Researchers of Leipzig and Vanderbilt Universities published a paper in the journal “Bioorganic & Medicinal Chemistry” showing the results of their collaborative project on carbaborane research. The paper, published in March 2011, describes new synthesis strategies of indomethacin derivatives with inorganic carbaborane clusters. Indomethacin is a very potent cyclooxygenase (COX)-1 and COX-2 inhibitor with clinical significance as anti-inflammatory drug , The carbaborane-modified drug candidates showed also COX inhibition activity, depending on the carbaborane isomer and the connection pattern. The results gave general insights into the applicability of carbaboranes as drug entities. Synthesis and evaluation of carbaborane derivatives of indomethacin as cyclooxygenase inhibitors Matthias Scholz(1), Anna L. Blobaum(2), Lawrence J. Marnett(2) and
The 3rd Cooperation Workshop of Leipzig and Vanderbilt Universities took place in Leipzig on May 25th until 29th, 2011. It was organized by the Top-Level Research Area 3 “Molecular and Cellular Communication” (PbF3) Six faculty from Vanderbilt University visited Leipzig, participated in a scientific symposium, and used the opportunity to get in touch close contact with researchers from Leipzig University and non-university institutions. The guests were heartily welcomed by new university rector, Prof. Dr. Beate A. Schücking on Wednesday evening at the top of Leipzig’s old university building, now the Panorama Tower in the city center. On Thursday, a public scientific symposium took place at the seminar building, eagerly visited by