPO or Topical Application of rHuEPO Gel. Drug Design, Development and Therapy. 2015: 9, 2565-2579

J. Shirazi R, Bader A, Ebert S, Schmidt C, Sedaghati B, Schulz-Siegmund M, Zscharnack M. Isolation and Characterization of CD271+ Stem Cells Derived from Sheep Dermal Skin. Cells Tissues Organs. 2014;200(2):141-52. Epub 2015 May 13

Wegener M, Bader A, Giri S. Regenerate hearts using adult stem cells and induced pluripotent stem cells: New challenges on new targets on heart for safer drug development for heart diseases. Drug Discov Today. 2015 Jun;20(6):667-685. Epub 2015 Feb 23. Review.

Heublein H,  Bader A, Giri S. Preclinical and clinical evidence of stem cell therapies for diabetic wounds: Therapeutic targets for regenerating diabetic wounds. Drug Discov Today. 2015 Jun;20(6):703-717. Epub 2015 Jan 17. Review.

Reinhardt M, Giri S, Bader A. Preclinical challenges and clinical target of nanomaterials in regenerative medicine. (Under revision). Book Chapter. Book chapter. Diverse Applications of Nanotechnology in Biomedicine, Chemistry, and Engineering. Advances in Chemical and Materials Engineering. IGI Global Book Series ACME. Hershey, USA 2015, 350-371



Reinhardt M, Bader A, Giri S. Devices for stem cell isolation and delivery: Current need for drug discovery and cell therapy. Review. Expert Review of Medical Devices. 2015 May;12(3):353-64. Epub 2014 Dec 25

Giri S, Bader A. Immortalization of human fetal hepatocyte by ectopic expression of human telomerase reverse transcriptage, human papilloma virus (E7) and simian virus 40 large T (SV40 T) antigen is an important milestone towards bioartificial liver support. J Clin Exp Hepatol. 2014 Sep;4(3):191-201. Epub 2014 Sep 18.

Giri S, Bader A. Low cost and high quality new drug discovery process using patient-derived induced pluripotent stem cells. Drug Discov Today. 2015 Jan;20(1):37-49. Epub 2014 Nov 15.

Acikgöz A, Langsch A, Bader A, Giri S. Potential Interactions of Herbal Extracts of St. John´s Wort with Metabolites of Diazepam in an Organotypical Sandwich Culture of Primary Porcine Hepatocytes. British Journal of Phamaceutical research 4 (15), 1840-1860, 2014

Giri S, Bader A. Shortcut route for generation of functional hepatocyte cells from human skin allogenically for autologous treatment of chronic liver diseases.  Journal of Clinical and Experimental Hepatology, Volume 4, Issue 1, March 2014, Pages 74-78

Giri S, Bader A. Preclinical liver bud engineering towards clinical target for liver diseases. Journal of Clinical and Experimental Hepatology, Volume 4, Issue 1, March 2014, Pages 71-74



Günter CI, Rezaeian F, Harder Y, Lohmeyer JA, Egert S, Bader A, Schilling AF, Machens HG. Erythropoetin in der Plastischen Chirurgie. Handchir Mikrochir Plast Chir. 2013 Apr;45(2):108-19. Epub 2013 Apr 29. German. Erratum in: Handchir Mikrochir Plast Chir. 2013 Aug;45(4):252. Harder, Y [added]; Bader, A [added]

Acikgöz A, Giri s, Cho MG, Bader A. Morphological and Functional Analysis of Hepatocyte Spheroids Generated on Poly-HEMA-Treated Surfaces under the Influence of Fetal Calf Serum and Nonparenchymal Cells. Biomolecules 2013, 3(1), 242-269

Salerno S, Morelli S, Drioli E, Bader A, de Bartolo L. Biofabrication of Layered Membrane Systems by using human hepatocytes and endothelial cells: A Comperative study. Current Tissue Engineering, 2013, 2, 109-118

Günter CI, Bader A, Dornseifer U, Egert S, Sebastian D, Grieb G, Wolter T, Pallua N, von Wild T, Siemers F, Mailänder P, Thamm O, Ernert C, Steen M, Sievers R, Reichert B, Rahmanian-Schwarz A, Schaller H, Hartmann B, Otte M, Kehl V, Ohmann C, Jelkmann W, Machens HG. A multi-center study on the regenerative effects of erythropoietin in burn and scalding injuries: study protocol for a randomized controlled trial. Trials. 2013 May 3;14(1):124. Epub ahead of print

Giri S, Braumann UD, Giri P, Acikgöz A, Scheibe P, Nieber K, Bader A. Nanostructured self-assembling peptides as a defined extracellular matrix for long-term functional maintenance of primary hepatocytes in a bioartificial liver modular device. Int J Nanomedicine. 2013;8:1525-39. Epub 2013 Apr 18

Giri S, Bader A. Engineering biomimetic microenvironment using biomaterials, soluble signals for ex vivo expansion and differentiation of stem cells: Strategic challenges for creation of clinical grades for stem cell therapy. In: Biomaterials for Stem Cell Therapy: State of Art and Vision for the Future. CRC Press. Taylor & Francis Group, January 15, 2013. 279-316, Editor DeBartolo L, Bader A.



Elliot M, DeCoppi P, Speffiorin S, Roebuck D, Butler C, Samuel E, Clowly C, McLarenC, FierensA, Vondrys D, Cochrane L, Jephson C, Janes S, Beaumont NJ, Cogan T, Bader A, Seifalian A, , Hsuan J, Lowdell M, P, Birchall M. Two-year follow up of a stem cell based, tissue engineered organ replacement in a child.  Lancet. 2012 Sep 15;380(9846):994-1000. Epub 2012 Jul 26

Acikgöz A, Giri S, Bader A. Nannolevel drug metabolites detection in an organotypical culture of primary human hepatocytes and porcine hepatocytes with special reference to two compartment model. International Journal of Nanomedicine. International Journal of Nanomedicine 2012: 7, 5859-5872

Leal-Egaña A, Frisch A, Heidebrecht F, Díaz-Cuencac A, Nowicki M, Bader A, Käs J. Tuning liver stiffness against tumours: An in vitro study using entrapped cells in tumour-like microcapsules. J of the Mechanical Behavior of Biomedical Materials. J Mech Behav Biomed Mater. 2012 May;9:113-21. Epub 2012 Jan 31

Pavlica S, Milosevic J, Keller M, Schulze M, Piscioneri A, DeBartolo L, Darsow K, Bartel S, Lange H,
Bader A. Erythropoietin enhances cell proliferation and survival of human fetal neuronal progenitors in normoxia. Brain Res. 2012 May 3;1452:18-28. Epub 2012 Feb 25

Jungebluth P,
Bader A, Baiguera S, Möller S, Jaus M, Mei Ling Lim, Fried K, Kjartansdóttir KR, Go T, Nave H, Harringer W, Lundin V, Teixeira AI, Macchiarini P. The concept of in vivo airway tissue engineering. Biomaterials. 2012 Jun;33(17):4319-26. Epub 2012 Mar 21

Bader A, Ebert S, Giri S, Kremer M, Liu S, Nerlich A, Guenter C, Smith D, Machens H-G. Skin regeneration with conical and hair follicle structure of deep second degree scalding injuries via combined expression of EPO receptor and beta common receptor by local subcutaneous injection of nanosized rhEPO. Int J Nanomedicine. 2012;7:1227-37. Epub 2012 Mar 6

Bader A, Peters O, Keller M, Pavlica S. (2011) Paracetamol treatment increases telomerase activity in rat embryonic liver cells (short communication). Pharmacol Rep. 2011 Nov;63(6):1435-41

DeBartolo L,
Bader A, Lendlein A, DeGrey A, Cucio E, Drioli E. Bio-Hybrid Organs and Tissues for Patient Therapy:  a Future Vision for 2030. Chemical Engineering and Processing. 51 (2012) 79-87



Bader A, Pavlica S, Deiwick A, Lotkova H, Kucera O, Darsow K, Bartel S, Schulze M, Lange HA, Cervinkova Z. Proteomic analysis to display the effect of low doses of Erythropoietin on rat liver regeneration. Life Sci. 2011 Dec 5;89(23-24):827-33. Epub 2011 Aug 18.

Mofidi A,
Bader A, Pavlica S. (2011) The use of Erythropoietin and ist Derivatives to Treat Spinal Cord Injury. Mini Rev Med Chem. 2011 Aug 1;11(9):763-70.

Pavlica S., Schmitmeier S, Gloeckner P, Piscioneri A, Peinemann F, Krohn K, Siegmud-Schulz M, Laera S, DeBartolo L,
Bader A. Effects of native and NH3 plasma functionalized polimeric membranes on the gene expression profiles of primary hepatocytes. J Tissue Eng Regen Med. 2012 Jun;6(6):486-96. Epub 2011 Jul 13

Leal-Egaña A, Dietrich-Braumann U, Díaz-Cuenca A, Nowicki M,
Bader A. Determination of Pore Size Distribution at the Cell-Hydrogel Interface. J Nanobiotechnology. 2011 May 27;9(1):24.

Marquass B, Schulz R, Hepp P, Zscharnack M, Aigner T, Schmidt S, Stein F, Richter R, Osterhoff G, Aust G, Josten C,
Bader A. Matrix-Associated Implantation of Predifferentiated Mesenchymal Stem Cells Versus Articular Chondrocytes: In Vivo Results of Cartilage Repair After 1 Year. Am J Sports Med. 2011 Jul;39(7):1401-12. Epub 2011 Apr 28

Giri S, Acikgöz A, Pathak P, Gutschker S, Krusten A, Nieber K,
Bader A. Three Dimensional Cultures of Rat Liver Cells Using a Natural Self-assembling Nanoscaffold in a Clinically Relevant Bioreactor for Bioartificial Liver Construction: J Cell Physiol. 2012 Jan;227(1):313-27.

Jungebluth P, Luedde M, Ferrer E, Luedde T, Vucur M, Peinado VI, Go T, Schreiber C, Richthofen MV,
Bader A, Haag J, Darsow KH, Bartel SJ, Lange HA, Furlani D, Steinhoff G, Macchiarini P. Mesenchymal stem cells restore lung function by recruiting resident and non-resident proteins. Cell Transplant. 2011;20(10):1561-74. Epub 2011 Mar 7.

Giri S,
Bader A. Improved Preclinical Safety Assessment using Micro-BAL Devices: The Potential Impact on Human Discovery and Drug Attrition. Drug Discov Today. 2011 May;16(9-10):382-97. Epub 2011 Feb 24

Bader A, Lorenz K, Richter A, Scheffler K, Kern L, Ebert S, Giri S, Behrens M, Dornseifer U, Macciarini P, Machens HG. Role of trauma cytokines and erythropoietin and its therapeutic potential for acute and chronic wounds. Rejuvenation Research, 2011 Feb;14(1):57-66.



Muller D, Chim H, Bader A, Whiteman M, Schantz JT. Vascular guidance: Microstructural scaffold patterning for inductive neovascularisation. Stem Cells Int. 2010 Dec 1; 2011:547247

Marquass B, Somerson JS, Hepp P, Aigner T, Schwan S, Bader A, Josten C, Zscharnack M, Schulz RM. A novel MSC-seeded triphasic construct for the repair of osteochondral defects. J Orthop Res. 2010 Dec;28(12):1586-99

Glaser V. Interview with Prof. Dr. Augustinus Bader. Rejuvenation Research. August 2010, 13(4): 489-492. doi:10.1089/rej.2010.1087, Volume: 13 Issue 4: August 24, 2010, Epub August 9, 2010

Giri S, Nieber K, Bader A. Hepatotoxicity and hepatic metabolism of available drugs and xenobiotics: current problems and possible solutions in preclinical stages. Expert Opin Drug Metab Toxicol. 2010 Aug;6(8):895-917

Bader A
, Machens HG. rhErythropoietin plays a pivotal role as a topical stem cell activator to reverse effects of damage to the skin in aging and trauma.
Rejuvenation Research,

Piscioneri A, Campana C, Salerno S, Morelli S, Bader A, Giordano F, Drioli E, De Bartolo L. Biodegradable and synthetic membranes for the expansion functional differentiation of rat embryonic liver cells. (2010) Acta Biomater. 2011 Jan;7(1):171-9. Epub 2010 Aug 4.

Rupf T, Ebert S, Lorenz K, Salvetter J, Bader A. Cryopreservation of organotypical cultures based on 3D scaffolds Comparison of cryopreservation methods of skin substitutes composed of polymere matrices. Cryo Letters. 2010 Mar-Apr;31(2):157-68

Mauth C, Deiwick A, Steffen A, Pavlica S, Bader A. The influence of oxygen supply on metabolism of neural cells cultured on gas-permeable PTFE foil. (2010) Biotechnol Prog. 2010 Nov-Dec;26(6):1724-32. doi: 10.1002/btpr.478.

Maringka M, Giri S, Nieber K, Açikgöz A, Bader A. Biotransformation of diazepam in a clinical relevant flat membrane bioreactor model using primary porcine hepatocytes. Fundam Clin Pharmacol. 2011 Jun;25(3):343-53. doi: 10.1111/j.1472-8206.2010.00857.x.]

Zscharnack M, Hepp P, Richter R, Aigner T, Schulz R, Somerson J, Josten C, Bader A, Marquass B. Repair of Chronic Osteochondral Defects Using Predifferentiated Mesenchymal Stem Cells in an Ovine Model. Am J Sports Med. 2010 Sep;38(9):1857-69. Epub 2010 May 27

Chowdhury TT, Schulz RM, Rai SS, Thuemmler CB, Wuestneck N, Bader A, Homandberg GA. Biomechanical modulation of collagen fragment induced anabolic and catabolic activities in chondrocyte /agarose constructs. Arthritis Res Ther. 2010 May 12;12(3):R82. Epub 2010 May 12

Galle J, Bader A, Hepp P, Grill W, Fuchs B, Käs JA, Krinner A, Marquaß B, Müller K, Schiller J, Schulz RM, von Buttlar M, von der Burg E, Zscharnack M, Löffler M. Mesenchymal Stem Cells in Cartilage Repair: State of the Art and Methods to monitor Cell Growth, Differentiation and Cartilage Regenration.
Curr Med Chem. 2010;17(21):2274-91. Review

Bader A., Macchiarini P. Moving towards in situ tracheal regeneration: the bionic tissue engineered transplantation approach. J Cell Mol Med. 2010 Jul;14 (7):1877-89. Epub 2010 Apr 19

Giri S, Nieber K, Bader A. Hepatotoxicity and hepatic metabolism of available drugs and xenobiotics: current problems and possible solutions in preclinical stages. Expert Opin Drug Metab Toxicol. 2010 Aug;6(8):895-917.

Giri S, Weingartz U, Nieber K, Acikgöz A, Bader A. Cryopresvation of primary porcine hepatocyte in organotypical sandwich culture model in a clinical relevent flat membrane bioreactor. Biotechnol Lett. 2010 Jun;32(6):765-71. Epub 2010 Mar 7.

Go T, Jungebluth P, Baiguera S, Asnaghi A, Martorell J, Ostertag H, Mantero S, Teresa C M, Birchall M, Bader A, Macchiarini P. (2009) Both epithelial cells and mesenchymal stem cell-derived chondrocytes contribute to the survival of tissue-engineered airway transplants in pigs. J Thorac Cardiovasc Surg. 2010 Feb;139(2):437-43. Epub 2009 Dec 7

Maringka M, Giri S, Bader A. (2009) Preclinical characterization of primary porcine hepatocyte in a clinical relevant flat membrane bioreactor. Biomaterials. 2010 Jan; 31(1):156-72. Epub 2009 Oct 8.





Genové E, Schmitmeier S, Sala A, Borrós S, Bader A, Griffith LG, Semino CE. (2009) Functionalized self-assembling peptide hydrogel enhance maintenance of hepatocyte activity in vitro. J Cell Mol Med. 2009 Sep;13(9B):3387-97. Epub 2009 Nov 13.

Giri S, Nieber K, Acikgöz A, Pavlica S, Keller M, Bader A. (2009) Telomerase activity and hepatic functions of rat embryonic liver progenitor cell in nanoscaffold coated small scale bioreactor. Mol Cell Biochem. 2010 Mar;336(1-2):137-49. Epub 2009 Oct 9.

Pavlica S, Piscioneri A, Peinemann F, Keller M, Milosevic J, Staeudte A, Heilmann A, Schulz-Siegmund M, Laera S, Favia P, DeBartolo L., Bader A. (2009) Rat embryonic liver expansion and differentiation on NH3 plasma-grafted PEEK-WC-PU membranes. Biomaterials 30, 6514-6521, Epub 2009 Sep 1

Frühauf JH, Mertsching H; Giri S; Frühauf NR, Bader A. Porcine endogenous retrovirus (PERV) released by a bioartificial liver infects primary human cells (2009) . Liver Int. 2009 Nov;29(10):1553-61. Epub 2009 Aug 14.

Krinner A, Zscharnack M, Bader A, Drasdo D, Galle J. Impact of oxygen environment on mesenchymal stem cell expansion and chondrogenic differentiation. Cell Prolif. 2009 Aug;42(4):471-84

Kock LM, Schulz RM, van Donkelaar CC, Thümmler CB, Bader A, Ito K. RGD-dependent integrins are mechanotransducers in dynamically compressed tissue-engineered cartilage construct. J Biomech. 2009 Sep 18;42(13):2177-82. Epub 2009 Aug 5

Hepp P, Osterhoff G, Marquass B, Niederhagen M, Aigner T, Bader A, Josten C, Schulz RM. Perilesional changes of focal osteochondral defects in an ovine model and their relevance to human osteo chondral injuries. Journal of Bone and Joint Surgery - British Volume, 91(8), 1110-1119, (2009)

Heidebrecht F, Schulz I, Keller M, Behrens SE, Bader A. Improved Protocols for Protein and RNA Isolation from 3D Collagen Sandwich Cultures of Primary Hepatocytes. Anal Biochem. 2009 Oct 1;393(1):141-4. Epub 2009 Jun 17

Leal-Egaña A, Díaz-Cuenca A, Bader A. Determination of the decay rate constant for hepatocytes immobilized in alginate microcapsules. (2009) J Microencapsul. 2010; 27 (1) 86-93. Epub 2009 Jun 19

Salerno S, Piscioneri A, Laera S, Morelli S, Favia P, Bader A, Drioli E, De Bartolo L. Improved functions of human hepatocytes on NH(3) plasma-grafted PEEK-WC-PU membranes. (2009) Biomaterials 30, 4348-434356. Epub 2009 Jun 3

Shen C, Meng Q, Schmelzer E, Bader A. Gel entrapment culture of rat hepatocytes for investigation of tetracycline-induced toxicity. Toxicol Appl Pharmacol.  2009 Jul 15;238(2):178-87. Epub 2009 May 19.

Heidebrecht F, Heidebrecht A, Schulz I, Behrens SE, Bader A. (2009) Improved semiquantitative Western blot technique with increased quantification range. Journal of Immunological Methods. I2009 Jun 30; 345(1-2):40-8. Epub 2009 Apr 5

Langsch A, Giri S, Acikgöz A, Jasmund I, Frericks B, Bader A. Interspecies difference in liver specific functions and biotransformation of testosterone of primary rat, porcine and human hepatocyte in an organotypical sandwich culture. (2009) Toxikology letters. 2009 Aug 10;188(3):173-9. Epub 2009 Apr 2

Acikgöz A, Karim N, Giri S, Schmidt-Heck W, Bader A. (2008) Two compartment model of diazepam biotransformation in an organotypical culture of primary human hepatocytes. Toxicol Appl Pharmacol. 234 (2009) 179-91

Spanholtz T, Maichle A, Niedworok C, Stoeckelhuber BM, Krüger S, Wedel T, Aach T, Middeler G, Hellwig-Bürgel T, Bader A, Krengel S, Müller OJ, Franz WM, Lindenmaier W, Machens HG.
Timing and targeting of cell-based VEGF165 gene expression in ischemic tissue. J Surg Res. 2009 Jan;151(1):153-62. Epub 2008 Mar 13

De Bartolo L, Salerno S, Curcio E, Piscioneri A, Rende M, Morelli S, Tasselli F,
Bader A, Drioli E: Humanhepatocyte functions in a crossed hollow fiber membrane bioreactor. Biomaterials. 30 (2009) 2531-2543




Acikgöz A, Bader A. (2008) Von der Gewebezüchtung zur individuellen Geweberegeneration – Der Mensch als Bioreaktor. Journal für Verbraucherschutz und Lebensmittelsicherheit 3 2008 Supplement 1, 64-72

Vozzi F, Heinrich JM, Bader A, (2008) Ahluwalia AD. Connected Culture of Murine Hepatocytes and HUVEC in a Multicompartmental Bioreactor. Tissue Eng Part A. 2009 Jun; 15(6):1291-9

Zscharnak M, Poesel C,
Bader A and Galle J. (2008) Low oxygen improves expansion and subsequent chondrogenic differentiation of ovine mesenchymal stem cells. Cells Tissues Organs. 2008 Nov 25

Schulz RM, Wüstneck N, van Donkelaar C, Shelton J, Bader A (2008) Development and validation of a novel bioreactor system for load- and perfusion-controlled tissue engineering of chondrocyte-constructs. Biotechnology and Bioengineering, Volume 101, Issue 4, 1 November 2008, Pages 714-728, published online 2 May 2008

Lorenz K, Sicker M, Schmelzer E, Rupf T, Salvetter J, Schulz-Siegmund M, Bader A; Multilineage Differentiation Potential of Human Dermal Skin Derived Fibroblasts, original article accepted 28.02.08 in ExpDerm,  2008 Nov.; 17(11): 925-32. Epub Jun.14

Lorenz K, Rupf T, Salvetter J,
Bader A. Enrichment of human β1bri6bri/CD71dim keratinocytes after culture in Defined Media Cells Tissues Organs. 2009;189(6):382-90. Epub 2008 Aug 11

Fuchs B, Schiller J, Süß R, Zscharnack M, Bader A, Müller P, Schürenberg M, Becker M, Suckau D. Analysis of Stem Cell Lipids by Offline HPTLC-MALDI-TOF MS. Analytical and Bioanalytical Chemistry. 2008 Nov; 392 (5): 849-60. Epub 2008 Aug 5

Haberhauer M, Zernia G, Deiwick A, Pösel C, Bader A, Huster D, Schulz R.
Cartilage Tissue Engineering in Plasma and Whole Blood Scaffolds. Advances Materials 2008; Volume 20 Issue 11, June 4, 2008, 2061-2067. 

Schulz R, Zscharnack M, Hanisch I, Geiling M, Hepp P, Bader A. Cartilage Tissue Engineering by Collagen Matrix Associated Bone Marrow Derived Mesenchymal Stem Cells. Biomed Mater Eng. 2008;18(1):55-70. 

van Donkelaar CC, Schulz R. Review on patents for mechanical stimulation of articular cartilage tissue engineering. Recent Patents on Biomedical Engineering. Volume 1(1):1-12. 

Schmelzer E, Deiwick A, Bader A. Thrombopoietin is a growth factor for hepatic progenitors. Eur J Gastroenterol Hepatol. 2008 Mar;20(3):209-16.  



Jasmund I, Schwientek S, Acikgöz A, Langsch A, Machens HG, Bader A (2007). The Influence of Medium Composition and Matrix on Long-term Cultivation of Primary Porcine and Human Hepatocytes. Biomolecular Engineering 24:59-69. 

Meng Q, Ru J, Zhang G, Shen C, Schmitmeier S, Bader A. (2007) Re-evaluation of tacrine hepatotoxicity using gel entrapped hepatocytes. Toxicology Letters 168:140-147.

Schulz R, Bader A. Cartilage tissue engineering and bioreactor systems for the cultivation and simulation of chondrocytes. Eur Biophys J. 2007 Apr;36(4-5):539-68. Epub 2007 Feb 23. Review. 

Diekmann S,
Glockner P, Bader A. (2007) The Influence of different cultivation conditions on the metabolic functionality of encapsulated primary hepatocytes. International Journal of Artificial Organs 30:192-198.

Schulz J, Pretzsch M, Khalafi I, Deiwick A, Scheidt HA, von Salis-Soglio G, Bader A, Huster D. (2007) Quantitative Monitoring of Extracellular Matrix Production in Bone Implants by 13C and 31P Solid-State NMR Spectroscopy. Calcif Tissue International, 2007 Apr;80(4):275-85. Epub 2007 Apr 1. 

Hauschild G, Bader A, Uhr G., Meyer-Lindberg A, Fehr M (2007)Klinischer Einsatz von b-Tricalciumphosphat – Erfahrungen mit einem matrixorientierten Ansatz zur Osteoregenation, Tierärztliche Prax 2007; 35 (K) 5-13. 

Schmitmeier S, Langsch A, Schmidt-Heck W, Jasmund I, Bader A. (2007) Improvement of metabolic performance of primary hepatocytes in hyperoxic cultures by vitamin C in a novel small-scale bioreactor. Journal of Membrane Science 298, 2007, 30-40.

Curcio E, Salerno S, Barbieri G, De Bartolo L, Drioli E, Bader A. (2007) Mass transfer and metabolic reactions in hepatocyte spheroids cultured in rotating wall gas-permeable membrane system. Biomaterials. 2007 Dec;28(36):5487-97. Epub 2007 Sep 18. 



Leal-Egana A, Heinrich JM, Smith MD, Nowicki M, Bader A. (2006). A simple, non-destructive method for the fixation and immunostaining of cultured cells encapsulated in alginate. Biotechnology and Applied biochemistry 44:143-150.

 Schulz R, Hohle S, Zernia G, Zscharnack M, Schiller J, Bader A, Huster D. (2006) Analysis of extracellular matrix Production in Artificial Cartilage Constructs by Histology, Immunocytochemistry, Mass Spectrometry, and NMR Spectroscopy. Journal of Nanoscience and Nanotechnology 6:2368-2381

Diekmann S, Bader A, Schmitmeier S. (2006) Present and future developments in hepatic tissue engineering for liver support systems. Cytotechnology. 50:163-179.

DeBartolo L, Salerno S, Morelli S, Giorno L, Rende M, Memoli B, Procino A, Andreucci V, Bader A, Drioli E. (2006) Long-term maintenance of human hepatocytes in oxygen-permeable membrane bioreactor. Biomaterials 27:4794–4803.

Just L, Kürsten A, Borth-Bruhns T, Lindenmaier W, Rohde M, Dittmar K, Bader A. (2006) Formation of three-dimensional fetal myocardial tissue cultures from rat for long-term cultivation. Developmental dynamics 235:2200-2209.

Schmitmeier S, Langsch A, Jasmund I, Bader A. (2006). Development and characterization of a small-scale bioreactor based on a bioartificial hepatic culture model for predictive pharmacological in vitro screenings.  Biotechnolology & Bioengineering 95:1198-1206.

Schmitmeier S, Langsch A, Bader A. (2006) A membrane-based small scale bioreactor for accelerated in vitro drug screening with primary hepatocytes. Desalination 199:258-260.

Rocker D, Hesse F, Bader A, Wagner R. (2006) Intracellular Nucleotide Pools and Ratios as Tools for Monitoring Dedifferentiation of Primary Porcine Hepatocytes in Culture. Cytotechnology 51:119-132.

Karim N, Golz K, Bader A. (2006) The cardiovascular tissue-reactor: a novel device for the engineering of heart valves.
Artificial Organs 30:809-814.

 Klingmüller U, Bauer A, Bohl S, Breitkopf K, Dooley S, Zellmer S, Kern C, Merfort I, Sparna T, Donauer J, Walz G, Geyer M, Kreutz C, Hermes M, Walter D, Egger L, Neubert K, Borner C, Brulport M, Schormann W, Sauer C, Baumann F, Preiss R, Illes P, Nickel PJ, MacNelly S, Godoy P, Wiercinska E, Ciuclan L, Zeilinger K, Heinrich M, Zanger UM, Reuss M, Gebhardt R, Maiwald T, Timmer J, von Weizsäcker F, Hengstler JG. (2005) Primary mouse hepatocytes for systems biology approaches: a standardized in vitro system for modelling of signal transduction pathways. IEE Proceedings- Systems Biology 153:433-447. 

Schmelzer, E., Acikgoez,A., Fruehauf, N.R., Crome, O., Klempnauer, J., Christians, U., Bader, A. . Biotransformation of cyclosporin in matrix overlaid primary rat, porcine, and human hepatocytes.   Xenobiotica. 36:693-708.

Seleverstov, O., Bader, A. (2005) Evaluation of liver support systems for pre-clinical animal trials. Artificial Organs 30:815-821.

Seleverstov O, Zabirnyk O, Zscharnack M, Bulawina L, Heinrich JM, Yezhelyev M, Emmrich F, O’Regan R, Bader A. (2006) Quantum dots for human mesenchymal stem cells labelling, a size-dependent autophagy activation. Nano Letters 6:2826-2832.



K. Prank, M. Waring, U. Ahlvers, A. Bader, E. Penner, M. Möller, G. Brabant and C. Schöfl (2005) The precision of intracellular calcium spike timing in primary rat hepatocytes. Sys. Biol. 2:31-34.

Hauschild G., Merten H.-A., Bader A., Uhr G., Deiwick A., Meyer-Lindenberg A. (2005) Bioartificial bone grafting: Tarsal joint fusion in a dog using a bioartificial composite bone graft consisting of β-tricalciumphosphate and platelet rich plasma – A case report. Vet Comp Orthop Traumatol, 1/2005: 52-54.

Bader, A., Brückenschlag zwischen der präventiven und regenerativen Medizin. (2005) Anti Aging for professionals. Journal of preventive, regenerative and aesthetic medicine. 1/2005: 23-27.

Bader, A., Langsch, A., Jasmund, I. (2005) Perspectives for regenerative medicine: Alternatives to liver transplantation. Proceedings of the international school on advanced material science and technology: Advanced biomaterials, biomimetics, tissue engineering: 2004: 7-16.

Bader, A., Langsch, A., Jasmund, I.(2005). Use of a hollow fibre membrane oxygenator as a bioartificial liver device. Proceedings of the international school on advanced material science and technology: Advanced biomaterials, biomimetics, tissue engineering: 125- 141.

Hepp P, Bader A, Josten C, Rose T, Schulz R. (2005). Tissue engineering von Knorpelzellen. Arthroskopie. 18:233–238.



Wilkening S, Bader A Quantitative real-time polymerase chain reaction: methodical analysis and mathematical model. JBiomol Tech. 2004 Jun;15(2):107-11.

Fruhauf NR, Oldhafer KJ, Holtje M, Kaiser GM, Fruhauf JH, Stavrou GA, Bader A, Broelsch CE., A bioartificial liver support system using primary hepatocytes: A preclinical study in a new porcine hepatectomy model., Surgery. 2004 Jul;136(1):47-56.

Hauschild G, Bader A, Vor- und Nachteile synthetischer versus xenogener Knochenersatzmaterialien, Tierärztliche Praxis 2004, 32 (K): 67-70.

Schlesinger F, Meywirth J, Krampfl K, Grosskreutz J, Petri S, Mauth C, Just L, Bader A, Bufler J., Ligand-gated channels in early mesencephalic neuronal precursors: immunocytochemical and electrophysiological analysis. European Journal of Neuroscience. 2004;19(9):2371-6.

Wilkening S. and Bader A. Differential regulation of CYP3A4 and CYP3A7 by dimethylsulfoxide. Basic & Clinical Pharmacology & Toxicology 2004, 95(2), 92–93.



Wilkening S, Bader A., Influence of culture time on the expression of drug-metabolizing enzymes in primary human hepatocytes and hepatoma cell line HepG2., J Biochem Mol Toxicol. 2003;17(4):207-13.

Just L, Timmer M, Tinius J, Stahl F, Deiwick A, Nikkhah G, Bader A., Identification of human cells in brain xenografts and in neural co-cultures of rat by in situ hybridisation with Alu probe., J Neurosci Methods. 2003 Jun 15;126(1):69-77.

Wilkening S, Stahl F, Bader A., Comparison of primary human hepatocytes and hepatoma cell line Hepg2 with regard to their biotransformation properties., Drug Metab Dispos. 2003 Aug;31(8):1035-42.

Schmelzer E., Langsch A. and Bader A. (2003). 24- and 96- Well Bioreactors. In: New Hepatocyte In vitro Systems for Drug Metabolism: Metabolic Capacity and Recommendations for Application in Basic Research and Drug Development, Standard Operation Procedures. Gebhardt R.*, Hengstler J.G.*, Mueller D.*, Gloeckner R.*, Buenning P.*, Laube B.*, Schmelzer E.*, Ullrich M., Utesch D., Hewitt N., Ringel M., Reder Hilz B., Bader A., Langsch A., Koose T., Burger H.-J., Maas J., and Oesch F. (*contributed equally to this manuscript). Drug Metabolism Reviews, 35(2, 3):145-213.



De Bartolo L, Bader A, Morelli S, Drioli E, (2001) Evaluation of cell behaviour related to physico-chemical properties of polymeric membranes to be used in bioartificial organs, Biomaterials 23 (2002), 2485-2497.

Jasmund I, Bader A, (2002) Bioreactor developments for Tissue Engineering Applications by the example of the bioartificial liver. Advances in Biochemcial Éngineering / Biotechnology 74, 100-108.

Schmitmeier S, Thole H, Bader A, Bauer K, (2002) Purification and characterization of the thyrotropin-releasing hormone (TRH)-degrading serum enzyme and ist identification as a product of liver origin. E.J. Biochem. 269, 1278-1286, FEBS.

Jasmund I, Simmoteit R, Bader A, (2002) Cultivation of primary porcine hepatocytes in an OXY-HFB for use as Bioartificial Liver. Biotechnology Progress 2002:18,839-46.

Ringel M, Oesch F, Bader A, Gerl M, Klebach M, Quint M, Tanner B, Dillenburg W, Böttger T, Hengstler JG, (2002) Permissive and suppressive effects of dexamethasone on enzyme induction in hepatocyte cultures, Xenobiotica.

Bader A, Schnittmengen der rekonstruktiven Chirurgie im Bereich der Regenerativen Medizin. Chirurg 2002 73:428 - 434.

De Bartolo L, Bader A, Development of a hybrid liver-support device. MITAT Journal 2002:11(3)  123-134.

Langsch A, Jasmund I, Bader A. (2002) Potentials of tissue engineering as an alternative to organ transplantation. Tx Med 14 (2002): 146-150.

DeBartolo L, Bader A. (2002) Flat membrane bioreactor for the replacement of liver functions. Ernst Schering Res Found Workshop. 2002; (35):89-104. Review .



Moza, AK, Mertsching H, Herden T, Bader A, Haverich A, (2001) Heart valves from pigs and the porcine endogenous retrovirus: Experimental and clinical data to assess the probability of porcine endogenous retrovirus infection in human subjects. J Thorac Cardiovasc Surg. Apr; 121(4):697-701.

Langsch A, Bader A, (2001) Longterm stability of phase I and phase II enzymes of porcine liver cells in flat membrane bioreactors. Biotechnology and Bioengineering 76 (No. 2): 115-125.

Fruhauf NR, Kaiser GM, Nosser SA, Bader A, Oldhafer KJ, (2001) Large animal models for testing bioartificial liver support systems. Biomed Sci Instrum;37:511-6.

Hauschild G, Uhr G, Bader A, Meyer-Lindenberg A, Fehr M, (2001) Einsatz des bioartifiziellen Knochenersatzstoffes ß-Trikalziumphosphat zur chirurgishen Konsolidierung einer Pseudarthrose. Kleintierpraxis 46 (8):461-582.

De Bartolo L, Morelli S, Bader A, Drioli E, (2001) The influence of polymeric membrane surface free energy on cell metabolic functions, Journal of Materials Science: Materials in Medicine, 12:959-963.

De Bartolo L, Bader A, Morelli S, Drioli E, (2001) Membrane Bioartificial Organs: Requirements and Experimental Approaches La Chimica e l’Industria, Maggio: 1-6.

De Bartolo L, Bader A, Review of a flat membrane bioreactor as a bioartificial liver. Ann Transplant. 2001; 6 (3):40-6.

Hauschild G, Fehr M, Uhr G, Bader A. (2001) Die zukünftige Bedeutung von tissue Engineering für die Onkologie. Der Onkologe 7 (10): 1089-1096.




Bader A, Hansen T, Kirchner G, Allmeling C, Haverich A, Borlak JT, (2000) Primary porcine enterocyte spheroidal cultures to study drug oxidation. Brit. J. Pharmacology 129 331-342.

DeBartolo L, Jarosch v. Schweder G, Haverich A, Bader A, (2000) A novel full-scale flat membrane bioreactor utilizing porcine hepatocytes: Cell viability and tissue-specific functions. Biotechnology Progress 16, 102-108.

Hansen T, Borlak J, Bader A, (2000) Cytochrome P450 activity and protein expression in primary porcine enterocyte and hepatocyte cultures. Xenobiotica 30:27-46.

Bader A, DeBartolo L, Haverich A, (2000) High level benzodiazepine and ammonia clearance by flat membrane bioreactors with porcine liver cells. J Biotechnol 25:95-105.

Bader A, Steinhoff G, Strobl K, Schilling T, Brandes G, Mertsching H, Tsikas D, Froelich J, Haverich A, (2000) Engineering of human vascular aortic tissue based on a xenogeneic starter matrix. Transplantation 70:7-14.

Mertsching H, Karim N, Haverich A, Bader A, (2000) Investigations on biological saftey and immunologic aspects of chimeric bioartificial vessels in xenotransplantation. Transplant Proc 32:1165.

Högemann D, Baumann A, Rocker D, Bader A, (2000) In vitro model of the human liver parenchyma to study hepatotoxic side effects of Dy-EOB-DTPA. Investigative Radiology 25:373-379.

Karim N, Allmeling C, Hengstler J-G, Haverich A, Bader A, (2000) Diazepam metabolism and albumin secretion of porcine hepatocytes in collagen-sandwich after cryopreservation. Biotechnol Letters 22:1647-1652.

Teebken OE, Bader A, Steinhoff G, Haverich A, (2000) Tissue engineering of vascular grafts: Human cell seeding of decellularised porcine matrix. Eur J Vasc Endovasc Surg 19:381-386.

Shen, Z-L, Lassner F, Bader A, Becker M, Walter GF, Berger A, (2000) Cellular activity of resident macrophages during wallerian degeneration. Microsurgery 20:255-261.

Steinhoff G, Stock U, Karim N, Mertsching H, Timke A, Meliss R, Pethig K, Haverich A, Bader A, (2000) Tissue Engineering of pulmonary heart valves on allogeneic acellular matrix conduits in vivo restoration of valve tissue. Circulation 102 (19,3):III50-55.



Shen ZL, Lassner F, Becker M, Walter GF, Bader A, Berger A, (2000) Viabillity of cultured nerve grafts: An assessment of proliferation of Schwann cells and fibroblasts. Microsurgery 19:356-363.

Bader A
, Frühauf N, Tiedge M, Drinkgern M, Zech K, Borlak J, Steinhoff G, Haverich A, (1 0999) Enhanced oxygen delivery reverses anaerobic metabolic states in prolonged sandwich rat hepatocyte culture. Exp Cell Res. 246, 221-232.

Hildebrand H, Schmidt U, Kempka G, Jacob H, Ahr HJ, Ebener C, Goretzki PE, Bader A, (1999) An in vitro model for peroxisome proliferation utilizing primary hepatocytes in sandwich culture. Tox In Vitro 13, 265-273.

Karim N, Mertsching H, Haverich A, Bader A, (1999) Human vascular cells create new matrix when seeded into acellularized porcine aorta. Medical and Biological Engineering and Computing 37(2):596.



Jura H, Bader A, Frosch M, In-vitro activity of benzimidazoles against Echinococcus multilocularis metacestodes. (1998) Antimicrobial Agents and Chemotherapy 42, 1052-1056.

Bader A, Schilling T, Teebken O, Brandes G, Steinhoff G, Haverich A, (1998) Tissue engineering of heart valves - human endothelial cell seeding of detergent acellularized porcine valves. EJ Cardiovasc Surg 14, 279-284.

Bader A, Frühauf N, Zech K, Haverich A, Borlak J, (1998) Development of a small scale bioreactor for drug metabolism studies maintaining hepatospecific functions. Xenbiotica 28, 815-825.

Fahrig R, Rupp M, Steinkamp-Zucht A, Bader A, (1998) Use of primary rat and human hepatocyte sandwich cultures for activation of indirect carcinogens: Monitoring of DNA strand breaks and gene mutations in co-cultured cells. Tox in vitro. 12, 431-444.

Lampen A, Bader A, Bestmann T, Winkler M, Witte L, Sewing K-F, Borlak JT, (1998) Catalytic activities, protein- and mRNA-expression of cytochrome P450 isoenzymes in intestinal cell lines. Xenobiotica 28, 429-441.

McCully S, Cameron GA, Bader A, Hawksworth G, Borlak J, (1998) In vitro investigations of the interaction between terfenadine and tedisamil in human liver microsomes. Xenobiotica 28, 219-223.

Reimer P, Bader A, Weissleder, (1998) Preclinical assessment of hepatocyte-targeted MR contrast agents in stable human liver cell cultures. JMRI. 3, 687-689.

Teebken OE, Bader A, Steinhoff G, Haverich A, A new concept for substitutes in vascular surgery. (1998) Langenbecks Arch Chir Suppl Kongressbd 115, 1256-9.



Kern A, Bader A, Pichlmayr R, Sewing K-F, (1997) Drug metabolism in hepatocyte sandwich cultures of rats and humans. Biochem Pharmacol. 54, 761-772. Felix-Wankel Forschungspreis 1996. 

Reimer P, Bader A, Weissleder R, (1997) Application of a stable cell culture assay for the functional assessment of novel MR contrast agents. Eur Radiol. 7, 527-531.

Weinhold B, Bader A, Poli V, Rüther U, (1997) Interleukin-6 is necessary but not sufficient, for the induction of the human C-reactive protein in vivo. Biochem J. 325, 617-621.



Bader A, Knop E, Böker KHW, Crome O, Frühauf N, Gonschior A, Christians U, Esselman H, Pichlmayr R, Sewing KF, (1996) Tacrolimus (FK 506) metabolism in primary rat hepatocytes depends on extracellular matrix geometry. NS Arch Pharm. 353, 461-473. Felix-Wankel Forschungspreis 1996.

Bader A, Knop E, Kern A, Boker K, Frühauf N, Crome O, Esselmann H, Pape C, Kempka G, Sewing K-F, (1996) 3-D coculture of hepatic sinusoidal cells with primary hepatocytes-Design of an organotypical model. Exp Cell Res. 226, 223-33. Felix-Wankel Forschungspreis 1996.

Christians U, Bleck JS, Lampen A, Bader A, Thiesemann C, Kliem V, Repp H, Westhoff BM, Manns M, Sewing KF, (1996) Are cytochrome P450 3A enzymes in the small intestine responsible for different cyclosporine metabolite patterns in stable male and female renal allograft recipients after co-administration of diltiazem? Transplant Proc. 28, 2159-61.

Christians U, Schmidt G, Bader A, Lampen A, Schottmann R, Linck A, Sewing K-F, (1996) Identification of drugs inhibiting the in vitro metabolism of tacrolimus by human liver microsomes. Br J Clin Pharmacol. 41, 187-196.

Frühauf N, Bader A, Crome O, Steinhoff G, Haverich A, Pichlmayr R, (1996) Rapamycin biotransformation in primary rat sandwich hepatocytes. Exp Toxic Pathol. 48, 137-142.

Jura H, Bader A, Hartmann M, Maschek H. Frosch M, (1996) Hepatic tissue culture model for study of host-parasite interactions in alveolar echinococcosis. Infect Immun. 64, 3484-90.

Lampen A, Christians U, Bader A, Hackbarth I, Sewing K-F, (1996) Drug interactions and interindividual variability fo the small intestinal metabolism of ciclosporin. Pharmacology. 52, 159-168.

Lampen A, Christians U, Gonschior AK, Bader A, Hackbarth I, Engelhardt W, Sewing K-F, (1996) Metabolism of the macrolide immunosuppressant tacrolimus in the pig gut mucosa in the ussing chamber. Br J Pharmacology. 117, 1730-1734.



Bader A, Knop E, Böker K, Frühauf N, Schüttler W, Oldhafer K, Pichlmayr R, Sewing K-F, (1995) A novel bioreactor design for in vitro reconstruction of in vivo liver characteristics. Artif Organs. 19, 368-374.

Bader A
, Knop E, Fruhauf N, Crome O, Boker K, Christians U, Oldhafer K, Ringe B, Pichlmayr R, Sewing K-F, (1995) Reconstruction of liver tissue in vitro: geometry of characteristic flat bed, hollow fiber, and spouted bed bioreactors with reference to the in vivo liver. Artif Organs. 19, 941-50.

Bader A, Reimer P, Knop E, Christians U, Weissleder R, Sewing K-F, (1995) An organotypical in vitro model of the liver parenchyma for uptake studies of diagnostic MR receptor agents. Magn Res Imaging. 13, 991-996.

Bader A
, Reimer P, Knop E, Weissleder R, Sewing K-F, (1995) Receptor mediated endocytosis in matrix overlaid primary hepatocytes. J Exp Clin Cancer Res. 14, 185-7.

Christians U, Kohlhaw K, Surig T, Bader A, Schottmann R, Linck A, Ringe B, Sewing K-F, (1995) Parallel blood concentrations of second-generation cyclosporine metabolites and bilirubin in liver graft recipients. Ther Drug Monit. 17, 487-98.

Knop E, Bader A, Böker K, Pichlmayr R, Sewing K-F, (1995) Ultrastructural and functional differentiation of hepatocytes under long-term culture conditions. Anatomical Record. 242, 337-349.

Lampen A, Christians U, Guengerich FP, Watkins PB, Kolars JC, Bader A, Gonschior AK, Dralle H, Hackbarth I, Sewing K-F, (1995) Metabolism of the immunosuppressant tacrolimus in the small intestine: cytochrome P450, drug interactions, and interindividual variability. Drug Metab Dispos. 23, 1315-24. Best Paper Award of the American Society for Pharmacology and Experimental Therapeutics 1995.

Melzig MF, Wobus AM, Muller KW. Breitkreutz D, Werner S, Boukamp P, Bader A, Niehrs C, Fusenig NE, (1995) International conference on cell interactions in malignancy, development and differentiation. J Cancer Res Clin Oncol. 121, 757-63.



Bader A, Zech K, Crome O, Christians U, Pichlmayr R, Sewing K-F, (1994) Use of organotypical cultures of primary hepatocytes to analyze drug biotransformation in man and animals. Xenobiotica. 24, 623-633. Forschungspreis des Bundesgesundheitsministers 1993 für die Entwicklung von Alternativmethoden für Tierversuche.



Christians U, Spiekermann K, Bader A, Schottmann R, Linck A, Wonigeit K, Sewing K-F, Link, H. (1993) Cyclosporine metabolite pattern in blood from patients with acute GVHD after BMT. Bone Marrow Transplant. 12, 27-33.

Closs EI, Rinkes IH, Bader A, Yarmush ML, Cunningham JM, (1993) Retroviral infection and expression of cationic amino acid transporters in rodent hepatocytes. J Virol. 67, 2097-102.

Bader A, (1993) Leberzellkulturen: Anspruch und Wirklichkeit. In-vitro-Systeme. 9-10.

Bader A, Böker K, Christians U, Crome O, Frühauf N, Manns M, Pichlmayr R, Sewing K-F, (1994) Organotypical culture conditions for primary hepatocytes. Transplantationsmedizin. 6, 11-13.



Bader A, Rinkes IHB, Closs IE, Ryan CM, Toner M, Cunningham JM, Tompkins GR, Yarmush ML, (1992) A stable long-term hepatocyte culture system for studies of physiologic processes: Cytokine stimulation of the acute phase response in rat and human hepatocytes. Biotechnol Prog. 8, 219-225. Renate and Hans Lettre Fortbildungsstipendium der Deutschen Sektion der European Tissue Culture Society.



Bader A, Carrigan T, Gopalswamy N, Truelzsch DV, (1989) Reversible hematologic suppression during ranitidine treatment. Drugs Int Clin Pharm. 23, 507-508.

home Cell Techniques and Applied Stem Cell Biology, 10.09.2019