Summer School on Receptor Theory and GPCR signalling via G proteins and arrestins

/ August 28, 2012/ Events

Prof. Dr. Vsevolod Gurevich, Vanderbilt University, Nashville, TN

8 – 12 October 2012, Leipzig University

Arrestins are proteins which regulate the signalling and trafficking of hundreds of different G-protein-coupled receptors (GPCR). But arrestins also interact with other classes of membrane receptors and over 20 diverse types of soluble signalling protein. Arrestins can block GPCR coupling to G proteins in two ways. But they can also modify gene expression by increasing the transcription of certain genes.Several arrestin-binding partners play a key role in the signalling pathways regulating cell proliferation, survival and apoptosis. Since multiple genetic disorders can be associated with excessive signalling by mutant G-protein-coupled receptors, arrestin is an interesting target for therapeutic intervention. Vsevolod Gurevich uses different approaches for the investigation of arrestin functions ranging from basic biochemistry and X-ray crystallography to cell culture and transgenic animals. In his lectures, he will give an overview of receptor theory, explain key methods of studying receptors and receptor-initiated cell signalling as well as explain key signalling pathways initiated by GPCRs via activation of G proteins and arrestins.

If you want to attend the summer school, please register by sending an e-mail to Anja Pohl.

Further information (pdf): Schedule of Summer School on Receptor Theory