Immediate job openings of the SFB1423

Here you will find vacant vacancies in our Collaborative Research Centre:

PhD STUDENT POSITION / RESEARCH ASSISTANT (f/m/x)
(65% TVL EG13)

Molecular control of G protein-coupled receptor signaling

A PhD position is available starting 1 January 2021 at the Faculty of Life Sciences, Leipzig University, to study the activation of G protein-coupled receptors (GPCRs) within the newly established collaborative research project “Structural Dynamics of GPCR Activation and Signaling”, subproject B03 “Role of extracellular loop interactions in NPY receptor activation”.

GPCRs are the largest class of transmembrane proteins with a huge variety of ligands. They have essential functions in health and disease, and are the molecular target for one third of all current pharmaceuticals. Peptide- and protein-activated GPCRs are still underrepresented in the clinical intervention, but the number of peptide therapeutics is constantly increasing. Understanding how peptide ligands interact to their receptors, and which pathways are triggered downstream of receptor activation is an essential step toward the development of more potent and selective drugs. 

Specific focus:
(i) One main aim of the project is to identify and compare different contact interfaces of peptide ligands at their receptors with respect to their role for ligand affinity and activation of different signaling pathways (G protein, arrestin), eventually aiming at the rational design of functionally selective (biased) ligands. (ii) In another part of the project, we collaborate with C. elegans biologists in the network of the SFB1423 to develop simple in vivo testing platforms to evaluate the activity of biased ligands in a more physiological surrounding.

Your profile:
We seek a highly motivated and open-minded PhD student holding a recent M.Sc. degree in Biochemistry or Biology (or equivalent) with strong interest in GPCR biology. A solid background and practical experience in cell biology and molecular biology is expected. Experience in FRET/BRET techniques, fluorescence imaging, solid-phase peptide synthesis or molecular modeling are a plus. The successful candidate should be able to work independently as well as in a team, have good communication skills, and be fluent in English (written/spoken). Professional self-organization and data-handling are mandatory.

We offer:
We offer modern equipment in spacious labs, a multi-disciplinary approach with state-of-the-art techniques, and a good working atmosphere in a young team. The position is initially limited until 12/2023 with salary according to TVL EG 13-65% (with possibility of extension, third-party funds). Severely disabled persons are encouraged to apply and will be given preference in the case of equal suitability.

Interested?

Please send your application including motivation letter, CV, copies of certificates, abstract of Master´s thesis and contact information of two references (in a single pdf file) to . Review of applications will begin immediately and applications will be accepted until the position is filled.

Please note that applying by email is not entirely secure and may pose a privacy risk. The sender assumes full responsibility. By submitting your application, you give your consent that your personal data will be collected and stored for the purpose of the application process.

Research assistant – doctoral student (d) Rudolf Schönheimer Institute for Biochemistry

part-time 26 hours/week, limited (until 31.12.2023, third-party funds)
TV-L EG 13,  embedded in the newly established SFB1423 “Structural Dynamics of GPCR Activation and Signaling”

Starting date: at the next possible date

The challenges

  • Experimental work on the investigation of adhesion GPCRs
  • Application of molecular biological and protein biochemical methods
  • Cell Culture Technologies
  • Literature research and data analysis
  • Preparation of publications and presentation of research results

Your profile

  • a university degree in life sciences or equivalent
  • basic experience in cell culture, molecular biology and protein biochemistry, microscopy, immunohistochemistry
  • comprehensive English skills
  • Team spirit

All applications must be submitted in writing, quoting the tender number, as soon as possible and should be addressed to the Personnel Department of the Medical Faculty of Leipzig University, Liebigstraße 27, House E, 04103 Leipzig. Please do not use any application folders, but submit copies only, as your documents will be destroyed in accordance with data protection regulations at the end of the application procedure.

By submitting your application, you agree that your personal data provided in the application will be processed for the purpose of the application. You can find information on the collection and processing of personal data for applicants here.

For information on the application procedure, please contact Prof. Ines Liebscher  .

Severely handicapped applicants with equal aptitude will be given preferential consideration. Please enclose appropriate evidence with your application.

The Medical Faculty of Leipzig University with its more than 600 years of tradition is one of the largest research institutions in the Leipzig region. With more than 1,200 employees, it is the largest of a total of 14 faculties of Leipzig University and serves as a training centre for approximately 3,200 students of human medicine, dentistry and pharmacy.

LINK: https://www.uniklinikum-leipzig.de/stellenangebote/Seiten/Stellenausschreibung_6325.aspx

Here closed job advertisements in our Collaborative Research Centre are listed:

Characterizing the molecular interaction between the Y receptors and arrestin
Institute of Biochemistry, Leipzig University, Annette G. Beck-Sickinger

Position shall be filled as soon as possible.

GPCRs initiate pathways of intracellular signal transduction via G-proteins. Subsequently, GPCRs are phosphorylated and bind arrestin. As of now, we have some structure-based understanding of the interaction of GPCRs with G-proteins upon activation. The situation is much less satisfying for the interaction of arrestin with activated GPCRs. Currently, only crystal structures of the rhodopsin/arrestin complex exists determined with the very new femtosecond X-ray laser technology. , Several recent studies have demonstrated that ligand- and G-protein binding result in significant structural polymorphism and dynamic alterations of the individual conformations. It has become clear that the paradigm that GPCR signaling only occurs in response to one unique agonist-based activation is far too simple. The complex dynamic activation of GPCRs can be described by a complex energy landscape that is significantly altered upon ligand and G-protein binding. In contrast to aminergic GPCRs, there is hardly any data available for the conformational dynamics of peptide-binding GPCRs or the alteration of this dynamics due to G-protein or arrestin binding. Therefore, we aim at providing structural data on the active complex of Y receptors with arrestin as well as information on the modification of the equilibrium dynamics of the receptor upon agonist and arrestin binding. To achieve this, we will (i) combine peptide synthesis and protein ligation techniques to prepare NMR-active proteins with a few isolated isotopic labels and EPR-active proteins with introduced spin labels. (ii) We will use solution and solid-state NMR techniques to determine the backbone structure of segments of arrestin in interaction with Y receptors. (iii) We will determine structural constraints to determine the mutual orientation of the Y receptors and arrestin and will verify this with mutagenesis of both, arrestin and two subtypes of the Y receptors (Y1R and Y2R). (iv) The aim of this thesis is to investigate the molecular dynamics of the Y receptors in response to agonist and arrestin binding as well as dynamic alterations in response to conformational changes arrestin undergoes upon binding to the receptor.

Within the just approved CRC 1423 (Structural Dynamics of G-protein coupled Receptors) the project shall be placed and the candidate will work in a stimulatory environment including colleagues from structural biology and molecular modelling. Protein expression and ligation as well as characterization and biological testing will be part of this thesis.

Appropriate candidates are highly motivated team players, but also able to work self-reliantly. They should have a special interest into structural dynamics of G protein-coupled receptors and should be ready to deeply engage into that matter. Experiences in peptide synthesis, protein expression, cell culture and microscopy are welcome, but not mandatory.

The applicants need to hold an M. Sc. degree in chemistry, biochemistry or equivalent. Applications should contain a motivation letter, curriculum vitae, all relevant certificates and degrees as well as contact information of references and be emailed as single PDF to Prof. Dr. Annette Beck-Sickinger. Applications will be reviewed immediately and interviewed (personally/video).

PhD positions open at the Institute of Medical Physics and Biophysics at Leipzig University

Part-time, temporary employment, limited to 3 years, prolongation possible
Payment in accordance with TV-L

Starting date: as soon as possible

The ProteinFormatics laboratory at Leipzig University, located at the Institute of Medical Physics and Biophysics, offers an international and stimulating environment for G protein coupled receptor (GPCR) research, a key area in pharmacological research. Positions are open in the newly funded collaborative research centre CRC1423 on receptor dynamics, involving institutions from Leipzig, Berlin and Halle. GPCR dynamics plays an essential role in ligand bind-ing, receptor activation and specific downstream signaling. By means of molecular dynamics (MD) simulations we investigate the dynamic properties of GPCRs, evaluate important interaction sites with ligands and downstream signaling proteins with the aim to improve the understanding of GPCR function and to develop drugs with improved pharmacological properties.

Two highly motivated students are sought to contribute to the group’s efforts in this area of research. The successful applicants will be involved in set up and analysis of classical MD simulations and sampling of GPCRs conformational states to investigate binding of peptide ligands to GPCRs and evaluate the effect of ligand binding to G protein coupling, respectively. She/he will communicate results from computational analysis to collaboration partners and develop novel workflows for automated analysis. The framework of the project includes in addition to close collaborations with other theoretical and experimental research groups within the CRC, international collaborations such as with the BIH Einstein Visiting Fellow Prof. Brian Kobilka in Berlin.

The highly motivated candidates should have master in biophysics, bioinformatics, medicinal chemistry or a related field and extensive experience in setup and analysis of molecular dynamics simulations. Excellent communication and presentation skills and the ability to work in an international environment are expected. Expertise in GPCR related research, enhanced sampling techniques and machine learning would be considered a bonus. Familiarity with scientific programming would be considered an additional advantage.

Please send your application to .

Position shall be filled as soon as possible, but preferably before July 1st, 2020.

Severely handicapped applicants will be given priority over equally qualified applicants.

Prof. Dr. Peter Hildebrand
Institut für Medizinische Physik und Biophysik Universität Leipzig
Härtelstraße 16-18, D – 04107 Leipzig
+49 341 97 15 712

Berlin laboratory at Charité:
+49 30 450 524 190
+49 30 450 524 138

Master Thesis/Student assistent (d) – Receptor Signaling Group, MDC Berlin
Master thesis: “Investigating how receptor subcellular distribution affects signaling specificity”

G protein-coupled receptors (GPCRs) form the largest class of membrane-bound receptors and represent one of the most important drug targets. Activation of GPCRs by extracellular ligands leads to a highly complex intracellular signaling pattern. In the context of a DFG funded project, we are now investigating by means of advanced fluorescence spectroscopy and microscopy methods the the effect that subcellular localization of receptors has on modulating downstream signaling. The project will involve (i) molecular cloning of new constructs and receptor mutants which affect their interaction with intracellular structures, most prominently the cortical actin scaffold; (ii) single molecule fluorescence imaging of these receptors, their dynamics and their coupling to downstream effectors.

Requirements
The successful applicant will have a Bachelor’s degree in Molecular Biology, Biophysics, Biochemistry or scientifically-related areas. A background in cell culture and molecular cloning is expected. Experience with fluorescence microscopy is advantageous. The successful applicant should be highly motivated and willing to work in an interdisciplinary team of international scientists.

The MDC is an equal opportunity employer and supports gender equality.
Please, send your application including all documents indicating the registration number preferably by e-mail to as pdf files (2 files of 5 MB at the maximum) as we do not return any papers.

Salary: Collective agreement for student employees

Start date: As soon as possible

Limitation: 6 months

Application Period: 25.03.2020

Contact
Dr. Paolo Annibale ()
Prof. Dr. Martin J. Lohse ()

Postal address
Please, send your application including all documents indicating the registration number prefera-bly by e-mail to or as pdf files (2 files of 5 MB at the maximum) as we do not return any papers.

LINK: https://application.mdc-berlin.de/ or https://www.mdc-berlin.de/career/jobs/master-thesisstudentische-hilfskraft-m-f-d-9hw

Research assistant (d) (5895) Institute for Drug Development

full-time/part-time possible, limited to 2 years (with possibility of extension, third-party funding), TV-L EG 13

Starting date: at the next possible date

The challenges
New Institute for Drug Development at Leipzig University is looking for a postdoctoral researcher for the joint research project “Structural dynamics of GPCR activation and signal transduction”. Availability of the position is subject to approval of funds and is expected to start on 1 January 2020.

Your profile

  • scientific computing (C ++, Python, R, etc.)
  • computational biology (molecular dynamics, Monte Carlo, Rosetta, Gromacs, Amber, comparative modeling, ligand docking or similar)
  • machine learning (artificial neural networks, support vector machines, random forest or similar)
  • Experience with the discovery of GPCR agents (synthesis of small molecules, assaying or similar)

The Institute for Drug Development at Leipzig University, headed by Humboldt Professor Jens Meiler, integrates innovative, computer-aided approaches for the design of therapeutics with experimental validation and optimization.

All applications must be submitted in writing, quoting the call number (5895), by 02.03.2020 at the latest and should be addressed to the Personnel Department of the Medical Faculty of Leipzig University, Liebigstraße 27, House E, 04103 Leipzig. Please do not use any application folders, but submit copies only, as your documents will be destroyed in accordance with data protection regulations at the end of the application procedure.

By submitting your application, you agree that your personal data provided in the application will be processed for the purpose of the application. You can find information on the collection and processing of personal data for applicants here.

For information on the application procedure, please contact Anja Landsmann on 0341/ 97-15941 or .

Severely handicapped applicants with equal aptitude will be given preferential consideration. Please enclose appropriate supporting documents with your application.

The Medical Faculty of Leipzig University with its more than 600 years of tradition is one of the largest research institutions in the Leipzig region. With more than 1,200 employees, it is the largest of a total of 14 faculties of Leipzig University and serves as a training centre for approximately 3,200 students of human medicine, dentistry and pharmacy.

LINK: https://www.uniklinikum-leipzig.de/stellenangebote/Seiten/Stellenausschreibung_5895.aspx 

Research assistant – doctoral student (d) (5828) Rudolf Schönheimer Institute for Biochemistry

part-time 26 hours/week, limited (until 31.12.2023, third-party funds)
TV-L EG 13,  embedded in the newly established SFB1423 “Structural Dynamics of GPCR Activation and Signaling”

Starting date: at the next possible date

The challenges

  • experimental work on the investigation of adhesion GPCRs
  • Application of molecular biological and protein biochemical methods
  • Application in vitro and in vivo (Drosophila melanogaster) methods
  • Literature research and data analysis
  • Preparation of publications and presentation of research results

Your profile

  • a university degree in life sciences or equivalent
  • basic experience in cell culture, molecular biology and protein biochemistry, microscopy, immunohistochemistry
  • Experience in working with Drosophila melanogaster
  • comprehensive English skills
  • Team spirit

All applications must be submitted in writing, quoting the tender number, by 09.03.2020 at the latest and should be addressed to the Personnel Department of the Medical Faculty of Leipzig University, Liebigstraße 27, House E, 04103 Leipzig. Please do not use any application folders, but submit copies only, as your documents will be destroyed in accordance with data protection regulations at the end of the application procedure.

By submitting your application, you agree that your personal data provided in the application will be processed for the purpose of the application. You can find information on the collection and processing of personal data for applicants here.
For information on the application procedure, please contact Prof. Tobias Langenhan on 0341/ 97-22101 or .

Severely handicapped applicants with equal aptitude will be given preferential consideration. Please enclose appropriate evidence with your application.

The Medical Faculty of Leipzig University with its more than 600 years of tradition is one of the largest research institutions in the Leipzig region. With more than 1,200 employees, it is the largest of a total of 14 faculties of Leipzig University and serves as a training centre for approximately 3,200 students of human medicine, dentistry and pharmacy.

LINK: https://www.uniklinikum-leipzig.de/stellenangebote/Seiten/Stellenausschreibung_5828.aspx

Doctoral Position (d) Receptor Signaling Group, Department Signaling Processes of Receptors, MDC Berlin

The Max-Delbruck-Center (MDC) Berlin is a leading biomedical research institute dedicated to interdisciplinary research in the areas of Cardiovascular and Metabolic Diseases, Cancer, Function/Dysfunction of the Nervous System and Medical Systems Biology. We would like to open a doctoral position within the Receptor Signaling group, which focuses on the mechanisms of activation and signaling of G-protein coupled receptors (GPCR), and subsequent downstream events which lead to alterations in cell function. We are looking for a talented Doctoral Student to join our international team.

The position is funded within the framework of the DFG grant SFB1423 Structural Dynamics of GPCR Activation and Signaling, in collaboration between the University of Leipzig and the MDC-Berlin. The position has funding for up until December 31st 2023. Starting date is the first of March or a later date upon agreement with the candidate.

G protein-coupled receptors (GPCRs) form the largest class of membrane-bound receptors and represent one of the most important drug targets. Activation of GPCRs by extracellular ligands leads to a highly complex intracellular signaling pattern which is governed by a few so-called ‘second messengers’ such as cyclic nucleotides (cAMP and cGMP) and calcium. The position will be focused on addressing biophysical aspects of GPCR signaling, ranging from receptor localization and dynamics in primary cell lines to compartmentalization of second messengers such as cyclic adenosine monophosphate (cAMP).

In particular, a specific focus will be

  • GPCR dynamics and localization in adult cardiomyocytes, a question with important pharmacological and clinical implications.
  • Investigation of the role of receptor coupling to downstream effectors, and its modulation by the local environment of the cell. Cytoskeletal scaffolds and membrane curvature will be the prime biophysical focus.
  • Assessing the mechanism leading to second messenger compartmentalization in the cell, and its implications in health and disease

The research will be based upon a broad palette of techniques, centered on state-of-the-art optical methods including FRET, single-molecule and super-resolution microscopy. The successful candidate will enjoy the unique possibility of working within an international network of peers, consisting of partner labs in Berlin, Leipzig and Halle.

Requirements
The successful applicant will have a Master’s degree in Molecular Biology, Biochemistry Biophysics or scientifically related areas. Previous experience in optical microscopy, Practical experience in handling laboratory mice and molecular cloning will be considered advantageous. The successful applicant should be highly motivated and willing to work in an interdisciplinary team of international scientists.

The MDC is committed to diversity and actively supports equal opportunities for all employees regardless of their origin, religion, ideology, disability, age or sexual identity. Therefore, we are welcoming applications from all qualified individuals (m/f/d). Severely disabled persons will be given preferential treatment in the case of equal qualification. The MDC is certified by the “work and family” audit and provides an inclusive and family friendly environment.

The MDC is an equal opportunity employer and supports gender equality.

Applicants should submit their CV including, where present, a list of publications as well as the contact addresses of three referees. Please, send your application including all documents indicating the registration number preferably by e-mail to as pdf files (2 files of 5 MB at the maximum) as we do not return any papers.

Salary
PhD researchers are fully funded through an initial 3-year employment contract with the MDC, according to 65% TVöD 13 (monthly net payment of approximately 1600 EUR). Health and social insurance are included in the contract.

Start date: 12th of March or later date

Limitation: 31st December 2023

Application Period: 11th of March

LINK: https://www.mdc-berlin.de/career/jobs/doctoral-position-receptor-signaling-group

Fellowship 

The SFB1423 offers fellowships (up to 5 months) for doctoral projects in its subprojects for

  • Scholarships for PhD students with a master’s degree or diploma (university) in natural sciences
  • Scholarships for medical students (after first level of the Medical Exam)

Guest stay / Guest lecture

The Collaborative Research Center 1423 offers financial support for travel expenses for visiting researchers planning a lecture, seminar or joint research project on a topic related to our research area. If you are interested, please contact the responsible project leader and request support.

Unsolicited Application

You can send us an unsolicited application for:

  • Research Assistants & Employees
  • Doctoral students
  • Scientific assistants 

Please indicate your desired position and subproject in the cover letter. Please send your documents as PDF to . Further job advertisements from DFG-funded projects can be found here: Announcements from DFG-funded projects.