Prömel Lab

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Research

Team

Publications

Schöneberg T, Prömel S. (2019)
Latrophilins and Teneurins in invertebrates: no love for each other?
Front Neurosci.  13:154
Röthe J, Thor D, Winkler J, Knierim AB, Binder C, Huth S, Kraft R, Rothemund S, Schöneberg T, Prömel S. (2019)
Involvement of the Adhesion GPCRs Latrophilins in the Regulation of Insulin Release
Cell Rep.  26(6):1573-1584
Matúš D, Prömel S. (2018)
G Proteins and GPCRs in C. elegans Development: A Story of Mutual Infidelity.
Dev Biol.  6(4)
Nazarko O, Kibrom A, Winkler J, Stoveken H, Leon K, Salzman G, Merdas K, Lu Y, Narkhede P, Tall G, Prömel S, Araç D. (2018)
A comprehensive mutagenesis screen of the adhesion GPCR Latrophilin-1/ADGRL1
iScience  3:264-278
Scholz N, Guan C, Nieberler M, Grotemeyer A, Maiellaro I, Gao S, Beck S, Pawlak M, Sauer M, Asan E, Rothemund S, Winkler J, Prömel S, Nagel G, Langenhan T, Kittel RJ. (2017)
Mechano-dependent signaling by Latrophilin/CIRL quenches cAMP in proprioceptive neurons
Elife  8;6. pii: e28360
Demberg LM, Winkler J, Wilde C, Simon KU, Schön J, Rothemund S, Schöneberg T, Prömel S#, Liebscher I#. (2017)
Activation of adhesion GPCRs: agonist specificity of Stachel sequence-derived peptides
J Biol Chem.  17;292(11):4383-4394
# equal contribution and shared correspondence
Merkwitz C, Blaschuk O, Winkler J, Schulz A, Prömel S, Ricken AM. (2017)
Advantages and Limitations of Salmon-Gal/Tetrazolium Salt Histochemistry for the Detection of LacZ Reporter Gene Activity in Murine Epithelial Tissue.
Histochem Cytochem. 65(4):197-206

Strutt D, Schnabel R, Fiedler F, Prömel S. (2016)
Adhesion GPCRs Govern Polarity of Epithelia and Cell Migration.
Handb Exp Pharmacol. 234:249-274
Prömel S#, Fiedler F, Binder C, Schöneberg T, Thor D#. (2016)
Deciphering and modulating G protein signalling in C. elegans using the DREADD technology.
Sci Rep. 27;6:28901
# shared correspondence
Winkler J, Prömel S. (2016)
The adhesion GPCR latrophilin – a novel signaling cascade in oriented cell division and anterior-posterior polarity.
Worm 5(2) e1170274
Merkwitz C, Blaschuk O, Eplinius F, Winkler J, Prömel S, Schulz A, Ricken A. (2015)
A simple method for inducing estrous cycle stage-specific morphological changes in the vaginal epithelium of immature female mice.
Lab Anim. 0023677215617387
Müller A, Winkler J, Fiedler F, Sastradihardja T, Binder C, Schnabel R, Kungel J, Rothemund S, Hennig C, Schöneberg T, Prömel S. (2015)
Oriented cell division in the C. elegans embryo Is coordinated by G-protein signaling dependent on the Adhesion GPCR LAT-1.
PLoS Genet. 11(10):e1005624
Hamann J, Aust G, Araç D, Engel FB, Formstone C, Fredriksson R, Hall RA, Harty BL, Kirchhoff C, Knapp B, Krishnan A, Liebscher I, Lin HH, Martinelli DC, Monk KR, Peeters MC, Piao X, Prömel S, Schöneberg T, Schwartz TW, Singer K, Stacey M, Ushkaryov YA, Vallon M, Wolfrum U, Wright MW1, Xu L, Langenhan T, Schiöth HB. (2015)
International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G Protein-Coupled Receptors.
Pharmacol Rev. 67(2):338-674
Liebscher I, Ackley B, Araç D, Ariestanti DM, Aust G, Bae BI, Bista BR, Bridges JP, Duman JG, Engel FB, Giera S, Goffinet AM, Hall RA, Hamann J, Hartmann N, Lin HH, Liu M, Luo R, Mogha A, Monk KR, Peeters MC, Prömel S, Ressl S, Schiöth HB, Sigoillot SM, Song H, Talbot WS, Tall GG, White JP, Wolfrum U, Xu L, Piao X. (2014)
New functions and signaling mechanisms for the class of adhesion G protein-coupled receptors.
Ann N Y Acad Sci. 1333:43-64
Prömel S, Langenhan T, Araç D. (2013)
Matching structure with function: the GAIN domain of Adhesion-GPCR and PKD1-like proteins.
Trends Pharmacol Sci. 34: 470-8
Liebscher I, Schöneberg T, Prömel S. (2013)
Progress in demystification of adhesion GPCR.
Biol Chem. 394: 937-950
Araç D, Aust G, Calebiro D, Engel FB, Formstone C, Goffinet A, Hamann J, Kittel RJ, Liebscher I, Lin HH, Monk KR, Petrenko A, Piao X, Prömel S, Schiöth HB, Schwartz TW, Stacey M, Ushkaryov YA, Wobus M, Wolfrum U, Xu L, Langenhan T. (2012)
Dissecting signaling and functions of adhesion G protein-coupled receptors.
Ann N Y Acad Sci. 1276: 1-25
Prömel S, Frickenhaus M, Hughes S, Mestek L, Staunton D, Woollard A, Vakonakis I, Schöneberg T, Schnabel R, Russ AP, Langenhan T. (2012)
The GPS Motif Is a Molecular Switch for Bimodal Activities of Adhesion Class G Protein-Coupled Receptors.
Cell Rep. 2: 321-31
Prömel S, Waller-Evans H, Dixon J, Zahn D, Colledge WH, Doran J, Carlton MB, Grosse J, Schöneberg T, Russ AP, Langenhan T. (2012)
Characterization and functional study of a cluster of four highly conserved orphan adhesion-GPCR in mouse.
Dev. Dyn. 1: 1591-602
Gregory AP, Dendrou CA, Attfield KE, Haghikia A, Xifara DK, Butter F, Poschmann G, Kaur G, Lambert L, Leach OA, Prömel S, Punwani D, Felce JH, Davis SJ, Gold R, Nielsen FC, Siegel RM, Mann M, Bell JI, McVean G, Fugger L. (2012)
TNF receptor 1 genetic risk mirrors outcome of anti- TNF therapy in multiple sclerosis.
Nature 488: 508-11
Waller-Evans H, Prömel S, Langenhan T, Dixon J, Zahn D, Colledge WH, Doran J, Carlton MB, Davies B, Aparicio SA, Grosse J, Russ AP (2010)
The orphan adhesion-GPCR GPR126 is required for embryonic development in the mouse.
PLoS One 18;5(11):e14047
Langenhan T, Prömel S, Mestek L, Esmaeili B, Waller-Evans H, Kohara Y, Avery L, Vakonakis I, Schnabel R, Russ A (2009)
Latrophilin signaling links anterior-posterior tissue polarity and oriented cell divisions in the C. elegans embryo.
Dev. Cell 4: 494-504
Vakonakis I, Langenhan T, Prömel S, Russ A, Campbell ID (2008)
Solution Structure and Sugar-Binding Mechanism of Mouse Latrophilin-1 RBL: a 7TM Receptor-Attached Lectin-Like Domain.
Structure 16: 944-953