Publications of the SFB1423

Inside Cover by Ulrike Krug

Numerous publications have been produced within the framework of the SFB1423, which you will find below. The bibliographic information is linked to Pubmed or doi.org

Project-relevant publications within the SFB1423 are labled with the following text module“[author/s] acknowledge funding by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) through SFB1423, project number 421152132, subproject [number/s].”

Aydin Y, Coin I. Genetically encoded crosslinkers to address protein-protein interactions. Protein Sci. 2023; 32:e4637.

Aydin Y, Böttke T, Lam JH, Ernicke S, Fortmann A, Tretbar M, Zarzycka B, Gurevich VV, Katritch V, Coin I. Structural details of a Class B GPCR-arrestin complex revealed by genetically encoded crosslinkers in living cells. Nat Commun. 2023; 14:1151.

Di Ianni A, Tüting C, Kipping M, Ihling CH, Köppen J, Iacobucci C, Arlt C, Kastritis PL, Sinz A. Structural assessment of the full-length wild-type tumor suppressor protein p53 by mass spectrometry-guided computational modeling. Sci Rep. 2023 May 25;13(1):8497. 

Engelberger F, Zakary JD, Künze G. Guiding Protein Design Choices by Per-Residue Energy Breakdown Analysis with an Interactive Web Application. Front Mol Biosci. 2023; 10.

Entsie P, Kang Y, Amoafo EB, Schöneberg T, Liverani E. The Signaling Pathway of the ADP Receptor P2Y12 in the Immune System: Recent Discoveries and New Challenges. Int J Mol Sci. 2023; 24:6709.

Frenster JD, Erdjument-Bromage H, Stephan G, Ravn-Boess N, Wang S, Liu W, Bready D, Wilcox J, Kieslich B, Jankovic M, Wilde C, Horn S, Sträter N, Liebscher I, Schöneberg T, Fenyo D, Neubert TA, Placantonakis DG. PTK7 is a positive allosteric modulator of GPR133 signaling in glioblastoma. Cell Rep. 2023 Jun 23;42(7):112679.

Gupta A, Krupa P, Engberg O, Krupa M, Chaudhary A, Li MS, Huster D, Maiti S. Unusual Robustness of Neurotransmitter Vesicle Membranes against Serotonin-Induced Perturbations. J Phys Chem B. 2023 Mar 9;127(9):1947-1955.

Heng J, Hu Y, Pérez-Hernández G, Inoue A, Zhao J, Ma X, Sun X, Kawakami K, Ikuta T, Ding J, Yang Y, Zhang L, Peng S, Niu X, Li H, Guixà-González R, Jin C, Hildebrand PW, Chen C, Kobilka BK. Function and dynamics of the intrinsically disordered carboxyl terminus of β2 adrenergic receptor. Nat Commun. 2023 Apr 10;14(1):2005.

Junker H, Meiler J, Schoeder CT. Interplay of thermodynamics and evolution within the ternary ligand-GPCR-G protein complex. Curr Opin Struct Biol. 2023 Jul 17;82:102656.

Koehler Leman J, Künze G. Recent Advances in NMR Protein Structure Pre-diction with ROSETTA. Int J Mol Sci. 2023; 24:7835.

Künze G, Isermann B. Targeting biased signaling by PAR1: Function and molecular mechanism of parmodulins. Blood. 2023 Mar 23:blood.2023019775.

Ledwitch KV, Künze G, McKinney JR, Okwei E, Larochelle K, Pankewitz L, Ganguly S, Darling HL, Coin I, Meiler J. Sparse pseudocontact shift NMR data obtained from a non-canonical amino acid-linked lanthanide tag improves integral membrane protein structure prediction. J Biomol NMR. 2023 Apr 4.

Liessmann F, Künze G, Meiler J. Improving the Modeling of Extracellular Lig-and Binding Pockets in RosettaGPCR for Conformational Selection. Int J Mol Sci. 2023; 24:7788.

Lohse MJ, Bock A, Zaccolo M. G Protein-Coupled Receptor Signaling: New Insights Define Cellular Nanodomains. Annu Rev Pharmacol Toxicol. 2023 Sep 8. doi: 10.1146/annurev-pharmtox-040623-115054. Epub ahead of print. PMID: 37683278.

Marlow B, Kuenze G, Meiler J, Koehler Leman J. Docking cholesterol to integ-ral membrane proteins with Rosetta. PLoS Comput Biol. 2023; 19:e1010947.

Matúš D, Groß VE, Fiedler F, Post WB, Knierim AB, Schön JL, Schöneberg T, Prömel S. The N terminus-only (trans) function of the Adhesion GPCR Latrophilin-1 controls multiple processes in reproduction of C. elegans. bioRxiv. 2023.02.18.529090.

Mrestani A, Dannhäuser S, Pauli M, Kollmannsberger P, Hübsch M, Morris L, Langenhan T, Heckmann M, Paul MM. Nanoscaled RIM clustering at presynaptic active zones revealed by endogenous tagging. Life Sci Alliance. 2023 Sep 11;6(12):e202302021. doi: 10.26508/lsa.202302021. PMID: 37696575; PMCID: PMC10494931.

Okwei E, Smith ST, Bender BJ, Allison B, Ganguly S, Geanes A, Zhang X, Ledwitch K, Meiler J. Rosetta’s Predictive Ability for Low-Affinity Ligand Binding in Fragment-Based Drug Discovery. Biochemistry. 2023 Feb 7;62(3):700-709.

Papasergi-Scott MM, Pérez-Hernández G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G. Time-resolved cryo-EM of G protein activation by a GPCR. bioRxiv [Preprint]. 2023 Mar 21:2023.03.20.533387.

Pohl F, Seufert F, Chung Y, Volke D, Hoffmann R, Schöneberg T, Langenhan T, Hildebrand P, Sträter N. Structural basis of GAIN domain autoproteolysis and cleavage-resistance in the adhesion G-protein coupled receptors. bioRxiv. 2023.03.12.532270.

Sala D, Batebi H, Ledwitch K, Hildebrand PW, Meiler J. Targeting in silico GPCR conformations with ultra-large library screening for hit discovery. Trends Pharmacol Sci. 2023; 44:150-61.

Sala D, Engelberger F, Mchaourab HS, Meiler J. Modeling conformational states of proteins with AlphaFold. Curr Opin Struct Biol. 2023 Jun 29;81:102645.

Sala D, Hildebrand PW, Meiler J. Biasing AlphaFold2 to predict GPCRs and Kinases with user-defined functional or structural properties. Front Mol Biosci. 2023; 10:1121962.

Schmidt P, Vogel A, Schwarze B, Seufert F, Licha K, Wycisk V, Kilian W, Hildebrand PW, Mitschang L. Towards Probing Conformational States of Y2 Receptor Using Hyperpolarized 129Xe NMR. Molecules. 2023; 28(3):1424.

Scholz N, Dahse AK, Kemkemer M, Bormann A, Auger GM, Vieira Contreras F, Ernst LF, Staake H, Körner MB, Buhlan M, Meyer-Mölck A, Chung YK, Blanco-Redondo B, Klose F, Jarboui MA, Ljaschenko D, Bigl M, Langenhan T. Molecular sensing of mechano- and ligand-dependent adhesion GPCR dissociation. Nature. 2023 Mar;615(7954):945-953.

Schüß C, Vu O, Mishra NM, Tough IR, Du Y, Stichel J, Cox HM, Weaver CD, Meiler J, Emmitte KA, Beck-Sickinger AG. Structure-Activity Relationship Study of the High-Affinity Neuropeptide Y4 Receptor Positive Allosteric Modulator VU0506013. J Med Chem. 2023 Jul 13;66(13):8745-8766.

Seufert F, Chung YK, Hildebrand PW, Langenhan T. 7TM domain structures of adhesion GPCRs: what’s new and what’s missing? Trends Biochem Sci. 2023 Jun 20:S0968-0004(23)00131-7.

Smith AA, Pacull EM, Stecher S, Hildebrand PW, Vogel A, Huster D. Analysis of the Dynamics of the Human Growth Hormone Secretagogue Receptor Reveals Insights into the Energy Landscape of the Molecule. Angew Chem Int Ed Engl. 2023 May 19:e202302003.

Staritzbichler R, Ristic N, Stapke T, Hildebrand P. SmoothT – a server constructing low energy pathways from conformational ensembles for interactive visualization and enhanced sampling. Bioinformatics. 2023 Apr 5:btad176.

Streit M, Hemberger M, Häfner S, Knote F, Langenhan T, Beliu G. Optimized genetic code expansion technology for time-dependent induction of adhesion GPCR-ligand engagement. Protein Sci. 2023 Apr;32(4):e4614.

Tänzler D, Kipping M, Lederer M, Günther WF, Arlt C, Hüttelmaier S, Merkenschlager A, Sinz A. Effects of theophylline on ADCY5 activation-From cellular studies to improved therapeutic options for ADCY5-related dyskinesia patients. PLoS One. 2023 Mar 3;18(3):e0282593.

Woods H, Schiano DL, Aguirre JI, Ledwitch KV, McDonald EF, Voehler M, Meiler J, Schoeder CT. Computational modeling and prediction of deletion mutants. Structure. 2023; S0969-2126(23)00128-4.

Wygas MM, Laugwitz JM, Schmidt P, Elgeti M, Kaiser A. Dynamics of the Second Extracellular Loop Control Transducer Coupling of Peptide-Activated GPCRs. Int J Mol Sci. 2023 Jul 30;24(15):12197. doi: 10.3390/ijms241512197. PMID: 37569573; PMCID: PMC10419011.

Anton SE, Kayser C, Maiellaro I, Nemec K, Möller J, Koschinski A, Zaccolo M, Annibale P, Falcke M, Lohse MJ, Bock A. Receptor-associated independent cAMP nanodomains mediate spatiotemporal specificity of GPCR signaling. Cell. 2022 Mar 31;185(7):1130-1142.e11. doi: 10.1016/j.cell.2022.02.011. Epub 2022 Mar 15. PMID: 35294858.

Boltz HH, Sirbu A, Stelzer N, de Lanerolle P, Winkelmann S, Annibale P. The Impact of Membrane Protein Diffusion on GPCR Signaling. Cells. 2022 May 17;11(10):1660. doi: 10.3390/cells11101660. PMID: 35626696

Brown BP, Vu O, Geanes AR, Kothiwale S, Butkiewicz M, Lowe EW Jr, Mueller R, Pape R, Mendenhall J, Meiler J. Introduction to the BioChemical Library (BCL): An Application-Based Open-Source Toolkit for Integrated Cheminformatics and Machine Learning in Computer-Aided Drug Discovery. Front Pharmacol. 2022 Feb 21;13:833099. doi: 10.3389/fphar.2022.833099. PMID: 35264967; PMCID: PMC8899505. 

Catar R, Herse-Naether M, Zhu N, Wagner P, Wischnewski O, Kusch A, Kamhieh-Milz J, Eisenreich A, Rauch U, Hegner B, Heidecke H, Kill A, Riemekasten G, Kleinau G, Scheerer P, Dragun D, Philippe A. Autoantibodies Targeting AT1- and ETA-Receptors Link Endothelial Proliferation and Coagulation via Ets-1 Transcription Factor. Int J Mol Sci. 2022, 23, 244. doi: 10.3390/ijms23010244. PMID: 35008670.

Canzler S, Fischer M, Ulbricht D, Ristic N, Hildebrand PW, Staritzbichler R. ProteinPrompt: a webserver for predicting protein–protein interactions. Bioinformatics Advances, Volume 2, Issue 1, 2022, vbac059, https://doi.org/10.1093/bioadv/vbac059.

Del Alamo D, Sala D, Mchaourab HS, Meiler J. Sampling alternativev conformational states of transporters and receptors with AlphaFold2. eLife. 2022;11:e75751 DOI: 10.7554/eLife.75751.

Engberg O, Bocicchio A, Brandner AF, Gupta A, Dey S, Maiti S, Böckmann RA, Huster D. Serotonin alters the phase equilibrium of a ternary mixture of phospholipids and cholesterol. Front Physiol. 2022. 11:578868.

Gmach P, Bathe-Peters M, Telugu N, Miller DC, Annibale P. Fluorescence Spectroscopy of Low-Level Endogenous β-Adrenergic Receptor Expression at the Plasma Membrane of Differentiating Human iPSC-Derived Cardiomyocytes. Int J Mol Sci. 2022 Sep 8;23(18):10405. doi:10.3390/ijms231810405. PMID: 36142320; PMCID: PMC9499492.

Götze KJ, Mrestani A, Beckmann P, Krohn K, Le Duc D, Velluva A, Böhme MA, Heckmann M, Abou Jamra R, Lemke JR, Bläker H, Scholz N, Ljaschenko D, Langenhan T. Improving one-step scarless genome editing in Drosophila melanogaster by combining ovoD co-CRISPR selection with sgRNA target site masking. Biol Methods Protoc. 2022 Jan 12;7(1):bpac003. doi: 10.1093/biomethods/bpac003. PMID: 35087953; PMCID: PMC8789338.

Groß VE, Gershkovich MM, Schöneberg T, Kaiser A, Prömel S. NanoBRET in C. elegans illuminates functional receptor interactions in real time. BMC Mol Cell Biol. 2022 Jan 31;23(1):8. doi: 10.1186/s12860-022-00405-w. PMID: 35100990; PMCID: PMC8805316.
 

Höpfner F, Paisdzior S, Reininghaus N, Sohail I, Scheerer P, Annibale P, Biebermann H, Kühnen P. Evaluation of pharmacological rescue of Melanocortin-4 receptor nonsense mutations by aminoglycoside. Life. 2022; 12(11):1793.

Knapp B, Roedig J, Roedig H, Krzysko J, Horn N, Güler BE, Kusuluri DK, Yildirim A, Boldt K, Ueffing M, Liebscher I, Wolfrum U. Affinity Proteomics Identifies Interaction Partners and Defines Novel Insights into the Function of the Adhesion GPCR VLGR1/ADGRV1. Molecules. 2022; 27:3108.

Kühnen P, Biebermann H, Wiegand S. Pharmacotherapy in Childhood Obesity. Horm Res Paediatr. 2022; 95:177-192.

Kühnen P, Clément K. Long-Term MC4R Agonist Treatment in POMC-Deficient Patients. N Engl J Med. 2022; 387:852-854.

Liebscher I, Schöneberg T, Thor D. Stachel-mediated activation of adhesion G protein-coupled receptors: insights from cryo-EM studies. Signal Transduct Target Ther. 2022 Jul 9;7(1):227. doi: 10.1038/s41392-022-01083-y. PMID: 35810167; PMCID: PMC9271043.
 
Matúš D, Post WB, Horn S, Schöneberg T, Prömel S. Latrophilin-1 drives neuron morphogenesis and shapes chemo- and mechanosensation-dependent behavior in C. elegans via a trans function. Biochem Biophys Res Commun. 2022; 589:152-158. DOI: 10.1016/j.bbrc.2021.12.006.
 
Mitgau J, Franke J, Schinner C, Stephan G, Berndt S, Placantonakis DG, Kalwa H, Spindler V, Wilde C, Liebscher I. The N Terminus of Adhesion G Protein-Coupled Receptor GPR126/ADGRG6 as Allosteric Force Integrator. Front Cell Dev Biol. 2022 Jun 23;10:873278. doi: 10.3389/fcell.2022.873278. PMID: 35813217 ; PMCID: PMC9259995.
 
Musabirova G, Engberg O, Gupta A, Roy DS, Maiti S, Huster D. Serotonergic drugs modulate the phase behavior of complex lipid bilayers. Biochimie. 2022 Apr 18:S0300-9084(22)00101-8. doi: 10.1016/j.biochi.2022.04.006. Online ahead of print. PMID: 35447219.
 
Nemec K, Schihada H, Kleinau G, Zabel U, Grushevskyi EO, Scheerer P, Lohse MJ, Maiellaro I. Functional modulation of PTH1R activation and signaling by RAMP2. Proc Natl Acad Sci U S A. 2022 Aug 9;119(32):e2122037119. doi: 10.1073/pnas.2122037119. Epub 2022 Aug 1. PMID: 35914163.


Philippe A, Kleinau G, Gruner JJ, Wu S, Postpieszala D, Speck D, Heidecke H, Dowell SJ, Riemekasten G,
Hildebrand PW, Kamhieh-Milz J, Catar R, Szczepek M, Dragun D, Scheerer P. Molecular Effects of Auto-Antibodies on Angiotensin II Type 1 Receptor Signaling and Cell Proliferation. Int J Mol Sci. 2022 Apr 2;23(7):3984. doi: 10.3390/ijms23073984. PMID: 35409344.

Ping YQ, Xiao P, Yang F, Zhao RJ, Guo SC, Yan X, Wu X, Zhang C, Lu Y, Zhao F, Zhou F, Xi YT, Yin W, Liu FZ, He DF, Zhang DL, Zhu ZL, Jiang Y, Du L, Feng SQ, Schöneberg T, Liebscher I, Xu HE, Sun JP. Structural basis for the tethered peptide activation of adhesion GPCRs. Nature. 2022 Apr;604(7907):763-770. doi: 10.1038/s41586-022-04619-y. Epub 2022 Apr 13. PMID: 35418678. https://doi.org/10.1038/s41586-022-04619-y.

Reinhard F, Stadler PF. ExceS-A: An Exon-Centric Split Aligner. JIB. 2022; pp. 20210040.

Reininghaus N, Paisdzior S, Höpfner F, Jyrch S, Cetindag C, Scheerer P, Kühnen P, Biebermann H. A Setmelanotide-like Effect at MC4R Is Achieved by MC4R Dimer Separation. Biomolecules. 2022 Aug 15;12(8):1119. doi: 10.3390/biom12081119. PMID: 36009013.

Rudolf S, Kaempf K, Vu O, Meiler JBeck-Sickinger AGCoin I. Binding of Natural Peptide Ligands to the Neuropeptide Y5 Receptor. Angew Chem Int Ed Engl2022 Jan 26;61(5):e202108738. doi: 10.1002/anie.202108738. PMID:34822209.

Sala D, Del Alamo D, Mchaourab HSMeiler J. Modeling of protein conformational changes with Rosetta guided by limited experimental data. Structure. 2022 May 12:S0969-2126(22)00140-X. doi: 10.1016/j.str.2022.04.013. Online ahead of print. PMID: 35597243.

Schaller D, Lafond M, Stadler PF, Wieseke N, Hellmuth M. Indirect identification of horizontal gene transfer. Journal of Mathematical
Biology
volume 83, Article number: 10 (2021). https://doi.org/10.1007/s00285-021-01631-0.

Schulze AS, Kleinau G, Krakowsky R, Rochmann D, Das R, Worth CL, Krumbholz P, Scheerer P, Stäubert C. Evolutionary analyses reveal immune cell receptor GPR84 as a conserved receptor for bacteria-derived molecules. iScience. 2022 Sep 6;25(10):105087. doi: 10.1016/j.isci.2022.105087. eCollection 2022 Oct 21. PMID: 36164652.

Smith AA, Vogel A, Engberg O, Hildebrand PW, Huster D. A method to construct the dynamic landscape of a bio-membrane with experiment and simulation. Nat Commun. 2022 Jan 10;13(1):108. doi: 10.1038/s41467-021-27417-y. PMID: 35013165; PMCID: PMC8748619.

Speck D, Kleinau G, Szczepek M, Kwiatkowski D, Catar R, Philippe A, Scheerer P. Angiotensin and Endothelin Receptor Structures With Implications for Signaling Regulation and Pharmacological Targeting. Front Endocrinol (Lausanne). 2022 Apr 19;13:880002. doi: 10.3389/fendo.2022.880002 [Titel anhand dieser DOI in Citavi-Projekt übernehmen] . eCollection 2022. PMID: 35518926.

Speck D, Kleinau G, Meininghaus M, Erbe A, Einfeldt A, Szczepek M, Scheerer P, Pütter V. Expression and Characterization of Relaxin Family Peptide Receptor 1 Variants. Front Pharmacol. 2022 Jan 28;12:826112. doi: 10.3389/fphar.2021.826112. eCollection 2021. PMID: 35153771 Free PMC article.

Stadler PF, Will S. Bi-alignments with affine gaps costs. Algorithms Mol Biol. 2022 May 16;17(1):10. doi: 10.1186/s13015-022-00219-7. PMID: 35578255.

Staritzbichler R, Yaklich E, Sarti E, Ristic N, Hildebrand PW, Forrest LR. AlignMe: an update of the web server for alignment of membrane protein sequences. Nucleic Acids Res. 2022 May 24:gkac391. doi: 10.1093/nar/gkac391. Online ahead of print. PMID: 35609986

Stephan G, Frenster JD, Liebscher I, Placantonakis DG. Activation of the adhesion G protein-coupled receptor GPR133 (ADGRD1) by antibodies targeting its N-terminus. J Biol Chem. 2022 Apr 18:101949. doi: 10.1016/j.jbc.2022.101949. Online ahead of print. PMID: 35447113.

Tang T, Tan Q, Han S, Diemar A, Löbner K, Wang H, Schüß C, Behr V, Mörl K, Wang M, Chu X, Yi C, Keller M, Kofoed J, Reedtz-Runge S, Kaiser A, Beck-Sickinger AG, Zhao Q, Wu B. Receptor-specific recognition of NPY peptides revealed by structures of NPY receptors. Sci Adv. 2022 May 6;8(18):eabm1232. doi: 10.1126/sciadv.abm1232. Epub 2022 May 4. PMID: 35507650; PMCID: PMC9067930.

Ubbiali D, Fratini M, Piersimoni L, Ihling C, Kipping M, Heilmann I, Iacobucci C, Sinz A. Direct Observation of ‘Elongated’ Conformational States in α-Synuclein upon Liquid-Liquid Phase Separation. Angew Chem Int Ed Engl. 2022 Sep 17. doi: 10.1002/anie.202205726. Online ahead of print. PMID: 36115020.

Voss M, Kleinau G, Gimber N, Janek K, Bredow C, Thery F, Impens F, Schmoranzer J, Scheerer P, Kloetzel PM, Beling A. A cytosolic disulfide bridge-supported dimerization is crucial for stability and cellular distribution of Coxsackievirus B3 protein 3A. FEBS J. 2022 Jul;289(13):3826-3838. doi: 10.1111/febs.16368. Epub 2022 Feb 11. PMID: 35066984.

Vu O, Bender BJ, Pankewitz L, Huster S, Beck-Sickinger AG, Meiler J. The structural basis of peptide binding at class A G protein-coupled receptors. Molecules. 2022. 27:210.

Wei AAJ, Iacobucci C, Schultze W, Ihling CH, Arlt C, Sinz ADifferent Oligomeric States of the Tumor Suppressor p53 Show Identical Binding Behavior towards the S100β Homodimer. Chembiochem. 2022 Jun 3;23(11):e202100665. doi: 10.1002/cbic.202100665. Epub 2022 Apr 13. PMID: 35333001. 

Wilde C, Mitgau J, Suchý T, Schoeneberg T, Liebscher I. Translating the Force – mechano-sensing GPCRs. Am J Physiol Cell Physiol. 2022 Apr 13. doi: 10.1152/ajpcell.00465.2021. Online ahead of print. PMID: 35417266 Review.

Yang Y, Stensitzki T, Sauthof L, Schmidt A, Piwowarski P, Velazquez Escobar F, Michael N, Nguyen AD, Szczepek M, Brünig FN, Netz RR, Mroginski MA, Adam S, Bartl F, Schapiro I, Hildebrandt P, Scheerer P, Heyne K. Ultrafast proton-coupled isomerization in the phototransformation of phytochrome. Nat Chem. 2022 May 16. doi: 10.1038/s41557-022-00944-x. Online ahead of print. PMID: 35577919.

Zimmermann A, Vu O, Brüser A, Sliwoski G,  Marnett LJ, Meiler J, Schöneberg T. Mapping the Binding Sites of UDP and Prostaglandin E2 Glyceryl Ester in the Nucleotide Receptor P2Y6. ChemMedChem. 2022, e202100683.

Bathe-Peters M, Gmach P, Boltz HH, Einsiedel J, Gotthardt M, Hübner H, Gmeiner P, Lohse MJ, Annibale PVisualization of β-adrenergic receptor dynamics and differential localization in cardiomyocytes. Proc Natl Acad Sci U S A. 2021 Jun 8;118(23):e2101119118. doi: 10.1073/pnas.2101119118. PMID: 34088840. 

Bender BJ, Bock A, Nesheva DN, Perry-Hauser NA. Viewpoints on the First Transatlantic GPCR Symposium for Early-Career Investigators. ACS Pharmacol Transl Sci. 2021 Sep 23;4(5):1705-1711. doi: 10.1021/acsptsci.1c00203. PMID: 34661085; PMCID: PMC8506598.

Berndt S, Liebscher I. New Structural Perspectives in G Protein-Coupled Receptor-Mediated Src Family Kinase Activation. Int J Mol Sci. 2021 Jun 17;22(12):6489. doi: 10.3390/ijms22126489. PMID: 34204297; PMCID: PMC8233884.

Bock A, Bermudez M. Allosteric coupling and biased agonism in G protein-coupled receptors. FEBS J. 2021 Feb 23. doi: 10.1111/febs.15783. Epub ahead of print. PMID: 33621418.

Beliu G, Altrichter S, Guixà-González R, Hemberger M, Brauer I, Dahse AK, Scholz N, Wieduwild R, Kuhlemann A, Batebi H, Seufert F, Pérez-Hernández G, Hildebrand PW, Sauer M, Langenhan T. Tethered agonist exposure in intact adhesion/class B2 GPCRs through intrinsic structural flexibility of the GAIN domain. Mol Cell. 2021 Mar 4;81(5):905-921.e5. doi: 10.1016/j.molcel.2020.12.042. Epub 2021 Jan 25.

Boltz HH, Sirbu A, Stelzer N, Lohse MJ, Schütte C, Annibale P. Quantitative spectroscopy of single molecule interaction times. Opt Lett. 2021; 46:1538-1541. https://doi.org/10.1364/OL.413030

Chen J, Bi H, Pettersson ME, Sato DX, Fuentes-Pardo AP, Mo C, Younis S, Wallerman O, Jern P, Molés G, Gómez A, Kleinau G, Scheerer P, Andersson L. Functional differences between TSHR alleles associate with variation in spawning season in Atlantic herring. Commun Biol. 2021 Jun 25;4(1):795. doi: 10.1038/s42003-021-02307-7. PMID: 34172814.

Del Alamo D, Jagessar KL, Meiler JMchaourab HS. Methodology for rigorous modeling of protein conformational changes by Rosetta using DEER Distance Restraints. PLoS Comput Biol. 2021 Jun 16;17(6):e1009107. doi: 10.1371/journal.pcbi.1009107. Online ahead of print. PMID: 34133419.

Dey S, Surendran D, Engberg O, Gupta A, Fanibunda SE, Das A, Maity BK, Dey A, Visvakarma V, Kallianpur M, Scheidt HA, Walker G, Vaidya VA, Huster D, Maiti S. Altered Membrane Mechanics Provides a Receptor-Independent Pathway for Serotonin Action. Chemistry. 2021 May 12;27(27):7533-7541. doi: 10.1002/chem.202100328. Epub 2021 Mar 12. PMID: 33502812.

Frenster JD, Stephan G, Ravn-Boess N, Bready D, Wilcox J, Kieslich B, Wilde C, Sträter N, Wiggin GR, Liebscher I, Schöneberg T, Placantonakis DG. Functional impact of intramolecular cleavage and dissociation of adhesion G protein-coupled receptor GPR133 (ADGRD1) on canonical signaling. J Biol Chem. 2021 May 19:100798. doi: 10.1016/j.jbc.2021.100798. Epub ahead of print. PMID: 34022221.

Gershkovich MM, Groß VE, Vu O, Schoeder CT, Meiler J, Prömel S, Kaiser A. Structural Perspective on Ancient Neuropeptide Y-like System reveals Hallmark Features for Peptide Recognition and Receptor Activation. J Mol Biol. 2021 Apr 16;433(13):166992. doi: 10.1016/j.jmb.2021.166992. Epub ahead of print. PMID: 33865871.

Graffunder AS, Paisdzior S, Opitz R, Renko K, Kühnen P, Biebermann H. Design and Characterization of a Fluorescent Reporter Enabling Live-cell Monitoring of MCT8 Expression. Exp Clin Endocrinol Diabetes. 2021 Aug 5. doi: 10.1055/a-1522-8535. Online ahead of print. PMID: 34352913.

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Krug U, Gloge A, Schmidt P, Becker-Baldus J, Bernhard F, Kaiser A, Montag C, Gauglitz M, Vishnivetskiy SA, Gurevich VV, Beck-Sickinger AG, Glaubitz C, Huster D. The Conformational Equilibrium of the Neuropeptide Y2 Receptor in Bilayer Membranes. Angew Chem Int Ed Engl. 2020 Aug 13. doi: 10.1002/anie.202006075. Epub ahead of print. PMID: 32790043 and Inside Cover: The Conformational Equilibrium of the Neuropeptide Y2 Receptor in Bilayer Membranes (Angew. Chem. Int. Ed. 52/2020) https://doi.org/10.1002/anie.202014454.

Laugwitz JM, Haeri HH, Kaiser A, Krug U, Hinderberger D, Beck-Sickinger AG, Schmidt P. Probing the Y2 Receptor on Transmembrane, Intra- and Extra-Cellular Sites for EPR Measurements. Molecules. 2020 Sep 10;25(18):4143. doi: 10.3390/molecules25184143. PMID: 32927734; PMCID: PMC7571237.

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Schulze A, Kleinau G, Neumann S, Scheerer P, Schöneberg T, Brüser A. The intramolecular agonist is obligate for activation of glycoprotein hormone receptors. FASEB J. 2020 Jul 10. doi: 10.1096/fj.202000100R. Epub ahead of print. PMID: 32648604

Vogel A, Bosse M, Gauglitz M, Wistuba S, Schmidt P, Kaiser A, Gurevich VV, Beck-Sickinger AG, Hildebrand PW, Huster D. The Dynamics of the Neuropeptide Y Receptor Type 1 Investigated by Solid-State NMR and Molecular Dynamics Simulation. Molecules. 2020 Nov 24;25(23):5489. doi: 10.3390/molecules25235489. PMID: 33255213; PMCID: PMC7727705.