DFG/Collaborative Research Center 1423:
Structural Dynamics of GPCR Activation and Signaling

Cells communicate with each other and with their environment via receptors. The G-protein coupled receptors (GPCRs) are the largest group of membrane receptors and occur in almost all living organisms. In the Collaborative Research Centre 1423 „Structural Dynamics of GPCR Activation and Signal Transduction„, scientists from the life sciences, medicine, pharmacy and bioinformatics of our university are investigating the interactions of GPCRs, the peptide receptors and the adhesion receptors, which have so far been little studied, together with their partners at the Charité – Universitätsmedizin Berlin, the Max Delbrück Centre for Molecular Medicine in the Helmholtz Association and the Martin Luther University Halle-Wittenberg.

The aim of this CRC initiative is to  understand the structural dynamics of ligand binding, signal transduction, and downstream control of G protein- and arrestin-signaling pathways using native ligands as well as artificial probe molecules in conjunction with hybrid methods of structural biology including NMR, X-ray (conventional and serial protein X-ray crystallography at synchrotrons and free electron lasers), cryo-electron microscopy, mass spectrometry and computational methods (molecular modeling and dynamics). Phenomena such as biased signaling are tackled using assays that target specific signaling pathways. Results are tied in with a phylogenetic analysis of GPCRs, arrestins and G proteins.  One goal of the CRC is to clarify the dynamic structural states of these GPCRs in order to understand their functions. This could lead to the development of novel therapeutics for this class of GPCRs.

Projects of the SFB 1423

News & Events of the SFB 1423

News & Events

On this page you will find a compilation of current news and events.

Seminars

The current seminars within the framework of graduate education can be found on this page.

Publications

Numerous publications have been produced within the framework of the SFB 1423.

Jobs

Here you will find vacant vacancies in our Collaborative Research Centre.

Latest news of the SFB 1423

Prof. Dr. Jens Meiler und Prof. Dr. Annette G. Beck-Sickinger im Institut für Biochemie. Foto: Universität Leipzig / Swen Reichhold

DFG Grant for SFB

The University’s new Collaborative Research Centre (CRC), “Structural Dynamics of GPCR Activation and Signal Transduction”, will focus on how cells

Post

Leipzig University
Faculty of Life Sciences
Institute of Biochemistry

Brüderstrasse 34
04103 Leipzig
Germany

Project information

DFG Project number
421152132
Funding period 
2020 – 2023
Coordinating university
Leipzig University