[Press Release HHUD] Researchers at Heinrich Heine University Düsseldorf (HHU) have succeeded in identifying a previously unknown regulator of the Notch signaling pathway in nematodes, which positively modulates and thus amplifies the Notch signaling pathway. The team led by Prof. Dr. Simone Prömel at the Institute of Cell Biology presented this in a new study, which has now been published in the journal Nature Communications.
Original publication
Post WB, Groß VE, Matúš D, Charnay I, Liessmann F, Seufert F, Hildebrand P, Meiler J, Kaiser A, Schöneberg T, Prömel S. Notch activity is modulated by the aGPCR Latrophilin binding the DSL ligand in C. elegans. Nat Commun. 2025 Jul 12;16(1):6461. doi: 10.1038/s41467-025-61730-0. PMID: 40651965; PMCID: PMC12255766.
(CRC 1423 authors: Prof. Dr. Simone Prömel, Dr. Anette Kaiser, Prof. Dr. Torsten Schöneberg, Prof. Dr. Jens Meiler, Prof. Dr. Peter Hildebrand.)