Dear friends of the SFB1423,as this special year comes to an end, we want to thank you for the constructive

Cells communicate with each other and with their environment via receptors. The G-protein coupled receptors (GPCRs) are the largest group of membrane receptors and occur in almost all living organisms. In the Collaborative Research Centre 1423 „Structural Dynamics of GPCR Activation and Signal Transduction„, scientists from the life sciences, medicine, pharmacy and bioinformatics of our university are investigating the interactions of GPCRs, the peptide receptors and the adhesion receptors, which have so far been little studied, together with their partners at the Charité – Universitätsmedizin Berlin, the Max Delbrück Centre for Molecular Medicine in the Helmholtz Association and the Martin Luther University Halle-Wittenberg.
The aim of this CRC initiative is to understand the structural dynamics of ligand binding, signal transduction, and downstream control of G protein- and arrestin-signaling pathways using native ligands as well as artificial probe molecules in conjunction with hybrid methods of structural biology including NMR, X-ray (conventional and serial protein X-ray crystallography at synchrotrons and free electron lasers), cryo-electron microscopy, mass spectrometry and computational methods (molecular modeling and dynamics). Phenomena such as biased signaling are tackled using assays that target specific signaling pathways. Results are tied in with a phylogenetic analysis of GPCRs, arrestins and G proteins. One goal of the CRC is to clarify the dynamic structural states of these GPCRs in order to understand their functions. This could lead to the development of novel therapeutics for this class of GPCRs.
On this page you will find a compilation of current news and events.
The current seminars within the framework of graduate education can be found on this page.
Numerous publications have been produced within the framework of the SFB 1423.
Here you will find vacant vacancies in our Collaborative Research Centre.
Dear friends of the SFB1423,as this special year comes to an end, we want to thank you for the constructive
We cordially invite you to a talk about "Cryo-Electron Microscopy of Cellular Metabolism" by Jun-Prof. Dr. Panagiotis KastritisMartin-Luther University of Halle-Wittenberg,
We cordially invite you to a two week block online seminar “Solution NMR integrated with Computational Modeling to study Membrane Proteins” by:
We cordially invite you to an online seminar by: Diego del Alamo, Vanderbilt University, Nashville, USA, on September 22nd, 4
The scientific module "Expression and Preparation of GPCRs" will take place October 5-7, 2020. Topics include: protein production of extracellular
In the last weeks the following publications have been published within the SFB1423. Be amazed and read them yourself. Bock
We are happy to announce the first version of the CRC1423 Summer School held from September 14-18, 2020. The meeting
Although it is still almost 2 months until the ECSF2.0 meeting in Berlin in May, we decided to postpone the
[JANUARY 09, 2020 / CHRISTINA ANDERS / MDC News ] The DFG is funding two new research projects at the
The University’s new Collaborative Research Centre (CRC), “Structural Dynamics of GPCR Activation and Signal Transduction”, will focus on how cells
Leipzig University
Faculty of Life Sciences
Institute of Biochemistry
Brüderstrasse 34
04103 Leipzig
Germany
DFG Project number
421152132
Funding period
2020 – 2023
Coordinating university
Leipzig University