Project Group T – Transfer

T1: Sulfated glycoaminoglycans as coating for endoprostheses to improve osseointegratione individualized biomaterials

The ongoing demographic changes result in a considerable increase in patients with the need for bone defect filling and joint replacement. Systemic diseases that result in impaired bone healing and osseointegration of implants represent further challenges. These require the development of novel functional biomaterials with improved osseointegrative properties. Within this newly formed transfer project we aim to use our knowledge about the regenerative abilities of extracellular matrix components to significantly improve the osseointegration of orthopaedic implants. Together with Mathys Orthopädie GmbH, Mörsdorf, as an industry partner we will therefore establish coating procedures for existing biomaterial products and optimize the process considering the material shelf life, reproducibility and sterilization process to meet the requirements for medical product approval. The bioactivity will be tested both in vitro and finally validated in a relevant preclinical large animal model. This will serve the long-term goal to identify a novel coating that significantly enhances implant integration and enable the clinical application of these individualized biomaterials.

Industry partner:

Mathys Orthopädie GmbH Mörsdorf
An den Trillers Büschen 2
07646 Mörsdorf

Contact: Dipl.-Ing. Carolin Witt
Phone: 036428 494 610


  1. Koehler L, Ruiz-Gómez G, Balamurugan K, Rother S, Freyse J, Möller S, Schnabelrauch M, Köhling S, Djordjevic S, Scharnweber D, Rademann J, Pisabarro MT, Hintze V. Dual Action of Sulfated Hyaluronan on Angiogenic Processes in Relation to Vascular Endothelial Growth Factor-A. Sci Rep. 2019 Dec 2;9(1):18143. doi: 10.1038/s41598-019-54211-0.
  2. Rother S, Krönert V, Hauck N, Berg A, Moeller S, Schnabelrauch M, Thiele J, Scharnweber D, Hintze V. Hyaluronan/collagen hydrogel matrices containing high-sulfated hyaluronan microgels for regulating transforming growth factor-β1. J Mater Sci Mater Med. 2019 May 24;30(6):65. doi: 10.1007/s10856-019-6267-1.
  3. Schneider M, Rother S, Möller S, Schnabelrauch M, Scharnweber D, Simon JC, Hintze V, Savkovic V. Sulfated hyaluronan-containing artificial extracellular matrices promote proliferation of keratinocytes and melanotic phenotype of melanocytes from the outer root sheath of hair follicles. J Biomed Mater Res A. 2019 Aug;107(8):1640-1653. doi: 10.1002/jbm.a.36680. Epub 2019 Apr 23.
  4. Wojak-Ćwik IM, Rumian Ł, Krok-Borkowicz M, Hess R, Bernhardt R, Dobrzyński P, Möller S, Schnabelrauch M, Hintze V, Scharnweber D, Pamuła E. Synergistic effect of bimodal pore distribution and artificial extracellular matrices in polymeric scaffolds on osteogenic differentiation of human mesenchymal stem cells. Mater Sci Eng C Mater Biol Appl. 2019 Apr;97:12-22. doi: 10.1016/j.msec.2018.12.012. Epub 2018 Dec 7.


Prof. Dr. med. Lorenz Hofbauer

TU Dresden, University Hospital "Carl Gustav Carus" Medical Clinic III
Fetscherstraße 47, 01307 Dresden

Phone: +49 (0)351 458-3173

Prof. Dr. med. Stefan Rammelt

TU Dresden, Carl Gustav Carus" University Hospital
Clinic and Polyclinic for Trauma and Reconstructive Surgery
Fetscher Straße 74, 01307 Dresden

Phone: +49 (0)351 458-2208

Dr. rer.nat. Matthias Schnabelrauch

Research Field Biomaterials
Prüssingstraße 27 B
07745 Jena

Phone: +49 (0)3641 282512