From May 11 – 13, 2022 the Project Leader and Members of the SFB1423 meets at the Hotel Kloster Nimbschen (Grimma).The
International Symposium
26.-29.09.2022 Save the date
DFG/Collaborative Research Center 1423:
Structural Dynamics of GPCR Activation and Signaling
Cells communicate with each other and with their environment via receptors. The G protein-coupled receptors (GPCRs) are the largest group of membrane receptors and occur in almost all living organisms. In the Collaborative Research Centre 1423 „Structural Dynamics of GPCR Activation and Signaling„, scientists from the life sciences, medicine, pharmacy and bioinformatics of our university are investigating the interactions of GPCRs, the peptide receptors and the adhesion receptors, which have so far been little studied, together with their partners at the Charité – Universitätsmedizin Berlin, the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and the Martin Luther University Halle-Wittenberg.
The aim of this CRC initiative is to understand the structural dynamics of ligand binding, signal transduction, and downstream control of G protein- and arrestin-signaling pathways using native ligands as well as artificial probe molecules in conjunction with hybrid methods of structural biology including NMR, X-ray (conventional and serial protein X-ray crystallography at synchrotrons and free electron lasers), cryo-electron microscopy, mass spectrometry and computational methods (molecular modeling and dynamics). Phenomena such as biased signaling are tackled using assays that target specific signaling pathways. Results are tied in with a phylogenetic analysis of GPCRs, arrestins and G proteins. One goal of the CRC is to clarify the dynamic structural states of these GPCRs in order to understand their functions. This could lead to the development of novel therapeutics for this class of GPCRs.
Projects of the SFB 1423
News & Events of the SFB 1423
News & Events
On this page you will find a compilation of current news and events.
Seminars
The current seminars within the framework of graduate education can be found on this page.
Publications
Numerous publications have been produced within the framework of the SFB 1423.
Jobs
Here you will find vacant vacancies in our Collaborative Research Centre.
Latest news of the SFB 1423
Small changes, but essential!
Researchers discover molecular mechanisms of signal recognition of the neuropeptide system(Press release 2022/085 from 05/05/2022) The human body consists of trillions
How mechanical stimuli trigger
International GPCR research collaboration deciphers structure of active receptors (Press release 2022/072 from 14/04/2022, written by Peggy Darius) Breathing, seeing, hearing
Winter School of the
Twice a year, the Graduate School of the SFB1423 organizes a doctoral meeting that acts as a forum to present
Communication between cells is
(written by Katharina Reichert, Leipzig University Magazin 16.03.2022) So-called G protein-coupled receptors (GPCRs) form the largest group of membrane receptors and
New SFB1423 publications available
At the end of a long research work is the publication of their results. Be amazed and read them yourself.Catar
Season´s Greetings
Dear friends of the SFB1423, The whole team of the SFB1423 wishes you MERRY CHRISTMAS and a HAPPY and HEALTHY
4GPCRnet – International Symposium
We cordially invite you to the 4GPCRnet International Symposium that will take place September 26-29, 2022 in Leipzig, Germany. The event is organized
Insight into the molecular
New joint Publication by subproject A01, A05, Z03, B02 and C01/Z04: Activation of the G-protein-coupled MC4R receptor by the drug
Scientific Module – Exploring
We cordially invite you to a one week block online seminar “Exploring Biomolecules in 3D: Principles and Applications of Computational
Long Night of Sciences
The “Long Night of the Sciences” will take place digitally on Friday, 16 July 2021. The SFB1423 is participating with
Scientific Talk – Uncovering
Prof. Patrick Barth (EPFL*) will give a scientific talk about Uncovering and reprogramming GPCR signaling bycomputational design within our Lecturer
Scientific Module – GPCR
The scientific module "GPCR downstream effectors, it’s all about enzyme kinetics" will take place June 23-25, 2020. Topics include: Downstream effectors
New joint publication of
Clustering of receptors can have the same effect as binding a signalling moleculeCell Biology: Signal Transduction Without Signal[Press release 2021/042
GENDER-WORKSHOPS 2021: Equal opportunities
The SFB1423, the TRR67 and the SFB1052 pool gender equality measures, ideas and offers, in order to sustainably establish the
New joint publication of
[Press release 2021/032 from 10/02/2021; author: Nina Vogt] In order for a drug to be effective at the right places
Dr. Simone Prömel appointed
Congratulations: Dr. Simone Prömel was appointed W2 Professor of Cell Biology at HHU on January 21, 2021.Prof. Prömel's research focuses
Season Greetings
Dear friends of the SFB1423,as this special year comes to an end, we want to thank you for the constructive
Scientific Talk
We cordially invite you to a talk about "Cryo-Electron Microscopy of Cellular Metabolism" by Jun-Prof. Dr. Panagiotis KastritisMartin-Luther University of Halle-Wittenberg,
Scientific Module
We cordially invite you to a two week block online seminar “Solution NMR integrated with Computational Modeling to study Membrane Proteins” by:
Scientific Talk – Making
We cordially invite you to an online seminar by: Diego del Alamo, Vanderbilt University, Nashville, USA, on September 22nd, 4
Scientific Module – Expression
The scientific module "Expression and Preparation of GPCRs" will take place October 5-7, 2020. Topics include: protein production of extracellular
New SFB1423 publications available
In the last weeks the following publications have been published within the SFB1423. Be amazed and read them yourself. Bock
1st virtual Summer School
We are happy to announce the first version of the CRC1423 Summer School held from September 14-18, 2020. The meeting
Postponed: Second Early Career
Although it is still almost 2 months until the ECSF2.0 meeting in Berlin in May, we decided to postpone the
Award for new research
[JANUARY 09, 2020 / CHRISTINA ANDERS / MDC News ] The DFG is funding two new research projects at the
DFG Grant for SFB
The University’s new Collaborative Research Centre (CRC), “Structural Dynamics of GPCR Activation and Signal Transduction”, will focus on how cells
Trailer of the SFB 1423
Post
Leipzig University
Faculty of Life Sciences
Institute of Biochemistry
Brüderstrasse 34
04103 Leipzig
Germany
Social Media
Project information
DFG Project number (GEPRIS)
421152132
Funding period
2020 – 2023
Coordinating university
Leipzig University