Publications of the Transregio 67
Numerous publications have been produced within the framework of the Transregio, which you will find below. The bibliographic information is linked to Pubmed.
Simon JC, Werner C. 12 years more than just skin and bones: the CRC Transregio 67. Biological Chemistry, vol. 402, no. 11, 2021, pp. 1269-1270. https://doi.org/10.1515/hsz-2021-0353.
Spiller S, Clauder F, Bellmann-Sickert K, Beck-Sickinger AG. Improvement of wound healing by the development of ECM-inspired biomaterial coatings and controlled protein release. Biological Chemistry, vol. 402, no. 11, 2021, pp. 1271-1288. https://doi.org/10.1515/hsz-2021-0144.
Torregrossa M, Kakpenova A, Simon JC, Franz S. Modulation of macrophage functions by ECM-inspired wound dressings – a promising therapeutic approach for chronic wounds. Biological Chemistry, vol. 402, no. 11, 2021, pp. 1289-1307. https://doi.org/10.1515/hsz-2021-0145.
Ullm F, Pompe T. Fibrillar biopolymer-based scaffolds to study macrophage-fibroblast crosstalk in wound repair. Biological Chemistry, vol. 402, no. 11, 2021, pp. 1309-1324. https://doi.org/10.1515/hsz-2021-0164.
Anderegg U, Halfter N, Schnabelrauch M, Hintze V. Collagen/glycosaminoglycan-based matrices for controlling skin cell responses. Biological Chemistry, vol. 402, no. 11, 2021, pp. 1325-1335. https://doi.org/10.1515/hsz-2021-0176.
Künze G, Huster D, Samsonov SA. Investigation of the structure of regulatory proteins interacting with glycosaminoglycans by combining NMR spectroscopy and molecular modeling – the beginning of a wonderful friendship. Biological Chemistry, vol. 402, no. 11, 2021, pp. 1337-1355. https://doi.org/10.1515/hsz-2021-0119.
Krieghoff J, Gronbach M, Schulz-Siegmund M, Hacker MC. Biodegradable macromers for implant bulk and surface engineering. Biological Chemistry, vol. 402, no. 11, 2021, pp. 1357-1374. https://doi.org/10.1515/hsz-2021-0161.
Schiller J, Lemmnitzer K, Dürig JN, Rademann J. Insights into structure, affinity, specificity, and function of GAG-protein interactions through the chemoenzymatic preparation of defined sulfated oligohyaluronans. Biological Chemistry, vol. 402, no. 11, 2021, pp. 1375-1384. https://doi.org/10.1515/hsz-2021-0165.
Schnabelrauch M, Schiller J, Möller S, Scharnweber D, Hintze V. Chemically modified glycosaminoglycan derivatives as building blocks for biomaterial coatings and hydrogels. Biological Chemistry, vol. 402, no. 11, 2021, pp. 1385-1395. https://doi.org/10.1515/hsz-2021-0171.
Schulze S, Rothe R, Neuber C, Hauser S, Ullrich M, Pietzsch J, Rammelt S. Men who stare at bone: multimodal monitoring of bone healing. Biological Chemistry, vol. 402, no. 11, 2021, pp. 1397-1413. https://doi.org/10.1515/hsz-2021-0170.
Salbach-Hirsch J, Rauner M, Hofbauer C, Hofbauer LC. New insights into the role of glycosaminoglycans in the endosteal bone microenvironment. Biological Chemistry, vol. 402, no. 11, 2021, pp. 1415-1425. https://doi.org/10.1515/hsz-2021-0174.
Großkopf H, Vogel S, Müller CD, Köhling S, Dürig JN, Möller S, Schnabelrauch M, Rademann J, Hempel U, von Bergen M, Schubert K. Identification of intracellular glycosaminoglycan-interacting proteins by affinity purification mass spectrometry. Biological Chemistry, vol. 402, no. 11, 2021, pp. 1427-1440. https://doi.org/10.1515/hsz-2021-0167.
Balamurugan K, Koehler L, Dürig JN, Hempel U, Rademann J, Hintze V, Pisabarro MT. Structural insights into the modulation of PDGF/PDGFR-β complexation by hyaluronan derivatives. Biological Chemistry, vol. 402, no. 11, 2021, pp. 1441-1452. https://doi.org/10.1515/hsz-2021-0173.
Kühn S, Freyse J, Atallah P, Rademann J, Freudenberg U, Werner C. Tuning the network charge of biohybrid hydrogel matrices to modulate the release of SDF-1. Biological Chemistry, vol. 402, no. 11, 2021, pp. 1453-1464. https://doi.org/10.1515/hsz-2021-0175.
Vogel S, Ullm F, Müller CD, Pompe T, Hempel U. Impact of binding mode of low-sulfated hyaluronan to 3D collagen matrices on its osteoinductive effect for human bone marrow stromal cells. Biological Chemistry, vol. 402, no. 11, 2021, pp. 1465-1478. https://doi.org/10.1515/hsz-2021-0212.
Krieghoff J, Kascholke C, Loth R, Starke A, Koenig A, Schulz-Siegmund M, Hacker MC. Composition-controlled degradation behavior of macroporous scaffolds from three-armed biodegradable macromers. Polymer Degradation and Stability 2021. https://doi.org/10.1016/j.polymdegradstab.2021.109775.
Al-Maawi S, Rother S, Halfter N, Fiebig KM, Moritz J, Moeller S, Schnabelrauch M, Kirkpatrick CJ, Sader R, Wiesmann HP, Scharnweber D, Hintze V, Ghanaati S. Covalent linkage of sulfated hyaluronan to the collagen scaffold Mucograft® enhances scaffold stability and reduces proinflammatory macrophage activation in vivo. Bioact. Mater. 2021, doi: 10.1016/ j.bioactmat.2021.06.008; shared senior authorship.
Anderegg U, Halfter N, Schnabelrauch M, Hintze, V. Collagen/ glycosaminoglycan-based matrices for controlling skin cell responses. Biol. Chem. 2021, doi: 10.1515/hsz-2021-0176.
Balamurugan K, Koehler L, Dürig J-N, Hempel U, Rademann J, Hintze V, Pisabarro MT. Structural insights into the modulation of PDGF/PDGFR-β complexation by hyaluronan derivatives. Biol Chem 2021, doi: 10.1515/hsz-2021-0173.
Dietrich K, Fiedler IA, Kurzyukova A, López-Delgado AC, McGowan LM, Geurtzen K, Hammond CL, Busse B, Knopf F. Skeletal biology and disease modeling in zebrafish. J Bone Miner Res 2021. doi: 10.1002/jbmr.4256 .
Hauck S, Zager P Halfter N, Wandel E, Torregrossa M, Kakpenova A, Rother S, Ordieres M, Räthel S, Berg A, Möller S, Schnabelrauch M, Simon JC, Hintze V, Franz S. Collagen/hyaluronan based hydrogels releasing sulfated hyaluronan improve dermal wound healing in diabetic mice via reducing inflammatory macrophage activity. Bioactive Materials 2021, 6, 4342–4359.DOI: 10.1016/j.bioactmat.2021.04.026.
Keil S, Gupta M, Brand M, Knopf F. Heparan sulfate proteoglycan expression in the regenerating zebrafish fin. Developmental Dynamics 1-13, 2021, doi.org/10.1002/dvdy.321.
Krieghoff J, Rost J, Kohn-Polster C, Müller B, Koenig A, Flath T, Schulz-Siegmund M, Schulze FP, Hacker M. Extrusion-Printing of Multi-Channeled Two-Component Hydrogel Constructs from Gelatinous Peptides and Anhydride-Containing Oligomers. Biomedicines 2021, 9, 370, doi:10.3390/biomedicines9040370.
Nawaz HA, Schröck K, Schmid M, Krieghoff J, Maqsood I, Kascholke C, Kohn-Polster C, Schulz-Siegmund M, Hacker MC. Injectable oligomer-cross-linked gelatine hydrogels via anhydride-amine-conjugation. Journal of Materials Chemistry B 2021; 9, 2295-2307, https://doi.org/10.1039/D0TB02861D.
Rother S, Ruiz-Gómez G, Koehler L, Balamurugan K, Fiebig KM, Galiazzo VD, Hempel U, Moeller S, Schnabelrauch M, Waltenberger J, Pisabarro MT, Scharnweber D, Hintze V. Hyaluronan/collagen hydrogels with sulfated glycosaminoglycans maintain VEGF165 activity and fine-tune endothelial cell response. ACS Appl. Bio Mater. 2021, 4, 1, 494–506.
Schnabelrauch M, Schiller J, Möller S, Scharnweber D, Hintze V. Chemically modified glycosaminoglycan derivatives as building blocks for biomaterial coatings and hydrogels. Biol. Chem. 2021, doi: 10.1515/hsz-2021-0171.
Logie C, Schaik T, Pompe T, Pietsch K. Fibronectin-functionalization of 3D collagen networks supports immune tolerance and inflammation suppression in human monocyte-derived macrophages. Biomaterial Volume 268, January 2021. https://doi.org/10.1016/j.biomaterials.2020.120498
Gronbach M, Mitrach F, Lidzba V, Müller B, Möller S, Rother S, Salbach-Hirsch J, Hofbauer LC, Schnabelrauch M, Hintze V, Hacker MC, Schulz-Siegmund M. Scavenging of Dickkopf-1 by macromer-based biomaterials covalently decorated with sulfated hyaluronan displays pro-osteogenic effects. Acta Biomater. 2020 Sep 15;114:76-89. doi: 10.1016/j.actbio.2020.07.017. Epub 2020 Jul 13. PMID: 32673749.
Gronbach M, Mitrach F, Möller S, Rother S, Friebe S, Mayr SG, Schnabelrauch M, Hintze V, Hacker MC, Schulz-Siegmund M. A versatile macromer-based glycosaminoglycan (sHA3) decorated biomaterial for pro-osteogenic scavenging of Wnt antagonists. Pharmaceutics 2020, 12(11):1037.
Colditz J, Picke AK, Hofbauer LC, Rauner M. Contributions of Dickkopf-1 to Obesity-Induced Bone Loss and Marrow Adiposity. JBMR Plus. 2020 Apr 28;4(6):e10364. doi: 10.1002/jbm4.10364. PMID: 2537550; PMCID: PMC7285751.
Clauder F, Möller S, Köhling S, Bellmann-Sickert K, Rademann J, Schnabelrauch M, Beck-Sickinger A G. Peptide-mediated surface coatings for the release of wound-healing cytokines. J Tissue Eng Regen Med 2020, September 6. DOI:10.1002/term.3123.
Förster Y, Schulze S, Penk A, Neuber C, Möller S, Hintze V, Scharnweber D, Schnabelrauch M, Pietzsch J, Huster D, Rammelt S. The influence of different artificial extracellular matrix implant coatings on the regeneration of a critical size femur defect in rats. Mater Sci Eng C Mater Biol Appl. 2020, 116:111157.
Hassan G, Forsman N, Wan X, Keurulainen L, Bimbo L, Stehl S, van Charante F, Chrubasik M, Prakash A, Johansson L-S, Mullen D, Johnston B, Zimmermann R, Werner C, Yli-Kauhaluoma J, Coenye T, Saris P, Österberg M, Moreira V. Non-leaching, highly biocompatible nanocellulose surfaces that efficiently resist fouling by bacteria in an artificial dermis model. ACS Applied Bio Materials 2020, June 22. DOI: 10.1021/acsabm.0c00203
Krieghoff J, Picke AK, Salbach-Hirsch J, Rother S, Heinemann C, Bernhardt R, Kascholke C, Möller S, Rauner M, Schnabelrauch M, Hintze V, Scharnweber D, Schulz-Siegmund M, Hacker MC, Hofbauer LC, Hofbauer C. Increased pore size of scaffolds improves coating efficiency with sulfated hyaluronan and mineralization capacity of osteoblasts. Biomater Res. 2019; 23:26. doi: 10.1186/s40824-019-0172-z.
Rothe R, Hauser S, Neuber C, Laube M, Schulze S, Rammelt S, Pietzsch J. Adjuvant Drug-Assisted Bone Healing: Advances and Challenges in Drug Delivery Approaches. Pharmaceutics 2020, 12, 428; doi:10.3390/pharmaceutics12050428.
Pant K, Neuber C, Zarschler K, Wodtke J, Meister S, Haag R, Pietzsch J, Stephan H. Active Targeting of Dendritic Polyglycerols for Diagnostic Cancer Imaging. Small. 2019 Dec 26. https://doi.org/10.1002/smll.201905013.
Penk A, Baumann L, Huster D, Samsonov SA. NMR and molecular modeling reveal specificity of the interactions between CXCL14 and glycosaminoglycans. Glycobiology. 2019 Sep 20;29(10):715-725. doi: 10.1093/glycob/cwz047.
Ahlfeld T, Schuster FP, Förster Y, Quade M, Akkineni AR, Rentsch C, Rammelt S, Gelinsky M, Lode A. 3D Plotted Biphasic Bone Scaffolds for Growth Factor Delivery: Biological Characterization In Vitro and In Vivo. Adv Healthc Mater 2019 Mar 6:e1801512. doi: 10.1002/adhm.201801512
Godoy-Santos AL, Lopes D, Giarola I, de Cesar-Netto C, Rammelt S. Changes in cartilage, synovial cells and synovial fluid after malleolar fractures: What its importance for post-traumatic ankle osteoarthitis? FussSprungg 17: 68-74, 2019
Koehler L, Ruiz-Gómez G, Balamurugan K, Rother S, Freyse J, Möller S, Schnabelrauch M, Köhling S, Djordjevic S, Scharnweber D, Rademann J, Pisabarro MT, Hintze V. Dual Action of Sulfated Hyaluronan on Angiogenic Processes in Relation to Vascular Endothelial Growth Factor-A. Sci Rep. 2019 Dec 2;9(1):18143. doi: 10.1038/s41598-019-54211-0.
Kratochvil I, Hofmann T, Rother S, Schlichting R, Moretti R, Scharnweber D, Hintze V, Escher BI, Meiler J, Kalkhof S, von Bergen M. Mono(2-ethylhexyl) phthalate (MEHP) and mono(2-ethyl-5-oxohexyl) phthalate (MEOHP) but not di(2-ethylhexyl) phthalate (DEHP) bind productively to the peroxisome proliferator-activated receptor γ. Rapid Commun Mass Spectrom. 2019 May;33 Suppl 1:75-85. doi: 10.1002/rcm.8258. Epub 2019 Jan 1.
Krieghoff J, Picke AK, Salbach-Hirsch J, Rother S, Heinemann C, Bernhardt R, Kascholke C, Möller S, Rauner M, Schnabelrauch M, Hintze V, Scharnweber D, Schulz-Siegmund M, Hacker MC, Hofbauer LC, Hofbauer C. Increased pore size of scaffolds improves coating efficiency with sulfated hyaluronan and mineralization capacity of osteoblasts. Biomater Res. 2019; 23:26. doi: 10.1186/s40824-019-0172-z.
Laube M, Kniess T, Neuber C, Haase-Kohn C, Pietzsch J. Fluorine-18 Labeling of S100 Proteins for Small Animal Positron Emission Tomography. Methods Mol Biol. 2019; 1929:461-485.
Lee PS, Hess R, Friedrichs J, Haenchen V, Eckert H, Cuniberti G, Rancourt D, Krawetz R, Hintze V, Gelinsky M, Scharnweber D. Recapitulating bone development events in a customised bioreactor through interplay of oxygen tension, medium pH, and systematic differentiation approaches. J Tissue Eng Regen Med. 2019 Sep;13(9):1672-1684. doi: 10.1002/term.2921. Epub 2019 Jul 15.
Neuber C, Schulze S, Förster Y, Hofheinz F, Wodke J, Möller S, Schnabelrauch M, Hintze V, Scharnweber D, Rammelt S, Pietzsch J. Biomaterials in repairing rat femoral defects: In vivo insights from small animal positron emission tomography/computed tomography (PET/CT) studies. Clin Hemorheol Microcirc. 2019; 73:177-194. doi: 10.3233/CH-199208.
Rauner M, Baschant U, Roetto A, Pellegrino RM, Rother S, Salbach-Hirsch J, Weidner H, Hintze V, Campbell G, Petzold A, Lemaitre R, Henry I, Bellido T, Theurl I, Altamura S, Colucci S, Muckenthaler MU, Schett G, Komla-Ebri DSK, Bassett JHD, Williams GR, Platzbecker U, Hofbauer LC. Transferrin receptor 2 controls bone mass and pathological bone formation via BMP and Wnt signaling. Nature Metabolism 2019; 1:111–24.
Rothe R, Schulze S, Neuber C, Hauser S, Rammelt S, Pietzsch J. Adjuvant drug-assisted bone healing: Part I – Modulation of inflammation. Clin Hemorheol Microcirc. 2019; 73: 381–408.
Rothe R, Schulze S, Neuber C, Hauser S, Rammelt S, Pietzsch J. Adjuvant drug-assisted bone healing: Part II – Modulation of angiogenesis. Clin Hemorheol Microcirc. 2019; 73: 409-438.
Rothe R, Schulze S, Neuber C, Hauser S, Rammelt S, Pietzsch J. Adjuvant drug-assisted bone healing: Part III – Further strategies for local and systemic modulation. Clin Hemorheol Microcirc. 2019; 73: 439–488.
Rother S, Krönert V, Hauck N, Berg A, Moeller S, Schnabelrauch M, Thiele J, Scharnweber D, Hintze V. Hyaluronan/collagen hydrogel matrices containing high-sulfated hyaluronan microgels for regulating transforming growth factor-β1. J Mater Sci Mater Med. 2019 May 24;30(6):65. doi: 10.1007/s10856-019-6267-1.
Schmidt JR*, Geurtzen K*, von Bergen M, Schubert K#, Knopf F#. Glucocorticoid treatment leads to aberrant ion and macromolecular transport in regenerating zebrafish fins. Front Endocrinol. 2019; 10:674. * equal contribution # co-corresponding authors.
Schneider M, Rother S, Möller S, Schnabelrauch M, Scharnweber D, Simon JC, Hintze V, Savkovic V. Sulfated hyaluronan-containing artificial extracellular matrices promote proliferation of keratinocytes and melanotic phenotype of melanocytes from the outer root sheath of hair follicles. J Biomed Mater Res A. 2019 Aug;107(8):1640-1653. doi: 10.1002/jbm.a.36680. Epub 2019 Apr 23.
Spiller S, Panitz N, Dwi Putra Limasale Y, Atallah PM, Schirmer L, Bellmann-Sickert K, Blaszkiewicz J, Koehling S, Freudenberg U, Rademann J, Werner C, Beck-Sickinger AG. Modulation of Human CXCL12 Binding Properties to Glycosaminoglycans To Enhance Chemotactic Gradients. ACS Biomater Sci Eng. 2019; doi.org/10.1021/acsbiomaterials.9b01139.
Thönes S, Rother S, Wippold T, Blaszkiewicz J, Balamurugan K, Moeller S, Ruiz-Gómez G, Schnabelrauch M, Scharnweber D, Saalbach A, Rademann J, Pisabarro MT, Hintze V, Anderegg U. Hyaluronan/collagen hydrogels containing sulfated hyaluronan improve wound healing by sustained release of heparin-binding EGF-like growth factor. Acta Biomater. 2019 Mar 1;86:135-147. doi: 10.1016/j.actbio.2019.01.029 . Epub 2019 Jan 17.
Ullm F, Riedl P, Machado de Amorim A, Patzschke A, Weiß R, Hauschildt S, Franke K, Anderegg U, and Pompe T. 3D Scaffold-Based Macrophage Fibroblast Coculture Model Reveals IL-10 Dependence of Wound Resolution Phase. Adv. BIOSYSTEMS 05 December 2019 doi: 10.1002/adbi.201900220
Wojak-Ćwik IM, Rumian Ł, Krok-Borkowicz M, Hess R, Bernhardt R, Dobrzyński P, Möller S, Schnabelrauch M, Hintze V, Scharnweber D, Pamuła E. Synergistic effect of bimodal pore distribution and artificial extracellular matrices in polymeric scaffolds on osteogenic differentiation of human mesenchymal stem cells. Mater Sci Eng C Mater Biol Appl. 2019 Apr;97:12-22. doi: 10.1016/j.msec.2018.12.012. Epub 2018 Dec 7.
Xu Y, Patsis PA, Hauser S, Voigt D, Rothe R, Günther M, Cui M, Yang X, Wieduwild R, Eckert K, Neinhuis C, Akbar TF, Minev IR, Pietzsch J, Zhang J. Cytocompatible, injectable and electroconductive soft adhesives with hybrid covalent/non-covalent dynamic network. Adv Sci. 2019; 6:1802077. DOI: 10.1002/advs.201802077.
Ansorge M, Pompe T. Systems for localized release to mimic paracrine cell communication in vitro. J Control Release. 2018; 278:24-36.
Atallah P, Schirmer L, Tsurkan M, Putra Limasale YD, Zimmermann R, Werner C, Freudenberg U. In situ-forming, cell-instructive hydrogels based on glycosaminoglycans with varied sulfation patterns. Biomaterials. 2018; 181:227-239.
Betz VM, Kochanek S, Rammelt S, Müller PE, Betz OB, Messmer C. Recent advances in gene-enhanced bone tissue engineering. J Gene Med 2018 Mar 30:e3018. doi: 10.1002/jgm.3018.
Corsuto L, Rother S, Koehler L, Bedini E, Moeller S, Schnabelrauch M, Hintze V, Schiraldi C, Scharnweber D. Sulfation degree not origin of chondroitin sulfate derivatives modulates keratinocyte response. Carbohydr Polym. 2018; 191:53-64.
Geurtzen K, Knopf F. Adult Zebrafish Injury Models to Study the Effects of Prednisolone in Regenerating Bone Tissue. J Vis Exp. 2018; 140:e58429.
Herbert D, Franz S, Popkova Y, Anderegg U, Schiller J, Schwede K, Lorz A, Simon JC, Saalbach A. High fat diet exacerbates early psoriatic skin inflammation independent of obesity: Saturated fatty acids as key players. J Invest Dermatol. 2018; 138:1999-2009.
Kratochvil I, Hofmann T, Rother S, Schlichting R, Moretti R, Scharnweber D, Hintze V, Escher BI, Meiler J, Kalkhof S, von Bergen M. MEHP and MEOHP but not DEHP bind productively to the peroxisome proliferator-activated receptor ?. Rapid Commun Mass Spectrom. 2018.[Epub ahead of print]
Kuchar M, Neuber C, Belter B, Bergmann R, Lenk J, Wodtke R, Kniess T, Steinbach J, Pietzsch J, Löser R. Evaluation of Fluorine-18-Labeled ?1(I)-N-Telopeptide Analogs as Substrate-Based Radiotracers for PET Imaging of Melanoma-Associated Lysyl Oxidase. Front Chem. 2018; 6:121.
Möginger U, Grunewald S, Hennig R, Kuo CW, Schirmeister F, Voth H, Rapp E, Khoo KH, Seeberger P, Simon JC, Kolarich D. Alterations of the human skin N- and O-glycome in basal- and squamous cell carcinoma. Front Oncol. 2018; 8:70.
Müller C, Ansorge M, Espig M, Zschoche S, Schiller J, Pompe T: Covalent binding of maleic anhydride copolymer monolayers to polyacrylamide hydrogels. Macromol Chem Phys. 2018, in press.
Neuber C, Belter B, Meister S, Hofheinz F, Bergmann R, Pietzsch HJ, Pietzsch J. Overexpression of Receptor Tyrosine Kinase EphB4 Triggers Tumor Growth and Hypoxia in A375 Melanoma Xenografts: Insights from Multitracer Small Animal Imaging Experiments. Molecules. 2018, 23(2).
Nordsieck K, Baumann L, Hintze V, Pisabarro MT, Schnabelrauch M, Beck-Sickinger AG, Samsonov SA. The effect of interleukin-8 truncations on its interactions with glycosaminoglycans. Biopolymers. 2018; 109:e23103.
Picke AK, Campbell GM, Blüher M, Krügel U, Schmidt FN, Tsourdi E, Winzer M, Rauner M, Vukicevic V, Busse B, Salbach-Hirsch J, Tuckermann JP, Simon JC, Anderegg U, Hofbauer LC, Saalbach A. Thy-1 (CD90) promotes bone formation and protects against obesity. Sci Transl Med. 2018; 10:eaao6806.
Picke AK, Campbell GM, Schmidt FN, Busse B, Rauner M, Simon JC, Anderegg U, Hofbauer LC, Saalbach A. Thy-1 Deficiency Augments Bone Loss in Obesity by Affecting Bone Formation and Resorption. Front Cell Dev Biol 2018;6:127.
Picke AK, Sylow L, Møller LLV, Kjøbsted R, Schmidt FN, Steejn MW, Salbach-Hirsch J, Hofbauer C, Blüher M, Saalbach A, Busse B, Rauner M, Hofbauer LC. Differential effects of high-fat diet and exercise training on bone and energy metabolism. Bone. 2018, 116:120-134.
Rentsch B, Bernhardt A, Henß A, Ray S, Rentsch C, Schamel M, Gbureck U, Gelinsky M, Rammelt S, Lode A. Trivalent chromium incorporated in a crystalline calcium phosphate matrix accelerates materials degradation and bone formation in vivo. Acta Biomater 2018 Mar 15;69:332-341. doi: 10.1016/j.actbio.2018.01.010
Sapudom J, Kalbitzer L, Wu X, Martin S, Kroy K, Pompe T. Fibril bending stiffness of 3D collagen matrices instructs spreading and clustering of invasive and non-invasive breast cancer cells. Biomaterials. 2018; 193:47-57.
Schmidt JR, Vogel S, Moeller S, Kalkhof S, Schubert K, von Bergen M, Hempel U. Sulfated hyaluronic acid and dexamethasone possess a synergistic potential in the differentiation of osteoblasts from human bone marrow stromal cells. J Cell Biochem, 2018 Nov 28. doi: 10.1002/jcb.28158
Schneider M, Lohrenz A, Cross M, Hacker MC, Simon JC, Savkovic V. A human serum-enriched medium formulation supports high viability and marker expression in primary melanocyte cultures from the outer root sheath and epidermis. Exp Dermatol. 2018, 27:87-90.
Schulze S, Wehrum D, Dieter P, Hempel U. A supplement-free osteoclast-osteoblast co-culture for preclinical application. J Cell Physiol 2018;233:4391-4400.
Thiele S, Zimmer A, Göbel A, Rachner TD, Rother S, Fuessel S, Froehner M, Wirth MP, Muders MH, Baretton GB, Jakob F, Rauner M, Hofbauer LC. Role of WNT5A receptors FZD5 and RYK in prostate cancer cells. Oncotarget. 2018, 9:27293-304.
Wodtke R, Hauser C, Ruiz-Gómez G, Jäckel E, Bauer D, Lohse M, Wong A, Pufe J, Ludwig FA, Fischer S, Hauser S, Greif D, Pisabarro MT, Pietzsch J, Pietsch M, Löser R. N?-Acryloyllysine Piperazides as Irreversible Inhibitors of Transglutaminase 2: Synthesis, Structure-Activity Relationships, and Pharmacokinetic Profiling. J Med Chem. 2018, 61:4528-60.
Aliperta R, Welzel PB, Bergmann R, Freudenberg U, Berndt N, Feldmann A, Arndt C, Koristka S, Stanzione M, Cartellieri M, Ehninger A, Ehninger G, Werner C, Pietzsch J, Steinbach J, Bornhäuser M, Bachmann MP. Cryogel-supported stem cell factory for customized sustained release of bispecific antibodies for cancer immunotherapy. Sci Rep. 2017;7:42855.
Ansorge M, Sapudom J, Chkolnikov M, Wilde M, Anderegg U, Möller S, Schnabelrauch M, Pompe T. Mimicking paracrine TGF-ß1 signals during myofibroblast differentiation in 3D collagen networks. Scientific Reports. 2017, 7:5664.
Becher J, Moeller S, Schnabelrauch M. Building blocks for artificial extracellular matrices bases on cross-linkable polysaccahride and glucosaminoglycan sulfates. Mater Sci Forum. 2017;879:1270-5.
Betz VM, Keller A, Foehr P, Thirion C, Salomon M, Rammelt S, Zwipp H, Burgkart R, Jansson V, Müller PE, Betz OB. BMP-2 gene activated muscle tissue fragments for osteochondral defect regeneration in the rabbit knee. J Gene Med e2979; ePub Jul 25, 2017. doi: 10.1002/jgm.2972
Bhowmick S, Rother S, Zimmermann H, Lee PS, Moeller S, Schnabelrauch M, Koul V, Scharnweber D. Reciprocal influence of hMSCs/HaCaT cultivated on electrospun scaffolds. J Mater Sci Mater Med. 2017, 28(8):128.
Bhowmick S, Rother S, Zimmermann H, Lee PS, Moeller S, Schnabelrauch M, Koul V, Jordan R, Hintze V, Scharnweber D. Biomimetic electrospun scaffolds from main extracellular matrix components for skin tissue engineering application – The role of chondroitin sulfate and sulfated hyaluronan. Mater Sci Eng C Mater Biol Appl. 2017, 79:15-22.
Ferrer RA, Saalbach A, Grünwedel M, Lohmann N, Forstreuter I, Saupe S, Wandel E, Simon JC, Franz S. Dermal Fibroblasts Promote Alternative Macrophage Activation Improving Impaired Wound Healing. J Invest Dermatol. 2017, 137:941-950.
Förster Y, Bernhard R, Hintze V, Möller S, Scharnweber D, Schnabelrauch M, Rammelt S. Collagen/Glycosaminoglycan coatings enhance new bone formation in a critical size bone defect – a pilot study in rats. Mater Sci Eng C. 2017, 71:84-92.
Friedemann M, Kalbitzer L, Franz S, Moeller S, Schnabelrauch M, Simon JC, Pompe T, Franke K. Instructing human macrophage polarization by stiffness and glycosaminoglycan functionalization in 3D collagen networks. Adv Healthc Mater. 2017, 6.
Geurtzen K, Vernet A, Freidin A, Rauner M, Hofbauer LC, Schneider JE, Brand M, Knopf F. Immune Suppressive and Bone Inhibitory Effects of Prednisolone in Growing and Regenerating Zebrafish Tissues. J Bone Miner Res 2017, 32: 2476-2488.
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Gvaramia D, Müller E, Müller K, Atallah P, Tsurkan M, Freudenberg U, Bornhäuser M, Werner C. Combined influence of biophysical and biochemical cues on maintenance and proliferation of hematopoietic stem cells. Biomaterials. 2017,138:108-117.
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Jouy F, Lohmann N, Wandel E, Ruiz-Gómez G, Pisabarro MT, Beck-Sickinger AG, Schnabelrauch M, Moeller S, Simon JC, Kalkhof S, von Bergen M, Franz S. Sulfated hyaluronan attenuates inflammatory signaling pathways in macrophages involving induction of antioxidants. Proteomics. 2017. [Epub ahead of print]
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Kascholke C, Loth T, Kohn-Polster C, Möller S, Bellstedt P, Schulz-Siegmund M, Schnabelrauch M, Hacker M. Dual-functional hydrazide-reactive and anhydride containing oligomeric hydrogel building blocks. Biomacromolecules. 2017, 18:683-694.
Khosla S, Hofbauer LC. Osteoporosis treatment: recent developments and ongoing challenges. Lancet Diabetes Endocrinol. 2017;5:898-907.
Kniess T, Laube M, Wüst F, Pietzsch J. Technetium-99m based small molecule radiopharmaceuticals and radiotracers targeting inflammation and infection. Dalton Trans. 2017; 46(42):14435-51.
Koehler L, Samsonov S, Rother S, Vogel S, Köhling S, Moeller S, Schnabelrauch M, Rademann J, Hempel U, Pisabarro MT, Scharnweber D, Hintze V. Sulfated Hyaluronan Derivatives Modulate TGF-?1:Receptor Complex Formation: Possible Consequences for TGF-?1 Signaling. Sci Rep. 2017, 7(1):1210.
Kohn-Polster C, Bhatmagar D, Woloszyn DJ, Richtmyer M, Strake A, Springwald AH, Franz S, Schulz-Siegmund M, Kaplan HM, Kohn J, Hacker MC. Dual-Component Gelatinous Peptide/Reactive Oligomer Formulations as Conduit Material and Luminal Filler for Peripheral Nerve Regeneration. Int J Mol Sci. 2017 May 21;18(5).
Lohmann N, Schirmer L, Atallah P, Wandel E, Ferrer RA, Werner C, Simon JC, Franz S*, Freudenberg U*. Glycosaminoglycan-based hydrogels capture inflammatory chemokines and rescue wound healing deficiency. Sci Transl Med. 2017;9(386). *equal contribution
Metzger W, Rother S, Pohlemann T, Möller S, Schnabelrauch M, Hintze V, Scharnweber D. Evaluation of cell-surface interaction using a 3D spheroid cell culture model on artificial extracellular matrices. Mater Sci Eng C. 2017;73:310-8.
Müller BM, Loth R, Hoffmeister PG, Zühl F, Kalbitzer L, Hacker MC, Schulz-Siegmund M. Surface modification of copolymerized films from three-armed biodegradable macromers – an analytical platform for modified tissue engineering scaffolds. Acta Biomater. 2017, 51:148-160.
Neuber C, Förster Y, Hofheinz F, Rammelt S, Pietzsch J. [18F]Fluorid- und [18F]FDG-PET/CT zur Beurteilung der Biomaterial-unterstützten Geweberegeneration bei einem kritischen Knochendefektmodell der Ratte. Nuklearmedizin 2017; 56:A42-A43.
Rother S, Samsonov SA, Möller S, Schnabelrauch M, Rademann J, Blaszkiewicz J, Köhling S, Waltenberger J, Pisabarro MT, Scharnweber D, Hintze V. Sulfate hyaluronan alters endothelial cell activation in vitro by controlling the biological activity of the angiogenic factors vascular endothelial growth factor-A and tissue inhibitor of metalloproteinase-3. CS Appl Mater Interfaces. 2017, 9(11):9539-9550.
Sapudom J, Waschke J, Franke K, Hlawitschka M, Pompe T. Quantitative label-free single cell tracking in 3D biomimetic matrices. Sci Rep. 2017; 26(7):14135.
Sapudom J, Ullm F, Martin S, Kalbitzer L, Naab J, Möller S, Schnabelrauch M, Anderegg U, Schmidt S, Pompe T. Molecular weight specific impact of soluble and immobilized hyaluronan on CD44 expressing melanoma cells in 3D collagen matrices. Acta Biomater. 2017;50:259-70.
Sapudom J, Wu X, Chkolnikov M, Ansorge M, Anderegg U, Pompe T. Fibroblast fate regulation by time dependent TGF-ß1 and IL-10 stimulation in biomimetic 3D matrices. Biomater Sci. 2017, 5(9):1858-1867.
Schulz MC, Kowald J, Estenfelder S, Jung R, Kuhlisch E, Eckelt U, Mai R, Hofbauer LC, Stroszczynski C, Stadlinger B. Site-specific variations in bone mineral density under systemic conditions inducing osteoporosis in minipigs. Front Physiol. 2017;8:426.
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Szulc P, Chapurlat R, Hofbauer LC. Prediction of fractures and major cardiovascular events in men using serum osteoprotegerin levels: The prospective STRAMBO study. J Bone Miner Res. 2017;32:2288-96.
Tsourdi E, Lademann F, Ominsky MS, Rijntjes E, Köhrle J, Misof BM, Roschger P, Klaushofer K, Hofbauer LC, Rauner M. Sclerostin blockade and zoledronic acid improve bone mass and strength in male mice with exogenous hyperthyroidism. Endocrinology. 2017;158:3765-77.
Weber HM, Tsurkan MV, Magno V, Freudenberg U, Werner C. Heparin-based hydrogels induce human renal tubulogenesis in vitro. Acta Biomater. 2017, 57:59-69.
Anders G, Hassiepen U, Theisgen S, Heymann S, Muller L, Panigada T, Huster D, Samsonov SA. The Intrinsic Pepsin Resistance of Interleukin-8 Can be Explained from a Combined Bioinformatical and Experimental Approach. IEEE/ACM Trans Comput Biol Bioinform. 2016. [Epub ahead of print]
Ansorge M, Rastig N, Steinborn R, König T, Baumann L, Möller S, Schnabelrauch M, Cross M, Werner C, Beck-Sickinger AG, Pompe T. Short-range cytokine gradients to mimic paracrine cell interactions in vitro. J Control Release. 2016. [Epub ahead of print]
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Campbell GM, Tiwari S, Hofbauer C, Picke AK, Rauner M, Huber G, Peña JA, Damm T, Barkmann R, Morlock MM, Hofbauer LC, Glüer CC. Effects of parathyroid hormone on cortical porosity, non-enzymatic glycation and bone tissue mechanics in rats with type 2 diabetes mellitus. Bone. 2016, 82:116-21.
Förster Y, Schmidt JR, Wissenbach DK, Pfeiffer SEM, Baumann S, Hofbauer LC, von Bergen M, Kalkhof S, Rammelt S. Microdialysis sampling from wound fluids enables quantitative assessment of cytokines, proteins, and metabolites reveals bone defect-specific molecular profiles. PLoS One. 2016;11:e0159580.
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Hammer N, Huster D, Boldt A, Hädrich C, Koch H, Möbius R, Schulze-Tanzil G, Scheidt HA. A preliminary technical study on sodium dodecyl sulfate-induced changes of the nano-structural and macro-mechanical properties in human iliotibial tract specimens. J Mech Behav Biomed Mater. 2016; 61:164-173.
Hempel U, Müller K, Preissler C, Noack C, Boxberger S, Dieter P, Bornhäuser M, Wobus M. Human bone marrow stromal cells: A reliable, challenging tool for in vitro osteogenesis and bone tissue engineering approaches. Stem Cells Int. 2016;2016:7842191.
Hendrikx S, Kascholke C, Flath T, Schumann D, Gressenbuch M, Schulze FP, Hacker MC, Schulz-Siegmund M. Indirect rapid prototyping of sol-gel hybrid glass scaffolds for bone regeneration – Effects of organic crosslinker valence, content and molecular weight on mechanical properties. Acta Biomater. 2016;35:318-29.
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Köhling S, Künze G, Lemmnitzer K, Bermudez M, Wolber G, Schiller J, Huster D, Rademann J. Chemoenzymatic synthesis of nanosulfated tetrahyaluronan with a paramagnetic tag for studying its complex with interleukin-10. Chemistry. 2016, 22:5563-5574.
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Martin S, Wang H, Rathke T, Anderegg U, Möller S, Schnabelrauch M, Pompe T, Schmidt S. Polymer hydrogel particles as biocompatible AFM probes to study CD44 / hyaluronic acid interactions on cells. Polymer. 2016;102:342-349.
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Panitz N, Theisgen S, Samsonov SA, Gehrke JP, Baumann L, Bellmann-Sickert K, Köhling S, Pisabarro MT, Rademann J, Huster D, Beck-Sickinger AG. The structural investigation of glycosaminoglycan binding to CXCL12 displays distinct interaction sites. Glycobiology. 2016;26:1-13.
Picke AK, Salbach-Hirsch J, Hintze V, Rother S, Rauner M, Kascholke C, Möller S, Bernhardt R, Rammelt S, Pisabarro MT, Ruiz-Gómez G, Schnabelrauch M, Schulz-Siegmund M, Hacker MC, Scharnweber D, Hofbauer C, Hofbauer LC. Sulfated hyaluronan improves bone regeneration of diabetic rats by binding sclerostin and enhancing osteoblast function. Biomaterials. 2016;96:11-23.
Picke AK, Gordaliza Alaguero I, Campbell GM, Glüer CC, Salbach-Hirsch J, Rauner M, Hofbauer LC, Hofbauer C. Bone defect regeneration and cortical bone parameters of type 2 diabetic rats are improved by insulin therapy. Bone. 2016;82:108-115.
Rother S, Samsonov SA, Hempel U, Vogel S, Moeller S, Blaszkiewicz J, Köhling S, Schnabelrauch M, Rademann J, Pisabarro MT, Hintze V, Scharnweber D. Sulfated hyaluronan alters the interaction profile of TIMP-3 with the endocytic receptor LRP-1 cluster II and IV and increases the extracellular TIMP-3 level of human bone marrow stromal cells. Biomacromolecules. 2016; 17:3252-3261.
Rother S, Samsonov SA, Hofmann T, Blaszkiewicz J, Köhling S, Moeller S, Schnabelrauch M, Rademann J, Kalkhof S, von Bergen M, Pisabarro MT, Scharnweber D, Hintze V. Structural and functional insights into the interaction of sulfated glycosaminoglycans with tissue inhibitor of metalloproteinase-3 – a possible regulatory role on extracellular matrix homeostasis. Acta Biomater. 2016, 45:143-54.
Ruiz-Gómez G, Hawkins JC, Philipp J, Künze G, Wodtke R, Löser R, Fahmy K, Pisabarro MT. Rational structure-based rescaffolding approach to de novo design of interleukin 10 (IL-10) receptor-1 mimetics. PLoS One. 2016; 11: e0154046.
Samsonov SA, Pisabarro MT. Computational analysis of interactions in structurally available protein-glycosaminoglycan complexes. Glycobiology. 2016; 26:850-61.
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Savkovic V, Flämig F, Schneider M, Sülflow K, Loth T, Lohrenz A, Hacker MC, Schulz-Siegmund M, Simon JC. Polycaprolactone fiber meshes provide a 3D environment suitable for cultivation and differentiation of melanocytes from the outer root sheath of hair follicle. J Biomed Mater Res A. 2016;104:26-36.
Schirmer L, Atallah P, Werner C, Freudenberg U. StarPEG-heparin hydrogels to protect and sustainably deliver IL-4. Adv Healthc Mater. 2016;5:3154-64.
Schmidt JR, Kliemt S, Preissler C, Möller S, von Bergen M, Hempel U*, Kalkhof S*. Osteoblast-released matrix vesicles – Regulation of activity and composition by sulfated and non-sulfated glycosaminoglycans. Mol Cell Proteomics. 2016;15:558-572. (*shared senior authors)
Schneider M, Sülflow K, Loth T, Schulz-Siegmund M, Hacker M, Simon JC, Savkovic V. Melanocytes from the outer root sheath of human hair and epidermal melanocytes display improved melanotic features in the niche provided by cGEL, oligomer-cross-linked gelatin-based hydrogel. J Biomed Mater Res A. 2016;104:3115-26.
Sedaghati B, Jahroomishirazi R, Starke A, Hacker MC, Schulz-Siegmund M. Rat Osteosarcoma Cells as a Therapeutic Target Model for Osteoregeneration via Sclerostin Knockdown. Cells Tissues Organs. 2016;201:366-379.
Stelzner K, Herbert D, Popkova Y, Lorz A, Schiller J, Gericke M, Klöting N, Blüher M, Franz S, Simon JC, Saalbach A. Free fatty acids sensitize dendritic cells to amplify TH1/TH17-immune responses. Eur J Immunol. 2016;46:2043-53.
Sülflow K, Schneider M, Loth T, Kascholke C, Schulz-Siegmund M, Hacker MC, Simon JC, Savkovic V. Melanocytes from the outer root sheath of human hair and epidermal melanocytes display improved melanotic features in the niche provided by cGEL, oligomer-cross-linked gelatin-based hydrogel. J Biomed Mater Res A. 2016;104:3115-26.
Taubenberger AV, Bray LJ, Haller B, Shaposhnykov A, Binner M, Freudenberg U, Guck J, Werner C. 3D extracellular matrix interactions modulate tumour cell growth, invasion and angiogenesis in engineered tumour microenvironments. Acta Biomater. 2016;36:73-85.
Vogel S, Arnoldini S, Möller S, Schnabelrauch M, Hempel U. Sulfated hyaluronan alters fibronectin matrix assembly and promotes osteogenic differentiation of human bone marrow stromal cells. Scientific Reports. 2016; 6:36418.
Andrault PM, Samsonov SA, Weber G, Coquet L, Nazmi K, Bolscher J, Lalmanach AC, Jouenne T, Bromme D, Pisabarro MT, Lalmanach G, Lecaille F. The antimicrobial peptide LL-37 is both a substrate of cathepsins S and K and a selective inhibitor of cathepsin L. Biochemistry. 2015;54:2785-98.
Altgärde N, Eriksson C, Peerboom N, Phan-Xuan T, Moeller S, Schnabelrauch M, Svedhem S, Trybala E, Bergström T, Bally M. Mucin-like Region of Herpes Simplex Virus Type 1 Attachment Protein Glycoprotein C (gC) Modulates the Virus-Glycosaminoglycan Interaction. J Biol Chem. 2015;290:21473-21485.
Betz VM, Betz OB, Rosin T, Keller A, Thirion C, Salomon M, Manthey S, Augat P, Jansson V, Müller PE, Rammelt S, Zwipp H. The effect of BMP-7 gene activated muscle tissue implants on the repair of large segmental bone defects. Injury. 2015; 46: 2351-8.
Bray LJ, Binner M, Holzheu A, Friedrichs J, Freudenberg U, Hutmacher DW, Werner C. Multi-parametric hydrogels support 3D in vitro bioengineered microenvironment models of tumour angiogenesis. Biomaterials. 2015;53:609-620.
De Barros RRM, Novaes AB, Korn P, Queiroz A, de Almeida ALG, Hintze V, Scharnweber D, Bierbaum S, Stadlinger. Bone Formation in a Local Defect around Dental Implants Coated with Extracellular Matrix Components. Clin Implant Dent Relat Res. 2015;17:742-57.
Elschner C, Noack C, Preißler C, Krause A, Scheler U, Hempel U. In vitro response of human mesenchymal stem cells to titanium coated PEEK films and their suitability for magnetic resonance imaging. Journal of Materials Science & Technology.2015, 31:427-436.
Franz S, Muñoz LE, Heyder P, Herrmann M, Schiller M. Unconventional apoptosis of polymorphonuclear neutrophils (PMN): staurosporine delays exposure of phosphatidylserine and prevents phagocytosis by M?-2 macrophages of PMN. Clin Exp Immunol. 2015, 179:75-84.
Freudenberg U, Zieris A, Chwalek K, Tsurkan MV, Maitz MF, Atallah P, Levental KR, Eming SA, Werner C. Heparin desulfation modulates VEGF release and angiogenesis in diabetic wounds. J Control Release. 2015, 220:79-88.
Gehrcke JP, Pisabarro MT. Identification and characterization of a glycosaminoglycan binding site on interleukin-10 via molecular simulation methods. J Mol Graph Model. 2015;62:97-104.
Hacker MC, Nawaz HA. Multi-Functional Macromers for Hydrogel Design in Biomedical Engineering and Regenerative Medicine. Int J Mol Sci. 2015 Nov 19;16:27677-706.
Hofmann T, Fischer AW, Meiler J, Kalkhof S. Protein structure prediction guided by crosslinking restraints – A systematic evaluation of the impact of the crosslinking spacer length. Methods. 2015;89:79-90.
Hofmann T, Samsonov SA, Pichert A, Lemmnitzer K, Schiller J, Huster D, Pisabarro MT, von Bergen M, Kalkhof S. Structural analysis of the interleukin-8/glycosaminoglycan interactions by amide hydrogen/deuterium exchange mass spectrometry. Methods. 2015, 89:45-53.
Jouy F, Müller SA, Wagner J, Otto W, von Bergen M, Tomm JM. Integration of conventional quantitative and phospho-proteomics reveals new elements in activated Jurkat T-cell receptor pathway maintenance. Proteomics. 2015;15:25-33.
Kalbitzer L, Franke K, Moeller S, Schnabelrauch M, Pompe T. Glycosaminoglycan functionalization of mechanically and topologically defined collagen matrices. J Mater Chem B2015; 3: 8902-8910.
Lemmnitzer K, Griesinger H, Süß R, Matheis K, Schulz M, Schiller J. Analysis of glycosaminoglycan oligosaccharides by combined HPTLC/MALDI-TOF MS: reduced silica gel thickness leads to improved spectral qualities and reduced side reactions. Chromatographia. 2015; 78:1409-13.
Lemmnitzer K, Süß R, Schiller J. TLC – MALDI MS of carbohydrates. IN: Kowalska T, Sajewicz M, Sherma J, “Planar Chromatography – Mass Spectrometry”, Taylor and Francis Verlag.
Loth R, Loth T, Schwabe K, Bernhardt R, Schulz-Siegmund M, Hacker MC. Highly adjustable biomaterial networks from three-armed biodegradable macromers. Acta Biomater. 2015;26:82-96.
Matheis K, Fuchs B, Lemmnitzer K, Süß R, Griesinger H, Minarik S, Oberle M, Schulz M, Schiller J. Combining TLC separation with MS detection – A revival of TLC. J Glycom Lipidom 2015;5:e125.
Noack C, Hempel U, Preissler C, Dieter P. Prostaglandin E2 impairs osteogenic and facilitates adipogenic differentiation of human mesenchymal stromal cells. Prostaglandins, Leukotrienes & Essential Fatty Acids. 2015;94:91-98.
Picke AK, Gordaliza Alaguero I, Campbell GM, Glüer CC, Salbach-Hirsch J, Rauner M, Hofbauer LC, Hofbauer C. Bone defect regeneration and cortical bone parameters of type 2 diabetic rats are improved by insulin therapy. Bone. 2015; pii: S8756-3282(15)00236-7.
Rother S, Salbach-Hirsch J, Moeller S, Seemann T, Schnabelrauch M, Hofbauer LC, Hintze V, Scharnweber D. Bioinspired Collagen/ Glycosaminoglycan- Based Cellular Microenvironments for Tuning Osteoclastogenesis. CS Appl Mater Interfaces. 2015;7:23787-97.
Salbach-Hirsch J, Samsonov SA, Hintze V, Hofbauer C, Picke AK, Rauner M, Gehrcke JP, Moeller S, Schnabelrauch M, Scharnweber D, Pisabarro MT, Hofbauer LC. Structural and functional insights into sclerostin-glycosaminoglycan interactions in bone. Biomaterials. 2015;67:335-345.
Samsonov SA, Bichmann L, Pisabarro MT. Coarse-grained model of glycosaminoglycans. J Chem Inf Model, 2015;55:114-24.
Sapudom J, Rubner S, Martin S, Thönes S, Anderegg U, Pompe T. The interplay of fibronectin functionalization and TGF-ß1 presence on fibroblast proliferation, differentiation and migration in 3D matrices. Biomaterials Science. 2015; 3:1291-1301.
Scharnweber D, Hübner L, Rother S, Hempel U, Anderegg U, Samsonov SA, Pisabarro MT, Hofbauer L, Schnabelrauch M, Franz S, Simon JC, Hintze V. Glycosaminoglycan derivates: promising candidates for the design of functional biomaterials. J Mater Sci: Mater Med, 2015;26:232.
Schiller J, Becher J, Möller S, Lemmnitzer K, Riemer T, Schnabelrauch M. Characterization and chemical Modification of Glycosaminoglycans of the extracellular Matrix. IN: “Sulfated Polysaccharides”, Nova Science Publishers, 2015.
Thrivikramana G, Poh SL, Hess R, Haenchen V, Basub B, Scharnweber D. Interplay of Substrate Conductivity, Cellular Microenvironment and Pulsatile Electrical Stimulation towards Osteogenesis of Human MSCs in vitro. ACS Appl Mater Interfaces. 2015,41:23015-28.
Tsourdi E, Rijntjes E, Köhrle J, Hofbauer LC, Rauner M. Hyperthyroidism and hypothyroidism in male mice and their effects on bone mass, bone turnover, and the Wnt inhibitors sclerostin and dickkopf-1. Endocrinology. 2015; 156: 3517-27.
van der Smissen A, Hoffmeister PG, Friedrich N, Watarai A, Hacker MC, Schulz-Siegmund M, Anderegg U. Artificial extracellular matrices support cell growth and matrix synthesis of human dermal fibroblasts in macroporous 3D scaffolds. J Tissue Eng Regen Med. 2015. [Epub ahead of print]
Watarai A, Schirmer L, Thönes S, Freudenberg U, Werner C, Simon JC, Anderegg U. TGFß functionalized starPEG-heparin hydrogels modulate human dermal fibroblast growth and Differentiation. Acta Biomater. 2015;25:65-75.
Wodtke R, Ruiz-Gómez G, Kuchar M, Pisabarro MT, Novotná P, Urbanová M, Steinbach J, Pietzsch J, Löser R. Cyclopeptides containing the DEKS motif as conformationally restricted collagen telopeptide analogues: synthesis and conformational analysis. Org Biomol Chem., 2015;13(6):1878-96.
Anderegg U, Simon J, Averbeck M. More than just a filler – the role of hyaluronan for skin homeostasis. Exp Dermatol. 2014;23:295-303.
Beck-Sickinger AG, Panitz N. Semi-synthesis of chemokines. Curr Opin ChemBiol. 2014;22:100-7.
Dudeck J, Rehberg S, Bernhardt R, Schneiders W, Zierau O, Manjubala I, Goebbels J, Vollmer G, Fratzl P, Scharnweber D, Rammelt S. Increased bone remodelling around titanium implants coated with chondroitin sulfate in ovariectomized rats. Acta Biomater. 2014;10:2855-2865.
Hamann C, Picke AK, Campbell GM, Balyura M, Rauner M, Bernhardt R, Huber G, Morlock MM, Günther KP, Bornstein SR, Glüer CC, Ludwig B, Hofbauer LC. Effects of parathyroid hormone on bone mass, bone strength and bone regeneration in male rats with type 2 diabetes mellitus. Endocrinology. 2014;155:1197-206.
Hempel U, Preissler C, Vogel S, Möller S, Hintze V, Becher J, Schnabelrauch M, Rauner M, Hofbauer LC, Dieter P. Artificial extracellular matrices with oversulfated glycosaminoglycan derivatives promote the differentiation of osteoblast-precursor cells and premature osteoblasts. Biomed Res Int. 2014;2014:938368.
Hempel U, Matthäus C, Preissler C, Möller S, Hintze V, Dieter P. Artificial matrices with high-sulfated glycosaminoglycans and collagen are anti-inflammatory and pro-osteogenic for human mesenchymal stromal cells. J Cell Biochem. 2014;115:1561-71.
Hintze V, Miron A, Möller S, Schnabelrauch M, Heinemann S, Worch H, Scharnweber D. Artificial extracellular matrices of collagen and sulphated hyaluronan enhance the differentiation of human mesenchymal stem cells in the presence of dexamethasone. J Tissue Eng Regen Med. 2014;8: 314-24.
Hintze V, Samsonov SA, Anselmi M, Möller S, Becher J, Schnabelrauch M, Scharnweber D, Pisabarro MT. Sulfated glycosaminoglycans exploit the conformational plasticity of bone morphogenetic protein-2 (BMP-2) and alter the interaction profile with its receptor. Biomacromolecules, 2014;15:3083-92.
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Stadlinger B, Terheyden H. Kommunikation der Zellen. Die Osseointegration. DVD (deutsch). Den Trailer für das Video finden Sie hier. Zu beziehen ist die DVD über den Quintessenz-Verlag.
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