(07/04/2016 by Anett Albrecht): A joint publication of Leipzig and Vanderbilt scientists was published in June 2016 in the prestigious journal “PLoS One”. The article continues the series of numerous publications that have emerged already from the long-term collaboration between the Leipzig and Vanderbilt University. Abstract: The human neuropeptide Y4 receptor (Y4R) and its native ligand, pancreatic polypeptide, are critically involved in the regulation of human metabolism by signaling satiety and regulating food intake, as well as increasing energy expenditure. Thus, this receptor represents a putative target for treatment of obesity. With respect to new approaches to treat complex metabolic disorders, especially in multi-receptor systems, small molecule allosteric modulators have been
