Call 2021: Offering research internship for Students on Bachelor- or Master level

The Max Kade Foundation (MKF, www.maxkadefoundation.org) supports an international research exchange between Vanderbilt and Leipzig Universities. Specifically, MKF provides funds of three‐four undergraduate students from each university to conduct a 10 week summer internship at the respective partner university. Travel costs and a weekly stipend are provided. They target rising junior and rising senior students at Vanderbilt University.…

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16-20.08.2021: Module “Exploring Biomolecules in 3D: Principles and Applications of Computational Structural Biology”

We cordially invite you to a one week block online seminar “Exploring Biomolecules in 3D: Principles and Applications of Computational Structural Biology” by: Prof. Dr. Jens Meiler(Leipzig University, Coordinator)Dr. Georg Kuenze(Leipzig University)Prof. Dr. Jarrod Smith(Vanderbilt University / USA)Prof. Dr. Rocco Moretti(Vanderbilt University / USA) DATE16 – 20. August 2021, EST (13. August 2021 technical setup) The class will meet virtually on…

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07-18.12.2020: Module “Solution NMR integrated with Computational Modeling to study Membrane Proteins”

We cordially invite you to a two week block online seminar “Solution NMR integrated with Computational Modeling to study Membrane Proteins” by: Prof. Dr. Jens Meiler(Leipzig University, Vanderbilt University / USA, Organizer)Prof. Dr. Chuck Sanders(Vanderbilt University / USA)Dr. Georg Künze(Leipzig University, Vanderbilt University / USA)Dr. Davide Sala(Leipzig University) DATE07 – 18. December 2020, 3 – 5 p.m. CEST (15:00 – 17:00…

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22.09.2020: Virtual Talk “Making the most of sparse data: Modeling the glutamate-GABA antiporter using double electron-electron resonance spectroscopy data” (Diego del Alamo, Vanderbilt University)

Diego del Alamo (Vanderbilt University, Nashville, USA) Abstract: The glutamate-GABA antiporter GadC is a 52 kDa membrane transporter protein that contributes to acid resistance in pathogenic bacteria such as Listeria monocytogenes and Shigella flexneri. Because the only published structure was determined crystallographically under conditions where it is inactive, the low-pH active conformation remains unknown. The study of this…

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07.-21.08.2020: Virtual Course “Computational methods to study protein structure and dynamics” (Hildebrand, Meiler, Smith, Moretti)

Syllabus – CPBP 8330 – Special Topics in Protein BiochemistryCOMPUTATIONAL METHODS TO STUDY PROTEIN STRUCTURE AND DYNAMICS Course Description:Biomolecules undergo constant motions and fluctuations in their native environment. Many of these motions are directly related to function: Channels have to open or close, transporters change their form to conduct molecules and receptors undergo conformational changes to transmit signals…

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Scientists find human antibodies against COVID-19

[article written by Peggy Darius Leipzig University] The COVID 19 pandemic poses a major threat to global health and currently there is little medical response. In addition, there is a lack of a profound understanding of the molecular mechanisms of the body's immune system. An international team has now succeeded in scientifically describing highly active neutralizing human antibodies…

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Old home and new challenge

[article only in german language, article written by Dr. Katarina Werneburg Leipzig University / picture: Christian Hüller / Universität Leipzig, SUK] Alte Heimat und neue Herausforderung Was sind die Forschungsschwerpunkte unserer Professoren? Was ist ihnen in der Lehre wichtig, und haben unsere Experten eigentlich auch Hobbys oder ein Lebensmotto? Im LUMAG stellt sich auch heute wieder einer unserer…

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University Success for Three Collaborative Research Centres

[Press Release 25/11/2019, Leipzig University 234/2019 by Carsten Heckmann / Photo: Leipzig University, Swen Reichhold] Further boost for top-level research at Leipzig University: New Collaborative Research Centre gets go-ahead and two more are extended. The University’s new Collaborative Research Centre (CRC), “Structural Dynamics of GPCR Activation and Signal Transduction”, will focus on how cells communicate via important receptors.…

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Dr. Torben Schiffner: HIV vaccine development using rational protein design

December 19, 2019; 12:30: Talk at the at Fraunhofer Institute for Cell Therapy and Immunology - IZI Abstract: Despite decades of intensive research, a vaccine capable of protecting against HIV-1 infection remains elusive. The immuno-evasion strategies employed by the HIV-1 envelope glycoprotein have been a significant challenge to progress in the field. However,  antibodies capable of neutralizing most…

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Call 2020: Offering research internship for Students on Bachelor- or Master level

The Max Kade Foundation (MKF, www.maxkadefoundation.org) supports an international research exchange between Vanderbilt and Leipzig Universities. Specifically, MKF provides funds of three‐four undergraduate students from each university to conduct a 10 week summer internship at the respective partner university. Travel costs and a weekly stipend are provided. They target rising junior and rising senior students at Vanderbilt University.…

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Prof. Tony Capra: Diagnosing the Legacy of Neanderthal Interbreeding on Modern Humans

December 12, 2019; 14:00: Talk at the Department of Evolutionary Genetics Location:Seminar Area Genetics Abstract: [will be annouced soon] Contact: Max-Planck-Institut für evolutionäre Anthropologie Janet Kelso (mail: ) Website: https://www.eva.mpg.de/genetics/index.html

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Lecture on “Modeling protein mutations with Rosetta” at Leipzig University

December 05-19, 2019. This course teach theoretical and practical aspects of computational biology including the integration of Human Genetics with Molecular Modeling. It focus on aspects of protein sequence alignments, secondary structure prediction, comparative modeling, protein-protein and protein-ligand docking, structure-based drug design, virtual screening, the relationship of protein sequence, structure, variation, and disease. This course includes a practical…

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Lecture on “New approaches for practical and time efficient cloning, construct design and the strategic selection of protein-protein interaction techniques” at Vanderbilt University

September 4-10, 2019: Syllabus – CPBP 8330 – Special Topics in Protein Biochemistry: Dr. Dr. Ines LiebscherLeipzig University, Medical Faculty, Institute of Biochemistry Date 04 – 10 September 2019 VenueDepartments of Chemistry, Pharmacology, and Biomedical Informatics, Center for Structural Biology, and Institute of Chemical Biology, 465 21st Ave South, BIOSCI/MRBIII, Room 5131, Nashville, TN 37232-8725 Program: Research techniques…

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The Alexander von Humboldt Foundation awarded Prof. Dr. Jens Meiler

[article written by Dr. Katarina Werneburg Leipzig University / picture: Humboldt-Stiftung/Elbmotion] The Alexander von Humboldt Foundation awarded Prof. Dr. Jens Meiler the highly endowed Alexander von Humboldt Professorship. The 44-year-old is one of the world’s most distinguished researchers in the field of computer-aided drug discovery. The Alexander von Humboldt Professorship is Germany’s most valuable research prize. “I am…

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Apply for Max Kade Scholarship 2019

Unique Opportunities in Gaining Research Experience in Germany and USA The Max Kade Foundation (MKF, www.maxkadefoundation.org) supports an international research exchange between Vanderbilt and Leipzig Universities. Specifically, MKF provides funds of three undergraduate students from each university to conduct a 10 week summer internship at the respective partner university in 2019 (May – December). The Max Kade Foundation…

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Lecture on “Modeling Proteins guided by Electron Paramagnetic Resonance and Mass Spectrometry” at Leipzig University

December 11-18, 2018; Biochemical Lecture – Special Topics in Biochemistry Lecture on “Modeling Proteins guided by Electron Paramagnetic Resonance and Mass Spectrometry” 11.-14.12.2018, 01 PM - 04 PM Module 1: Molecular Modeling Prof. Jens Meiler (Vanderbilt University/USA) *Introduction to Structural Biology *Protein Structure Prediction with Rosetta *Protein Structure Prediction from EPR DATA 17.-19.12.2018, 09 AM - 4 PM…

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Summer School on “Peptide-Activated GPCRs: Ligand Binding And Signal Transduction” at Vanderbilt University

October 20-24, 2018; Syllabus – CPBP 8330 – Special Topics in Ligand-Protein Recognition Prof. Dr. Annette G. Beck-Sickinger, Leipzig University, Faculty of Life Sciences, Institute of Biochemistry Date October 20-24, 2018 Venue Departments of Chemistry, Pharmacology, and Biomedical Informatics, Center for Structural Biology, and Institute of Chemical Biology, 465 21st Ave South, BIOSCI/MRBIII, Room 5131, Nashville, TN 37232-8725…

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Researchers of Vanderbilt and Leipzig University discover ligand binding modes at the neuropeptide Y Y1 receptor

(30/04/2018 by Anett Albrecht): A joint publication of Leipzig and Vanderbilt scientists was published in April 2018 in the prestigious journal “Nature”. The article continues the series of numerous publications that have emerged already from the long-term collaboration between the Leipzig and Vanderbilt University. Abstract: Neuropeptide Y (NPY) receptors belong to the G-protein-coupled receptor superfamily and have important…

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Universities extend partnership by another ten years

[press release written by Susann Huster/Anett Albrecht, April 10, 2018] The cooperation between the University of Leipzig and Vanderbilt in Nashville (USA) has been contractually sealed for another ten years. A few days ago, the rectors of both universities signed a Memorandum of Understanding. The American Max Kade Foundation had previously approved an application for funding from project…

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Max Kade Scholarship 2018: Unique Opportunities in Gaining Research Experience in Germany and USA

The Max Kade Foundation (MKF, www.maxkadefoundation.org) supports an international research exchange between Vanderbilt and Leipzig Universities. Specifically, MKF provides funds of three undergraduate students from each university to conduct a 10 week summer internship at the respective partner university in 2018 (May – September). The Max Kade Foundation Scholarship Program is open for highly motivated and excellent foreign…

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Lecture on “Innovative Computational Methods for Protein Structure Prediction, Drug Discovery, and Therapeutic Design” at Leipzig University

Biochemical Colloquium – Special Topics in Biochemistry: Prof. Dr. Jens Meiler, Center for Structural Biology, Departments of Chemistry, Pharmacology, and Biomedical Informatics, Vanderbilt University, Nashville Tenessee Date October 24, 2017 / 5 PM Venue Leipzig University, ITP - Institute for Theoretical Physics, Lecture Hall, Linnéstraße 5, 04103 Leipzig, Germany. Backround The protein folding problem – i.e. predicting the…

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Lecture on “G PROTEIN-COUPLED RECEPTORS: FROM CLONING TO FUNCTIONAL READ-OUT” at Vanderbilt University

Syllabus – CPBP 330 – Special Topics in Protein Biochemistry Dr. Dr. Ines Liebscher Leipzig University, Medical Faculty, Institute of Biochemistry Date 02 – 06 October 2017 Venue Departments of Chemistry, Pharmacology, and Biomedical Informatics, Center for Structural Biology, and Institute of Chemical Biology, 465 21st Ave South, BIOSCI/MRBIII, Room 5131, Nashville, TN 37232-8725 This course will focus…

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International Cooperation: Max-Kade Foundation extends the international fellowship program between Nashville and Leipzig

The Center of Structural Biology (Vanderbilt University) and the Institute of Biochemistry (Leipzig University) has secured funds for an international fellowship program from the Max Kade Foundation for the period 2017 to 2021. The Max Kade Foundation takes pride in participating and sponsoring various programs which encourage the exchange of academic ideas among universities and colleges in the…

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Apply for Max Kade Scholarship 2017

Unique Opportunities in Gaining Research Experience in Germany and USA The Max Kade Foundation (MKF, www.maxkadefoundation.org) supports an international research exchange between Vanderbilt and Leipzig Universities. Specifically, MKF provides funds of three undergraduate students from each university to conduct a 10 week summer internship at the respective partner university in 2017 (May – December). The Max Kade Foundation…

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DAAD RISE Programm: CALL 2017

The German Academic Exchange Service (Deutscher Akademischer Austauschdienst, DAAD) announced a new call for its program “Research Internships in Science and Engineering” (RISE) for summer internship in 2017. The program works in both ways. German and American Ph.D. students submit internship offers for undergraduates students for a duration of 8 to 12 weeks. German bachelor students can work…

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Short report by Henrike Indrischek: Binding Capability of Visual Arrestins to the Coated Pit Machinery at Vanderbilt University (May 05 – July 28)

by Henrike Indrischek (phd student at Leipzig University): During my research stay at Vanderbilt university this summer, I worked on the biochemical characterization of the interaction of clathrin and visual arrestin in the laboratory of Seva Gurevich and the modeling of this interaction with computational methods in the laboratory of Jens Meiler. The cytosolic arrestin proteins mediate desensitization…

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Researchers of Vanderbilt and Leipzig University discover small-molecule modulators of the human Y4 receptor

(07/04/2016 by Anett Albrecht): A joint publication of Leipzig and Vanderbilt scientists was published in June 2016 in the prestigious journal "PLoS One". The article continues the series of numerous publications that have emerged already from the long-term collaboration between the Leipzig and Vanderbilt University. Abstract: The human neuropeptide Y4 receptor (Y4R) and its native ligand, pancreatic polypeptide,…

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Lecture on “Regulation of Exocytosis by inhibitory GPCRs and Gbg subunits” at Leipzig University

Biochemical Colloquium – Special Topics in Biochemistry: Prof. Dr. Heidi Hamm, Vanderbilt University Department of Pharmacology, Nashville, TN, USA Date July 13, 2016 / 3 PM Venue Departments of Bioscience, Pharmacy and Psychology, Institute of Biochemistry, Small Lecture Hall (1st Floor), Brüderstraße 34, 04103 Leipzig, Germany. Backround Prof. Hamms work is focused on understanding the molecular basis of…

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Course on “In vitro Preparation of Membrane Proteins – from Target DNA to NMR Spectra” at Vanderbilt University

Graduate Course – Special Topics in Protein Biochemistry Dr. Peter Schmidt, Leipzig University, Faculty of Medicine, Institute for Medical Physics and Biophysics Date The class will meet on six days in July always 9:35-12:15. Dates will be finalized with class participants. This is a one credit course. Venue Departments of Chemistry, Pharmacology, and Biomedical Informatics, Center for Structural…

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Short report by Mario Schubert: HTS to Identify and Characterize Small Molecule Allosteric Modulators of the Human Y4 Receptor at Vanderbilt University (Oct 19 – Dec 15)

During an internship in the lab of Dave Weaver at Vanderbilt University, I got the opportunity to gain more information about the Y4R, by testing a variety of similar structurally related compounds. I was introduced in the workflow of a high throughput screening laboratory. The technical equipment in the Vanderbilt HTS center makes it possible to test thousands…

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Short Report by Axel Fischer & Gregory Sliwoski: INTEGRATION OF LIMITED EXPERIMENTAL DATA INTO ENSEMBLE PREDICTION at Leipzig University (Nov 14 – Dec 22)

The objective of our visit was deepening the collaboration between Leipzig University and Vanderbilt University regarding the integration of limited experimental data into protein ensemble prediction. During this visit Axel Fischer presented a method to integrate cross-linking data into protein structure prediction methods at the 5th Symposium on Structural Proteomics in Halle. Following subsequent discussions with Dr. Stefan…

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Scientists of Vanderbilt and Leipzig University improved drug effects of Indomethacin

(Leipzig/Nashville, 02/03/2016): Scientists at Leipzig University and Vanderbilt University (USA) reduced the side effects of Indomethacin by altering the so-called boron cluster molecule of this drug. This molecule have a spherical shape - composed of boron, hydrogen and carbon atoms. The active ingredient causes an inhibition of the enzyme cyclooxygenase, which plays an important role in production of…

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Professor Jens Meiler received Friedrich Wilhelm Bessel Research Award

(by David Salisbury, Vanderbilt University): Associate Professor of Chemistry Jens Meiler has received a Friedrich Wilhelm Bessel Research Award from the Alexander von Humboldt Foundation in Bonn, Germany. The award is given to scholars based on their “outstanding research accomplishments and exceptional promise for the future.” Individuals are nominated by German scholars and must have received their Ph.D.…

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Short Report by Brain Bender: Expression of Y2R Variants for EPR Structural Studies at Leipzig University (Aug 21 – Oct 14)

This fall I was awarded the opportunity to return to Leipzig University to work in the lab of Dr. Daniel Huster. This research exchange corresponded nicely with the 11th International NPY-PYY-PP Conference. At the conference I was able to interact with many people in the field of neuropeptide Y (NPY) and its related peptide hormones. At this conference,…

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Apply for MAX KADE SHOLARSHIP 2016: Unique Opportunities in Gaining Research Experience in Germany and USA

The Max Kade Foundation (MKF, www.maxkadefoundation.org) supports an international research exchange between Vanderbilt and Leipzig Universities. Specifically, MKF provides funds of three undergraduate students from each university to conduct a 10 week summer internship at the respective partner university in 2016 (May – September). The Max Kade Foundation Scholarship Program is open for highly motivated and excellent foreign…

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Max-Kade Scholarship 2015: Short-Reports

In 2015 eight students on Bachelor- or Master level got the Max-Kade Scholarship to participate in ongoing research projects between Vanderbilt University and the University of Leipzig. Hereby their short research and travel reports are listed... Ryan Xin (Undergraduate Student at Vanderbilt University): Semisynthetic Preparation of Ga Fusion Proteins to Investigate Receptor Interaction (Laboratory of Prof. Dr. Annette…

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Short Report by Dr. Wilma Neumann: BIOLOGICAL EVALUATION OF CARBORANE-CONTAINING COX INHIBITORS at Vanderbilt University (SEPT 09 – SEPT 19)

written by Wilma Neumann (postdoctoral associate at Leipzig University): Over the last years, the groups of Prof. Evamarie Hey-Hawkins (Institute of Inorganic Chemistry, Leipzig University) and Prof. Larry Marnett (Department of Biochemistry, Vanderbilt University School of Medicine) have developed a very fruitful collaboration, supported by the Leipzig-Vanderbilt collaboration project. Recently, we described a very potent and selective inhibitor…

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Short Report of Gregory Sliwoski: STUDYING SMALL-MOLECULE MODULATORS OF THE Y4 RECEPTOR at University of Leipzig (AUG 20 – SEPT 10)

by Gregory Sliwoski (doctoral student at Vanderbilt University): After completing my M.S. in pharmacology from Vanderbilt University under Prof. Dr. Jens Meiler in 2012, I joined Annette Beck-Sickinger's lab at Leipzig University to further study the neuropeptide Y4 receptor (Y4R). This particular trip is my fourth stay in Leipzig in the collaboration between the labs of Prof. Dr.…

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Announcement: Scientific and Methode Modules “COMPUTATIONAL STRUCTURAL BIOLOGY WITH ROSETTA” at Leipzig University

This course teach theoretical and practical aspects of computational biology including the integration of Human Genetics with Molecular Modeling. It focus on aspects of protein sequence alignments, secondary structure prediction, comparative modeling, protein-protein and protein-ligand docking, structure-based drug design, virtual screening, the relationship of protein sequence, structure, variation, and disease. This course includes a practical section and is…

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OFFERING RESEARCH INTERNSHIP – MAX KADE Scholarship for Students on Bachelor- or Master level: Call 2016

The Max Kade Foundation (MKF, www.maxkadefoundation.org) supports an international research exchange between Vanderbilt and Leipzig Universities. Specifically, MKF provides funds of three‐four undergraduate students from each university to conduct a 10 week summer internship at the respective partner university. Travel costs up to $2000 and a weekly stipend of $400 are provided. They target rising junior and rising…

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Lecture on “Structural analysis of protein complexes by mass spectrometry and computational modelling – basics and applications of a beautiful combination” at Vanderbilt

Center for Structural Biology Dr. Stefan Kalkhof, Post-Doc, Mass Spectrometry Group, Department of Proteomics, Helmholtz-Centre for Environmental Research - UFZ, Leipzig, Germany Date 05 June 2015 Venue Center for Structural Biology, 465 21st Ave South, BIOSCI/MRBIII, Vanderbilt University, Nashville, TN 37221

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Course on “Site-specific protein labeling and incorporation of unnatural amino acids in live cells” at Vanderbilt University

Syllabus – CPBP 330 – Special Topics in Protein Biochemistry Dr. Irene Coin, Leipzig University, Faculty of Life Sciences, Institute of Biochemistry Date 14 – 21 July 2015 Venue Departments of Chemistry, Pharmacology, and Biomedical Informatics, Center for Structural Biology, and Institute of Chemical Biology, 465 21st Ave South, BIOSCI/MRBIII, Room 5144B, Nashville, TN 37232-8725 The student will…

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It is the sound of music – a remarkable partnership: Researchers from Leipzig and Nashville investigate molecular mechanisms

by Carsten Heckmann (LUMAG, 01-2015, 03/12/2015): To name the cities of Leipzig and Nashville in a sentence, could comes up with the idea: it could go on music. Classic here - Country there. But this is no topic for this research report. There is also the research field biochemistry - with a remarkable partnership between both universities. To…

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Dicovering interaction mode of specific carbaborane derivatives with GPCRs at Vanderbilt University

by Peter Schmidt (postdoc at Leipzig University): GPCRs have been shown to play a crucial role in a variety of diseases, such as obesity, metabolic diseases and cancer. Accordingly, they are an attractive target for the investigation of new pharmaceuticals. Di-carba-closo-dodecaboranes(12) (closo-C2B12H12 or carbaboranes) were recently established as pharmacophores. Their unique properties (hydrophobicity, three-dimensional aromaticity, etc.) make them…

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Max-Kade Scholarship 2014: Short-Reports

2014 eight students on Bachelor- or Master level got the Max-Kade Scholarship to participate in ongoing research projects between Vanderbilt University and the University of Leipzig. Hereby there short research and travel reports: Luise Spormann (Undergraduate Student at Leipzig University): CYCLOOXYGENASE STRUCTURE, FUNCTION AND INHIBITION (Laboratory of Prof. Dr. Lawrence Marnett / July-October 2014) I worked in Dr.…

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Scientific and Methode Modules “Computational Structural Biology with ROSETTA”

Date 08 – 19 December 2014 Venue Biotechnologisch-Biomedizinisches Zentrum (BBZ), Seminar room 1.1, Deutscher Platz 5, 04103 Leipzig Responsible scientists Prof. Dr. Jens Meiler (Vanderbilt University) Prof. Dr. Annette Beck-Sickinger (Leipzig University) Dr. Jonathan Sheehan (Vanderbilt University) Dr. Rene Meier (Leipzig University) Aims Teach theoretical and practical aspects of computational structural biology using the Rosetta software. Basics Biochemistry,…

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Identification of new target GPCR at Vanderbilt University

by Antje Brüser (postdoc at Leipzig University): I had the possibility to join Vanderbilt University from March 26th – July 11th 2014 as a visiting scholar to initiate a new project between our group (headed by Prof. Torsten Schöneberg) and the group of Prof. Larry Marnett. We focus in our lab on orphan G-protein coupled receptors (oGPCR) and…

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Biological evaluation of modified COX inhibitors at Vanderbilt University

by Wilma Neumann (doctoral student at Leipzig University): After a successful start-up of a new collaboration project last autumn followed by a joint publication earlier this year, the group of Prof. Larry Marnett again welcomed me in their lab during my second research stay at Vanderbilt between May 21st and June 21st, 2014. Continuing our project on conjugates…

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Research stay at the Division of Nephrology and Hypertension at the Vanderbilt University Medical Center (VUMC)

by Thomas Ebert (postdoc at Leipzig University): From January 3rd, 2014 – April 4th 2014, I had the opportunity to stay at the Division of Nephrology and Hypertension at the Vanderbilt University Medical Center (VUMC) in Nashville, Tennessee as a visiting scholar. In our group in Leipzig (headed by Prof. Mathias Fasshauer), we focus on adipocyte-secreted proteins, so…

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