Twice a year all members of the SFB1423 meet for a retreat to discuss the progress of the project.

>> short news here 

Prof. Dr. Heike Biebermann and Prof. Dr. Peter Kühnen will give a talk about there research group and the main research topics. 

More information + registration here … 

https://research.uni-leipzig.de/sfb1423/graduate-school/ 

Prof. Dr. Evi Kostenis will give a talk within the SFB1423 lecturer series.

Title: “FR900359: nature’s weapon and treasure trove for basic and translational research”

Venue (hybrid):
Small Lecture hall (225, 2 floor),  Institute of Biochemistry, Brüderstraße 34, 04103 Leipzig (3-G rules, capacity: 37 persons)

Zoom-Meeting: https://uni-leipzig.zoom.us/j/63731717253?pwd=dFcrdmxPNkFKd1FLa1JNM2JtY29NUT09 (Meeting-ID: 637 3171 7253, Kenncode: 384580)

We are pleased to welcome Franziska Heydenreich, PhD, from the MRC Laboratory of Molecular Biology, Cambridge, UK, to give her talk:

“Molecular origins and principles governing adrenaline efficacy and potency in the human β2-adrenergic receptor.”

Please dial-in via Zoom link:
https://uni-leipzig.zoom.us/j/63731717253?pwd=dFcrdmxPNkFKd1FLa1JNM2JtY29NUT09

(Meeting-ID: 637 3171 7253; Code: 384580)

We look forward to seeing you!

Scientific Module “Drosophila as an in vivo model in GPCR research”

This three day module consits of lectures and practical courses and covers the following topics:

• Classical discoveries concerning signal transduction made with animal models: TRP channels, olfactory receptors, EGF pathway, circadian cycle, apoptosis

• Molecular methods for Drosophila research: CRISPR/Cas9, GAL4/UAS, RNAi, MIMIC

• Drosophila as model to study pathologies – chances and limitations

Registration via email to Juliane Adler

Dr. Paolo Annibale will give a talk about his research group and the main research topics. 

Please feel invited to join our next SFB1423 lecture:

Dr. Matthias Elgeti (University of California, Los Angeles & Leipzig University, Germany) 

Title “New biomolecular EPR lab in Leipzig”

Via Zoom:

Zoom-Meeting beitreten
https://uni-leipzig.zoom.us/j/63731717253?pwd=dFcrdmxPNkFKd1FLa1JNM2JtY29NUT09

Meeting-ID: 637 3171 7253
Kenncode: 384580

Please feel invited to join our next SFB1423 lecture:

Prof. Dr. Andreas Thum (Leipzig University, Faculty Life Sciences) 

Title “From connectome to behavior to GPCR signaling: an analysis using the Drosophila larval model organism.”

Via Zoom:
https://uni-leipzig.zoom.us/j/63731717253?pwd=dFcrdmxPNkFKd1FLa1JNM2JtY29NUT09

Meeting-ID: 637 3171 7253
Code: 384580

Please feel invited to join our next SFB1423 lecture:

Prof. Dr. Erkan Karakas (Vanderbilt University, Department
of Molecular Physiology and Biophysics)

Titel: 
“Structural basis for activation and gating of IP3 receptor calcium channels”

The lecture will be held via Zoom:
https://uni-leipzig.zoom.us/j/63261926503?pwd=cEwzSGVxYTJzY29NQUFscTd2OGtzZz09

Please feel invited to join our next SFB1423 lecture:

Dr. Christina Lamers (Department of Pharmaceutical Sciences, University of Basel, Switzerland)

Titel: 
“Chemically modified phage display to discover macrocyclic peptides.“

The lecture will be held via Zoom:
https://uni-leipzig.zoom.us/j/63731717253?pwd=dFcrdmxPNkFKd1FLa1JNM2JtY29NUT09

Meeting-ID: 637 3171 7253
Code: 384580

Please feel invited to join our next SFB1423 lecture:

Prof. Dr. Hassane Mchaourab (Vanderbilt University, Department
of Molecular Physiology and Biophysics)

Titel:
“EPR in the age of cryoEM: Two recent stories.”

The lecture will be held via Zoom:
https://uni-leipzig.zoom.us/j/63261926503?pwd=cEwzSGVxYTJzY29NQUFscTd2OGtzZz09

14:00 – 15:00
Woman in Science – Professional Career Insight:
Dr. Steffi Marung (Leipzig University, Global and European Studies)

15:00 – 17:00
Networking for Young Female Researchers
Siofra McSherry (Scienza Science Coaching Berlin)

It is widespread consensus that networking skills are a vital ingredient in a successful academic career. Yet, we rarely talk about the gender-specific challenges that female researchers face in this area. The workshop will interactively elaborate on the issue and help develop approaches to action.

Link:
https://research.uni-leipzig.de/sfb1423/pooling-gender-workshop-2021/

We present our Collaborativ Research Center during the annual DIES ACADEMICUS 2021 at Leipzig University.

>> Program overview

14:00 – 15:00
Woman in Science – Professional Career Insight:
Dr. Dr. Diana Le Duc (Leipzig University, Human Genetics)

15:00 – 17:00
Equal Opportunities in Academic Teaching
Melanie Bittner (Toolbox Gender&Diversity in Academic Teaching at FU Berlin)

Student diversity is part of the reality of everyday university life. However, there are still inequalities based on race, class, gender and other social categories in higher education. What does this mean for your courses? How can you create a space that considers the diversity of students as positive value and actively contributes to equal opportunities for all students?  This interactive presentation will focus on the reflection of inequality in higher education as well as hands-on-advice for academic teaching.

Link:
https://research.uni-leipzig.de/sfb1423/pooling-gender-workshop-2021/

Title: Project Management for Scientists & Researchers (Classic&Agile)

Registration:
https://research.uni-leipzig.de/sfb1423/graduate-school/

14:00 – 15:00
Woman in Science – Professional Career Insight:
Dr. Rima Chakaroun (Universitätsklinikum Leipzig, Nephrology)

15:00 – 17:00
Job Application Training & Tips
Dr. Matthias Schwarzkopf (Coaching and Training)

The workshop will aim to inform participants about the main challenges of writing applications for jobs in science. Furthermore, questions are answered: What are the “standard documents”?  What information should I get in advance?  Why am I relevant to the job – developing your own visibility.

Link:
https://research.uni-leipzig.de/sfb1423/pooling-gender-workshop-2021/

14:00 – 15:00
Woman in Science – Professional Career Insight:
Prof. Dr. Dr. Ines Liebscher (Leipzig University, Medical Faculty)

15:00 – 17:00
Gender Bias: How to act!
Sven Goglin (Goglin Science Management)

In practice, despite equality concepts, equality officers, support measures and an increased awareness of the need for equal opportunities, there are still hurdles and a need for action. In the workshop, the participants will be informed and encouraged to exchange information about the following: What gender biases exist at universities and how do they work? Which barriers do especially young female scientists face at universities? Which options for action/good practices have proven successful.

Link:
https://research.uni-leipzig.de/sfb1423/pooling-gender-workshop-2021/

Title: Time- and Self-management in Academia (Part II)

Registration:
https://research.uni-leipzig.de/sfb1423/graduate-school/

Prof. Dr. Tobias Langenhan and Dr. Nicole Scholz will give a talk about their research field. 

Title: Time- and Self-management in Academia (Part I)

Registration:
https://research.uni-leipzig.de/sfb1423/graduate-school/

Prof. Dr. Annette Beck-Sickinger and Dr. Anette Kaiser will give a talk about new research findings. 

Twice a year all members of the SFB1423 meet for a retreat to discuss the progress of the project. 

This years summerschool will take place in presence. Please find more information here: https://research.uni-leipzig.de/sfb1423/graduate-school/ 

Know your Competencies – find your job and your career: Industry

Please find more information here: https://research.uni-leipzig.de/sfb1423/graduate-school/ 

We cordially invite you to a one week block online seminar “Exploring Biomolecules in 3D: Principles and Applications of Computational Structural Biology” by:

Prof. Dr. Jens Meiler
(Leipzig University, Coordinator)
Dr. Georg Künze
(Leipzig University)
Prof. Dr. Jarrod Smith
(Vanderbilt University / USA)
Prof. Dr. Rocco Moretti
(Vanderbilt University / USA)

DATE
16 – 20. August 2021, 8 a.m. – 3 p.m. CEST (15:00 – 22:00 Uhr Leipzig, 13.08.2021 technical setup)

Registration and Program:
https://research.uni-leipzig.de/vanderbilt/16-20-08-2021-module-exploring-biomolecules-in-3d-principles-and-applications-of-computational-structural-biology/ 

Friederike Höpfner and Nina Reininghaus will give a talk about their research.

The “Long Night of the Sciences” will take place digitally on Friday, 16 July 2021. The SFB1423 is participating with a contribution (in german language):

click here to watch the video:
GPCRs – Wir wollen wissen wie sie funktionieren.

G-Protein-gekoppelte Rezeptoren (GPCR) sind lebenswichtige Bausteine im menschlichen Körper. Ohne sie können Lebewesen weder riechen noch sehen; die Signalüber­tragung im Gehirn bräche zusammen und unser Körper könnte den Blutdruck nicht regulieren. Der SFB1423 erforscht diese Rezeptoren und schaut sich der Wirkungsweise ganz genau an. Wir stellen unser Forschungsthema vor und nehmen GPCRs unter die Lupe. 

Title
“Uncovering and reprogramming GPCR signaling bycomputational design”

Prof. Dr. Patrick Barth
Associate Professor (SwissFederal Institute of Technology (EPFL) Institute of Bioengineering Laboratoryof Protein and Cell Engineering) / Adjunct Associate Professor Baylor College of Medicine Department of Pharmacology and Chemical Biology

Zoom-Meeting (updated link)
https://uni-leipzig.zoom.us/j/62023799786?pwd=QUhqbml3RnVHcnNCVWt5MkVCNllqdz09

Meeting-ID: 620 2379 9786
Kenncode: 095545

Dr. Andreas Bock will give a talk about his research field. 

more information
https://research.uni-leipzig.de/sfb1423/graduate-school/ 

more information
https://research.uni-leipzig.de/sfb1423/graduate-school/ 

15:00 – 15:30
Woman in Science- Career insight: Prof. Dr. Martina Rauner (Uniklinikum Dresden, Medizin)

15:30 – 17:00
In schwierigen Gesprächen bestehen I
Monika Wimmer (Medientraining für Wissenschaftler*innen)

Registration
Please send an Email to  or via online registration form.

Title: My visibility as a scientific expert for recruiters on LinkedIn & ResearchGate

Registration:
https://research.uni-leipzig.de/sfb1423/graduate-school/

14:00 – 14:30
Woman in Science- Career insight: Prof. Dr. Irene Coin (Universität Leipzig, Biochemie)

14:30 – 17:30
Leadership: Führen von Teams I Neela Enke, Scienza-Coaching für Forschende, Berlin)

Registration
Please send an Email to  or via online registration form.

Prof. Jens Meiler will give a talk about his research field.

The Research Academy of the Leipzig University is organizing the Promotion Day on May 20, 2021. In this context, the SFB1423 will participate with a consultation hours from 1 – 3 pm.

Feel free to join this event:
https://www.ral.uni-leipzig.de/research-academy-leipzig/veranstaltungsportal/tag-der-promotion-2021/ 

Scientific Talk by
Dr. Alexander Hauser
(Department of Drug Design and Pharmacology, University of Copenhagen)

Title:
Computational receptor biology – Data science approaches to new physiological ligand discovery and towards an understanding of individual drug response variation.

Title: Know your Competencies – find your job and your career: Academia

Registration:
https://research.uni-leipzig.de/sfb1423/graduate-school/

Twice a year all members of the SFB1423 meet for a retreat to discuss the progress of the project.

Scientific Talk by
Dr. Qiuyan Chen (Prof. John Tesmer lab / Purdue University / USA)

Title:
Structure of the rhodopsin–rhodopsin kinase complex defines the rules of engagement between G protein-coupled receptors (GPCRs) and GPCR kinases

Registration
Please send an Email to .

More information coming soon.

We cordially invite you to a two week block online seminar “Solution NMR integrated with Computational Modeling to study Membrane Proteins” by:

Prof. Dr. Chuck Sanders
(Vanderbilt University / USA)
Dr. Georg Künze
(Leipzig University, Vanderbilt University / USA)
Dr. Davide Sala
(Leipzig University)

DATE
07 – 18. December 2020, 3 – 4 p.m. CEST (15:00 – 17:00 Uhr Leipzig).

AIMS
Teach theoretical and practical aspects of integrating solution NMR with computational modelling to study membrane protein computational structure, dynamics, and function.

BASICS
Biochemistry, amino acid structure, peptide bond, secondary structure, tertiary structure, biological membrane, protein sensors, protein transporters, protein channels

COURSE DESCRIPTION
The Module includes theoretical and practical aspects of protein sequence alignments, secondary structure prediction, comparative modeling, protein-protein and protein-ligand docking. Structure-based drug design, virtual screening. The relationship of protein sequence, structure, variation, and disease.

REGISTRATION
Please send an E-Mail to .

funded by Vanderbilt Leipzig University Partnerschip:
Max Kade Foundation

Cryo-Electron Microscopy of Cellular Metabolism
15.12.2020 I 4 pm I virtually

by Jun-Prof. Dr. Panagiotis Kastritis
Martin-Luther University of Halle-Wittenberg, Halle (Saale), Germany

Sign in by sending an Email to

Together with SFB1052 and TRR67 we presented our Collaborativ Research Centers during a virtual poster session of the annual DIES ACADEMICUS 2020 at Leipzig University. 

Twice a year all members of the SFB1423 meet for a retreat to discuss the progress of the project.

Poster sessions are an integral part of almost every scientific conference. Their purpose is to highlight research results, visualize them, and stimulate discussion. To draw your audience in, you need a crystal-clear message, a text format optimized for best legibility and well-chosen graphics. And above all, you need to think well through how to organize your research content on the huge A0 poster format.

Basic rules of graphic design and layout technique will help you to present your work in a visually well-structured and appealing way. The training shows you how to present your research efficiently and provides enough time to put directly into practice what you have learned.

Mareike Hemberger (Langenhan Group B06) will give an overview of her current work. Anett Albrecht will give a short insight in “Lab book guidelines & handling of research data” (30min). 

The scientific module “Expression and Preparation of GPCRs” will take place October 5-7, 2020.

A detailed program will follow soon – Topics include:

• protein production of extracellular domains in HEK293 cells and protein quality control
• protein glycosylation and its control in HEK293 cell expression
• E.coli expression
• cell free expression
• functional reconstitution in lipid membranes
• Sf9/Hi5 expression of GPCRs and G-proteins
• solubilization and purification
• sample preparation for X-ray crystallography or Cryo-EM
• and more

Participating Project Leaders :
Prof. Dr. Norbert Sträter // Dr. Peter Schmidt // Dr. Patrick Scheerer

Registration
Please send an E-Mail to .

Diego del Alamo
Vanderbilt University, Nashville, USA, on September 22nd, 4 p.m. CEST (16:00 Uhr Leipzig).

“Making the most of sparse data: Modeling the glutamate-GABA antiporter using double electron-electron resonance spectroscopy data”

The glutamate-GABA antiporter GadC is a 52 kDa membrane transporter protein that contributes to acid resistance in pathogenic bacteria such as Listeria monocytogenes and Shigella flexneri. Because the only published structure was determined crystallographically under conditions where it is inactive, the low-pH active conformation remains unknown. The study of this protein is challenged by the fact that its size precludes either traditional solution-state NMR or cryo-EM. I therefore used double electron-electron resonance (DEER) spectroscopy to monitor the protein at both high and low pH. These distance distributions, measured in lipid nanodiscs, suggest that GadC does not sample the conformation that was crystallographically resolved. Although I wanted to generate a structural model of GadC at both high and low pH, the sparseness of the data (approximately one restraint per twenty residues) presented a challenge that could only be addressed with novel sampling and scoring methods. In this presentation I will discuss these methods and how they could allow researchers to more effectively leverage sparse distance data collected using DEER to model conformational changes in integral membrane proteins. The sampling strategy I developed combines six-dimensional rigid-body transformations of secondary structural elements with fragment insertion, while the improvements in scoring focused on developing more realistic and statistically sound scoring functions. Both methods have the potential to widen the range and improve the accuracy of conformational changes that can be modeled using DEER spectroscopy.

Join via Zoom:
https://us02web.zoom.us/j/707142249?pwd=WnQ1VnIwQ254YTFnaVY2QXdKRFpoUT09

Meeting-ID: 707 142 249 // Kenncode: 439414

This year´s Summer School will take place virtually (> proposed program).

Workshops

• Prof. Dr. Daniel Huster (Good Scientific Practice)
• Dr. Carsten Rohr (Presentation – Efficiency – Writing)

Guest – Speaker

• Dr. Martha Sommer (Institute of Medical Physics and Biophysics, Charité Berlin, My twenty years’ obsession with arrestin-GPCR interactions
• Dr. Lars Baumann (Bayer AG, Research & Development, Pharmaceuticals, Lab head “Peptide Drug Innovations”) 

Syllabus – CPBP 8330 – Special Topics in Protein Biochemistry
COMPUTATIONAL METHODS TO STUDY PROTEIN STRUCTURE AND DYNAMICS

Date and Time:
The class will meet on 6 days in the weeks of August 10th and August 17th always 9:00 a.m. -12:00 p.m. MWF. The laboratory portion will proceed on the same dates 1:00-4:00 p.m. The laboratory portion on August 7th is to sort out computational issues prior to the start of the course. Additionally, relevant, recent literature will be assigned for reading. This is a one credit course.
*Times subject to change due to remote-style teaching

Room:
Virtually via Zoom.

Registration:
Students who wish to take the class for credit should register as soon as possible! Students, postdocs, and faculty who wish to audit the class are welcome. Please send a note to Jens Meiler ().

Grading:
There will be a multiple choice exam (50%) at the end of the course and the laboratory portion will be graded (50%).

The next online PhD-Meeting will take place on Wednesday, July 22 at 3 PM. Victoria Most will give a talk about her research project.

Dr. Nadine Utz
German BioImaging – Society for Microscopy and Image Analysis, c/o Universität Konstanz

Microscopy data: challenges of research data management and first approaches

Agenda

• Research data management at the local level: high fluctuation of staff –> Locatability and allocation of research data often not given
• FAIR data principle: findable, accessible, interoperable, reusable
• Comparison with other technologies: e.g. Protein Data Bank, UniProt
• Complexity of microscopy data and definition of meta data
• National and international efforts in the field of Image Data Management

Location  Online-Talk via Zoom

Registration  Please send an Email to . 

The meeting will take place on Thursday, February 27^th, 10-12 AM at Leipzig University, Faculty of Life Sciences, Seminar room SR111/112, Talstraße 33, 04103 Leipzig.

Dr. Davide Sala
Fondazione Sacconi, Milan, Italy

Computational investigation of (metallo) proteins structure and dynamics

Abstract

Proteins that require one or more metal ions to perform their biochemical function are called metalloproteins. To date, metalloproteins are estimated to be one-third of all proteins in most of the organisms and are involved in many fundamental biochemical processes. In this regard, the large diffusion of powerful and cost-effective GPGPU units has allowed the computational exploration of a number of biological processes using techniques based on molecular dynamics (MD). Thus, computational methods as MD can be exploited to investigate metalloproteins structural properties and the role of metal ions in their dynamics.

Location:
Institut für Biophysik
Härtelstraße 16 – 22, Seminarraum 017, erreichbar über den Hofeingang