29.11.2020: Virtual Talk “Small-molecule inhibitors of cancer-related protein-protein interactions” (Prof. Thorsten Berg, Faculty of Chemistry and Mineralogy at Leipzig University)

/ October 18, 2020/ Events, Students

We would like to invite you to our next VULU Lecture given by

Prof. Dr. Thorsten Berg, Faculty of Chemistry and Mineralogy at Leipzig University

Small-molecule inhibitors of cancer-related protein-protein interactions

Protein-protein interactions form the basis of most biological processes, but represent very challenging targets for small organic molecules. The focus of our current research is to develop and apply innovative methods for the efficient design of small organic modulators of protein-protein interactions. These methods are applied for the synthesis and functional characterization of highly potent modulators of pre-selected protein-protein interactions. The presentation will give an overview on our recent work in the following areas: 1) development of selective inhibitors of the transcription factors STAT5a and STAT5b, 2) generation of bioactive molecules in living cells by isomer-free SPAAC, and 3) development of hydrophobically-tagged inhibitors of the Plk1 PBD and the p53/MDM2 interaction.