Collaborative Paper published in Journal of Biological Chemistry

/ January 6, 2011/ News, Research

First results of the successful collaboration between Leipzig University (Germany) and Vanderbilt University, Nashville (Tennessee, USA) have been published in the Journal of Biological Chemistry by end of 2010. Researchers from the labs of Annette G. Beck-Sickinger (Leipzig University) and Vsevolod V. Gurevich (Vanderbilt University) investigated the mechanism and regulation of neuropeptide Y2 receptor internalization. For the first time, the corporate publication “Ligand-induced internalization and recycling of the human neuropeptide Y2 receptor is regulated by its carboxyl-terminal tail” reports on specific sequences located in the receptor’s C-terminus which determine arrestin-dependent/independent internalization and recycling events, thus contributes to a better understanding of the regulation of G protein-coupled receptor trafficking pathways.

Cornelia Walther, Stefanie Nagel, Luis E. Gimenez, Karin Mörl, Vsevolod V. Gurevich, and Annette G. Beck-Sickinger: Ligand-induced Internalization and Recycling of the Human Neuropeptide Y2 Receptor Is Regulated by Its Carboxyl-terminal Tail J. Biol. Chem. 2010 285: 41578-41590.