Woman Power at Research and Transfer Center b-ACT matter

b-ACTmatter scientist to take part in the Exist-Women start-up initiative from mid-January

Biotechnologist Subhashini Singh will be funded by the Federal Ministry of Economics and Climate Protection (BMWK ) from mid-January via the EXIST-Women start-up programme.

The young scientist completed her Master’s degree in “Development of point-of-care devices for the detection of carbapenem-resistant bacteria” in Mumbai, India, and has been working in Dr Henri Franquelim’s Biomimetic Nanotechnology junior research group at the Research and Transfer Centre for Bioactive Matter b-ACTmatter since 2022. Her research focus is in the field of Membrane-active DNA origami for biosensing and antimicrobial applications. As the demand for DNA-origami nanostructures has been surging a lot due to their easy chemical modification and self-assembly properties, she would like to utilize her knowledge to develop a groundbreaking platform for targeting membrane-active pathogens by developing origami sensors.

With the EXIST funding programme, the BMWK supports start-up networks, universities and non-university research institutions in their start-up projects. The aim is to improve the start-up climate at universities and non-university research institutions and to increase the number of technology-orientated and knowledge-based spin-offs from research institutions. The EXIST-Women programme is part of the initiative and specifically promotes start-up projects by female university graduates, scientists and students and is implemented at Leipzig University by the SMILE start-up initiative.

The programme enables Singh to familiarise herself with the topics of start-ups and self-employment and to network and exchange ideas with other prospective female founders. The funding includes a 3-month scholarship and a programme of events, advice and support for one year.

Biotechnologist Subhashini Singh . photo: b-ACT^matter
Biotechnologist Subhashini Singh will receive funding through the EXIST-Women start-up programme from mid-January. Photo: b-ACT^matter

“Cell Physics 2023” conference in Saarbrücken

Members from the b-ACTmatter Biomimetic Nanotechnology group (Dr. Henri G. Franquelim, Subhasini Singh and Rayehe Mamaghaniyeh) attended the international “Cell Physics 2023” conference in Saarbrücken, Germany between October 10 – 13, 2023; meeting co-organized by the German Society for Cell Biology (DGZ, DGZ Annual Meeting) and Collaborative Research Center, SFB 1027.

Here, Rayehe Mamaghaniyeh won a best poster award sponsored by ibidi GmbH, with her poster entitled “Targeting Phase Separation on Membranes Using Fatty Acid-Functionalized DNA Origami”. In this presented work, Rayehe developed amphipathic DNA origami nanostructures with selective affinity for specific lipid phases on model membranes. As biological membranes are heterogenous in lipid composition and this variety can affect cell functions, this work may then open new avenues to target important biological processes, such as signaling, membrane trafficking, and/or viral infections.

Dr. Henri Franquelim, Rayehe Mamaghaniyeh and Subhasini Singh
Rayehe Mamaghaniyeh with her poster