Call 2023: Offering research internship for Students on Bachelor- or Master level (Deadline is September 15, 2022)

Call 2023: Offering research internship for Students on Bachelor- or Master level (Deadline is September 15, 2022)

The Max Kade Foundation (MKF, www.maxkadefoundation.org) supports an international research exchange between Vanderbilt and Leipzig Universities. Specifically, MKF provides funds of three‐four undergraduate students from each university to conduct a 10 week summer internship at the respective partner university. Travel costs and a weekly stipend are provided. They target rising junior and rising senior students at Vanderbilt University. To select the recipients of the stipend, we collect research project descriptions from around twenty core laboratories that support the collaboration between Vanderbilt and Leipzig Universities. Descriptions are provided by the graduate student or post‐doctoral mentor who will advise the undergraduate student. It is encouraged that the undergraduate student conducts research on the

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Apply for  Max Kade Scholarship 2022

Apply for Max Kade Scholarship 2022

Unique Opportunities in Gaining Research Experience in Germany and USA The Max Kade Foundation (MKF, www.maxkadefoundation.org) supports an international research exchange between Vanderbilt and Leipzig Universities. Specifically, MKF provides funds of three undergraduate students from each university to conduct a 10 week summer internship at the respective partner university in 2019 (May – December). The Max Kade Foundation Scholarship Program is open for highly motivated and excellent foreign applicants with a BSc, MSc or equivalent degrees (obtained during the past year). Internship offer in Leipzig for Undergraduate Students from Vanderbilt University  Evolutionary Guided Design of Novel PET-Degrading Enzymes to increase Thermostability Dr. Georg Künze (Institute for Drug Development) Analysis of Ternary

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Call 2021: Offering research internship for Students on Bachelor- or Master level

Call 2021: Offering research internship for Students on Bachelor- or Master level

The Max Kade Foundation (MKF, www.maxkadefoundation.org) supports an international research exchange between Vanderbilt and Leipzig Universities. Specifically, MKF provides funds of three‐four undergraduate students from each university to conduct a 10 week summer internship at the respective partner university. Travel costs and a weekly stipend are provided. They target rising junior and rising senior students at Vanderbilt University. To select the recipients of the stipend, we collect research project descriptions from around twenty core laboratories that support the collaboration between Vanderbilt and Leipzig Universities. Descriptions are provided by the graduate student or post‐doctoral mentor who will advise the undergraduate student. It is encouraged that the undergraduate student conducts research on the

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Scientists find human antibodies against COVID-19

Scientists find human antibodies against COVID-19

[article written by Peggy Darius Leipzig University] The COVID 19 pandemic poses a major threat to global health and currently there is little medical response. In addition, there is a lack of a profound understanding of the molecular mechanisms of the body’s immune system. An international team has now succeeded in scientifically describing highly active neutralizing human antibodies against the corona virus SARS-CoV-2. Humboldt Professor Jens Meiler of the University of Leipzig contributed to the study, which has now been published in the scientific journal “Nature”. Highly active neutralizing human antibodies against the coronavirus SARS-CoV-2 can be used for the development of vaccines and can also be used as therapy in

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Old home and new challenge

Old home and new challenge

[article only in german language, article written by Dr. Katarina Werneburg Leipzig University / picture: Christian Hüller / Universität Leipzig, SUK] Alte Heimat und neue Herausforderung Was sind die Forschungsschwerpunkte unserer Professoren? Was ist ihnen in der Lehre wichtig, und haben unsere Experten eigentlich auch Hobbys oder ein Lebensmotto? Im LUMAG stellt sich auch heute wieder einer unserer neuberufenen Professoren vor. Diesmal ist es Jens Meiler vom neu gegründeten Institut für Wirkstoffentwicklung. Sein Fachgebiet ist die computergestützte Wirkstoffforschung. Herr Meiler, woher kommen Sie und was haben Sie studiert? Ich bin in Leipzig geboren und aufgewachsen. Nach meinem Abitur am Wilhelm-Ostwald Gymnasium studierte ich Chemie an der Universität Leipzig. Was waren Ihre

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University Success for Three Collaborative Research Centres

University Success for Three Collaborative Research Centres

[Press Release 25/11/2019, Leipzig University 234/2019 by Carsten Heckmann / Photo: Leipzig University, Swen Reichhold] Further boost for top-level research at Leipzig University: New Collaborative Research Centre gets go-ahead and two more are extended. The University’s new Collaborative Research Centre (CRC), “Structural Dynamics of GPCR Activation and Signal Transduction”, will focus on how cells communicate via important receptors. Its spokesperson will be Professor Annette G. Beck-Sickinger. Applications for a second funding period were also successful for the projects “Arctic Climate Change (AC)³” (spokesperson: Professor Manfred Wendisch, Leipzig Institute for Meteorology) and “Processes of Spatialization under the Global Condition” (spokesperson: Professor Matthias Middell, head of Leipzig University’s Centre for Area Studies). Brief

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Call 2020: Offering research internship for Students on Bachelor- or Master level

Call 2020: Offering research internship for Students on Bachelor- or Master level

The Max Kade Foundation (MKF, www.maxkadefoundation.org) supports an international research exchange between Vanderbilt and Leipzig Universities. Specifically, MKF provides funds of three‐four undergraduate students from each university to conduct a 10 week summer internship at the respective partner university. Travel costs and a weekly stipend are provided. They target rising junior and rising senior students at Vanderbilt University. To select the recipients of the stipend, we collect research project descriptions from around twenty core laboratories that support the collaboration between Vanderbilt and Leipzig Universities. Descriptions are provided by the graduate student or post‐doctoral mentor who will advise the undergraduate student. It is encouraged that the undergraduate student conducts research on the

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The Alexander von Humboldt Foundation awarded Prof. Dr. Jens Meiler

The Alexander von Humboldt Foundation awarded Prof. Dr. Jens Meiler

[article written by Dr. Katarina Werneburg Leipzig University / picture: Humboldt-Stiftung/Elbmotion] The Alexander von Humboldt Foundation awarded Prof. Dr. Jens Meiler the highly endowed Alexander von Humboldt Professorship. The 44-year-old is one of the world’s most distinguished researchers in the field of computer-aided drug discovery. The Alexander von Humboldt Professorship is Germany’s most valuable research prize. “I am delighted that the long-standing research partnership between Leipzig University and Vanderbilt University has now culminated in Jens Meiler’s Humboldt Professorship. This will unlock new horizons for Professor Beck-Sickinger’s already highly successful area of research into molecular mechanisms. It will also considerably strengthen our degree program in Pharmacy at the Faculty of Medicine,” commented

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Apply for  Max Kade Scholarship 2019

Apply for Max Kade Scholarship 2019

Unique Opportunities in Gaining Research Experience in Germany and USA The Max Kade Foundation (MKF, www.maxkadefoundation.org) supports an international research exchange between Vanderbilt and Leipzig Universities. Specifically, MKF provides funds of three undergraduate students from each university to conduct a 10 week summer internship at the respective partner university in 2019 (May – December). The Max Kade Foundation Scholarship Program is open for highly motivated and excellent foreign applicants with a BSc, MSc or equivalent degrees (obtained during the past year). Internship offer in Leipzig for Undergraduate Students from Vanderbilt University  Analysis of Ternary Complexes of G-Protein Coupled Receptors Using Molecular Dynamics Simulations. Prof. Dr. Hildebrand/Dr. Vogel (Institute of Biophysics) Structural

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Researchers of Vanderbilt and Leipzig University discover ligand binding modes at the neuropeptide Y Y1 receptor

Researchers of Vanderbilt and Leipzig University discover ligand binding modes at the neuropeptide Y Y1 receptor

(30/04/2018 by Anett Albrecht): A joint publication of Leipzig and Vanderbilt scientists was published in April 2018 in the prestigious journal “Nature”. The article continues the series of numerous publications that have emerged already from the long-term collaboration between the Leipzig and Vanderbilt University. Abstract: Neuropeptide Y (NPY) receptors belong to the G-protein-coupled receptor superfamily and have important roles in food intake, anxiety and cancer biology 1,2 . The NPY-Y receptor system has emerged as one of the most complex networks with three peptide ligands (NPY, peptide YY and pancreatic polypeptide) binding to four receptors in most mammals, namely the Y1, Y2, Y4 and Y5 receptors, with different affinity and selectivity 3

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Universities extend partnership by another ten years

Universities extend partnership by another ten years

[press release written by Susann Huster/Anett Albrecht, April 10, 2018] The cooperation between the University of Leipzig and Vanderbilt in Nashville (USA) has been contractually sealed for another ten years. A few days ago, the rectors of both universities signed a Memorandum of Understanding. The American Max Kade Foundation had previously approved an application for funding from project leaders Prof. Dr. Annette Beck-Sickinger from the Institute of Biochemistry at the Leipzig University and Prof. Dr. Jens Meiler from Vanderbilt University: The foundation will also support the exchange with 50,000 dollars (40,000 euros) per year between 2017 and 2021. “We hope that the already established excellent relations with Vanderbilt University will continue

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Max Kade Scholarship 2018: Unique Opportunities in Gaining Research Experience in Germany and USA

Max Kade Scholarship 2018: Unique Opportunities in Gaining Research Experience in Germany and USA

The Max Kade Foundation (MKF, www.maxkadefoundation.org) supports an international research exchange between Vanderbilt and Leipzig Universities. Specifically, MKF provides funds of three undergraduate students from each university to conduct a 10 week summer internship at the respective partner university in 2018 (May – September). The Max Kade Foundation Scholarship Program is open for highly motivated and excellent foreign applicants with a BSc, MSc or equivalent degrees (obtained during the past year). Identification of functional protein-protein-interactions of the ecto- and endodomain of adhesion G protein-coupled receptors (Prof. Dr. Vsevolod Gurevich) Investigation of Ligand Binding at the Chemokine-Like Receptor 1 (Prof. Dr. Jens Meiler) Rosetta docking of allosteric modulators to the Y4 receptor.

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Lecture on “Innovative Computational Methods for Protein Structure Prediction, Drug Discovery, and Therapeutic Design” at Leipzig University

Lecture on “Innovative Computational Methods for Protein Structure Prediction, Drug Discovery, and Therapeutic Design” at Leipzig University

Biochemical Colloquium – Special Topics in Biochemistry: Prof. Dr. Jens Meiler, Center for Structural Biology, Departments of Chemistry, Pharmacology, and Biomedical Informatics, Vanderbilt University, Nashville Tenessee Date October 24, 2017 / 5 PM Venue Leipzig University, ITP – Institute for Theoretical Physics, Lecture Hall, Linnéstraße 5, 04103 Leipzig, Germany. Backround The protein folding problem – i.e. predicting the three-dimensional structure of a protein from its amino acid sequence alone – is an unsolved problem in computational biology. I will present a novel computational approach to this problem that assembles protein tertiary structure from predicted secondary structure elements. I will demonstrate how this algorithm can be combined with limited EPR- and NMR-spectroscopic

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International Cooperation: Max-Kade Foundation extends the international fellowship program between Nashville and Leipzig

International Cooperation: Max-Kade Foundation extends the international fellowship program between Nashville and Leipzig

The Center of Structural Biology (Vanderbilt University) and the Institute of Biochemistry (Leipzig University) has secured funds for an international fellowship program from the Max Kade Foundation for the period 2017 to 2021. The Max Kade Foundation takes pride in participating and sponsoring various programs which encourage the exchange of academic ideas among universities and colleges in the United States and in German-speaking countries (www.maxkadefoundation.org). The foundation recently awarded the Vanderbilt-Leipzig research exchange program a second grant to cover the travel and support of six undergraduate student exchanges, as well as two faculty exchanges per year. The students will travel to their respective university and join a research project under a

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Apply for Max Kade Scholarship 2017

Apply for Max Kade Scholarship 2017

Unique Opportunities in Gaining Research Experience in Germany and USA The Max Kade Foundation (MKF, www.maxkadefoundation.org) supports an international research exchange between Vanderbilt and Leipzig Universities. Specifically, MKF provides funds of three undergraduate students from each university to conduct a 10 week summer internship at the respective partner university in 2017 (May – December). The Max Kade Foundation Scholarship Program is open for highly motivated and excellent foreign applicants with a BSc, MSc or equivalent degrees (obtained during the past year). Internship offer in Leipzig for Undergraduate Students from Vanderbilt University  Investigation of allosteric modulation of the human Y4 receptor Prof. Dr. Annette Beck-sickinger / Mario Schubert (Institute of Biophysics) Preparation

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DAAD RISE Programm: CALL 2017

DAAD RISE Programm: CALL 2017

The German Academic Exchange Service (Deutscher Akademischer Austauschdienst, DAAD) announced a new call for its program “Research Internships in Science and Engineering” (RISE) for summer internship in 2017. The program works in both ways. German and American Ph.D. students submit internship offers for undergraduates students for a duration of 8 to 12 weeks. German bachelor students can work as research interns at U.S. universities and U.S. undergraduates can work in labs of German universities. The DAAD provides stipends to help cover living expenses, the partner universities and research institutes provide housing assistance. The call is applicable for all fields of biology, chemistry, physics, earth sciences and engineering. Please visit for further

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Journal of Biological Chemistry selects Vanderbilt-Leipzig article as paper of the week

Journal of Biological Chemistry selects Vanderbilt-Leipzig article as paper of the week

The joint publication of Hu, Stern, Gimenez, Wanka, Zhu, Rossi, Meister, Inoue, Beck-Sickinger, Gurevich and Wess was named as “Paper of the Week” by the Journal of Biological Chemistry’s editorial board, landing it in the top 2 percent of all papers published over the year in the journal. The joint publication focussed on designer receptors exclusively activated by a designer drug – short DREADDs. This are CNO sensitive designer G protein-coupled receptors which are able to activate heterotrimeric G proteins and also trigger arrestin-dependent signaling. In the present study the development of a mutationally modified version of a non-biased DREADD derived from the M3 muscarinic receptor that can activate Gq/11 with

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Short report by Mario Schubert: HTS to Identify and Characterize Small Molecule Allosteric Modulators of the Human Y4 Receptor at Vanderbilt University (Oct 19 – Dec 15)

Short report by Mario Schubert: HTS to Identify and Characterize Small Molecule Allosteric Modulators of the Human Y4 Receptor at Vanderbilt University (Oct 19 – Dec 15)

During an internship in the lab of Dave Weaver at Vanderbilt University, I got the opportunity to gain more information about the Y4R, by testing a variety of similar structurally related compounds. I was introduced in the workflow of a high throughput screening laboratory. The technical equipment in the Vanderbilt HTS center makes it possible to test thousands of different chemical compounds in a very short time. Therefore, I learned to perform Ca2+-flux based signal transduction screening assays to monitor the activation of the Y4R. Using this system, I could test new hit compounds out of the ongoing screening for activity and selectivity. Furthermore, I tested structurally similar compounds of a

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Short Report by Axel Fischer & Gregory Sliwoski: INTEGRATION OF LIMITED EXPERIMENTAL DATA INTO ENSEMBLE PREDICTION at Leipzig University (Nov 14 – Dec 22)

Short Report by Axel Fischer & Gregory Sliwoski: INTEGRATION OF LIMITED EXPERIMENTAL DATA INTO ENSEMBLE PREDICTION at Leipzig University (Nov 14 – Dec 22)

The objective of our visit was deepening the collaboration between Leipzig University and Vanderbilt University regarding the integration of limited experimental data into protein ensemble prediction. During this visit Axel Fischer presented a method to integrate cross-linking data into protein structure prediction methods at the 5th Symposium on Structural Proteomics in Halle. Following subsequent discussions with Dr. Stefan Kalkhof and Tommy Hofmann, work on an algorithm to efficiently simulate cross-link conformations was continued. In a preliminary study, the algorithm significantly improves the accuracy with which protein structures can be predicted. Additionally, Axel developed an algorithm to integrate solid-state nuclear magnetic resonance (ssNMR) data into the protein structure prediction software BCL::Fold. While

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Scientists of Vanderbilt and Leipzig University improved drug effects of Indomethacin

Scientists of Vanderbilt and Leipzig University improved drug effects of Indomethacin

(Leipzig/Nashville, 02/03/2016): Scientists at Leipzig University and Vanderbilt University (USA) reduced the side effects of Indomethacin by altering the so-called boron cluster molecule of this drug. This molecule have a spherical shape – composed of boron, hydrogen and carbon atoms. The active ingredient causes an inhibition of the enzyme cyclooxygenase, which plays an important role in production of inflammations and pain. But Indomethacin also leads to severe side effects. The scientists changed the drug, so that it blocks only the pathological form of the enzyme. The other form, which controls important physiological processes in the body, would barely be affected. The results underline the potential of boron clusters in pharmacytical application

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Professor Jens Meiler received Friedrich Wilhelm Bessel Research Award

Professor Jens Meiler received Friedrich Wilhelm Bessel Research Award

(by David Salisbury, Vanderbilt University): Associate Professor of Chemistry Jens Meiler has received a Friedrich Wilhelm Bessel Research Award from the Alexander von Humboldt Foundation in Bonn, Germany. The award is given to scholars based on their “outstanding research accomplishments and exceptional promise for the future.” Individuals are nominated by German scholars and must have received their Ph.D. in the last 18 years. In addition to a monetary prize, award winners are invited to spend a period of up to one year collaborating on a long-term research project. Meiler, who has an international reputation in the field of structural biology, will be collaborating with colleagues at Leipzig University on studies of

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Apply for MAX KADE SHOLARSHIP 2016: Unique Opportunities in Gaining Research Experience in Germany and USA

Apply for MAX KADE SHOLARSHIP 2016: Unique Opportunities in Gaining Research Experience in Germany and USA

The Max Kade Foundation (MKF, www.maxkadefoundation.org) supports an international research exchange between Vanderbilt and Leipzig Universities. Specifically, MKF provides funds of three undergraduate students from each university to conduct a 10 week summer internship at the respective partner university in 2016 (May – September). The Max Kade Foundation Scholarship Program is open for highly motivated and excellent foreign applicants with a BSc, MSc or equivalent degrees (obtained during the past year). Internship offer in Leipzig for Undergraduate Students at Vanderbilt University (Date: May – August 2016) “Genetic Incorporation of Photocrosslinking Amino Acids: Binding Pattern of β-Arrestins on a Class B GPCR“ Laboratory Principal Investigator: Dr. Irene Coin Graduate Mentor in host

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Max-Kade Scholarship 2015: Short-Reports

Max-Kade Scholarship 2015: Short-Reports

In 2015 eight students on Bachelor- or Master level got the Max-Kade Scholarship to participate in ongoing research projects between Vanderbilt University and the University of Leipzig. Hereby their short research and travel reports are listed… Ryan Xin (Undergraduate Student at Vanderbilt University): Semisynthetic Preparation of Ga Fusion Proteins to Investigate Receptor Interaction (Laboratory of Prof. Dr. Annette Beck-Sickinger & Stefan Ernicke / May-July 2015) In my time at Leipzig University, I learned a great deal from my mentor, Stefan Ernicke, and the rest of the laboratory. Before my internship with the Max Kade Foundation, I had never worked extensively in molecular biology. After my time with the Beck-Sickinger lab, I

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Short Report of Gregory Sliwoski: STUDYING SMALL-MOLECULE MODULATORS OF THE Y4 RECEPTOR at University of Leipzig (AUG 20 – SEPT 10)

by Gregory Sliwoski (doctoral student at Vanderbilt University): After completing my M.S. in pharmacology from Vanderbilt University under Prof. Dr. Jens Meiler in 2012, I joined Annette Beck-Sickinger’s lab at Leipzig University to further study the neuropeptide Y4 receptor (Y4R). This particular trip is my fourth stay in Leipzig in the collaboration between the labs of Prof. Dr. Jens Meiler (Vanderbilt) and Prof. Dr. Annette Beck-Sickinger (Leipzig). This collaboration combines computational modeling with cell-based signaling and mutategensis assays to characterize the activation of Y4R and discover new compounds that may enhance Y4R signaling. Signaling through this receptor has been shown to be a potential avenue for treatment of obesity and related

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OFFERING RESEARCH INTERNSHIP – MAX KADE Scholarship for Students on Bachelor- or Master level:  Call 2016

OFFERING RESEARCH INTERNSHIP – MAX KADE Scholarship for Students on Bachelor- or Master level: Call 2016

The Max Kade Foundation (MKF, www.maxkadefoundation.org) supports an international research exchange between Vanderbilt and Leipzig Universities. Specifically, MKF provides funds of three‐four undergraduate students from each university to conduct a 10 week summer internship at the respective partner university. Travel costs up to $2000 and a weekly stipend of $400 are provided. They target rising junior and rising senior students at Vanderbilt University. To select the recipients of the stipend, they collect research project descriptions from around twenty core laboratories that support the collaboration between Vanderbilt and Leipzig Universities. Descriptions are provided by the graduate student or post‐doctoral mentor who will advise the undergraduate student. It is encouraged that the undergraduate

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It is the sound of music – a remarkable partnership: Researchers from Leipzig and Nashville investigate molecular mechanisms

It is the sound of music – a remarkable partnership: Researchers from Leipzig and Nashville investigate molecular mechanisms

by Carsten Heckmann (LUMAG, 01-2015, 03/12/2015): To name the cities of Leipzig and Nashville in a sentence, could comes up with the idea: it could go on music. Classic here – Country there. But this is no topic for this research report. There is also the research field biochemistry – with a remarkable partnership between both universities. To bridge 7,500 kilometer is not difficult for Prof. Dr. Annette Beck-Sickinger and Prof. Dr. Jens Meiler (Vanderbilt University). Sometimes they feel more like neighbors. “We work extremely well together,” says the Leipzig professor at the Institute of Biochemistry. More than 20 joint publications have appeared since 2008, emerged from around 30 joint projects.

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Dicovering interaction mode of specific carbaborane derivatives with GPCRs at Vanderbilt University

by Peter Schmidt (postdoc at Leipzig University): GPCRs have been shown to play a crucial role in a variety of diseases, such as obesity, metabolic diseases and cancer. Accordingly, they are an attractive target for the investigation of new pharmaceuticals. Di-carba-closo-dodecaboranes(12) (closo-C2B12H12 or carbaboranes) were recently established as pharmacophores. Their unique properties (hydrophobicity, three-dimensional aromaticity, etc.) make them interesting targets for drug development. In this project, specific carbaborane derivatives will be prepared and used either as conjugates with peptides of the melanotropin (MSH) or neuropeptide Y (NPY) family, or as small molecules that impart their action via GPCRs to study and understand their influence on the selectivity and activity. NPY binds

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Max-Kade Scholarship 2014: Short-Reports

Max-Kade Scholarship 2014: Short-Reports

2014 eight students on Bachelor- or Master level got the Max-Kade Scholarship to participate in ongoing research projects between Vanderbilt University and the University of Leipzig. Hereby there short research and travel reports:

Identification of new target GPCR at Vanderbilt University

by Antje Brüser (postdoc at Leipzig University): I had the possibility to join Vanderbilt University from March 26th – July 11th 2014 as a visiting scholar to initiate a new project between our group (headed by Prof. Torsten Schöneberg) and the group of Prof. Larry Marnett. We focus in our lab on orphan G-protein coupled receptors (oGPCR) and the Marnett lab is working on COX inhibitors. Since years they have been interested in products of the COX-2 pathway and the identification of receptors which they bind to. In our new cooperation we have the knowledge and expertise to search and functional analysis of oGPCR. During my stay at the Marnett lab

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Biological evaluation of modified COX inhibitors at Vanderbilt University

by Wilma Neumann (doctoral student at Leipzig University): After a successful start-up of a new collaboration project last autumn followed by a joint publication earlier this year, the group of Prof. Larry Marnett again welcomed me in their lab during my second research stay at Vanderbilt between May 21st and June 21st, 2014. Continuing our project on conjugates of cisplatin and COX inhibitors for use as antitumor agents, Brenda Crews, Cristina Daniel, and Kebreab Ghebreselasie actively supported me with the biological evaluation of new conjugates I had prepared in Leipzig. I am also very thankful to Cristina for introducing me to further molecular biology techniques and for her great effort performing

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Research stay at the Division of Nephrology and Hypertension at the Vanderbilt University Medical Center (VUMC)

Research stay at the Division of Nephrology and Hypertension at the Vanderbilt University Medical Center (VUMC)

by Thomas Ebert (postdoc at Leipzig University): From January 3rd, 2014 – April 4th 2014, I had the opportunity to stay at the Division of Nephrology and Hypertension at the Vanderbilt University Medical Center (VUMC) in Nashville, Tennessee as a visiting scholar. In our group in Leipzig (headed by Prof. Mathias Fasshauer), we focus on adipocyte-secreted proteins, so called adipokines, in renal dysfunction. To investigate adipokines in diabetic nephropathy (DN), a severe consequence of long-term diabetes mellitus, animal studies are vitally important. The group of Prof. Raymond C. Harris (Chief of the Division of Nephrology and Hypertension at VUMC) introduced the enos db/db-mouse as the currently best mouse model to study

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Leipzig PhD use high performance computational ressources for protein modeling

by Tristan Zellmann (doctoral student at Leipzig University): I had the opportunity to stay at Jens Meilers lab in Nashville from 11/27/13 to 12/06/13 as well as from 01/27/14 to 03/22/14 to complete the modeling for an upcoming publication. During my stay, I had the opportunity to take part in two great, american traditions – arriving the day just before Thanksgiving, I got invited to an actual Thanksgiving dinner, featuring delicious turkey, mashed potatoes, gravy, buttery carrots and even pumpkin pie. Another culinary and cultural highlight was a super bowl party complete with chili, buffalo wings and lots of snacks, even if the Seattle Seahawks seemed to dominate a bit too

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Research Stay at Vanderbilt University on Arrestin Proteins

by Lizzy Wanka (doctoral student at Leipzig University): In the autumn of 2013, I had the great opportunity to visit Prof. Dr. Vsevolod V. Gurevich`s lab at the Vanderbilt university for 12 weeks. Prof. Gurevich and his group work with arrestin proteins and investigate among others their binding to receptors and other signaling proteins. I wanted to study the binding of different arrestin mutants to NPY receptors and NPY receptor chimera. Together with Dr. Luis E. D. Gimenez, I performed various bioluminescence resonance energy transfer assays and learned a lot about the arrestin recruitment and the optimization of this assay. The discussions about analyzing the data were revealing and very helpful.

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Max-Kade Foundation Partners with VU-LU Collaboration

Max-Kade Foundation Partners with VU-LU Collaboration

The Vanderbilt-Leipzig Collaboration is pleased to announce its partnership with the Max Kade Foundation to support the exchange of students and faculty between the universities. The Max Kade Foundation takes pride in participating and sponsoring various programs which encourage the exchange of academic ideas among universities and colleges in the United States and in German-speaking countries (www.maxkadefoundation.org). The foundation recently awarded the Vanderbilt-Leipzig research exchange program a grant to cover the travel and support of six undergraduate student exchanges, as well as two faculty exchanges per year. The students will travel to their respective university and join a research project under a senior supervisor. They will be engaged for ten weeks

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Vanderbilt, Leipzig research collaboration sees strong results

Vanderbilt, Leipzig research collaboration sees strong results

written by Matt Windsor: During the past two weeks, the fifth international symposium between Leipzig and Vanderbilt universities was held on the Vanderbilt campus, as seven Leipzig faculty members presented a series of chemical biology-related lectures. The symposium offered an opportunity to highlight the ongoing success of the international collaboration. To date, there have been 17 joint publications between research groups at the two universities. This summer, the first federally funded research grant resulting from the collaboration was awarded by the National Institutes of Health (NIH). The project is aimed at developing drugs for a specific type of protein known as a G protein-coupled receptor (GPCR). The grant was spearheaded by

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Vanderbilt Undergraduate Student in Leipzig

by Hannah Berke (undergraduate student at Vanderbilt University): My two months spent in Leipzig were a wonderful experience. The work in the lab was informative and enjoyable and living in Leipzig changed my life. My stay in Leipzig was extremely fun and gave me the opportunity to travel and experience Europe and Germany specifically. The city itself is a perfect size, very similar to Nashville, and I lived in an area that was about a 5 minute tram ride or 20 minute walk from the city center, or “Mitte,” that is full of shops and restaurants. The abundance of parks and cafes made it easy to spend time outside – barbecuing,

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DAAD RISE Program: Call 2014

DAAD RISE Program: Call 2014

The German Academic Exchange Service (Deutscher Akademischer Austauschdienst, DAAD) announced a new call for its program “Research Internships in Science and Engineering” (RISE) for summer internship in 2014. The program works in both ways. German and American Ph.D. students submit internship offers for undergraduates students for a duration of 8 to 12 weeks. German bachelor students can work as research interns at U.S. universities and U.S. undergraduates can work in labs of German universities. The DAAD provides stipends to help cover living expenses, the partner universities and research institutes provide housing assistance. The call is applicable for all fields of biology, chemistry, physics, earth sciences and engineering. Please visit for further

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New Grant supports joint Research Project between Vanderbilt and Leipzig Universities

Annette Beck-Sickinger and Torsten Schoeneberg from Leipzig University and Jens Meiler from Vanderbilt University receive a grant “Ensemble Docking Interrogates Structural Determinants of Ligand-Protein Interactions” that is jointly funded by the National Science Foundation (NSF) and the Deutsche Forschungsgemeinschaft (DFG). The grant will develop a novel docking algorithm that leverages Structure-Activity-Relations (SAR) and apply this algorithm to understand regulation of G-Protein Coupled Receptors (GPCRs). Project Summary

Symposium and New Grants bolster Vanderbilt-Leipzig Partnership

Symposium and New Grants bolster Vanderbilt-Leipzig Partnership

Two new grants and a summer symposium with workshops highlight ongoing collaboration efforts between Vanderbilt University and Leipzig University: 1) Vanderbilt University received a grant from the Max Kade Foundation in support of an undergraduate and graduate student exchange program in collaboration with Leipzig University. The collaboration is spearheaded by Drs. Jens Meiler (Vanderbilt University) and Annette Beck-Sickinger (Leipzig University). 2) The Meiler and Weaver laboratories at Vanderbilt University received a grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK, NIH) for the development of “Small Molecule Probes to Investigate Structure and Function of Y Receptors.” This project is a collaboration with Annette Beck-Sickinger at Leipzig University,

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The Leipzig Connection

The Leipzig Connection

by David Salisbury | posted at news.vanderbilt.edu: In 2007, while Jens Meiler was visiting his parents in Germany, the associate professor of chemistry was invited to give a lecture at his alma mater, the University of Leipzig. “When I gave that talk on my research in structural and chemical biology, I found a tremendous amount of interest in what we are doing at Vanderbilt and learned that there is a great deal of complementary research going on in Leipzig,” Meiler said. In fact, Meiler stirred up so much interest that two years later Annette Beck-Sickinger, professor of biochemistry and bioorganic chemistry at Leipzig, spent her sabbatical at Vanderbilt. During her visit

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DAAD RISE Program: Call 2013

DAAD RISE Program: Call 2013

The German Academic Exchange Service (Deutscher Akademischer Austauschdienst, DAAD) announced a new call for its program “Research Internships in Science and Engineering” (RISE) for summer internship in 2013. The program works in both ways. German and American Ph.D. students submit internship offers for undergraduates students for a duration of 8 to 12 weeks. German bachelor students can work as research interns at U.S. universities and U.S. undergraduates can work in labs of German universities. The DAAD provides stipends to help cover living expenses, the partner universities and research institutes provide housing assistance. The call is applicable for all fields of biology, chemistry, physics, earth sciences and engineering. Please visit for further information:

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Vanderbilt PhD students in Leipzig

Vanderbilt PhD students in Leipzig

Stephanie and Liz are graduate students in the Meiler Laboratory at Vanderbilt University.  They both work on the computational investigation of GPCRs and their interactions with various ligands. They recently took the opportunity to do a month-long research internship at Leipzig University in conjunction with their collaborators, who perform the wet-lab experiments associated with the proteins they model. Herein, they reflect on their experiences. Liz Dong: For 4 weeks, I worked with the lab of Dr. Torsten Schöneberg on a project involving P2Y12, a receptor involved in platelet aggregation. My part of the project was to build a model of P2Y12 using Rosetta and dock known ligands into the model to

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DAAD RISE Program: Call 2012

DAAD RISE Program: Call 2012

The German Academic Exchange Service (Deutscher Akademischer Austauschdienst, DAAD) announced a new call for its program “Research Internships in Science and Engineering” (RISE) for summer internship in 2012. The program works in both ways. German and American Ph.D. students submit internship offers for undergraduates students for a duration of 8 to 12 weeks.  German bachelor students can work as research interns at U.S. universities and U.S. undergraduates can work in labs of German universities. The DAAD provides stipends to help cover living expenses, the partner universities and research institutes provide housing assistance. The call is applicable for all fields of biology, chemistry, physics, earth sciences and engineering. Please visit for further

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Liz Dong Receives DAAD Short Term Research Grant

Liz Dong of the Jens Meiler lab at Vanderbilt recently received a short term research grant to study at the Univeristy of Leipzig in Leipzig, Germany. She will spend one month this fall developing a computational method that will allow for the binding pose of a drug within a receptor to be determined. Her method will be guided by experimental data collected on drugs that bind G-protein coupled receptors, working with the lab of Torsten Schöneberg. Congrats, Liz!

Collaborative Paper published in “Bioorganic & Medicinal Chemistry”

Researchers of Leipzig and Vanderbilt Universities published a paper in the journal “Bioorganic & Medicinal Chemistry” showing the results of their collaborative project on carbaborane research. The paper, published in March 2011, describes new synthesis strategies of indomethacin derivatives with inorganic carbaborane clusters. Indomethacin is a very potent cyclooxygenase (COX)-1 and COX-2 inhibitor with clinical significance as anti-inflammatory drug , The carbaborane-modified drug candidates showed also COX inhibition activity, depending on the carbaborane isomer and the connection pattern. The results gave general insights into the applicability of carbaboranes as drug entities. Synthesis and evaluation of carbaborane derivatives of indomethacin as cyclooxygenase inhibitors Matthias Scholz(1), Anna L. Blobaum(2), Lawrence J. Marnett(2) and

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Collaborative Paper published in Journal of Biological Chemistry

First results of the successful collaboration between Leipzig University (Germany) and Vanderbilt University, Nashville (Tennessee, USA) have been published in the Journal of Biological Chemistry by end of 2010. Researchers from the labs of Annette G. Beck-Sickinger (Leipzig University) and Vsevolod V. Gurevich (Vanderbilt University) investigated the mechanism and regulation of neuropeptide Y2 receptor internalization. For the first time, the corporate publication “Ligand-induced internalization and recycling of the human neuropeptide Y2 receptor is regulated by its carboxyl-terminal tail” reports on specific sequences located in the receptor’s C-terminus which determine arrestin-dependent/independent internalization and recycling events, thus contributes to a better understanding of the regulation of G protein-coupled receptor trafficking pathways. Cornelia Walther,

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Details from 4 Vanderbilt Students about their DAAD-RISE Internships at Leipzig

[by Ross Barajas, Aaron Coonley, Deanna Joe, and Dan Viox] Germany is a country with a rich history and a thriving culture, a leader in scientific discoveries, and a desired destination for many, including four undergraduate students from Vanderbilt University. Through the German Academic Exchange Service (DAAD), we each applied for Research Internship in Science and Engineering (RISE) internships in the winter of 2009. We were awarded scholarships to the University of Leipzig, a university with which Vanderbilt University already has an established collaboration. Over our stay of three months, we were able to develop extensive research skills, learning and working under our mentors—Ph.D. candidates at the university.  Ross Barajas worked

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Two Leipzig students at Vanderbilt

Sabina Kanton and Henrike Indrischek (biochemistry undergraduates from Leipzig University) took the opportunity to visit Vanderbilt University for a 5 week research stay in September and October 2010 with a special tender of the DAAD RISE program. Here is their report about this experience. Why Vanderbilt University? Both of us wanted to gain practical experience and get an insight into the work of a research group abroad. We were just curious to get to know the atmosphere of such a prominent American university and of course were keen on improving our scientific English. Research projects I (Henrike Indrischek) worked in the group of Hassane Mchaourab at the Institute of Molecular Biology

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Report on summer internships at Vanderbilt 2010

Report on summer internships at Vanderbilt 2010

In 2010 several students from Leipzig University had the opportunity for a research stay at Vanderbilt University. Stefanie Nagel and Anette Schreiber, students of the Master’s degree program in biochemistry at Leipzig University, were two of these. Thanks to the cooperation of Leipzig University and Vanderbilt University in Nashville (Tenneessee, USA), they participated in a 10-week student exchange in summer 2010 and report here shortly their experience. Stefanie Nagel: I performed my internship at Vanderbilt University in the workgroup of Prof. Vsevolod (Seva) Gurevich, Department of Pharmacology, a recognized expert on the field of arrestin proteins. The aim of my project was to characterize the interaction between the human neuropeptide Y

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