Publications of the SFB1423
Numerous publications have been produced within the framework of the SFB1423, which you will find below. The bibliographic information is linked to Pubmed or doi.org.
Project-relevant publications within the SFB1423 are labled with the following text module: “[author/s] acknowledge funding by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) through SFB1423, project number 421152132, subproject [number/s].”
Anthofer L, Gmach P, Uretmen Kagiali ZC, Kleinau G, Rotter J, Opitz R, Scheerer P, Beck-Sickinger AG, Wolf P, Biebermann H, Bechmann I, Kühnen P, Krude H, Paisdzior S. Melanocortin-4 Receptor PLC Activation Is Modulated by an Interaction with the Monocarboxylate Transporter 8. Int J Mol Sci. 2024 Jul 10;25(14):7565. doi: 10.3390/ijms25147565. PMID: 39062808; PMCID: PMC11277258.
Batebi H, Pérez-Hernández G, Rahman SN, Lan B, Kamprad K, Shi M, Speck D, Tiemann JKS, Guixà-González R, Reinhardt F, Stadler PF, Papasergi-Scott MM, Skiniotis G, Scheerer P, Kobilka BK, Mathiesen JM, Liu X, Hildebrand PW. Mechanistic insights into G-protein coupling with an agonist-bound G-protein-coupled receptor. Nature Struct Mol Biol (2024). https://doi.org/10.1038/s41594-024-01334-2.
Belyaeva J, Elgeti M. Exploring protein structural ensembles: Integration of sparse experimental data from electron paramagnetic resonance spectroscopy with molecular modeling methods. Elife. 2024 Sep 16;13:e99770. doi: 10.7554/eLife.99770. PMID: 39283059; PMCID: PMC11405019.
Birgül Iyison N, Abboud C, Abboud D, Abdulrahman AO, Bondar AN, Dam J, Georgoussi Z, Giraldo J, Horvat A, Karoussiotis C, Paz-Castro A, Scarpa M, Schihada H, Scholz N, Güvenc Tuna B, Vardjan N. ERNEST COST action overview on the (patho)physiology of GPCRs and orphan GPCRs in the nervous system. Br J Pharmacol. 2024 Jun 2. https://doi.org/10.1111/bph.16389.
Bock A, Irannejad R, Scott JD. cAMP signaling: a remarkably regional affair. Trends Biochem Sci. 2024 Feb 2:S0968-0004(24)00018-5.
Bredow C, Thery F, Wirth EK, Ochs S, Kespohl M, Kleinau G, Kelm N, Gimber N, Schmoranzer J, Voss M, Klingel K, Spranger J, Renko K, Ralser M, Mülleder M, Heuser A, Knobeloch KP, Scheerer P, Kirwan J, Brüning U, Berndt N, Impens F, Beling A. ISG15 blocks cardiac glycolysis and ensures sufficient mitochondrial energy production during Coxsackievirus B3 infection. Cardiovasc Res. 2024 Feb 3:cvae026. doi: 10.1093/cvr/cvae026 . Epub ahead of print. PMID: 38309955 .
Buhlan M, Ljaschenko D, Scholz N#, Langenhan T#. Experimental modulation of physiological force application on leg joint neurons in intact Drosophila melanogaster. Nature Protocols. 2024; 19:113-126. DOI: 10.1038/s41596-023-00907-7.
Dietzsch AN, Al-Hasani H, Altschmied J, Bottermann K, Brendler J, Haendeler J, Horn S, Kaczmarek I, Körner A, Krause K, Landgraf K, Le Duc D, Lehmann L, Lehr S, Pick S, Ricken A, Schnorr R, Schulz A, Strnadová M, Velluva A, Zabri H, Schöneberg T, Thor D, Prömel S. Dysfunction of the adhesion G protein-coupled receptor latrophilin 1 (ADGRL1/LPHN1) increases the risk of obesity. Signal Transduct Target Ther. 2024 Apr 26;9(1):103. doi: 10.1038/s41392-024-01810-7. PMID: 38664368; PMCID: PMC11045723.
Claff T, Mahardhika AB, Vaaßen VJ, Schlegel JG, Vielmuth C, Weiße RH, Sträter N, Müller CE. Structural Insights into Partial Activation of the Prototypic G Protein-Coupled Adenosine A2A Receptor. ACS Pharmacol Transl Sci. 2024 Apr 29;7(5):1415-1425. https://doi.org/10.1021/acsptsci.4c00051.
Eisenhuth P, Liessmann F, Moretti R, Meiler J. REvoLd: Ultra-Large Library Screening with an Evolutionary Algorithm in Rosetta. ArXiv [Preprint]. 2024 Apr 26:arXiv:2404.17329v1. http://www.ncbi.nlm.nih.gov/pmc/articles/pmc11071537/.
Elwakiel A, Gupta D, Rana R, Manoharan J, Al-Dabet MM, Ambreen S, Fatima S, Zimmermann S, Mathew A, Li Z, Singh K, Gupta A, Pal S, Sulaj A, Kopf S, Schwab C, Baber R, Geffers R, Götze T, Alo B, Lamers C, Kluge P, Kuenze G, Kohli S, Renné T, Shahzad K, Isermann B. Factor XII signaling via uPAR-integrin β1 axis promotes tubular senescence in diabetic kidney disease. Nat Commun. 2024 Sep 11;15(1):7963. doi: 10.1038/s41467-024-52214-8. PMID: 39261453; PMCID: PMC11390906.
Haxhiraj D, Kuropka B, Brencher E, Rosenberger D, Brandt h, Speck D, Scheerer P, Brügger B, Clementi C, Freund C. T cell interaction partners of DHHC20. bioRxiv 2024.02.14.580290; doi: https://doi.org/10.1101/2024.02.14.580290.
Huster D, Maiti S, Herrmann A. Phospholipid Membranes as Chemically and Functionally Tunable Materials. Adv Mater. 2024 Mar 8:e2312898. doi: 10.1002/adma.202312898 .
Ianni AD, Ihling CH, Vranka T, Matoušek V, Sinz A, Iacobucci C. Evaluating Imide-Based Mass Spectrometry-Cleavable Cross-Linkers for Structural Proteomics Studies. JACS Au. 2024 Jul 16;4(8):2936-2943. doi: 10.1021/jacsau.4c00282. PMID: 39211594; PMCID: PMC11350583.
Ji R-L, Jiang S-S, Kleinau G, Scheerer P, Tao Y-X. Are Melanocortin Receptors Present in Extant Protochordates? Biomolecules 2024, 14, 1120. https://doi.org/10.3390/biom14091120.
Kuhn CK, Stenzel U, Berndt S, Liebscher I, Schöneberg T, Horn S. The repertoire and structure of adhesion GPCR transcript variants assembled from publicly available deep-sequenced human samples. Nucleic Acids Res. 2024 Feb 29:gkae145. doi: 10.1093/nar/gkae145.
Langenhan T. Modularization of adhesion G protein-coupled receptor (aGPCR) structure: how alternative splicing regulates synaptogenesis. Signal Transduct Target Ther. 2024 Apr 24;9(1):106. doi: 10.1038/s41392-024-01829-w . PMID: 38658561 ; PMCID: PMC11043342.
Makkonen K, Jännäri M, Crisóstomo L, Kuusi M, Patyra K, Melnyk V, Linnossuo V, Ojala J, Ravi R, Löf C, Mäkelä JA, Miettinen P, Laakso S, Ojaniemi M, Jääskeläinen J, Laakso M, Bossowski F, Sawicka B, Stożek K, Bossowski A, Kleinau G, Scheerer P, FinnGen F, Reeve MP, Kero J. Mechanisms of thyrotropin receptor-mediated phenotype variability deciphered by gene mutations and M453T-knockin model. JCI Insight. 2024 Jan 9;9(4):e167092. doi: 10.1172/jci.insight.167092. PMID: 38194289.
Manoharan J, Rana R, Kuenze G, Gupta D, Elwakiel A, Ambreen S, Wang H, Banerjee K, Zimmermann S, Singh K, Gupta A, Fatima S, Kretschmer S, Schaefer L, Zeng-Brouwers J, Schwab C, Al-Dabet MM, Gadi I, Altmann H, Koch T, Poitz DM, Baber R, Kohli S, Shahzad K, Geffers R, Lee-Kirsch MA, Kalinke U, Meiler J, Mackman N, Isermann B. Tissue factor binds to and inhibits interferon-α receptor 1 signaling. Immunity. 2024 Jan 9;57(1):68-85.e11.
Matúš D, Post WB, Groß VE, Knierim AB, Kuhn CK, Fiedler F, Tietgen DB, Schön JL, Schöneberg T, Prömel S. The N terminus-only (trans) function of the Adhesion GPCR Latrophilin-1 controls multiple processes in reproduction of C. elegans. G3 (Bethesda). 2024 Sep 7:jkae206. doi: 10.1093/g3journal/jkae206. Epub ahead of print. PMID: 39243387.
Melancon K, Pliushcheuskaya P, Meiler J, Künze G. Targeting ion channels with ultra-large library screening for hit discovery. Front Mol Neurosci. 2024 Jan 5;16:1336004.
Nagl M, Mönnich D, Rosier N, Schihada H, Sirbu A, Konar N, Reyes-Resina I, Navarro G, Franco R, Kolb P, Annibale P, Pockes S. Fluorescent Tools for the Imaging of Dopamine D2 -Like Receptors. Chembiochem. 2024 Jan 15;25(2):e202300659. doi: 10.1002/cbic.202300659 .
Papasergi-Scott MM, Pérez-Hernández G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G. Time-resolved cryo-EM of G-protein activation by a GPCR. Nature. 2024. doi: 10.1038/s41586-024-07153-1.
Philipp M, Moth CW, Ristic N, Tiemann JKS, Seufert F, Panfilova A, Meiler J, Hildebrand PW, Stein A, Wiegreffe D, Staritzbichler R. MutationExplorer: a webserver for mutation of proteins and 3D visualization of energetic impacts. Nucleic Acids Res. 2024 Apr 22:gkae301. doi: 10.1093/nar/gkae301 . Epub ahead of print. PMID: 38647044 .
Reinhardt F, Kaiser A, Prömel S, Stadler PF. Evolution of Neuropeptide Y/RFamide-like receptors in Nematodes. Heliyon. 2024; 10:14 e34473. doi.org/10.1016/j.heliyon.2024.e34473.
Röthe J, Kraft R, Ricken A, Kaczmarek I, Matz-Soja M, Winter K, Dietzsch AN, Buchold J, Ludwig MG, Liebscher I, Schöneberg T, Thor D. The adhesion GPCR GPR116/ADGRF5 has a dual function in pancreatic islets regulating somatostatin release and islet development. Commun Biol. 2024 Jan 16;7(1):104.
Rojas Echeverri JC, Hause F, Iacobucci C, Ihling CH, Tänzler D, Shulman N, Riffle M, MacLean BX, Sinz A. A Workflow for Improved Analysis of Cross-Linking Mass Spectrometry Data Integrating Parallel Accumulation-Serial Fragmentation with MeroX and Skyline. Anal Chem. 2024 May 2. doi: 10.1021/acs.analchem.4c00829. Epub ahead of print. PMID: 38696819.
Rosier N, Mönnich D, Nagl M, Schihada H, Sirbu A, Konar N, Reyes-Resina I, Navarro G, Franco R, Kolb P, Annibale P, Pockes S. Shedding Light on the D1 -Like Receptors: A Fluorescence-Based Toolbox for Visualization of the D1 and D5 Receptors. Chembiochem. 2024 Jan 15;25(2):e202300658. doi: 10.1002/cbic.202300658 .
Roy DS, Gozzi M, Engberg O, Adler J, Huster D, Maiti S. Membrane-Mediated Allosteric Action of Serotonin on a Noncognate G-Protein-Coupled Receptor. J Phys Chem Lett. 2024 Feb 15;15(6):1711-1718. doi: 10.1021/acs.jpclett.3c02340 .
Scharf MM, Humphrys LJ, Berndt S, Di Pizio A, Lehmann J, Liebscher I, Nicoli A, Niv MY, Peri L, Schihada H, Schulte G. The dark sides of the GPCR tree – research progress on understudied GPCRs. Br J Pharmacol. 2024 Feb 10. doi: 10.1111/bph.16325 .
Schoneberg T. Modulating Vertebrate Physiology by Genomic Fine-Tuning of GPCR Functions. Physiol Rev. 2024 Jul 25. doi: 10.1152/physrev.00017.2024. Epub ahead of print. PMID: 39052017.
Schüß C, Behr V, Beck-Sickinger AG. Illuminating the neuropeptide Y4 receptor and its ligand pancreatic polypeptide from a structural, functional, and therapeutic perspective. Neuropeptides. 2024 Feb 24;105:102416. doi: 10.1016/j.npep.2024.102416 .
Sirbu A, Bathe-Peters M, Kumar JLM, Inoue A, Lohse MJ, Annibale P. Cell swelling enhances ligand-driven β-adrenergic signaling. Nat Commun. 2024 Sep 7;15(1):7822. doi: 10.1038/s41467-024-52191-y. PMID: 39242606; PMCID: PMC11379887.
Smith ST, Cassada JB, Von Bredow L, Erreger K, Webb EM, Trombley TA, Kalbfleisch JJ, Bender BJ, Zagol-Ikapitte I, Kramlinger VM, Bouchard JL, Mitchell SG, Tretbar M, Shoichet BK, Lindsley CW, Meiler J, Hamm HE. Discovery of Protease-Activated Receptor 4 (PAR4)-Tethered Ligand Antagonists Using Ultralarge Virtual Screening. ACS Pharmacol Transl Sci. 2024 Mar 21;7(4):1086-1100. doi: 10.1021/acsptsci.3c00378 . PMID: 38633591 ; PMCID: PMC11020070.
Sohail I, Laurin SA, Kleinau G, Chunila V , Kagiali ZCUK, Lohse MJ, Scheerer P, Bouvier M, McCormick P, Annibale P, Biebermann H. MRAP2 modifies the signaling and oligomerization state of the melanocortin-4 receptor. bioRxiv 2024.; doi: https://doi.org/10.1101/2024.04.09.588099.
Useini A, Schwerin IK, Künze G, Sträter N. Structural Studies on the Binding Mode of Bisphenols to PPARγ. Biomolecules. 2024 May 30;14(6):640. doi: 10.3390/biom14060640. PMID: 38927044 ; PMCID: PMC11202036.
Vieira Contreras F, Auger GM, Müller L, Richter V, Huetteroth W, Seufert F, Hildebrand PW, Scholz N, Thum AS, Ljaschenko D, Blanco-Redondo B, Langenhan T. The adhesion G-protein-coupled receptor mayo/CG11318 controls midgut development in Drosophila. Cell Rep. 2024 Jan 4;43(1):113640. doi: 10.1016/j.celrep.2023.113640.
Zhao J, Elgeti M, O’Brien ES, Sár CP, Ei Daibani A, Heng J, Sun X, White E, Che T, Hubbell WL, Kobilka BK, Chen C. Ligand efficacy modulates conformational dynamics of the µ-opioid receptor. Nature. 2024 May;629(8011):474-480. doi: 10.1038/s41586-024-07295-2 . Epub 2024 Apr 10. PMID: 38600384; PMCID: PMC11078757.
Aydin Y, Coin I. Genetically encoded crosslinkers to address protein-protein interactions. Protein Sci. 2023; 32:e4637.
Aydin Y, Böttke T, Lam JH, Ernicke S, Fortmann A, Tretbar M, Zarzycka B, Gurevich VV, Katritch V, Coin I. Structural details of a Class B GPCR-arrestin complex revealed by genetically encoded crosslinkers in living cells. Nat Commun. 2023; 14:1151.
Buhlan M, Ljaschenko D, Scholz N#, Langenhan T#. Experimental modulation of physiological force application on leg joint neurons in intact Drosophila melanogaster. Nature Protocols. 2013; 1–14.
Coin I, Huster D. Ready for the sheet: β-strand folding of phosphorylation clusters guides GPCR binding to arrestin. Structure. 2023 Nov 2;31(11):1289-1291.
Di Ianni A, Tüting C, Kipping M, Ihling CH, Köppen J, Iacobucci C, Arlt C, Kastritis PL, Sinz A. Structural assessment of the full-length wild-type tumor suppressor protein p53 by mass spectrometry-guided computational modeling. Sci Rep. 2023 May 25;13(1):8497.
Engelberger F, Zakary JD, Künze G. Guiding Protein Design Choices by Per-Residue Energy Breakdown Analysis with an Interactive Web Application. Front Mol Biosci. 2023; 10.
Entsie P, Kang Y, Amoafo EB, Schöneberg T, Liverani E. The Signaling Pathway of the ADP Receptor P2Y12 in the Immune System: Recent Discoveries and New Challenges. Int J Mol Sci. 2023; 24:6709.
Frenster JD, Erdjument-Bromage H, Stephan G, Ravn-Boess N, Wang S, Liu W, Bready D, Wilcox J, Kieslich B, Jankovic M, Wilde C, Horn S, Sträter N, Liebscher I, Schöneberg T, Fenyo D, Neubert TA, Placantonakis DG. PTK7 is a positive allosteric modulator of GPR133 signaling in glioblastoma. Cell Rep. 2023 Jun 23;42(7):112679.
Fu C, Huang W, Tang Q, Niu M, Guo S, Langenhan T, Song G, Yan J. Unveiling Mechanical Activation: GAIN Domain Unfolding and Dissociation in Adhesion GPCRs. Nano Lett. 2023; 25;23(20):9179-9186.
Giesecke Y, Asimi V, Stulberg V, Kleinau G, Scheerer P, Koksch B, Grötzinger C. Is the Neuropeptide PEN a Ligand of GPR83? Int J Mol Sci. 2023 Oct 12;24(20):15117.
Gupta A, Krupa P, Engberg O, Krupa M, Chaudhary A, Li MS, Huster D, Maiti S. Unusual Robustness of Neurotransmitter Vesicle Membranes against Serotonin-Induced Perturbations. J Phys Chem B. 2023 Mar 9;127(9):1947-1955.
Hegner B, Kretzschmar T, Zhu N, Kleinau G, Zhao H, Kamhieh-Milz J, Hilger J, Schindler R, Scheerer P, Riemekasten G, Philippe A, Catar R. Autoimmune activation and hypersensitization of the AT1 and ETA receptors contributes to vascular injury in scleroderma renal crisis. Rheumatology (Oxford). 2023 Jun 1;62(6):2284-2293. doi: 10.1093/rheumatology/keac594. PMID: 36227102.
Heng J, Hu Y, Pérez-Hernández G, Inoue A, Zhao J, Ma X, Sun X, Kawakami K, Ikuta T, Ding J, Yang Y, Zhang L, Peng S, Niu X, Li H, Guixà-González R, Jin C, Hildebrand PW, Chen C, Kobilka BK. Function and dynamics of the intrinsically disordered carboxyl terminus of β2 adrenergic receptor. Nat Commun. 2023 Apr 10;14(1):2005.
Junker H, Meiler J, Schoeder CT. Interplay of thermodynamics and evolution within the ternary ligand-GPCR-G protein complex. Curr Opin Struct Biol. 2023 Jul 17;82:102656.
Kieslich B, Weiße RH, Brendler J, Ricken A, Schöneberg T, Sträter N. The dimerized pentraxin-like domain of the adhesion G protein-coupled receptor 112 (ADGRG4) suggests function in sensing mechanical forces. J Biol Chem. 2023 Oct 18;299(12):105356.
Kleinau G, Ali AH, Wiechert F, Szczepek M, Schmidt A, Spahn CMT, Liebscher I, Schöneberg T, Scheerer P. Intramolecular activity regulation of adhesion GPCRs in light of recent structural and evolutionary information. Pharmacol Res. 2023 Nov;197:106971.
Koehler Leman J, Künze G. Recent Advances in NMR Protein Structure Pre-diction with ROSETTA. Int J Mol Sci. 2023; 24:7835.
Künze G, Isermann B. Targeting biased signaling by PAR1: Function and molecular mechanism of parmodulins. Blood. 2023 Mar 23:blood.2023019775.
Ledwitch KV, Künze G, McKinney JR, Okwei E, Larochelle K, Pankewitz L, Ganguly S, Darling HL, Coin I, Meiler J. Sparse pseudocontact shift NMR data obtained from a non-canonical amino acid-linked lanthanide tag improves integral membrane protein structure prediction. J Biomol NMR. 2023 Apr 4.
Liessmann F, Künze G, Meiler J. Improving the Modeling of Extracellular Lig-and Binding Pockets in RosettaGPCR for Conformational Selection. Int J Mol Sci. 2023; 24:7788.
Lohse MJ, Bock A, Zaccolo M. G Protein-Coupled Receptor Signaling: New Insights Define Cellular Nanodomains. Annu Rev Pharmacol Toxicol. 2023 Sep 8. Epub ahead of print.
Marlow B, Kuenze G, Meiler J, Koehler Leman J. Docking cholesterol to integ-ral membrane proteins with Rosetta. PLoS Comput Biol. 2023; 19:e1010947.
Matúš D, Groß VE, Fiedler F, Post WB, Knierim AB, Schön JL, Schöneberg T, Prömel S. The N terminus-only (trans) function of the Adhesion GPCR Latrophilin-1 controls multiple processes in reproduction of C. elegans. bioRxiv. 2023.02.18.529090.
Mrestani A, Dannhäuser S, Pauli M, Kollmannsberger P, Hübsch M, Morris L, Langenhan T, Heckmann M, Paul MM. Nanoscaled RIM clustering at presynaptic active zones revealed by endogenous tagging. Life Sci Alliance. 2023 Sep 11;6(12):e202302021.
Nagl M, Mönnich D, Rosier N, Schihada H, Sirbu A, Konar N, Reyes-Resina I, Navarro G, Franco R, Kolb P, Annibale P, Pockes S. Fluorescent Tools for the Imaging of Dopamine D2 -Like Receptors. Chembiochem. 2023 Nov 9:e202300659. Epub ahead of print.
Okwei E, Smith ST, Bender BJ, Allison B, Ganguly S, Geanes A, Zhang X, Ledwitch K, Meiler J. Rosetta’s Predictive Ability for Low-Affinity Ligand Binding in Fragment-Based Drug Discovery. Biochemistry. 2023 Feb 7;62(3):700-709.
Papasergi-Scott MM, Pérez-Hernández G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G. Time-resolved cryo-EM of G protein activation by a GPCR. bioRxiv [Preprint]. 2023 Mar 21:2023.03.20.533387.
Pohl F, Seufert F, Chung Y, Volke D, Hoffmann R, Schöneberg T, Langenhan T, Hildebrand P, Sträter N. Structural basis of GAIN domain autoproteolysis and cleavage-resistance in the adhesion G-protein coupled receptors. bioRxiv. 2023.03.12.532270.
Rosier N, Mönnich D, Nagl M, Schihada H, Sirbu A, Konar N, Reyes-Resina I, Navarro G, Franco R, Kolb P, Annibale P, Pockes S. Shedding Light on the D1 -Like Receptors: A Fluorescence-Based Toolbox for Visualization of the D1 and D5 Receptors. Chembiochem. 2023 Nov 9:e202300658.
Sala D, Batebi H, Ledwitch K, Hildebrand PW, Meiler J. Targeting in silico GPCR conformations with ultra-large library screening for hit discovery. Trends Pharmacol Sci. 2023; 44:150-61.
Sala D, Engelberger F, Mchaourab HS, Meiler J. Modeling conformational states of proteins with AlphaFold. Curr Opin Struct Biol. 2023 Jun 29;81:102645.
Sala D, Hildebrand PW, Meiler J. Biasing AlphaFold2 to predict GPCRs and Kinases with user-defined functional or structural properties. Front Mol Biosci. 2023; 10:1121962.
Schmidt A, Kalms J, Lorent C, Katz S, Frielingsdorf S, Evans RM, Fritsch J, Siebert E, Teutloff C, Armstrong FA, Zebger I, Lenz O, Scheerer P. Stepwise conversion of the Cys6[4Fe-3S] to a Cys4[4Fe-4S] cluster and its impact on the oxygen tolerance of [NiFe]-hydrogenase. Chem Sci. 2023 Sep 20;14(40):11105-11120. doi: 10.1039/d3sc03739h. PMID: 37860641.
Schmidt P, Vogel A, Schwarze B, Seufert F, Licha K, Wycisk V, Kilian W, Hildebrand PW, Mitschang L. Towards Probing Conformational States of Y2 Receptor Using Hyperpolarized 129Xe NMR. Molecules. 2023; 28(3):1424.
Scholz N#, Dahse AK, Kemkemer M, Bormann A, Auger GM, Vieira Contreras F, Ernst LF, Staake H, Körner MB, Buhlan M, Meyer-Mölck A, Chung YK, Blanco-Redondo B, Klose F, Jarboui MA, Ljaschenko D, Bigl M, Langenhan T#. Molecular sensing of mechano- and ligand-dependent adhesion GPCR dissociation. Nature. 2023 Mar;615(7954):945-953.
Schüß C, Vu O, Mishra NM, Tough IR, Du Y, Stichel J, Cox HM, Weaver CD, Meiler J, Emmitte KA, Beck-Sickinger AG. Structure-Activity Relationship Study of the High-Affinity Neuropeptide Y4 Receptor Positive Allosteric Modulator VU0506013. J Med Chem. 2023 Jul 13;66(13):8745-8766.
Selvasingh JA, McDonald EF, Neufer PD, McKinney JR, Meiler J, Ledwitch KV. Dark nanodiscs for evaluating membrane protein thermostability by differential scanning fluorimetry. Biophys J. 2023 Nov 20:S0006-3495(23)00719-1.
Seufert F, Chung YK, Hildebrand PW, Langenhan T. 7TM domain structures of adhesion GPCRs: what’s new and what’s missing? Trends Biochem Sci. 2023 Jun 20:S0968-0004(23)00131-7.
Smirnova J, Loerke J, Kleinau G, Schmidt A, Bürger J, Meyer EH, Mielke T, Scheerer P, Bock R, Spahn CMT, Zoschke R. Structure of the actively translating plant 80S ribosome at 2.2 Å resolution. Nat Plants. 2023 Jun;9(6):987-1000. doi: 10.1038/s41477-023-01407-y. Epub 2023 May 8. PMID: 37156858.
Smith AA, Pacull EM, Stecher S, Hildebrand PW, Vogel A, Huster D. Analysis of the Dynamics of the Human Growth Hormone Secretagogue Receptor Reveals Insights into the Energy Landscape of the Molecule. Angew Chem Int Ed Engl. 2023 May 19:e202302003.
Staritzbichler R, Ristic N, Stapke T, Hildebrand P. SmoothT – a server constructing low energy pathways from conformational ensembles for interactive visualization and enhanced sampling. Bioinformatics. 2023 Apr 5:btad176.
Streit M, Hemberger M, Häfner S, Knote F, Langenhan T, Beliu G. Optimized genetic code expansion technology for time-dependent induction of adhesion GPCR-ligand engagement. Protein Sci. 2023 Apr;32(4):e4614.
Strutt H, Warrington S, Madathil ACK, Langenhan T, Strutt D (2023) Molecular symmetry breaking in the Frizzled-dependent planar polarity pathway. Current Biology. Accepted.
Tänzler D, Kipping M, Lederer M, Günther WF, Arlt C, Hüttelmaier S, Merkenschlager A, Sinz A. Effects of theophylline on ADCY5 activation-From cellular studies to improved therapeutic options for ADCY5-related dyskinesia patients. PLoS One. 2023 Mar 3;18(3):e0282593.
Thane M, Paisios E, Stöter T, Krüger AR, Gläß S, Dahse AK, Scholz N, Gerber B, Lehmann DJ, Schleyer M. High-resolution analysis of individual Drosophila melanogaster larvae uncovers individual variability in locomotion and its neurogenetic modulation. Open Biol. 2023 Apr;13(4):220308.
Woods H, Schiano DL, Aguirre JI, Ledwitch KV, McDonald EF, Voehler M, Meiler J, Schoeder CT. Computational modeling and prediction of deletion mutants. Structure. 2023; S0969-2126(23)00128-4.
Wygas MM, Laugwitz JM, Schmidt P, Elgeti M, Kaiser A. Dynamics of the Second Extracellular Loop Control Transducer Coupling of Peptide-Activated GPCRs. Int J Mol Sci. 2023 Jul 30;24(15):12197.
Anton SE, Kayser C, Maiellaro I, Nemec K, Möller J, Koschinski A, Zaccolo M, Annibale P, Falcke M, Lohse MJ, Bock A. Receptor-associated independent cAMP nanodomains mediate spatiotemporal specificity of GPCR signaling. Cell. 2022 Mar 31;185(7):1130-1142.e11. doi: 10.1016/j.cell.2022.02.011. Epub 2022 Mar 15. PMID: 35294858.
Boltz HH, Sirbu A, Stelzer N, de Lanerolle P, Winkelmann S, Annibale P. The Impact of Membrane Protein Diffusion on GPCR Signaling. Cells. 2022 May 17;11(10):1660. doi: 10.3390/cells11101660. PMID: 35626696
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