Publications of the SFB1423
Numerous publications have been produced within the framework of the SFB1423, which you will find below. The bibliographic information is linked to Pubmed or doi.org.
Project-relevant publications within the SFB1423 are labled with the following text module: “[author/s] acknowledge funding by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) through SFB1423, project number 421152132, subproject [number/s].”
Aydin Y, Coin I. Genetically encoded crosslinkers to address protein-protein interactions. Protein Sci. 2023; 32:e4637.
Aydin Y, Böttke T, Lam JH, Ernicke S, Fortmann A, Tretbar M, Zarzycka B, Gurevich VV, Katritch V, Coin I. Structural details of a Class B GPCR-arrestin complex revealed by genetically encoded crosslinkers in living cells. Nat Commun. 2023; 14:1151.
Engelberger F, Zakary JD, Künze G. Guiding Protein Design Choices by Per-Residue Energy Breakdown Analysis with an Interactive Web Application. Front Mol Biosci. 2023; 10.
Entsie P, Kang Y, Amoafo EB, Schöneberg T, Liverani E. The Signaling Pa-thway of the ADP Receptor P2Y12 in the Immune System: Recent Discoveries and New Challenges. Int J Mol Sci. 2023; 24:6709.
Frenster JD, Erdjument-Bromage H, Liu W, Stephan G, Ravn-Boess N, Bready D, Wilcox J, Kieslich B, Jankovic M, Wilde C, Horn S, Sträter N, Liebscher I, Schöneberg T, Fenyo D, Neubert TA, Placantonakis DG. PTK7 is a positive allosteric modulator of GPR133 (ADGRD1) signaling in GBM. bioRxiv. 2022.06. 15.496232.
Gupta A, Krupa P, Engberg O, Krupa M, Chaudhary A, Li MS, Huster D, Maiti S. Unusual Robustness of Neurotransmitter Vesicle Membranes against Serotonin-Induced Perturbations. J Phys Chem B. 2023 Mar 9;127(9):1947-1955.
Heng J, Hu Y, Pérez-Hernández G, Inoue A, Zhao J, Ma X, Sun X, Kawakami K, Ikuta T, Ding J, Yang Y, Zhang L, Peng S, Niu X, Li H, Guixà-González R, Jin C, Hildebrand PW, Chen C, Kobilka BK. Function and dynamics of the intrinsically disordered carboxyl terminus of β2 adrenergic receptor. Nat Commun. 2023 Apr 10;14(1):2005.
Koehler Leman J, Künze G. Recent Advances in NMR Protein Structure Pre-diction with ROSETTA. Int J Mol Sci. 2023; 24:7835.
Künze G, Isermann B. Targeting biased signaling by PAR1: Function and molecular mechanism of parmodulins. Blood. 2023 Mar 23:blood.2023019775.
Ledwitch KV, Künze G, McKinney JR, Okwei E, Larochelle K, Pankewitz L, Ganguly S, Darling HL, Coin I, Meiler J. Sparse pseudocontact shift NMR data obtained from a non-canonical amino acid-linked lanthanide tag improves integral membrane protein structure prediction. J Biomol NMR. 2023 Apr 4.
Liessmann F, Künze G, Meiler J. Improving the Modeling of Extracellular Lig-and Binding Pockets in RosettaGPCR for Conformational Selection. Int J Mol Sci. 2023; 24:7788.
Marlow B, Kuenze G, Meiler J, Koehler Leman J. Docking cholesterol to integ-ral membrane proteins with Rosetta. PLoS Comput Biol. 2023; 19:e1010947.
Matúš D, Groß VE, Fiedler F, Post WB, Knierim AB, Schön JL, Schöneberg T, Prömel S. The N terminus-only (trans) function of the Adhesion GPCR Latrophilin-1 controls multiple processes in reproduction of C. elegans. bioRxiv. 2023.02.18.529090.
Okwei E, Smith ST, Bender BJ, Allison B, Ganguly S, Geanes A, Zhang X, Ledwitch K, Meiler J. Rosetta’s Predictive Ability for Low-Affinity Ligand Binding in Fragment-Based Drug Discovery. Biochemistry. 2023 Jan 10. doi: 10.1021/acs.biochem.2c00649. Online ahead of print. PMID: 36626571
Pohl F, Seufert F, Chung Y, Volke D, Hoffmann R, Schöneberg T, Langenhan T, Hildebrand P, Sträter N. Structural basis of GAIN domain autoproteolysis and cleavage-resistance in the adhesion G-protein coupled receptors. bioRxiv. 2023.03.12.532270.
Sala D, Batebi H, Ledwitch K, Hildebrand PW, Meiler J. Targeting in silico GPCR conformations with ultra-large library screening for hit discovery. Trends Pharmacol Sci. 2023; 44:150-61.
Sala D, Hildebrand PW, Meiler J. Biasing AlphaFold2 to predict GPCRs and Kinases with user-defined functional or structural properties. Front Mol Biosci. 2023; 10:1121962.
Schmidt P, Vogel A, Schwarze B, Seufert F, Licha K, Wycisk V, Kilian W, Hildebrand PW, Mitschang L. Towards Probing Conformational States of Y2 Receptor Using Hyperpolarized 129Xe NMR. Molecules. 2023; 28(3):1424.
Scholz N, Dahse AK, Kemkemer M, Bormann A, Auger GM, Vieira Contreras F, Ernst LF, Staake H, Körner MB, Buhlan M, Meyer-Mölck A, Chung YK, Blanco-Redondo B, Klose F, Jarboui MA, Ljaschenko D, Bigl M, Langenhan T. Molecular sensing of mechano- and ligand-dependent adhesion GPCR dissociation. Nature. 2023; doi: 10.1038/s41586-023-05802-5. Online ahead of print.
Staritzbichler R, Ristic N, Stapke T, Hildebrand P. SmoothT – a server constructing low energy pathways from conformational ensembles for interactive visualization and enhanced sampling. Bioinformatics. 2023 Apr 5:btad176.
Streit M, Hemberger M, Häfner S, Knote F, Langenhan T, Beliu G. Optimized genetic code expansion technology for time-dependent induction of adhesion GPCR-ligand engagement. Protein Sci. 2023 Apr;32(4):e4614.
Tänzler D, Kipping M, Lederer M, Günther WF, Arlt C, Hüttelmaier S, Merkenschlager A, Sinz A. Effects of theophylline on ADCY5 activation-From cellular studies to improved therapeutic options for ADCY5-related dyskinesia patients. PLoS One. 2023 Mar 3;18(3):e0282593.
Woods H, Schiano DL, Aguirre JI, Ledwitch KV, McDonald EF, Voehler M, Meiler J, Schoeder CT. Computational modeling and prediction of deletion mutants. Structure. 2023; S0969-2126(23)00128-4.
Anton SE, Kayser C, Maiellaro I, Nemec K, Möller J, Koschinski A, Zaccolo M, Annibale P, Falcke M, Lohse MJ, Bock A. Receptor-associated independent cAMP nanodomains mediate spatiotemporal specificity of GPCR signaling. Cell. 2022 Mar 31;185(7):1130-1142.e11. doi: 10.1016/j.cell.2022.02.011. Epub 2022 Mar 15. PMID: 35294858.
Boltz HH, Sirbu A, Stelzer N, de Lanerolle P, Winkelmann S, Annibale P. The Impact of Membrane Protein Diffusion on GPCR Signaling. Cells. 2022 May 17;11(10):1660. doi: 10.3390/cells11101660. PMID: 35626696
Brown BP, Vu O, Geanes AR, Kothiwale S, Butkiewicz M, Lowe EW Jr, Mueller R, Pape R, Mendenhall J, Meiler J. Introduction to the BioChemical Library (BCL): An Application-Based Open-Source Toolkit for Integrated Cheminformatics and Machine Learning in Computer-Aided Drug Discovery. Front Pharmacol. 2022 Feb 21;13:833099. doi: 10.3389/fphar.2022.833099. PMID: 35264967; PMCID: PMC8899505.
Catar R, Herse-Naether M, Zhu N, Wagner P, Wischnewski O, Kusch A, Kamhieh-Milz J, Eisenreich A, Rauch U, Hegner B, Heidecke H, Kill A, Riemekasten G, Kleinau G, Scheerer P, Dragun D, Philippe A. Autoantibodies Targeting AT1- and ETA-Receptors Link Endothelial Proliferation and Coagulation via Ets-1 Transcription Factor. Int J Mol Sci. 2022, 23, 244. doi: 10.3390/ijms23010244. PMID: 35008670.
Canzler S, Fischer M, Ulbricht D, Ristic N, Hildebrand PW, Staritzbichler R. ProteinPrompt: a webserver for predicting protein–protein interactions. Bioinformatics Advances, Volume 2, Issue 1, 2022, vbac059, https://doi.org/10.1093/bioadv/vbac059.
Del Alamo D, Sala D, Mchaourab HS, Meiler J. Sampling alternativev conformational states of transporters and receptors with AlphaFold2. eLife. 2022;11:e75751 DOI: 10.7554/eLife.75751.
Engberg O, Bocicchio A, Brandner AF, Gupta A, Dey S, Maiti S, Böckmann RA, Huster D. Serotonin alters the phase equilibrium of a ternary mixture of phospholipids and cholesterol. Front Physiol. 2022. 11:578868.
Gmach P, Bathe-Peters M, Telugu N, Miller DC, Annibale P. Fluorescence Spectroscopy of Low-Level Endogenous β-Adrenergic Receptor Expression at the Plasma Membrane of Differentiating Human iPSC-Derived Cardiomyocytes. Int J Mol Sci. 2022 Sep 8;23(18):10405. doi:10.3390/ijms231810405. PMID: 36142320; PMCID: PMC9499492.
Götze KJ, Mrestani A, Beckmann P, Krohn K, Le Duc D, Velluva A, Böhme MA, Heckmann M, Abou Jamra R, Lemke JR, Bläker H, Scholz N, Ljaschenko D, Langenhan T. Improving one-step scarless genome editing in Drosophila melanogaster by combining ovoD co-CRISPR selection with sgRNA target site masking. Biol Methods Protoc. 2022 Jan 12;7(1):bpac003. doi: 10.1093/biomethods/bpac003. PMID: 35087953; PMCID: PMC8789338.
Höpfner F, Paisdzior S, Reininghaus N, Sohail I, Scheerer P, Annibale P, Biebermann H, Kühnen P. Evaluation of pharmacological rescue of Melanocortin-4 receptor nonsense mutations by aminoglycoside. Life. 2022; 12(11):1793.
Knapp B, Roedig J, Roedig H, Krzysko J, Horn N, Güler BE, Kusuluri DK, Yildirim A, Boldt K, Ueffing M, Liebscher I, Wolfrum U. Affinity Proteomics Identifies Interaction Partners and Defines Novel Insights into the Function of the Adhesion GPCR VLGR1/ADGRV1. Molecules. 2022; 27:3108.
Kühnen P, Biebermann H, Wiegand S. Pharmacotherapy in Childhood Obesity. Horm Res Paediatr. 2022; 95:177-192.
Kühnen P, Clément K. Long-Term MC4R Agonist Treatment in POMC-Deficient Patients. N Engl J Med. 2022; 387:852-854.
Philippe A, Kleinau G, Gruner JJ, Wu S, Postpieszala D, Speck D, Heidecke H, Dowell SJ, Riemekasten G, Hildebrand PW, Kamhieh-Milz J, Catar R, Szczepek M, Dragun D, Scheerer P. Molecular Effects of Auto-Antibodies on Angiotensin II Type 1 Receptor Signaling and Cell Proliferation. Int J Mol Sci. 2022 Apr 2;23(7):3984. doi: 10.3390/ijms23073984. PMID: 35409344.
Ping YQ, Xiao P, Yang F, Zhao RJ, Guo SC, Yan X, Wu X, Zhang C, Lu Y, Zhao F, Zhou F, Xi YT, Yin W, Liu FZ, He DF, Zhang DL, Zhu ZL, Jiang Y, Du L, Feng SQ, Schöneberg T, Liebscher I, Xu HE, Sun JP. Structural basis for the tethered peptide activation of adhesion GPCRs. Nature. 2022 Apr;604(7907):763-770. doi: 10.1038/s41586-022-04619-y. Epub 2022 Apr 13. PMID: 35418678. https://doi.org/10.1038/s41586-022-04619-y.
Reinhard F, Stadler PF. ExceS-A: An Exon-Centric Split Aligner. JIB. 2022; pp. 20210040.
Reininghaus N, Paisdzior S, Höpfner F, Jyrch S, Cetindag C, Scheerer P, Kühnen P, Biebermann H. A Setmelanotide-like Effect at MC4R Is Achieved by MC4R Dimer Separation. Biomolecules. 2022 Aug 15;12(8):1119. doi: 10.3390/biom12081119. PMID: 36009013.
Rudolf S, Kaempf K, Vu O, Meiler J, Beck-Sickinger AG, Coin I. Binding of Natural Peptide Ligands to the Neuropeptide Y5 Receptor. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202108738. doi: 10.1002/anie.202108738. PMID:34822209.
Sala D, Del Alamo D, Mchaourab HS, Meiler J. Modeling of protein conformational changes with Rosetta guided by limited experimental data. Structure. 2022 May 12:S0969-2126(22)00140-X. doi: 10.1016/j.str.2022.04.013. Online ahead of print. PMID: 35597243.
Schaller D, Lafond M, Stadler PF, Wieseke N, Hellmuth M. Indirect identification of horizontal gene transfer. Journal of Mathematical
Biology volume 83, Article number: 10 (2021). https://doi.org/10.1007/s00285-021-01631-0.
Schulze AS, Kleinau G, Krakowsky R, Rochmann D, Das R, Worth CL, Krumbholz P, Scheerer P, Stäubert C. Evolutionary analyses reveal immune cell receptor GPR84 as a conserved receptor for bacteria-derived molecules. iScience. 2022 Sep 6;25(10):105087. doi: 10.1016/j.isci.2022.105087. eCollection 2022 Oct 21. PMID: 36164652.
Smith AA, Vogel A, Engberg O, Hildebrand PW, Huster D. A method to construct the dynamic landscape of a bio-membrane with experiment and simulation. Nat Commun. 2022 Jan 10;13(1):108. doi: 10.1038/s41467-021-27417-y. PMID: 35013165; PMCID: PMC8748619.
Speck D, Kleinau G, Szczepek M, Kwiatkowski D, Catar R, Philippe A, Scheerer P. Angiotensin and Endothelin Receptor Structures With Implications for Signaling Regulation and Pharmacological Targeting. Front Endocrinol (Lausanne). 2022 Apr 19;13:880002. doi: 10.3389/fendo.2022.880002 [Titel anhand dieser DOI in Citavi-Projekt übernehmen] . eCollection 2022. PMID: 35518926.
Speck D, Kleinau G, Meininghaus M, Erbe A, Einfeldt A, Szczepek M, Scheerer P, Pütter V. Expression and Characterization of Relaxin Family Peptide Receptor 1 Variants. Front Pharmacol. 2022 Jan 28;12:826112. doi: 10.3389/fphar.2021.826112. eCollection 2021. PMID: 35153771 Free PMC article.
Stadler PF, Will S. Bi-alignments with affine gaps costs. Algorithms Mol Biol. 2022 May 16;17(1):10. doi: 10.1186/s13015-022-00219-7. PMID: 35578255.
Staritzbichler R, Yaklich E, Sarti E, Ristic N, Hildebrand PW, Forrest LR. AlignMe: an update of the web server for alignment of membrane protein sequences. Nucleic Acids Res. 2022 May 24:gkac391. doi: 10.1093/nar/gkac391. Online ahead of print. PMID: 35609986
Stephan G, Frenster JD, Liebscher I, Placantonakis DG. Activation of the adhesion G protein-coupled receptor GPR133 (ADGRD1) by antibodies targeting its N-terminus. J Biol Chem. 2022 Apr 18:101949. doi: 10.1016/j.jbc.2022.101949. Online ahead of print. PMID: 35447113.
Tang T, Tan Q, Han S, Diemar A, Löbner K, Wang H, Schüß C, Behr V, Mörl K, Wang M, Chu X, Yi C, Keller M, Kofoed J, Reedtz-Runge S, Kaiser A, Beck-Sickinger AG, Zhao Q, Wu B. Receptor-specific recognition of NPY peptides revealed by structures of NPY receptors. Sci Adv. 2022 May 6;8(18):eabm1232. doi: 10.1126/sciadv.abm1232. Epub 2022 May 4. PMID: 35507650; PMCID: PMC9067930.
Ubbiali D, Fratini M, Piersimoni L, Ihling C, Kipping M, Heilmann I, Iacobucci C, Sinz A. Direct Observation of ‘Elongated’ Conformational States in α-Synuclein upon Liquid-Liquid Phase Separation. Angew Chem Int Ed Engl. 2022 Sep 17. doi: 10.1002/anie.202205726. Online ahead of print. PMID: 36115020.
Voss M, Kleinau G, Gimber N, Janek K, Bredow C, Thery F, Impens F, Schmoranzer J, Scheerer P, Kloetzel PM, Beling A. A cytosolic disulfide bridge-supported dimerization is crucial for stability and cellular distribution of Coxsackievirus B3 protein 3A. FEBS J. 2022 Jul;289(13):3826-3838. doi: 10.1111/febs.16368. Epub 2022 Feb 11. PMID: 35066984.
Vu O, Bender BJ, Pankewitz L, Huster S, Beck-Sickinger AG, Meiler J. The structural basis of peptide binding at class A G protein-coupled receptors. Molecules. 2022. 27:210.
Wei AAJ, Iacobucci C, Schultze W, Ihling CH, Arlt C, Sinz A. Different Oligomeric States of the Tumor Suppressor p53 Show Identical Binding Behavior towards the S100β Homodimer. Chembiochem. 2022 Jun 3;23(11):e202100665. doi: 10.1002/cbic.202100665. Epub 2022 Apr 13. PMID: 35333001.
Wilde C, Mitgau J, Suchý T, Schoeneberg T, Liebscher I. Translating the Force – mechano-sensing GPCRs. Am J Physiol Cell Physiol. 2022 Apr 13. doi: 10.1152/ajpcell.00465.2021. Online ahead of print. PMID: 35417266 Review.
Yang Y, Stensitzki T, Sauthof L, Schmidt A, Piwowarski P, Velazquez Escobar F, Michael N, Nguyen AD, Szczepek M, Brünig FN, Netz RR, Mroginski MA, Adam S, Bartl F, Schapiro I, Hildebrandt P, Scheerer P, Heyne K. Ultrafast proton-coupled isomerization in the phototransformation of phytochrome. Nat Chem. 2022 May 16. doi: 10.1038/s41557-022-00944-x. Online ahead of print. PMID: 35577919.
Zimmermann A, Vu O, Brüser A, Sliwoski G, Marnett LJ, Meiler J, Schöneberg T. Mapping the Binding Sites of UDP and Prostaglandin E2 Glyceryl Ester in the Nucleotide Receptor P2Y6. ChemMedChem. 2022, e202100683.
Bathe-Peters M, Gmach P, Boltz HH, Einsiedel J, Gotthardt M, Hübner H, Gmeiner P, Lohse MJ, Annibale P. Visualization of β-adrenergic receptor dynamics and differential localization in cardiomyocytes. Proc Natl Acad Sci U S A. 2021 Jun 8;118(23):e2101119118. doi: 10.1073/pnas.2101119118. PMID: 34088840.
Bender BJ, Bock A, Nesheva DN, Perry-Hauser NA. Viewpoints on the First Transatlantic GPCR Symposium for Early-Career Investigators. ACS Pharmacol Transl Sci. 2021 Sep 23;4(5):1705-1711. doi: 10.1021/acsptsci.1c00203. PMID: 34661085; PMCID: PMC8506598.
Berndt S, Liebscher I. New Structural Perspectives in G Protein-Coupled Receptor-Mediated Src Family Kinase Activation. Int J Mol Sci. 2021 Jun 17;22(12):6489. doi: 10.3390/ijms22126489. PMID: 34204297; PMCID: PMC8233884.
Bock A, Bermudez M. Allosteric coupling and biased agonism in G protein-coupled receptors. FEBS J. 2021 Feb 23. doi: 10.1111/febs.15783. Epub ahead of print. PMID: 33621418.
Beliu G, Altrichter S, Guixà-González R, Hemberger M, Brauer I, Dahse AK, Scholz N, Wieduwild R, Kuhlemann A, Batebi H, Seufert F, Pérez-Hernández G, Hildebrand PW, Sauer M, Langenhan T. Tethered agonist exposure in intact adhesion/class B2 GPCRs through intrinsic structural flexibility of the GAIN domain. Mol Cell. 2021 Mar 4;81(5):905-921.e5. doi: 10.1016/j.molcel.2020.12.042. Epub 2021 Jan 25.
Boltz HH, Sirbu A, Stelzer N, Lohse MJ, Schütte C, Annibale P. Quantitative spectroscopy of single molecule interaction times. Opt Lett. 2021; 46:1538-1541. https://doi.org/10.1364/OL.413030
Chen J, Bi H, Pettersson ME, Sato DX, Fuentes-Pardo AP, Mo C, Younis S, Wallerman O, Jern P, Molés G, Gómez A, Kleinau G, Scheerer P, Andersson L. Functional differences between TSHR alleles associate with variation in spawning season in Atlantic herring. Commun Biol. 2021 Jun 25;4(1):795. doi: 10.1038/s42003-021-02307-7. PMID: 34172814.
Del Alamo D, Jagessar KL, Meiler J, Mchaourab HS. Methodology for rigorous modeling of protein conformational changes by Rosetta using DEER Distance Restraints. PLoS Comput Biol. 2021 Jun 16;17(6):e1009107. doi: 10.1371/journal.pcbi.1009107. Online ahead of print. PMID: 34133419.
Dey S, Surendran D, Engberg O, Gupta A, Fanibunda SE, Das A, Maity BK, Dey A, Visvakarma V, Kallianpur M, Scheidt HA, Walker G, Vaidya VA, Huster D, Maiti S. Altered Membrane Mechanics Provides a Receptor-Independent Pathway for Serotonin Action. Chemistry. 2021 May 12;27(27):7533-7541. doi: 10.1002/chem.202100328. Epub 2021 Mar 12. PMID: 33502812.
Frenster JD, Stephan G, Ravn-Boess N, Bready D, Wilcox J, Kieslich B, Wilde C, Sträter N, Wiggin GR, Liebscher I, Schöneberg T, Placantonakis DG. Functional impact of intramolecular cleavage and dissociation of adhesion G protein-coupled receptor GPR133 (ADGRD1) on canonical signaling. J Biol Chem. 2021 May 19:100798. doi: 10.1016/j.jbc.2021.100798. Epub ahead of print. PMID: 34022221.
Gershkovich MM, Groß VE, Vu O, Schoeder CT, Meiler J, Prömel S, Kaiser A. Structural Perspective on Ancient Neuropeptide Y-like System reveals Hallmark Features for Peptide Recognition and Receptor Activation. J Mol Biol. 2021 Apr 16;433(13):166992. doi: 10.1016/j.jmb.2021.166992. Epub ahead of print. PMID: 33865871.
Graffunder AS, Paisdzior S, Opitz R, Renko K, Kühnen P, Biebermann H. Design and Characterization of a Fluorescent Reporter Enabling Live-cell Monitoring of MCT8 Expression. Exp Clin Endocrinol Diabetes. 2021 Aug 5. doi: 10.1055/a-1522-8535. Online ahead of print. PMID: 34352913.
Heyder NA, Kleinau G, Speck D, Schmidt A, Paisdzior S, Szczepek M, Bauer B, Koch A, Gallandi M, Kwiatkowski D, Bürger J, Mielke T, Beck-Sickinger A, Hildebrand P, Spahn CMT, Hilger D, Schacherl M, Biebermann H, Hilal T, Kühnen P, Kobilka BK, Scheerer P. Structures of active melanocortin-4 receptor−Gs-protein complexes with NDP-α-MSH and setmelanotide. Cell Research. 2021, 31(11):1176-1189. doi: 10.1038/s41422-021-00569-8. PMID: 34561620.
Hong TI, Hwang KS, Choi TI, Kleinau G, Scheerer P, Bang JK, Jung SH, Kim CH. Zebrafish Bioassay for Screening Therapeutic Candidates Based on Melanotrophic Activity. Int J Mol Sci. 2021; 22:9313. https://doi.org/10.3390/ijms22179313.
Işbilir A, Serfling R, Möller J, Thomas R, De Faveri C, Zabel U, Scarselli M, Beck-Sickinger AG, Bock A, Coin I, Lohse MJ, Annibale P. Determination of G-protein–coupled receptor oligomerization by molecular brightness analyses in single cells. Nat Protoc. 2021. https://doi.org/10.1038/s41596-020-00458-1.
Li B, Mendenhall J, Capra JA, Meiler J. A Multitask Deep-Learning Method for Predicting Membrane Associations and Secondary Structures of Proteins. J Proteome Res. 2021 Jul 8. doi: 10.1021/acs.jproteome.1c00410. Epub ahead of print. PMID: 34236204.
Matús D, Post WB, Horn S, Schöneberg T, Prömel S. Latrophilin-1 drives neuron morphogenesis and shapes chemo- and mechanosensation-dependent behavior in C. elegans via a trans function. Biochem Biophys Res Commun. 2021 Dec 5;589:152-158. doi: 10.1016/j.bbrc.2021.12.006. Online ahead of print. PMID: 34922196.
Piersimoni L, Kastritis PL, Arlt C, Sinz A. Cross-Linking Mass Spectrometry for Investigating Protein Conformations and Protein-Protein Interactions – A Method for All Seasons. Chemical Reviews Article ASAP. 2021. DOI: 10.1021/acs.chemrev.1c00786.
Schöneberg T, Liebscher I. Mutations in G Protein–Coupled Receptors: Mechanisms, Pathophysiology and Potential Therapeutic Approaches. Pharamcological Reviews. 2021; 73:89-119. doi: https://doi.org/10.1124/pharmrev.120.000011.
Smolič T, Tavčar P, Horvat A, Černe U, Halužan Vasle A, Tratnjek L, Kreft ME, Scholz N, Matis M, Petan T, Zorec R, Vardjan N. Astrocytes in stress accumulate lipid droplets. Glia. 2021 Feb 20. doi: 10.1002/glia.23978. Epub ahead of print. PMID: 33609060. https://doi.org/10.1002/glia.23978.
Staritzbichler R, Ristic N, Goede A, Preissner R, Hildebrand PW. Voronoia 4-ever. Nucleic Acids Res. 2021 Jun 9:gkab466. doi: 10.1093/nar/gkab466. Epub ahead of print. PMID: 34107038.
Suchý T, Kaczmarek I, Maricic T, Zieschang C, Schöneberg T, Thor D, Liebscher I. Evaluating the feasibility of Cas9 overexpression in 3T3-L1 cells for generation of genetic knock-out adipocyte cell lines. Adipocyte. 2021 Dec;10(1):631-645. doi: 10.1080/21623945.2021.1990480. PMID: 34915813.
Tang T, Hartig C, Chen Q, Zhao W, Kaiser A, Zhang X, Zhang H, Qu H, Yi C, Ma L, Han S, Zhao Q, Beck-Sickinger AG, Wu B. Structural basis for ligand recognition of the neuropeptide Y Y2 receptor. Nat Commun. 2021 Feb 2;12(1):737. doi: 10.1038/s41467-021-21030-9. PMID: 33531491; PMCID: PMC7854658.
Vu O, Bender BJ, Pankewitz L, Huster D, Beck-Sickinger AG, Meiler J. The Structural Basis of Peptide Binding at Class A G Protein-Coupled Receptors. Molecules. 2021 Dec 30;27(1):210. doi:10.3390/molecules27010210. PMID: 35011444 Review.
Wallach T, Mossmann ZJ, Szczepek M, Wetzel M, Machado R, Raden M, Miladi M, Kleinau G, Krüger C, Dembny P, Adler D, Zhai Y, Kumbol V, Dzaye O, Schüler J, Futschik M, Backofen R, Scheerer P, Lehnardt S. MicroRNA-100-5p and microRNA-298-5p released from apoptotic cortical neurons are endogenous Toll-like receptor 7/8 ligands that contribute to neurodegeneration. Mol Neurodegener. 2021 Nov 27;16(1):80. doi:10.1186/s13024-021-00498-5. PMID: 34838071.
Wanka L, Behr V, Beck-Sickinger AG. Arrestin-dependent internalization of rhodopsin-like G protein-coupled receptors. Biol Chem. 2021 May 26. doi: 10.1515/hsz-2021-0128. Epub ahead of print. PMID: 34036761.
Wittlake A, Prömel S, Schöneberg T. The Evolutionary History of Vertebrate Adhesion GPCRs and Its Implication on Their Classification. Int J Mol Sci. 2021 Oct 30;22(21):11803. doi: 10.3390/ijms222111803. PMID: 34769233; PMCID: PMC8584163.
Wolf P, Mohr A, Gavins G, Behr V, Mörl K, Seitz O, Beck-Sickinger AG. Orthogonal Peptide-Templated Labeling Elucidates Lateral ETA R/ETB R Proximity and Reveals Altered Downstream Signaling. Chembiochem. 2021 Oct 26. doi: 10.1002/cbic.202100340. Epub ahead of print. PMID: 34699123.
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