Scientists of Vanderbilt and Leipzig University improved drug effects of Indomethacin

Scientists of Vanderbilt and Leipzig University improved drug effects of Indomethacin

(Leipzig/Nashville, 02/03/2016): Scientists at Leipzig University and Vanderbilt University (USA) reduced the side effects of Indomethacin by altering the so-called boron cluster molecule of this drug. This molecule have a spherical shape – composed of boron, hydrogen and carbon atoms. The active ingredient causes an inhibition of the enzyme cyclooxygenase, which plays an important role in production of inflammations and pain. But Indomethacin also leads to severe side effects. The scientists changed the drug, so that it blocks only the pathological form of the enzyme. The other form, which controls important physiological processes in the body, would barely be affected. The results underline the potential of boron clusters in pharmacytical application

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Professor Jens Meiler received Friedrich Wilhelm Bessel Research Award

Professor Jens Meiler received Friedrich Wilhelm Bessel Research Award

(by David Salisbury, Vanderbilt University): Associate Professor of Chemistry Jens Meiler has received a Friedrich Wilhelm Bessel Research Award from the Alexander von Humboldt Foundation in Bonn, Germany. The award is given to scholars based on their “outstanding research accomplishments and exceptional promise for the future.” Individuals are nominated by German scholars and must have received their Ph.D. in the last 18 years. In addition to a monetary prize, award winners are invited to spend a period of up to one year collaborating on a long-term research project. Meiler, who has an international reputation in the field of structural biology, will be collaborating with colleagues at Leipzig University on studies of

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Short Report by Brain Bender: Expression of Y2R Variants for EPR Structural Studies at Leipzig University (Aug 21 – Oct 14)

Short Report by Brain Bender: Expression of Y2R Variants for EPR Structural Studies at Leipzig University (Aug 21 – Oct 14)

This fall I was awarded the opportunity to return to Leipzig University to work in the lab of Dr. Daniel Huster. This research exchange corresponded nicely with the 11th International NPY-PYY-PP Conference. At the conference I was able to interact with many people in the field of neuropeptide Y (NPY) and its related peptide hormones. At this conference, people from many diverse fields came together to discuss their research. I heard talks on the role of NPY in cancer, obesity, and development of new receptor agonists. This greatly expanded on my knowledge of the physiological role of NPY and its receptors in the brain and throughout the body. One really great

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Apply for MAX KADE SHOLARSHIP 2016: Unique Opportunities in Gaining Research Experience in Germany and USA

Apply for MAX KADE SHOLARSHIP 2016: Unique Opportunities in Gaining Research Experience in Germany and USA

The Max Kade Foundation (MKF, www.maxkadefoundation.org) supports an international research exchange between Vanderbilt and Leipzig Universities. Specifically, MKF provides funds of three undergraduate students from each university to conduct a 10 week summer internship at the respective partner university in 2016 (May – September). The Max Kade Foundation Scholarship Program is open for highly motivated and excellent foreign applicants with a BSc, MSc or equivalent degrees (obtained during the past year). Internship offer in Leipzig for Undergraduate Students at Vanderbilt University (Date: May – August 2016) “Genetic Incorporation of Photocrosslinking Amino Acids: Binding Pattern of β-Arrestins on a Class B GPCR“ Laboratory Principal Investigator: Dr. Irene Coin Graduate Mentor in host

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Max-Kade Scholarship 2015: Short-Reports

Max-Kade Scholarship 2015: Short-Reports

In 2015 eight students on Bachelor- or Master level got the Max-Kade Scholarship to participate in ongoing research projects between Vanderbilt University and the University of Leipzig. Hereby their short research and travel reports are listed… Ryan Xin (Undergraduate Student at Vanderbilt University): Semisynthetic Preparation of Ga Fusion Proteins to Investigate Receptor Interaction (Laboratory of Prof. Dr. Annette Beck-Sickinger & Stefan Ernicke / May-July 2015) In my time at Leipzig University, I learned a great deal from my mentor, Stefan Ernicke, and the rest of the laboratory. Before my internship with the Max Kade Foundation, I had never worked extensively in molecular biology. After my time with the Beck-Sickinger lab, I

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Short Report by Dr. Wilma Neumann: BIOLOGICAL EVALUATION OF CARBORANE-CONTAINING COX INHIBITORS at Vanderbilt University (SEPT 09 – SEPT 19)

written by Wilma Neumann (postdoctoral associate at Leipzig University): Over the last years, the groups of Prof. Evamarie Hey-Hawkins (Institute of Inorganic Chemistry, Leipzig University) and Prof. Larry Marnett (Department of Biochemistry, Vanderbilt University School of Medicine) have developed a very fruitful collaboration, supported by the Leipzig-Vanderbilt collaboration project. Recently, we described a very potent and selective inhibitor of cyclooxygenase-2 (COX-2), a carborane-containing indomethacin analogue, which exhibits a novel binding mode in the COX enzyme pocket (W. Neumann, S. Xu, M. B. Sárosi, M. S. Scholz, B. C. Crews, K. Ghebreselasie, S. Banerjee, L. J. Marnett, E. Hey-Hawkins, ChemMedChem 2015, DOI: 10.1002/cmdc.201500199). In September 2015, I returned to Vanderbilt to continue

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Short Report of Gregory Sliwoski: STUDYING SMALL-MOLECULE MODULATORS OF THE Y4 RECEPTOR at University of Leipzig (AUG 20 – SEPT 10)

by Gregory Sliwoski (doctoral student at Vanderbilt University): After completing my M.S. in pharmacology from Vanderbilt University under Prof. Dr. Jens Meiler in 2012, I joined Annette Beck-Sickinger’s lab at Leipzig University to further study the neuropeptide Y4 receptor (Y4R). This particular trip is my fourth stay in Leipzig in the collaboration between the labs of Prof. Dr. Jens Meiler (Vanderbilt) and Prof. Dr. Annette Beck-Sickinger (Leipzig). This collaboration combines computational modeling with cell-based signaling and mutategensis assays to characterize the activation of Y4R and discover new compounds that may enhance Y4R signaling. Signaling through this receptor has been shown to be a potential avenue for treatment of obesity and related

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Announcement: Scientific and Methode Modules “COMPUTATIONAL STRUCTURAL BIOLOGY WITH ROSETTA” at Leipzig University

Announcement: Scientific and Methode Modules “COMPUTATIONAL STRUCTURAL BIOLOGY WITH ROSETTA” at Leipzig University

This course teach theoretical and practical aspects of computational biology including the integration of Human Genetics with Molecular Modeling. It focus on aspects of protein sequence alignments, secondary structure prediction, comparative modeling, protein-protein and protein-ligand docking, structure-based drug design, virtual screening, the relationship of protein sequence, structure, variation, and disease. This course includes a practical section and is intended for PhDs, PostDocs and Students. Registration Please register until end of November by sending an e-mail to Anett Albrecht ().

OFFERING RESEARCH INTERNSHIP – MAX KADE Scholarship for Students on Bachelor- or Master level:  Call 2016

OFFERING RESEARCH INTERNSHIP – MAX KADE Scholarship for Students on Bachelor- or Master level: Call 2016

The Max Kade Foundation (MKF, www.maxkadefoundation.org) supports an international research exchange between Vanderbilt and Leipzig Universities. Specifically, MKF provides funds of three‐four undergraduate students from each university to conduct a 10 week summer internship at the respective partner university. Travel costs up to $2000 and a weekly stipend of $400 are provided. They target rising junior and rising senior students at Vanderbilt University. To select the recipients of the stipend, they collect research project descriptions from around twenty core laboratories that support the collaboration between Vanderbilt and Leipzig Universities. Descriptions are provided by the graduate student or post‐doctoral mentor who will advise the undergraduate student. It is encouraged that the undergraduate

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Lecture on “Structural analysis of protein complexes by mass spectrometry and computational modelling – basics and applications of a beautiful combination” at Vanderbilt

Center for Structural Biology Dr. Stefan Kalkhof, Post-Doc, Mass Spectrometry Group, Department of Proteomics, Helmholtz-Centre for Environmental Research – UFZ, Leipzig, Germany Date 05 June 2015 Venue Center for Structural Biology, 465 21st Ave South, BIOSCI/MRBIII, Vanderbilt University, Nashville, TN 37221

Course on “Site-specific protein labeling and incorporation of unnatural amino acids in live cells” at Vanderbilt University

Course on “Site-specific protein labeling and incorporation of unnatural amino acids in live cells” at Vanderbilt University

Syllabus – CPBP 330 – Special Topics in Protein Biochemistry Dr. Irene Coin, Leipzig University, Faculty of Life Sciences, Institute of Biochemistry Date 14 – 21 July 2015 Venue Departments of Chemistry, Pharmacology, and Biomedical Informatics, Center for Structural Biology, and Institute of Chemical Biology, 465 21st Ave South, BIOSCI/MRBIII, Room 5144B, Nashville, TN 37232-8725 The student will become familiar with modern techniques to incorporate labels and biophysical probes into intact proteins, including chemical synthesis, enzymatic modification, biorthogonal labeling and direct ribosomal incorporation of unnatural moieties.

It is the sound of music – a remarkable partnership: Researchers from Leipzig and Nashville investigate molecular mechanisms

It is the sound of music – a remarkable partnership: Researchers from Leipzig and Nashville investigate molecular mechanisms

by Carsten Heckmann (LUMAG, 01-2015, 03/12/2015): To name the cities of Leipzig and Nashville in a sentence, could comes up with the idea: it could go on music. Classic here – Country there. But this is no topic for this research report. There is also the research field biochemistry – with a remarkable partnership between both universities. To bridge 7,500 kilometer is not difficult for Prof. Dr. Annette Beck-Sickinger and Prof. Dr. Jens Meiler (Vanderbilt University). Sometimes they feel more like neighbors. “We work extremely well together,” says the Leipzig professor at the Institute of Biochemistry. More than 20 joint publications have appeared since 2008, emerged from around 30 joint projects.

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Dicovering interaction mode of specific carbaborane derivatives with GPCRs at Vanderbilt University

by Peter Schmidt (postdoc at Leipzig University): GPCRs have been shown to play a crucial role in a variety of diseases, such as obesity, metabolic diseases and cancer. Accordingly, they are an attractive target for the investigation of new pharmaceuticals. Di-carba-closo-dodecaboranes(12) (closo-C2B12H12 or carbaboranes) were recently established as pharmacophores. Their unique properties (hydrophobicity, three-dimensional aromaticity, etc.) make them interesting targets for drug development. In this project, specific carbaborane derivatives will be prepared and used either as conjugates with peptides of the melanotropin (MSH) or neuropeptide Y (NPY) family, or as small molecules that impart their action via GPCRs to study and understand their influence on the selectivity and activity. NPY binds

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Max-Kade Scholarship 2014: Short-Reports

Max-Kade Scholarship 2014: Short-Reports

2014 eight students on Bachelor- or Master level got the Max-Kade Scholarship to participate in ongoing research projects between Vanderbilt University and the University of Leipzig. Hereby there short research and travel reports:

Scientific and Methode Modules “Computational Structural Biology with ROSETTA”

Scientific and Methode Modules “Computational Structural Biology with ROSETTA”

Date 08 – 19 December 2014 Venue Biotechnologisch-Biomedizinisches Zentrum (BBZ), Seminar room 1.1, Deutscher Platz 5, 04103 Leipzig Responsible scientists Prof. Dr. Jens Meiler (Vanderbilt University) Prof. Dr. Annette Beck-Sickinger (Leipzig University) Dr. Jonathan Sheehan (Vanderbilt University) Dr. Rene Meier (Leipzig University) Aims Teach theoretical and practical aspects of computational structural biology using the Rosetta software. Basics Biochemistry, amino acid structure, peptide bond, secondary structure, tertiary structure, small molecule binding, central dogma of molecular biology Contents Theoretical and practical aspects of protein sequence alignments, secondary structure prediction, comparative modeling, protein-protein and protein-ligand docking. Structure-based drug design, virtual screening. This course includes a laboratory sectio Methods Computational Algorithms Examination Final Written Exam

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Identification of new target GPCR at Vanderbilt University

by Antje Brüser (postdoc at Leipzig University): I had the possibility to join Vanderbilt University from March 26th – July 11th 2014 as a visiting scholar to initiate a new project between our group (headed by Prof. Torsten Schöneberg) and the group of Prof. Larry Marnett. We focus in our lab on orphan G-protein coupled receptors (oGPCR) and the Marnett lab is working on COX inhibitors. Since years they have been interested in products of the COX-2 pathway and the identification of receptors which they bind to. In our new cooperation we have the knowledge and expertise to search and functional analysis of oGPCR. During my stay at the Marnett lab

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Biological evaluation of modified COX inhibitors at Vanderbilt University

by Wilma Neumann (doctoral student at Leipzig University): After a successful start-up of a new collaboration project last autumn followed by a joint publication earlier this year, the group of Prof. Larry Marnett again welcomed me in their lab during my second research stay at Vanderbilt between May 21st and June 21st, 2014. Continuing our project on conjugates of cisplatin and COX inhibitors for use as antitumor agents, Brenda Crews, Cristina Daniel, and Kebreab Ghebreselasie actively supported me with the biological evaluation of new conjugates I had prepared in Leipzig. I am also very thankful to Cristina for introducing me to further molecular biology techniques and for her great effort performing

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Research stay at the Division of Nephrology and Hypertension at the Vanderbilt University Medical Center (VUMC)

Research stay at the Division of Nephrology and Hypertension at the Vanderbilt University Medical Center (VUMC)

by Thomas Ebert (postdoc at Leipzig University): From January 3rd, 2014 – April 4th 2014, I had the opportunity to stay at the Division of Nephrology and Hypertension at the Vanderbilt University Medical Center (VUMC) in Nashville, Tennessee as a visiting scholar. In our group in Leipzig (headed by Prof. Mathias Fasshauer), we focus on adipocyte-secreted proteins, so called adipokines, in renal dysfunction. To investigate adipokines in diabetic nephropathy (DN), a severe consequence of long-term diabetes mellitus, animal studies are vitally important. The group of Prof. Raymond C. Harris (Chief of the Division of Nephrology and Hypertension at VUMC) introduced the enos db/db-mouse as the currently best mouse model to study

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Summer School on CHEMICAL BIOLOGY OF GPCR LIGANDS

Summer School on CHEMICAL BIOLOGY OF GPCR LIGANDS

Prof. Dr. Annette G. Beck-Sickinger (Leipzig University, Institute of Biochemistry) 21-28 July 2014, Vanderbilt University Many ligands of GPCR belong to the family of peptides and proteins. This includes all class B GPCR ligands, e. g. calcitonin, glucagon and the pharmacologically relevant GLP-1, from which modified analogies have entered the anti-diabetic market recently (e. g. Exenentide, Liraglutide, etc.). But also in the family of class A GPCR different peptide and protein hormones (angiotensin, bradykinin, chemokines, FSH, etc.) play an important role in physiology. Peptide ligands have some unique properties. They can be obtained by solid phase peptide synthesis and chemically modified with specific side-chain protection strategies. This includes selective labeling with

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Leipzig PhD use high performance computational ressources for protein modeling

by Tristan Zellmann (doctoral student at Leipzig University): I had the opportunity to stay at Jens Meilers lab in Nashville from 11/27/13 to 12/06/13 as well as from 01/27/14 to 03/22/14 to complete the modeling for an upcoming publication. During my stay, I had the opportunity to take part in two great, american traditions – arriving the day just before Thanksgiving, I got invited to an actual Thanksgiving dinner, featuring delicious turkey, mashed potatoes, gravy, buttery carrots and even pumpkin pie. Another culinary and cultural highlight was a super bowl party complete with chili, buffalo wings and lots of snacks, even if the Seattle Seahawks seemed to dominate a bit too

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Research Stay at Vanderbilt University on Arrestin Proteins

by Lizzy Wanka (doctoral student at Leipzig University): In the autumn of 2013, I had the great opportunity to visit Prof. Dr. Vsevolod V. Gurevich`s lab at the Vanderbilt university for 12 weeks. Prof. Gurevich and his group work with arrestin proteins and investigate among others their binding to receptors and other signaling proteins. I wanted to study the binding of different arrestin mutants to NPY receptors and NPY receptor chimera. Together with Dr. Luis E. D. Gimenez, I performed various bioluminescence resonance energy transfer assays and learned a lot about the arrestin recruitment and the optimization of this assay. The discussions about analyzing the data were revealing and very helpful.

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Workshop at Vanderbilt: Mass Spectrometry based methods for protein structure analysis

by Dr. Stefan Kalkhof, Prof. Dr. Martin von Bergen and Prof. Dr. John McLean: In an one-week curse 30 PhD students and postdocs of the Vanderbilt University were introduced to modern mass spectrometry methods and recent technical developments. The participants were made familiar with the theory of H/D exchange, ion mobility, chemical crosslinking, and labeling techniques using chemicals or radicals. Furthermore, to give the participants a better feeling concerning the potential as well as advantages, experimental challenges, and limitations many own projects and experimental protocols were presented and critically discussed. Finally, a session was used to discuss how one could practically utilize the techniques to answer current questions of participant`s projects.

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Max-Kade Foundation Partners with VU-LU Collaboration

Max-Kade Foundation Partners with VU-LU Collaboration

The Vanderbilt-Leipzig Collaboration is pleased to announce its partnership with the Max Kade Foundation to support the exchange of students and faculty between the universities. The Max Kade Foundation takes pride in participating and sponsoring various programs which encourage the exchange of academic ideas among universities and colleges in the United States and in German-speaking countries (www.maxkadefoundation.org). The foundation recently awarded the Vanderbilt-Leipzig research exchange program a grant to cover the travel and support of six undergraduate student exchanges, as well as two faculty exchanges per year. The students will travel to their respective university and join a research project under a senior supervisor. They will be engaged for ten weeks

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Leipzig Post-Doctoral Fellow in Nashville / Vanderbilt University

by Stephan Theisgen (Post Doc at Leipzig University): From 16th September to 14th October I had the opportunity to visit Prof. Jens Meiler’s Lab where I wanted to perform some structural computations to complete a pending scientific paper. This turned out to be a major task for 4 weeks only. But together with Dr. David Nanneman, Stephanie Hirst DeLuca and Sam DeLuca, we managed to finish this ambitious project successfully. In the process, I learned a lot about computational structural biology and became familiar with an important method in this field. Beside the heavy scientific work, I enjoyed very much the special southern cuisine, visiting downtown Nashville and of course some

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Vanderbilt, Leipzig research collaboration sees strong results

Vanderbilt, Leipzig research collaboration sees strong results

written by Matt Windsor: During the past two weeks, the fifth international symposium between Leipzig and Vanderbilt universities was held on the Vanderbilt campus, as seven Leipzig faculty members presented a series of chemical biology-related lectures. The symposium offered an opportunity to highlight the ongoing success of the international collaboration. To date, there have been 17 joint publications between research groups at the two universities. This summer, the first federally funded research grant resulting from the collaboration was awarded by the National Institutes of Health (NIH). The project is aimed at developing drugs for a specific type of protein known as a G protein-coupled receptor (GPCR). The grant was spearheaded by

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Workshop at VU: Mass Spectrometry based methods for protein structure analysis

by Dr. Stefan Kalkhof, Prof. Dr. Martin von Bergen and Prof. Dr. John McLean: In an one-week curse 30 PhD students and postdocs of the Vanderbilt University were introduced to modern mass spectrometry methods and recent technical developments. The participants were made familiar with the theory of H/D exchange, ion mobility, chemical crosslinking, and labeling techniques using chemicals or radicals. Furthermore, to give the participants a better feeling concerning the potential as well as advantages, experimental challenges, and limitations many own projects and experimental protocols were presented and critically discussed. Finally, a session was used to discuss how one could practically utilize the techniques to answer current questions of participant`s projects.

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Vanderbilt Undergraduate Student in Leipzig

by Hannah Berke (undergraduate student at Vanderbilt University): My two months spent in Leipzig were a wonderful experience. The work in the lab was informative and enjoyable and living in Leipzig changed my life. My stay in Leipzig was extremely fun and gave me the opportunity to travel and experience Europe and Germany specifically. The city itself is a perfect size, very similar to Nashville, and I lived in an area that was about a 5 minute tram ride or 20 minute walk from the city center, or “Mitte,” that is full of shops and restaurants. The abundance of parks and cafes made it easy to spend time outside – barbecuing,

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DAAD RISE Program: Call 2014

DAAD RISE Program: Call 2014

The German Academic Exchange Service (Deutscher Akademischer Austauschdienst, DAAD) announced a new call for its program “Research Internships in Science and Engineering” (RISE) for summer internship in 2014. The program works in both ways. German and American Ph.D. students submit internship offers for undergraduates students for a duration of 8 to 12 weeks. German bachelor students can work as research interns at U.S. universities and U.S. undergraduates can work in labs of German universities. The DAAD provides stipends to help cover living expenses, the partner universities and research institutes provide housing assistance. The call is applicable for all fields of biology, chemistry, physics, earth sciences and engineering. Please visit for further

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New Grant supports joint Research Project between Vanderbilt and Leipzig Universities

Annette Beck-Sickinger and Torsten Schoeneberg from Leipzig University and Jens Meiler from Vanderbilt University receive a grant “Ensemble Docking Interrogates Structural Determinants of Ligand-Protein Interactions” that is jointly funded by the National Science Foundation (NSF) and the Deutsche Forschungsgemeinschaft (DFG). The grant will develop a novel docking algorithm that leverages Structure-Activity-Relations (SAR) and apply this algorithm to understand regulation of G-Protein Coupled Receptors (GPCRs). Project Summary

4th Vanderbilt-Leipzig Cooperation Workshop

4th Vanderbilt-Leipzig Cooperation Workshop

The 4th international scientific symposium was held with members of the Leipzig University and Vanderbilt University from the 6th to the 12th of July 2013 in Leipzig. The focus of this event taking place at the Biotechnological-Biomedical Center (BBZ) of the University of Leipzig was the further organization and consolidation of the university partnership (MOU) between Leipzig and Vanderbilt University. Likewise this event was set out to be a Kick-Off-Meeting for two new international junior research groups, which are funded by the State Ministry of Science and Arts through the European Social Fond (ESF) since July 1st. The fourth cooperation workshop (scientific symposium) is linked to the plans of the Leipzig

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Symposium and New Grants bolster Vanderbilt-Leipzig Partnership

Symposium and New Grants bolster Vanderbilt-Leipzig Partnership

Two new grants and a summer symposium with workshops highlight ongoing collaboration efforts between Vanderbilt University and Leipzig University: 1) Vanderbilt University received a grant from the Max Kade Foundation in support of an undergraduate and graduate student exchange program in collaboration with Leipzig University. The collaboration is spearheaded by Drs. Jens Meiler (Vanderbilt University) and Annette Beck-Sickinger (Leipzig University). 2) The Meiler and Weaver laboratories at Vanderbilt University received a grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK, NIH) for the development of “Small Molecule Probes to Investigate Structure and Function of Y Receptors.” This project is a collaboration with Annette Beck-Sickinger at Leipzig University,

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Summer School on Molecular Modeling at Leipzig University

Prof. Dr. Terry Lybrand, Vanderbilt University Nashville, USA 10. – 12. July 2013, Leipzig University Course description: This short course will cover basic background information and applications details for molecular mechanics calculations, including energy minimization and molecular dynamics simulations. Some basic theory will be presented, but the course will focus primarily on practical details for molecular mechanics calculations and will include numerous “hands-on” exercises, i.e., the students will get the opportunity to perform all necessary steps for typical calculations. We will discuss the capabilities and limitations of different types of calculations, the information required to perform useful calculations, and analysis techniques to allow you to extract useful information from these calculations.

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Summer School on EPR Spectroscopy at Leipzig University

15. – 18. July 2013, Leipzig University Prof. Dr. Hassane Mchaourab, Vanderbilt University Nashville, USA Course description: This is an advanced, intensive course directed at graduate students. It is intended to provide an overview of the EPR spectroscopy and its application to protein biophysics. Electron paramagnetic resonance is a magnetic resonance technique for the analysis of naturally occurring or introduced free radicals. In protein spin labeling, a stable free radical, spin label, is introduced specifically into the protein sequence via site-directed mutagenesis. The lectures will describe the technical and biochemical aspects of protein spin labeling, discuss the spectral parameters that are determined from EPR analysis of spin labeled proteins and their

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The Leipzig Connection

The Leipzig Connection

by David Salisbury | posted at news.vanderbilt.edu: In 2007, while Jens Meiler was visiting his parents in Germany, the associate professor of chemistry was invited to give a lecture at his alma mater, the University of Leipzig. “When I gave that talk on my research in structural and chemical biology, I found a tremendous amount of interest in what we are doing at Vanderbilt and learned that there is a great deal of complementary research going on in Leipzig,” Meiler said. In fact, Meiler stirred up so much interest that two years later Annette Beck-Sickinger, professor of biochemistry and bioorganic chemistry at Leipzig, spent her sabbatical at Vanderbilt. During her visit

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DAAD RISE Program: Call 2013

DAAD RISE Program: Call 2013

The German Academic Exchange Service (Deutscher Akademischer Austauschdienst, DAAD) announced a new call for its program “Research Internships in Science and Engineering” (RISE) for summer internship in 2013. The program works in both ways. German and American Ph.D. students submit internship offers for undergraduates students for a duration of 8 to 12 weeks. German bachelor students can work as research interns at U.S. universities and U.S. undergraduates can work in labs of German universities. The DAAD provides stipends to help cover living expenses, the partner universities and research institutes provide housing assistance. The call is applicable for all fields of biology, chemistry, physics, earth sciences and engineering. Please visit for further information:

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Summer School on Receptor Theory and GPCR signalling via G proteins and arrestins

Prof. Dr. Vsevolod Gurevich, Vanderbilt University, Nashville, TN 8 – 12 October 2012, Leipzig University Arrestins are proteins which regulate the signalling and trafficking of hundreds of different G-protein-coupled receptors (GPCR). But arrestins also interact with other classes of membrane receptors and over 20 diverse types of soluble signalling protein. Arrestins can block GPCR coupling to G proteins in two ways. But they can also modify gene expression by increasing the transcription of certain genes.Several arrestin-binding partners play a key role in the signalling pathways regulating cell proliferation, survival and apoptosis. Since multiple genetic disorders can be associated with excessive signalling by mutant G-protein-coupled receptors, arrestin is an interesting target for

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Summer School on Solid-State NMR Spectroscopy in Biology

Summer School on Solid-State NMR Spectroscopy in Biology

Prof. Dr. Daniel Huster, University of Leipzig 2 -11 October 2012, Vanderbilt University, Nashville, TN Due to the success of NMR studies on soluble molecules the original NMR spectroscopy on solid materials such as crystals, glasses, powders and polymers has long played an inferior role. However, in the last decade, solid-state NMR spectroscopy has widely been applied to complicated biological questions such as the study of aggregated and amyloidic protein states, membrane proteins, biological tissue or other molecular aggregates of large molecular mass. As there is no principle limit on the molecular mass of the investigated molecules and the fact that the resolution and sensitivity of the technique seems to constantly

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Vanderbilt PhD students in Leipzig

Vanderbilt PhD students in Leipzig

Stephanie and Liz are graduate students in the Meiler Laboratory at Vanderbilt University.  They both work on the computational investigation of GPCRs and their interactions with various ligands. They recently took the opportunity to do a month-long research internship at Leipzig University in conjunction with their collaborators, who perform the wet-lab experiments associated with the proteins they model. Herein, they reflect on their experiences. Liz Dong: For 4 weeks, I worked with the lab of Dr. Torsten Schöneberg on a project involving P2Y12, a receptor involved in platelet aggregation. My part of the project was to build a model of P2Y12 using Rosetta and dock known ligands into the model to

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DAAD RISE Program: Call 2012

DAAD RISE Program: Call 2012

The German Academic Exchange Service (Deutscher Akademischer Austauschdienst, DAAD) announced a new call for its program “Research Internships in Science and Engineering” (RISE) for summer internship in 2012. The program works in both ways. German and American Ph.D. students submit internship offers for undergraduates students for a duration of 8 to 12 weeks.  German bachelor students can work as research interns at U.S. universities and U.S. undergraduates can work in labs of German universities. The DAAD provides stipends to help cover living expenses, the partner universities and research institutes provide housing assistance. The call is applicable for all fields of biology, chemistry, physics, earth sciences and engineering. Please visit for further

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Liz Dong Receives DAAD Short Term Research Grant

Liz Dong of the Jens Meiler lab at Vanderbilt recently received a short term research grant to study at the Univeristy of Leipzig in Leipzig, Germany. She will spend one month this fall developing a computational method that will allow for the binding pose of a drug within a receptor to be determined. Her method will be guided by experimental data collected on drugs that bind G-protein coupled receptors, working with the lab of Torsten Schöneberg. Congrats, Liz!

Collaborative Paper published in “Bioorganic & Medicinal Chemistry”

Researchers of Leipzig and Vanderbilt Universities published a paper in the journal “Bioorganic & Medicinal Chemistry” showing the results of their collaborative project on carbaborane research. The paper, published in March 2011, describes new synthesis strategies of indomethacin derivatives with inorganic carbaborane clusters. Indomethacin is a very potent cyclooxygenase (COX)-1 and COX-2 inhibitor with clinical significance as anti-inflammatory drug , The carbaborane-modified drug candidates showed also COX inhibition activity, depending on the carbaborane isomer and the connection pattern. The results gave general insights into the applicability of carbaboranes as drug entities. Synthesis and evaluation of carbaborane derivatives of indomethacin as cyclooxygenase inhibitors Matthias Scholz(1), Anna L. Blobaum(2), Lawrence J. Marnett(2) and

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3rd Vanderbilt-Leipzig Cooperation Workshop

3rd Vanderbilt-Leipzig Cooperation Workshop

The 3rd Cooperation Workshop of Leipzig and Vanderbilt Universities took place in Leipzig on May 25th until 29th, 2011. It was organized by the Top-Level Research Area 3 “Molecular and Cellular Communication” (PbF3) Six faculty from Vanderbilt University visited Leipzig, participated in a scientific symposium, and used the opportunity to get in touch close contact with researchers from Leipzig University and non-university institutions. The guests were heartily welcomed by new university rector, Prof. Dr. Beate A. Schücking on Wednesday evening at the top of Leipzig’s old university building, now the Panorama Tower in the city center. On Thursday, a public scientific symposium took place at the seminar building, eagerly visited by

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Collaborative Paper published in Journal of Biological Chemistry

First results of the successful collaboration between Leipzig University (Germany) and Vanderbilt University, Nashville (Tennessee, USA) have been published in the Journal of Biological Chemistry by end of 2010. Researchers from the labs of Annette G. Beck-Sickinger (Leipzig University) and Vsevolod V. Gurevich (Vanderbilt University) investigated the mechanism and regulation of neuropeptide Y2 receptor internalization. For the first time, the corporate publication “Ligand-induced internalization and recycling of the human neuropeptide Y2 receptor is regulated by its carboxyl-terminal tail” reports on specific sequences located in the receptor’s C-terminus which determine arrestin-dependent/independent internalization and recycling events, thus contributes to a better understanding of the regulation of G protein-coupled receptor trafficking pathways. Cornelia Walther,

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2nd Vanderbilt-Leipzig Collaboration Workshop November 10-14, 2010

2nd Vanderbilt-Leipzig Collaboration Workshop November 10-14, 2010

In November, eight professors from Leipzig University traveled to Vanderbilt for the purpose of further developing the collaboration in education and research between Vanderbilt Leipzig Universities. They were accompanied by Dr. Martin Schlegel, the Vice Rector of Research at Leipzig University and Anja Landsmann, the Leipzig coordinator of this collaboration. The workshop began on Wednesday morning with research presentations by six Vanderbilt researchers: Borden Lacy, Walter Chazin, John McLean, Jeff Johnston, Brian Bachmann, and Larry Marnett. In the afternoon the guests from Leipzig University presented their research in a scientific symposium. Opening remarks were given by  Dr. Joel Harrington, Vanderbilt Associate Provost for Global Strategy, Dr. Martin Schlegel, and by Dr.

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Details from 4 Vanderbilt Students about their DAAD-RISE Internships at Leipzig

[by Ross Barajas, Aaron Coonley, Deanna Joe, and Dan Viox] Germany is a country with a rich history and a thriving culture, a leader in scientific discoveries, and a desired destination for many, including four undergraduate students from Vanderbilt University. Through the German Academic Exchange Service (DAAD), we each applied for Research Internship in Science and Engineering (RISE) internships in the winter of 2009. We were awarded scholarships to the University of Leipzig, a university with which Vanderbilt University already has an established collaboration. Over our stay of three months, we were able to develop extensive research skills, learning and working under our mentors—Ph.D. candidates at the university.  Ross Barajas worked

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Two Leipzig students at Vanderbilt

Sabina Kanton and Henrike Indrischek (biochemistry undergraduates from Leipzig University) took the opportunity to visit Vanderbilt University for a 5 week research stay in September and October 2010 with a special tender of the DAAD RISE program. Here is their report about this experience. Why Vanderbilt University? Both of us wanted to gain practical experience and get an insight into the work of a research group abroad. We were just curious to get to know the atmosphere of such a prominent American university and of course were keen on improving our scientific English. Research projects I (Henrike Indrischek) worked in the group of Hassane Mchaourab at the Institute of Molecular Biology

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2nd Scientific Workshop at Vanderbilt, November 2010

During November 10th – 14th, researchers from Leipzig University in Germany will visit Vanderbilt to deepen and expand a collaboration between the two Universities. Faculty from Leipzig University will present their research in a kick-off symposium on November 10, 1:30pm in 208 Light Hall. A wine and cheese reception will follow the presentations at 5:30pm, where the faculty will be present to discuss their research. This collaboration is supported by Vanderbilt’s International Office, the Institute for Chemical Biology, the Department of Chemistry, and the School of Arts & Sciences. This collaboration is also supported by the German Research Foundation (DFG) and the PbF3 of Leipzig University. On November 10th, 2010 in

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Report on summer internships at Vanderbilt 2010

Report on summer internships at Vanderbilt 2010

In 2010 several students from Leipzig University had the opportunity for a research stay at Vanderbilt University. Stefanie Nagel and Anette Schreiber, students of the Master’s degree program in biochemistry at Leipzig University, were two of these. Thanks to the cooperation of Leipzig University and Vanderbilt University in Nashville (Tenneessee, USA), they participated in a 10-week student exchange in summer 2010 and report here shortly their experience. Stefanie Nagel: I performed my internship at Vanderbilt University in the workgroup of Prof. Vsevolod (Seva) Gurevich, Department of Pharmacology, a recognized expert on the field of arrestin proteins. The aim of my project was to characterize the interaction between the human neuropeptide Y

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DAAD RISE Program: Call 2011

DAAD RISE Program: Call 2011

The German Academic Exchange Service (Deutscher Akademischer Austauschdienst, DAAD) announced a new call for its program “Research Internships in Science and Engineering” (RISE) for summer internship in 2011. The program works in both ways. German and American Ph.D. students submit internship offers for undergraduates students for a duration of 6 to 12 weeks.  German bachelor students can work as research interns at U.S. universities and U.S. undergraduates can work in labs of German universities. The DAAD provides stipends to help cover living expenses, the partner universities and research institutes provide housing assistance. The call is applicable for all fields of biology, chemistry, physics, earth sciences and engineering. Please visit for further

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Students from Vanderbilt with DAAD RISE in Leipzig

Students from Vanderbilt with DAAD RISE in Leipzig

The German Academic Exchange Service (Deutscher Akademischer Austauschdienst, DAAD) offers since 2005 a yearly program that gives undergraduates from U.S., Canadian and U.K. universities the opportunity for a research internship during the summer holiday weeks. In 2010 four students from Vanderbilt University used the collaborative efforts of the partnership to visit work groups in the fields of biochemistry (AG Beck-Sickinger), medicinal physics and biophysics (AG Huster), and environmental technology andmanagement (Prof. Holländer) to get a hands-on experience of the research at Leipzig University. They stayed 8 to 12 weeks here learning new methods and techniques as well as getting in touch with life in Germany. All of them enjoyed their stay

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