All multicellular organisms are
highly dependent on the
capacity developed by their cells to communicate with each other and
with their environment. G protein-coupled receptors (GPCRs) play a
central role in controlling this communication. These seven
transmembrane receptors regulate numerous physiological mechanisms in
health and disease and thus, bear an immense pharmacological potential.
One class of to date enigmatic GPCRs are Adhesion GPCRs (aGPCRs).
essential functions in processes such as neurobiology, immunology or
development and their unique architecture facilitating cell and matrix
interactions, Adhesion GPCRs are by far the most poorly understood
Simone Prömel, DPhil (Oxon)