Institute of Bioanalytical Chemistry
Prof. Dr. Norbert Sträter
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for Biotechnology and Biomedicine Institute of Bioanalytical Chemistry |
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| Structural
analysis of biopolymers Prof. Dr. Norbert Sträter |
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Welcome
to the homepage of the research group "Structural analysis of
biopolymers" at the Center for Biotechnology and Biomedicine in Leipzig!  Protein crystallography and Structural biochemistry The
most important method used in the laboratory is protein crystallography
for the determination of the 3D structures of proteins. Only on the
basis of the spatial structure, the molecular function of a protein can
be fully understood.
For protein production, the main tools are molecular biology methods,
bioanalytical
techniques and biochromatography.
Biocatalysis and Enzyme design With
the help of structural and biochemical methods we study the mode of
action of enzymes, which are of medical, pharmaceutical or
biotechnological interest. Enzymes find an increasing use as efficient
and environmentally clean catalysts especially for stereospecific or
regioselective organic synthesis ("White Biotechnology"). Based on the
3D structures and the molecular mechanism we design new
biocatalysts with novel specificities or even reactivities.
Enzymes as drug targets On
the basis of the spatial structure of a pharmaceutically interesting
enzymes, inhibitors as potential drugs can be developed rationally. Our
main interest here is purinergic signalling: extracellular signalling
pathways via ATP and other nucleotides.
Extracellular signalling
In addition to purinergic signalling we are studying the structure and
function of other proteins involved in extracellular signalling, mainly
adhesion GPCRs.
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